61. GEMdatabase - Selected Title TITLE alexander disease. DESCRIPTION This review focuses on the diagnosis, management,and genetic counseling of patients and families with alexander disease. http://www.gemdatabase.org/GEMDatabase/TitleDetailsOne.asp?TitleID=820

62. NINDS Alexander Disease Information Page More about NINDS alexander disease Information Page. Contact us Content forthis page. NINDS alexander disease Information Page. Reviewed 1201-2003 http://accessible.ninds.nih.gov/health_and_medical/disorders/alexand_doc.htm

Disorders - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus Main sections of the NINDS web site Home About NINDS Disorders-you are in this section ... Find People Disorders section pages and search Image Description Science For the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system. Select Topic Disorder Quick Links Alzheimer's Autism Cerebral Palsy Chronic Pain Epilepsy Headache Multiple Sclerosis Parkinson's Stroke Traumatic Brain Injury More about NINDS Alexander Disease Information Page Studies with patients Research literature Press release NINDS Search (search help) Contact us My privacy NINDS is part of the National Institutes of Health Contact us Content for this page NINDS Alexander Disease Information Page Reviewed 12-01-2003 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Alexander Disease? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Alexander Disease? Is there any treatment?

63. SMIL - Skandinavisk Medisinsk Informasjon For Legfolk Norsk Dansk Svensk norsk, Emner, A, B, C, D, E, F, G, H, I, J, K, L, M, N,O, P, Q, R, S, T, U, V, W, X, Y, Z, Æ, Ø, Å, 0-9. HJELP. Nevrologiske sykdommer alexander disease . http://www.smil.uio.no/index.php?columns=3&action=subject&letter=N&subject=506&c

64. Alexander Disease / Waisman Center http://www.waisman.wisc.edu/alexander/

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65. Alexander Disease Bibliography By Topic Messing, A. and Brenner, M. alexander disease GFAP mutations unify young andold. Lancet Neurology 2, 75, 2003. alexander disease a review and the gene. http://www.waisman.wisc.edu/alexander/bib-topic.html

Recent Reviews Genetics Familial - Putative Familial Adult Onset Recent Reviews Messing, A. and Brenner, M. Alexander disease: GFAP mutations unify young and old. Lancet Neurology GFAP mutations in Alexander disease. International Journal of Developmental Neuroscience 20:259-268, 2002. A. B. Johnson. Alexander disease: a review and the gene Int.J.Dev.Neurosci. Alexander disease: new insights from genetics. Journal of Neuropathology and Experimental Neurology Quinlan, R. (2001). Cytoskeletal catastrophe causes brain degeneration Nature Genetics Small heat shock proteins, the cytoskeleton, and inclusion body formation. Genetics A novel GFAP mutation and disseminated white matter lesions: adult Alexander disease? Europ. Neurol. Adult Alexander disease with autosomal dominant transmission: a distinct entity caused by mutation in the glial fibrillary acid protein gene. Arch.Neurol. Trollmann, R., Kraus, C., Orlova, N., Rupprecht, T., Wenzel, D., and Rauch, A. (2003). In vivo diagnosis of infantile Alexander disease by molecular genetic analysis of GFAP gene. Case report [German].

66. Alexander('s) Disease/Syndrome HOME. Alexander( s) Disease/Syndrome (Dysmyelinating Disease). alexander disease;Alexanders; alexander disease; alexander disease; Alexander s Disease; http://www.bdid.com/alexander.htm

HOME Alexander('s) Disease/Syndrome (Dysmyelinating Disease) Alexander disease Alexanders Alexander Disease Alexander disease ... ALEXANDER DISEASE Also see Leukodystrophy HOME

67. Central Nervous System Diseases alexander disease MCW Health Link (US). alexander disease - OMIM (US).About alexander disease - NORD (US). Hallervorden-Spatz Syndrome. http://www.mic.ki.se/Diseases/C10.228.html

search search staff sitemap ABOUT KAROLINSKA INSTITUTET ... print this page Diseases and Disorders Links pertaining to Central Nervous System Diseases Alert! Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Start Page Contents: Adrenoleukodystrophy Alzheimer Disease Arachnoiditis Brain Abscess ... Zellweger Syndrome Central Nervous System Diseases Nerve Cells [Lodish et al.] - Molecular Cell Biol., Chap 21, via NLM (US) Pathol. Images of the Central Nervous System - Univ of Utah (US) The Human Brain [JD MacArthur] The Global Brainstem '97 , the Cerebellum '97 , the Thalamus '97 , the Spinal Cord '97 - Univ. of Wisconsin (US) Mental Disorders Links Brain Diseases Brain Functions and Map - Centre for Neuro Skills The Whole Brain Atlas - Atlas Project/Harvard Medical School et al. (US) Dissections of the Real Brain [Williams et al] - Univ of Iowa (US) Anatomy of the Brain - AANS Leukodystrophy (not on MeSH) Leukodystrophy - NINDS The United Leukodystophy Foundation , including

68. Neurology -- Abstracts: Gorospe Et Al. 58 (10): 1494 Neurology 2002;5814941500 © 2002 American Academy of Neurology Molecularfindings in symptomatic and pre-symptomatic alexander disease patients. http://www.neurology.org/cgi/content/abstract/58/10/1494

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Figures Only for this Article Full Text of this Article PDF Version of this Article Citation Map ... Email this article to a friend Correspondence: Submit a response to this article Similar articles found in: Neurology Online PubMed PubMed Citation This Article has been cited by: other online articles Search PubMed for articles by: Gorospe, J. R. Hoffman, E. P. Alert me when: new articles cite this article Download to Citation Manager Collections under which this article appears: Metabolic disease (inherited) Leukodystrophies All Pediatric All Genetics Neurology American Academy of Neurology Molecular findings in symptomatic and pre-symptomatic Alexander disease patients J. R. Gorospe, MD PhD S. Naidu, MD A. B. Johnson, MD V. Puri, MD G. V. Raymond, MD S. D. Jenkins, MD R. C. Pedersen, MD D. Lewis, MD P. Knowles, MD R. Fernandez, MD D. De Vivo, MD M. S. van der Knaap, MD A. Messing, VMD PhD M. Brenner, PhD and E. P. Hoffman, PhD

69. Search Jablonski's Syndromes Database MedlinePlus Degenerative Nerve Diseases Stroke) Short Summary; alexander disease (National Institute of NeurologicalDisorders and Stroke) - Short Summary; Alpers Disease http://www.nlm.nih.gov/cgi/jablonski/syndrome_cgi?term=Alexander disease&field=n

70. James E. Goldman, MD, PhD We are also studying alexander disease, a leukodystrophy in which the braindoes not myelinate properly and astrocytes accumulate massive amounts of http://www.research.hs.columbia.edu/Faculty_Profiles/profiles/goldman_je.html

CUMC Home About Education Research ... Patient Care Faculty Profile Address: 630 West 168th Street Room 15-420 New York, NY 10032 Phone: Fax: jeg5@columbia.edu Education and Training M.D., Ph.D. New York Med College Affiliations Department of Pathology Psychiatry Stem Cell Consortium Taub Institute for Research on Alzheimer's Disease and the Aging Brain Training Graduate and Research Programs in Pathobiology MD/PhD Program James E. Goldman, M.D., Ph.D. Professor of Pathology Research Summary Neurodegenerative disorders Our lab has been tracing cell lineages in the developing mammalian CNS to study the origins of neurons and glia from immature neuroectodermal cells. Using recombinant retroviruses to transfer genes into progenitor cells, we have followed the migration and differentiation of immature cells of germinal zones in vivo and have determined time- and location-specific patterns of glial development. We are examining what roles environmental vs. lineage-controlled factors play in specifying cell fates. We are particularly interested in how progenitors migrate through the developing brain, focusing on molecular mechanisms that regulate the direction, the beginning and the cessation of migration. Our lab is also starting to examine these same type of mechanisms as they apply to glial tumor migration through the brain.

71. Cleveland Clinic Health System - Health Information Search Results The following information is available for the topic alexander disease.Please select one. Care Treatment. , alexander disease. New Search. http://www.cchs.net/health/getcontents.asp?DocID=do-query&TopicId=1272

72. Applied Genetics News: Gene Defect For Alexander Disease You are Here Articles Applied Genetics News Jan, 2001 Article.Gene Defect for alexander disease. Applied Genetics News, Jan, 2001. http://www.findarticles.com/cf_dls/m0DED/6_21/69709517/p1/article.jhtml

@import url(/css/us/style.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); Advanced Search Home Help IN all publications this publication Reference Automotive Business Computing Entertainment Health News Reference Sports YOU ARE HERE Articles Applied Genetics News Jan, 2001 Content provided in partnership with Print friendly Tell a friend Find subscription deals Gene Defect for Alexander Disease Applied Genetics News Jan, 2001 Scientists led by University of Wisconsin-Madison researcher Able Messing have pinpointed the gene responsible for a rare and devastating childhood brain disorder called Alexander disease, solving a 50-year-old mystery regarding its cause. Their work is reported in the January 3 issue of Nature Genetics. Musing's team discovered the gene after a genetic analysis of 13 cases of the disease. Because of the rarity of the disease, it took nearly two years to assemble enough cases from international sources to complete the study. Alexander disease is in a family of disorders called leukodystrophies, in which abnormalities arise in the myelin sheath. It often strikes infants before their first year of age and causes catastrophic damage throughout the nervous system. Most children do not survive past age six. Serendipity was on the side of the researchers in discovering the mutation. Messing and collaborator Michael Brenner of the University of Alabama-Birmingham developed a transgenic mouse that unexpectedly exhibited the hallmark traits of Alexander disease, which narrowed the field for finding the responsible gene.

73. Abstract 2000 alexander diseaseclassification revisited and isolation of a neonatalform. Neuropediatrics 2000 Apr;31(2)8692 alexander disease http://www.medizin.uni-tuebingen.de/~rtkolb/neurorad/publi/abstracts/00-008.html

Abstract Springer S, Erlewein R, Naegele T , Becker I, Auer D, Grodd W , Krageloh-Mann I Alexander diseaseclassification revisited and isolation of a neonatal form. Neuropediatrics 2000 Apr;31(2):86-92 Links to: Dept. of Neuroradiology University Hospital University Last change: 14-February-2001 M.Strayle-Batra

74. FORMULAIRE INSCRIPTION RECHERCHE WWW.LACHAINETTE.COM Translate this page Contacts Enfermedad seleccionada alexander diseaseId, First name, Country, Web. 1642, michéle, FRANCE, http://www.lachainette.com/ES/ContactsPathologie.php?Action=contacter&Id=1

75. FORMULAIRE INSCRIPTION RECHERCHE WWW.LACHAINETTE.COM Translate this page Contacts Rare disease selected alexander diseaseId, First name, Country, Web. 1642, michéle, FRANCE, http://www.lachainette.com/US/ContactsPathologie.php?Action=contacter&Id=1

76. Neuroguide.com - Human Neurological Diseases Web sites providing information on human neurological diseases can be accessedvia this section. alexander disease. alexander disease Information (NINDS). http://www.neuroguide.com/cgi-bin/pdistoc.pl?file=AlexanderDisease

77. Alexander Disease: New Insights From Genetics alexander disease New Insights From Genetics. Albee Messing, VMD, PhD, a , b JamesE. Goldman, MD, PhD, a Anne B. Johnson, MD, a and Michael Brenner, PhD a http://apt.allenpress.com/aptonline/?request=get-abstract&issn=0022-3069&volume=

78. Managing Pig Health, Treating Pig Diseases, Pig Health And Welfare. Practical manual providing detailed information on pigs, hogs, swine. This 600+ page book, written by Mike Muirhead and Tom alexander is written in an easily understandable format and is aimed at everyone involved in swine production, from the farmer to the professional. Web site gives book contents and has an order form. http://www.managingpighealth.com

Promote your business here Make ThePigSite your homepage! Friday, September 19, 2003 About News Books Book Draw ... FREE Weekly Newsletter Information Center Managing Pig Health Stockmanship Standards Quick Disease Guide Disease Problem Solver ... close Featured Articles Discussion Forums Business Directory Meet the Experts Our Main Sponsors Supporting Partners rl consulting Want your Company listed here? Click for more details Got Poultry? Why not visit us at: The PigSite Pig Health Management Area Browse Option You are in Managing Pig Health section of thePigSite.com where you can browse through over 600 pages of information on managing the health aspects of a pig or hog farm. The information in this section is taken from our book Managing Pig Health and the Treatment of Disease written by Mike Muirhead and Tom Alexander. If you would like to buy a copy of the book (for bedtime reading!) it can be purchased from our book shop If you would prefer to search the contents of this section you can do so by clicking here Select a Chapter to Browse Cptr 1. Anatomy, Physiology and technical terms

79. Chronic Fatigue Syndrome And The Alexander Technique How this centuryold method of releasing harmful stress can be of benefit to a patient with this disease. http://www.alexandertechnique.com/articles/chronicfatigue

Chronic Fatigue Syndrome and the Alexander Technique by Martin Finnegan What exactly is Chronic Fatigue Syndrome?* Sometimes referred to as ME or Myalgic Encephalomyelitis, it is a term that describes a chronic, debilitating disorder that affects the immune and central nervous system. Typical of its symptoms are a profound fatigue, totally out of proportion to a person's physical activity and independent of mood, plus a range of other symptoms that can affect any organ of the body. The causes of CFS are unknown. Indeed there appear to be any number of apparent causes and in many cases the onset seems to be linked to a stress to the immune system such as an acute infection, especially viral in nature. After the stress or virus has run its course the symptoms do not abate as you would expect but set in, becoming chronic and are often associated with profound fatigue and feelings of general malaise. Western medicine advocates rest, counseling, adjusting lifestyle and support as the best approach to treating CFS and this is all good advice. The problem, it seems to me is one of perception. The orthodox point of view perceives CFS as a thing. It is my opinion that CFS is not a thing at all, which is the reason that no cause and no diagnosis can be found. It is a process. A process of a human system running down, in a variety of ways, to such a point that it can't function properly anymore. In my own experience of CFS, it was exactly that and the solution was not to attempt to 'fix' a part of my body but to address the whole of 'me' and my life, in all its various aspects - physical, mental, emotional and spiritual. And the new model that I followed worked.

80. Metabolic Disorders matter disorders include alexander's disease, Canavan disease, Cockayne's syndrome, and PelizaeusMerzbacher's has been identified in alexander's disease, so the diagnosis must http://fmri.ucsd.edu/NeuroWeb/Text/br-500.htm

DEGENERATIVE AND METABOLIC DISORDERS John R. Hesselink, MD, FACR and Richard J. Hicks, MD DEGENERATIVE DISEASES Imaging of degenerative disorders with CT has generally been disappointing, and attempts have been made to apply MR to this area with hopes of demonstrating more specific findings. The key to the MR imaging of many of these disorders may rest in understanding the normal and pathologic distribution of iron in the brain. Iron is visualized as areas of hypointensity on T2-weighted and GRE imagescaused by local field inhomogeneity and magnetic susceptibility effects. Drayer and colleagues noted decreased signal in the globus pallidus, reticular substantia nigra, red nucleus, and dentate nucleus. These areas correlated closely with sites of preferential accumulation of ferric iron on Perls' stains in normal brains post mortem. This iron deposition becomes greater with increasing age, with iron stains first becoming positive at 6 months in the globus pallidum and at 3 to 7 years in the dentate nucleus. With advanced age (approximately the ninth decade), there may be enough iron deposition in the putamen to render it as hypointense as the globus pallidus. Iron may play a role in neurotransmitter metabolism, and several degenerative disorders have been reported to be associated with increased iron deposition in the brain. This has been described in Hallervorden-Spatz disease, Huntington's chorea, Parkinson's disease and multisystem atrophy variants, Alzheimer's disease, and multiple sclerosis.

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