1. NINDS Alexander Disease Information Page More about alexander disease, Studies with patients, Research literature, Pressreleases, Disclaimer, NINDS alexander disease Information Page Reviewed 1201-2003 http://www.ninds.nih.gov/health_and_medical/disorders/alexand_doc.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Alexander Disease Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Alexander Disease Information Page Reviewed 12-01-2003 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Alexander Disease? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Alexander Disease? Is there any treatment? There is no cure for Alexander disease, nor is there a standard course of treatment. Treatment of Alexander disease is symptomatic and supportive. What is the prognosis? The prognosis for individuals with Alexander disease is generally poor. Most children with the infantile form do not survive past the age of 6. Juvenile and adult onset forms of the disorder have a slower, more lengthy course. What research is being done?

2. Alexander Disease alexander disease. alexander disease is a rare, genetic, degenerative disorder of the nervous system alexander disease, which affects mostly males, usually begins at about 6 months http://healthlink.mcw.edu/article/921383447.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Neurology By keywords: Receive Health Link via email! Subscribe now >> Alexander Disease Alexander disease is a rare, genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath, the fatty coveringwhich acts as an insulatoron nerve fibers in the brain. Alexander disease, which affects mostly males, usually begins at about 6 months of age. Symptoms may include mental and physical retardation, dementia, enlargement of the brain and head, spasticity (stiffness of arms and/or legs), and seizures. In addition to the infantile form, juvenile and adult onset forms of the disorder have been reported. These forms occur less frequently and have a longer course of progression. Is there any treatment? There is no cure for Alexander disease, nor is there a standard course of treatment. Treatment of Alexander disease is symptomatic and supportive.

3. NORD - National Organization For Rare Disorders, Inc. alexander disease. To purchase fulltext report ($7.50) Copyright 1986, 1987,1988, 1990, 1993, 1995, 1999, 2000, 2002 Synonyms of alexander disease http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Alexander Dis

4. The Family Village / Library / Leukodystrophy Resources on Adrenoleukodystrophy, alexander disease, Canavan Disease, Krabbes Disease, Metachromatic Leukodystrophy, and Refsum's Disease. http://www.familyvillage.wisc.edu/lib_leukodystrophy.html

Leukodystrophy Types of Leukodystophy: Adrenoleukodystrophy, Alexander Disease, Canavan Disease, Krabbes Disease, Metachromatic Leukodystrophy, and Refsum's Disease Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search AltaVista for "Leukodystrophy" Who to Contact United Leukodystrophy Foundation (ULF) 2304 Highland Drive Sycamore IL 60718 (815) 895-2432 (fax) E-mail: ulf@tbcnet.com Website: http://www.ulf.org/ This is a nonprofit, voluntary health organization dedicated to providing patients and their families with information about their disease. In addition, it provides assistance in identifying sources of medical care, social services, and genetic counseling; establishing a communication network among families; increasing public awareness; acting as an information source for health care providers; and promoting and supporting research into causes, treatments, and prevention of the leukodystrophies. The ULF is supported solely by donations. Where to Go to Chat with Others ULF List of Online Discussion Groups Krabbes E-mail Contacts Inborn Errors of Metabolism Discussion Groups Learn More About It Adrenoleukodystrophy From PEDBASE Alexander Disease From Online Mendelian Inheritance in Man (OMIM) Canavan Disease From Online Mendelian Inheritance in Man (OMIM) Canavan's Disease From PEDBASE Krabbe Disease From Online Mendelian Inheritance in Man (OMIM) Krabbes Disease: Basic Information From the Krabbes Disease Homepage Metachromatic Leukodystrophy From PEDBASE

5. CCHS Clinical Digital Library Family Resources by Topic Metabolic Disorders. alexander disease Patient/Family Resources General Metabolic Disorders Patient/Family Resources. alexander disease Clinical Resources http://cchs-dl.slis.ua.edu/patientinfo/metabolism/inborn/lipid/leukodystrophies/

Patient/Family Resources by Topic: Metabolic Disorders Alexander Disease Patient/Family Resources Miscellaneous See also: Mental Retardation Patient/Family Resources Genetic Testing Patient/Family Resources General Genetic Disorders Patient/Family Resources General Metabolic Disorders Patient/Family Resources ... Alexander Disease Clinical Resources Na tional Institute of Neurological Disorders and Stroke: Homepage Disorders Information: List of documents Alexander Disease: Access document United Leukodystrophy Foundation: Homepage Introductions to the Leukodystrophies: Access document Alexanders Disease: Access document Miscellaneous Alexander Disease Patient/Family Resources The Family Village Library - Specific Diagnoses Card Catalog Table of contents Leukodystrophy: Access document Healthfinder (US DHHS): Homepage Genetics: List of documents National Library of Medicine MEDLINE plus Health Topics: Index Genetic Testing/Counseling: List of documents Genetic Disorders: List of documents Birth Defects: List of documents YAHOO - Health:Diseases and Conditions:Genetic Disorders Additional Genetic Disorders resources ( These sites have not been reviewed.

6. Alexander Disease - Medical Dictionary Definitions Of Popular Medical Terms alexander disease A slowly progressive and ultimately fatal brain disorder that most juvenile and adult forms of alexander disease typically experience ataxia and spasticity http://www.medterms.com/script/main/art.asp?articlekey=13493

7. Alexander Disease a CHORUS notecard document about alexander disease Feedback. Search. alexander disease. dysmyelinating disease. rare, sporadic Related documents leukodystrophy. dysmyelinating disease. adrenoleukodystrophy. PelizaeusMerzbacher syndrome http://chorus.rad.mcw.edu/doc/00017.html

CHORUS Collaborative Hypertext of Radiology Nervous system Feedback Search Alexander disease dysmyelinating disease rare, sporadic usually presents in 1st year megalencephaly: gradual enlargement of head retardation, convulsion, spasticity CT findings: decreased density of white matter frontal lobe predominance +/- dilated lateral ventricles Dx: brain bx Charles E. Kahn, Jr., MD - 2 February 1995 Last updated 26 May 2004 Medical College of Wisconsin

8. NINDS - News And Events Health. Sorry! There are no press releases for alexander disease. Useyour browser s Back button to return to your previous activity. http://www.ninds.nih.gov/health_and_medical/news.htm?url=/health_and_medical/dis

9. GeneReviews: Alexander Disease Your browser does not support HTML frames so you must view alexander diseasein a slightly less readable form. Please follow this link to do so. http://www.geneclinics.org/profiles/alexander/

Your browser does not support HTML frames so you must view Alexander Disease in a slightly less readable form. Please follow this link to do so.

10. Alexander Disease Information Diseases Database alexander disease Fibrinoid leukodystrophy, Disease Database Information http://www.diseasesdatabase.com/sieve/item1.asp?glngUserChoice=30685

11. NORD - National Organization For Rare Disorders, Inc. Primary Visual Agranulocytosis, Acquired Ahumada Del Castillo Syndrome Aicardi SyndromeAlagille Syndrome Albinism alexander disease Alkaptonuria Allan Herndon http://www.rarediseases.org/search/rdblist.html

Search NORD's Databases Read about diseases in NORD's Rare Disease Database. Find an organization in our Organizational Database. Index of Rare Diseases The A-to-Z of Rare Diseases Rare Disease Database Read about more than 1,100 rare diseases. View sample report Index of Organizations The A-to-Z of Organizations. Organizational Database Find a support group or other source of help. Database Subscriptions Many libraries, schools, universities, and hospitals subscribe to the Rare Disease Database. NORD's Washington Office Read about events on Capitol Hill, funding for rare-disease research, and other topics of interest from NORD's office in Washington, DC. 5 Oxoprolinuria ACTH Deficiency AIDS (Acquired Immune Deficiency Syndrome) AIDS Dysmorphic Syndrome ... HOME Last modified Thursday, February 19, 2004

12. Alexander Disease alexander disease. What is alexander disease? DESCRIPTION alexander diseaseis a rare, genetic, degenerative disorder of the nervous system. http://www.healthieryou.com/alexander.html

Select One Contact CME? Order? Register? Place an Ad? Print Pages? Ask a Colleague? More... ADD/ADHD Alcoholism Alzheimer's Anorexia Anxiety Bipolar Disorder Borderline Bulimia Children Compulsive Dementia Depression Dissociation Drug Abuse Eating Disorders Fear Forgetfulness Hyperactivity Mania Manic-Dep Mood Disorder Narcissistic Neurology Obsessive OCD Panic Paraphilias Phobia Personality Psychosis PTSD Schizophrenia Seasonal Mood Sexual Issues Social Phobia Suicidal Tic Disorders Violence Alexander Disease What is Alexander Disease? DESCRIPTION: Alexander disease is a rare, genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath, the fatty coveringwhich acts as an insulatoron nerve fibers in the brain. Alexander disease, which affects mostly males, usually begins at about 6 months of age. Symptoms may include mental and physical retardation, dementia, enlargement of the brain and head, spasticity (stiffness of arms and/or legs), and seizures. In addition to the infantile form, juvenile and adult onset forms of the disorder have been reported. These forms occur less frequently and have a longer course of progression. Is there any treatment?

13. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: Search results for alexander disease ALLFIELDS are shown below. Includetrials that are no longer recruiting patients. 5 studies were found. http://www.clinicaltrials.gov/search/term=Alexander Disease

Home Search Browse Resources ... About Search results for Alexander Disease [ALL-FIELDS] are shown below. Include trials that are no longer recruiting patients. 5 studies were found. Recruiting Omega-3 Fatty Acids that Affect the Immune System in Kidney Transplant Patients Condition: Kidney Diseases Recruiting BCX-1777 in Treating Patients With Refractory Cutaneous T-Cell Lymphoma Conditions: Cutaneous T-Cell Lymphoma; mycosis fungoides and Sezary syndrome Recruiting The Efficacy and Safety of Risperidone in the Treatment of Adolescents with Schizophrenia Condition: Schizophrenia Recruiting Fluorouracil, External-Beam Radiation Therapy, and Gemcitabine With or Without Brachytherapy Using Phosphorus P32 in Treating Patients With Locally or Regionally Advanced Unresectable Adenocarcinoma of the Pancreas Conditions: adenocarcinoma of the pancreas; stage II pancreatic cancer; stage III pancreatic cancer; stage IVA pancreatic cancer; stage IVB pancreatic cancer Recruiting Clodronate With or Without Chemotherapy and/or Tamoxifen in Treating Women With Stage I or Stage II Breast Cancer Conditions: stage I breast cancer; stage II breast cancer U.S. National Library of Medicine

14. Alexander S Disease Alexander s Disease. alexander disease is the first disease that is knownto be associated with GFAP mutations Brenner M, et al., 2001. http://moon.ouhsc.edu/kfung/JTY1/NeuroHelp/ZNE2IE01.htm

Alexander's Disease NeuroLearn NeuroHelp Leukodystrophy Background ... Differential Diagnosis BACKGROUND AND CLINICAL INFORMATION Head Summary: Alexander's disease is a leukodystrophy that is seen most commonly in infants or later childhood and is clinically a progressive, sometimes very slow, process with dementia, seizures and spasticity. Pathologically, it is a degenerative disorder of the CNS characterized by diffuse demyelination and rarefaction of the white matter, with little or no sparing of the arcuate fibers, and widespread accumulation of Rosenthal fibers. Generalized changes are most frequently seen but localized forms are also reported. Genetics: Probably a genetically inherited disease but the pattern of inheritance has not been established. Sequence analysis of DNA samples from patients representing different Alexander disease phenotypes revealed that most cases are with non-conservative mutations in the coding region of GFAP. Alexander disease is the first disease that is known to be associated with GFAP mutations [ Bren n er M , et al., 2001

15. Alexander Disease alexander disease is an extremely rare, progressive, neurological disorder that usually becomes apparent during infancy or early childhood. However, less commonly, cases have been described in decades of life (adult onset). alexander disease belongs to a group of http://hw.healthdialog.com/kbase/nord/nord56.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord56"; var hwDocTitle="Alexander Disease"; var hwRank="1"; var hwSectionHWID="nord56"; var hwSectionTitle=""; var hwSource="us6.0"; var hwProdCfgSerNo="wsh_html_003_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Alexander Disease Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Dysmyelogenic Leukodystrophy Dysmyelogenic Leukodystrophy-Megalobare Fibrinoid Degeneration of Astrocytes Fibrinoid Leukodystrophy Hyaline Panneuropathy Leukodystrophy with Rosenthal Fibers Megalencephaly with Hyaline Inclusion Megalencephaly with Hyaline Panneuropathy Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Hydrocephalus Multiple Sclerosis Astrocytoma, Malignant

16. CCHS Clinical Digital Library Clinical Resources by Topic Metabolic Disorders. alexander diseaseClinical Resources. alexander disease Access document. Clinical http://cchs-dl.slis.ua.edu/clinical/metabolism/inborn/lipid/leukodystrophies/ale

Clinical Resources by Topic: Metabolic Disorders Alexander Disease Clinical Resources Pediatrics Radiology Pathology Genetics ... Miscellaneous Resources See also: Genetic Testing Clinical Resources Mental Retardation Clinical Resources General Genetic Disorders Clinical Resources General Metabolic Disorders Clinical Resources ... Alexander Disease Patient/Family Resources Goetz: Textbook of Clinical Neurology 2nd Ed.-2003 (MD Consult): Table of contents Health Sciences Library subscription INFO Chapter 3 - Mood, Emotion, and Thought: Access document History and Definitions: Access document Clinical History: Access document Anatomy of Mood, Emotion, and Thought: Access document Examination of Mood, Emotion, and Thought: Access document Evaluation Guidelines: Access document Clinical Syndromes: Access document General Management Goals: Access document Reviews and Selected Updates: Access document References: Access document Chapter 30 - Storage Diseases: Neuronal Ceroid-Lipofuscinoses, Lipidoses, Glycogenoses, and Leukodystrophies: Access document Introduction: Access document Leukodystrophies: Access document Reviews and Selected Updates: Access document References: Access document Goldman: Cecil Textbook of Medicine 21st Ed.-2000 (MD Consult):

17. Alexander Disease / Library / The Family Village Library A B. alexander disease. alexander disease - Summary for Parents Fromthe alexander disease Project at the Waisman Center, University of Wisconsin. http://www.familyvillage.wisc.edu/lib_alex.html

Alexander Disease Who to Contact Learn More About It Research Web Sites ... Search Google for "Alexander Disease" Who to Contact United Leukodystrophy Foundation 2304 Highland Drive Sycamore, IL 60178 815-895-2432 (fax) E-mail: ulf@tbcnet.com Web: http://www.ulf.org/ The United Leukodystrophy Foundation (ULF), incorporated in 1982, is a nonprofit, voluntary health organization dedicated to providing patients and their families with information about their disease and assistance in identifying sources of medical care, social services, and genetic counseling; establishing a communication network among families; increasing public awareness and acting as an information source for health care providers; and promoting and supporting research into causes, treatments, and prevention of the leukodystrophies. Leukodystrophies are a group of genetic nervous system disorders affecting the myelin sheath, which insulates the axon through which nerve impulses are conducted. Learn More About It Alexander Disease - Summary for Parents From the Alexander Disease Project at the Waisman Center, University of Wisconsin Alexander Disease From Online Mendelian Inheritance in Man (OMIM) About Alexander Disease - Partners Leukodystrophy Service at MGH Research Alexander Disease Project Waisman Center, University of Wisconsin

18. Alexander Disease alexander disease Important It is possible that the main title of thereport alexander disease is not the name you expected. Please http://my.webmd.com/hw/health_guide_atoz/nord56.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Alexander Disease Important It is possible that the main title of the report Alexander Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Dysmyelogenic Leukodystrophy Dysmyelogenic Leukodystrophy-Megalobare Fibrinoid Degeneration of Astrocytes Fibrinoid Leukodystrophy Hyaline Panneuropathy Leukodystrophy with Rosenthal Fibers Megalencephaly with Hyaline Inclusion Megalencephaly with Hyaline Panneuropathy Disorder Subdivisions None General Discussion In infants and young children affected by Alexander Disease, associated symptoms and findings include a failure to grow and gain weight at the expected rate (failure to thrive); delays in the development of certain physical, mental, and behavioral skills that are typically acquired at particular stages (psychomotor retardation); and progressive enlargement of the head (macrocephaly). Additional features typically include sudden episodes of uncontrolled electrical activity in the brain (seizures); abnormally increased muscle stiffness and restriction of movement (spasticity); and progressive neurological deterioration. In some cases, there is hydrocephalus. In most cases, Alexander Disease appears to occur randomly for unknown reasons (sporadically), with no family history of the disease. In an extremely small number of cases, it is thought that the disorder may have affected more than one family member.

19. Alexander Disease alexander disease is an extremely rare, progressive, neurological disorder thatusually becomes apparent during infancy or early childhood. alexander disease. http://www.bchealthguide.org/kbase/nord/nord56.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord56"; var hwDocTitle="Alexander Disease"; var hwRank="1"; var hwSectionHWID="nord56"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Alexander Disease Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Dysmyelogenic Leukodystrophy Dysmyelogenic Leukodystrophy-Megalobare Fibrinoid Degeneration of Astrocytes Fibrinoid Leukodystrophy Hyaline Panneuropathy Leukodystrophy with Rosenthal Fibers Megalencephaly with Hyaline Inclusion Megalencephaly with Hyaline Panneuropathy Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Hydrocephalus Multiple Sclerosis Astrocytoma, Malignant Astrocytoma, Benign

20. OMIM - ALEXANDER DISEASE http://www3.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=203450

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