61. ¥Ø¿ýºK­n10-2 Baclofeninduced Reversible akinetic mutism. Current diagnosis of baclofen-inducedakinetic mutism is based on clinical history and the findings of EEG. http://www.neuro.org.tw/mag4-2.htm

²Ä¤Q¤@¤G¨÷²Ä¤G´ÁºK­n Spinal Muscular Atrophy: From Animal Model to Potential Treatments Ming-Shiun Tsai , Sue-Hong Wang , Li-Kai Tsai , and Hung Li Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan; Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan Abstract- Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by degeneration of the anterior horn cells of the spinal cord leading to muscular paralysis and atrophy. SMA is the second commonest genetic cause of death in childhood affecting approximately 1 in 10,000 live births, but no effective treatment is currently available. Due to gene deletions, mutations, or conversions, the telomeric copy of the survival of motor neuron (SMN) gene is abnormal in more than 96% of patients with clinically typical SMA. The identification of SMN-interacting protein strongly suggests that it is involved in the assembly of the spliceosome, processing of pre-mRNA splicing, transcription, and metabolism of ribosomal RNA. Mouse models of human SMA have been established through a combination of knockout and transgenic techniques. These SMA-like mice genotypically and phenotypically mimic SMA

62. Types Of Brain Injury akinetic mutism. akinetic mutism is a neurobehavioral condition thatresults when the dopaminergic pathways in the brain are damaged. http://www.biausa.org/Pages/types_of_brain_injury.html

Symptoms Coup-contre coup injury Diffuse Axonal Injury Second Impact Syndrome ... Open Head Injury A traumatic brain injury occurs when an outside force impacts the head hard enough to cause the brain to move within the skull or if the force causes the skull to break and directly hurts the brain. A direct blow to the head can be great enough to injure the brain inside the skull. A direct force to the head can also break the skull and directly hurt the brain. This type of injury can occur from motor vehicle crashes, firearms, falls, sports, and physical violence, such as hitting or striking with an object. A rapid acceleration and deceleration of the head can force the brain to move back and forth across the inside of the skull. The stress from the rapid movements pulls apart nerve fibers and causes damage to brain tissue. This type of injury often occurs as a result of motor vehicle crashes and physical violence, such as Shaken Baby Syndrome. Definition: Traumatic Brain Injury `Traumatic brain injury is an insult to the brain, not of a degenerative or congenital nature but caused by an external physical force, that may produce a diminished or altered state of consciousness, which results in an impairment of cognitive abilities or physical functioning. It can also result in the disturbance of behavioral or emotional functioning. These impairments may be either temporary or permanent and cause partial or total functional disability or psychosocial maladjustment. Adopted by the Brain Injury Association Board of Directors, February 22, 1986. This definition is not intended as an exclusive statement of the population served by the Brain Injury Association of America.

63. Volume 64 January - December 1941 akinetic mutism with an epidermoid cyst of the 3rd ventricle. H . Cairns, RC . Oldfield , JB . Pennybacker and D . Whitteridge. Pages 273 290. http://www3.oup.co.uk/jnls/supplements/braini/hdb/Volume_64/Issue_04/640273.sgm.

Volume 64: January - December 1941 Issue 4: December 1941 Abstract Akinetic mutism with an epidermoid cyst of the 3rd ventricle H Cairns RC Oldfield JB Pennybacker and D Whitteridge Pages: Part of the OUP Brain WWW service General Information Click here to register with OUP. This page is maintained by OUP admin Last updated 13 May 97 Part of the OUP Journals World Wide Web service Oxford University Press, 1997

64. Brain Injury Glossary A akinetic mutism A condition of silent, alert-appearing, immobility that characterizescertain subacute or chronic states of altered consciousness. http://www.waiting.com/glossarya.html

About Brain Injury A Glossary of Terms Beginning with "A" Please wait one moment while the glossary loads. Abnormal Aneurysm Aspiration Abscess ... Articulation Click on a letter to access terms or click the "on" button to browse entire glossary. A B C D ... W Or Go To: Intracranial Pressure Understanding Coma Rancho Los Amigos Scale/ The Levels of Coma Objectives of Neurosurgery ... A Guide to Brain Anatomy Abnormal - Not average, typical or usual; not normal. [Click Here to Return to List] Abscess - A localized collection of pus in a cavity. [Click Here to Return to List] Abstract Concept - A concept or idea not related to any specific instance or object and which potentially can be applied to many different situations or objects. Persons with cognitive deficits often have difficulty undestanding abstract concepts. [Click Here to Return to List] Abstract Thinking - Being able to apply abstract concepts to new situations and surroundings. [Click Here to Return to List] Acalculia - The inability to perform simple problems of arithmetic. [Click Here to Return to List] Accident - See Terms and Definitions Related to Insurance . With respect to prevention of injuries caused by motor vehicles, the preferred term is "crash", rather than accident, so as not to suggest that the event was unavoidable.

65. Creutzfeldt-Jakob Disease Surveillance System In Canada, May 2002 - Blood Safety in order of progression), 1 rapid progressive dementia 2 - involuntary movements(myoclonus, chorea, dystonia) 3 - akinetic mutism 4 - extrapyramidal symptoms http://www.hc-sc.gc.ca/pphb-dgspsp/hcai-iamss/cjd-mcj/cjdss-ssmcj/0502_e.html

Creutzfeldt-Jakob Disease CJD Home Page CJD-SS Family Information Physician Information ... Adobe Downloadable Document (493 KB) How to download PDF documents BULLETIN!!! Due to the recent use of new testing methods and techniques for 14-3-3 CSF protein analysis, we have noticed an increase in sensitivity of these techniques, resulting in a greater number of positive results. This phenomenon is being seen worldwide and is currently being assessed. It is therefore strongly recommended that the 14-3-3 protein analysis not be used as a screening test in the evaluation of Creutzfeldt-Jakob Disease patients, but rather as a test to be interpreted in conjunction with the overall clinical signs, symptoms and other investigations. May 2002 Highlights The 14-3-3 test must be used in conjunction with the overall clinical signs and symptoms of CJD. 121 confirmed cases of CJD identified by CJD-SS since inception. Incidence of CJD in Canada is as expected at 0.92 and 1.02 per million population.

66. ªL¥úÅï Âå®v 1995;14537541. 2. KL Lin, HS Wang, ML Chou, TN Rui Role of Cavum Septum. Pellucidumin akinetic mutism of Hydrocephalic Children. Pediatric. Neurology. http://www.cgmh.com.tw/chldhos/intr/c4a90/new_page_9.htm

¸g¾ú ¬ã¨s½×¤å ­Ó¤H­º­¶ ¸g¾ú 1. Resident, July, 1991 - July, 1994, Department of Pediatrics, Chang Gung Memorial Hospital 2. Chief Resident, July, 1994 - June, 1995, Department of Pediatrics, Chang Gung Children Hospital 3. Attending, since July, 1995, Department of Pediatrics, Chang Gung Children Hospital 4. Research fellow, July 2000 to August 2001, Laboratory for Brain Magnetic Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Chief, Division of Pediatric Neurology, Department of Pediatrics, Chang Gung Children Hospital , since October 1, 1999 ¦a¾_¥tþ¨a¥Á V.S. ¯«¸g¥Ö½§¯g­Ô¸s ¨­°ª¶i«×¸¨«á ÅéÀ˧ä¥X­ì¦] Åöíw¦W¤H¿ý «¢¦ò±d«Â¹Ï®ÑÀ]ªº¦a¤U«Ç ¦­¦w ¤U³· ... ¤µ¤Ñ¾Ç®Õ¦nª±¶Ü¡H ¬ã¨s½×¤å Publications : KL Lin , HS Wang, TN Rui: Sonographic Diagnosis of an Infant with a Corpus Callosum Lipoma with Extracranial Extension. Journal of Ultrasound in Medicine. 1995;14:537-541 KL Lin , HS Wang, ML Chou, TN Rui: Role of Cavum Septum Pellucidum in Akinetic Mutism of Hydrocephalic Children. Pediatric Neurology. 1997;16:156-159

67. Mr Brown Part 2 Mr Brown has developed severe myoclonic jerks alternating with akinetic mutism;awake, with eyes open, lying mute, immobile and unresponsive. akinetic mutism. http://www.staff.brad.ac.uk/pfotherg/HN0303L/Intake1/HN0303LMrBrown/MrBrown2int1

University intranet Module HN0303L Scenarios School of Health Passwords Nursing Division ... Feedback Main navigation: Home Module HN0303L Other interests Section navigation: Up Mr Brown part 3 Mr Brown: part 2 Session content and facilitator: Charlotte Tonge Please make sure you look at the learning outcomes and references for this session before you commence work. The following information is confidential and is only for intake 1 nursing students (adult branch) Module HN0303L: Complex and Changing Needs. All names have been changed to protect patient confidentiality (NMC 2002). This dynamic patient scenario has been adapted from Reuber et al (2001) Department of Neurology, Pinderfields General Hospital, Wakefield. Six months later. Mr Brown has been readmitted to the unit. There has been a rapid deterioration with progressive ataxia, confusion and agitation. He is unable to walk and is unaware of where he is . He calls out but cannot articulate words. He has lost weight. He is not tolerating food orally. His skin is in poor condition and he has red areas on his elbows and sacrum. He is incontinent of urine and faeces. What are the potential safety/risk issues for this patient? Identify any policies that may need to be followed and procedures/referrals required.

68. Curso De Neurología De La Conducta Y Demencias A clinical and pathologic study of akinetic mutism . Neurology 10 1021. Stateresembling akinetic mutism in basilar artery occlusion . Neurology 17 74-80. http://oaid.uab.es/nnc/html/entidades/web/15cap/c15_13.html

[1] Aggleton, J.P. (1992). The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction. J.P. Aggleton (ed.) Wiley-Liss, Nueva York. [2] Alexander, G.E., Delong, M.R., Strick, P.L. (1986). "Parallel organization of functionally segregated circuits linking the basal ganglia and cortex". Annu Rev Neurosci 9 [3] Alexopoulous, G.S., Meyers, B.S., Young, R.C., Campbell, S., Silberweig, D., Charlson, M. (1997) "Vascular depression hypothesis" Arch Gen Psychiatry [4] Ali-Cherif, A., Royere, M.L., Gosset, A., Poncet, M., Salamon, G., and Khalil, R. (1984). " Troubles du comportement et de l'activité mentale après intoxication oxycarbonée: lésions pallidales bilatérales" Rev Neurol [5] Amyes, E.W., y Nielsen, J.M. (1953). " Bilateral anterior cingulate gyrus lesions" Bull Los Angeles Neurol Soc [6] Aylward, E.H., Roberts Twillie, J.V., Barta, P.E., et al. (1994). "

69. BI Glossary A Inability to express thoughts in writing. akinetic mutism. akinetic mutism is exhibitedby persons with high brain stem lesions. Alcohol or Drug Dependency. http://www.birf.info/artman/publish/article_364.shtml

Quick Links BI Glossary A By BIRF Mar 30, 2004, 14:01 Email this page Print this page A Abstract Concept A concept or idea not related to any specific instance or object and which potentially can be applied to different situations. Persons with cognitive deficits often have difficulty understanding abstract concepts. Abstract Thinking Being able to apply abstract concepts to new situations. Abulia Usually associated with damage to a cerebellar vessel, abulia refers to an inability to make decisions or exercise will. It includes slow reaction and lack of spontaneity. Acalculia The inability to perform simple problems of arithmetic. Acceleration/Deceleration A closed head injury frequently sustained in a car accident, where the brain wrenches forward and backward, hitting the walls of the skull. Accommodate To use an alternative means to furnish with something needed or desired. Acetylcholine (ACH) A neurotransmitter that carries messages between the nerves and muscles. Action Potential This occurs when a neuron is activated and temporarily reverses the charge of a membrane from negative to positive, resulting in the release of a neurotransmitter. Acuity Sharpness or quality of a sensation.

70. [Intravitreal Endoscopic Visualization Of Intraocular Ganciclovir Devices: Impro Reversible akinetic mutism possibly induced by baclofen. A 76year-old man developedakinetic mutism after 3 days of receiving low-dosage baclofen. http://rx-drugs-online-usa.com/ref-drug-1/drug-1-research-abs6.417.html

DreamPharm Products: Lutein-20 Herbs for headache, fever, and migraine Milk thistle Saw palmetto ... contraceptive and related online research references Klin Monatsbl Augenheilkd. 1999 Feb;214(2):107-11. [Intravitreal endoscopic visualization of intraocular ganciclovir devices: improved long-term treatment of CMV retinitis] [Article in German] Koch FH, Gumbel HO, Hattenbach LO, Ohrloff C. Netzhaut- und Glaskorperchirurgie, Johann Wolfgang Goethe Universitat, Frankfurt am Main. J Control Release. 1999 May 1;59(1):119-22. A recombinant prodrug type approach for triggered delivery of streptokinase. Wang H, Song H, Yang VC. College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109-1065, USA. A novel prodrug type approach for triggered delivery of thrombolytic drugs without their associated hemorrhagic effects has been proposed. Presented herein is a rapid communication of preliminary observations that suggest the feasibility of the approach. A hirulog-streptokinase fusion protein (termed "HSK") possessing active thrombolytic functions has been successfully produced using recombinant DNA technology. The prodrug and triggered release features of this approach have been demonstrated by the inhibition of the plasminogen-activating activity of HSK via binding with thrombin and reversal of this inhibition by hirudin. Pharmacotherapy. 1999 Apr;19(4):468-70.

71. Publications J Neurol 1986, 2334447. Németh Gy, Hegedüs K, Molnár L akinetic mutism andlocked-in syndrome the functional-anatomical basis for their differentiation. http://www.neuropat.dote.hu/refer.html

Representative Publications Dissecting intracranial aneurysm. Arch Psychiatr Nervenkr, 1982, 232:25-32 Defects of elastic lamina in middle cerebral artery. Arch Psychiatr Nervenkr Experimental models of cerebral ischemia. J Cereb Blood Flow Metabol, 1983, 3:S387-S388 Primary cerebellar glioblastoma multiforme with an unusually long survival. J Neurosurg, 1983, 58:589-592 Burkitt-type lymphoma and reticulum-cell sarcoma. An unusual mixed form of two intracranial primary malignant lymphoma. Surg Neurol 1984, 21:23-29 Fibromuscular dysplasia of the basilar artery. Case report with autopsy verification. Arch Neurol 1984, 41:440-442 The adult form of subacute necrotizing encephalopathy. Surg Neurol, 1984, 21:572-576 Some observations on reticular fibers in the media of the major cerebral arteries. A comparative study of patients without vascular diseases and those with ruptured berry aneurysms. Surg Neurol 1984, 22:301-30 Direct involvement of intracerebral arteries in Takayasu's arteritis. Acta Neuropathol, 1984, 63:83-86 Case report of infarction in the region of the posterior spinal arteries.

72. Curriculum Vitae Translate this page 72, 87-88 (1985). Németh, Gy., Hegedüs, K., Molnár, L. akinetic mutism andlocked-in syndrome The functional-anatomical basis for their differentation. http://www.neuropat.dote.hu/explab/lmolnar.htm

Curriculum vitae Name: Date and place of birth: Education: 1941 - Graduated from High School June 1947 - M.D. ('sub laurea almae matris'), Medical School, University of Szeged, Hungary 1965 - Ph.D. in Physiology, University of Paris, Sorbonne, France 1966 - Ph.D. in Neurology, Hungarian Academy of Sciences 1977 - Doctor of Medical Sciences (D.Sci), Hungarian Academy of Sciences Board Certification: Neurology, Neurosurgery, Psychiatry Brief chronology of employment: 1959-1960 Visiting Scientist, Institute of Physiology, Cologne, Germany 1969 (Jan-April) Scientific Representative of the UNESCO, State University of Pernambuco, Recife, Brasil 1969-1992 Head, Department of Neurology and Psychiatry, University of Debrecen, Hungary Societies: International Brain Research Organization (IBRO) Member of "Kuratorium der Donau-Symposien für Neurologische Wissenschaften" "Founder member" of the International Society for Cerebral Blood Flow and Metabolism Honorary President of the Hungarian EEG and Clinical Ekectrophysiological Society Member der Deutschen Akademie der Naturforscher Leopoldina, Halle, Germany

73. Entrez PubMed time (CCT) of SEP was prolonged at admission. The value of MBP and CCTimproved with recovery from akinetic mutism. Publication Types http://www.biomedcentral.com/pubmed/1382734

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Intern Med. 1992 Jun;31(6):828-31. Related Articles, Links Leukoencephalopathy induced by tegafur: serial studies of somatosensory evoked potentials and cerebrospinal fluid. Hayashi R, Hanyu N, Kitahara A.

74. Vol.8 - 6. Diagnosis, Treatment And Care Of VCJD Patients unpleasant abnormal sensations 3 akinetic mutism paralysis and inability to speak4 IBD3 tab 9. Return to top of page © Crown Copyright 2000. Legal notice. http://www.bseinquiry.gov.uk/report/volume8/chaptee2.htm

Quick navigation menu Home The Inquiry Report Download report as PDF Evidence Contact details Order a copy Help Search Volume Specific - Index List of Acronyms Who's Who Volume 8: Variant CJD 6. Diagnosis, treatment and care of vCJD patients Symptoms of vCJD On 21 March 1996, the CJDSU circulated to all neurologists in the UK a description of the clinical and pathological features of the new phenotype. The clinical features of the new phenotype of CJD described in the circular were as follows: An early age of onset or death (average 27.6 years, range 18-41 years). A prolonged duration of illness (average 13.1 months, range 7.5-24 months). A predominantly psychiatric presentation including anxiety, depression, withdrawal and progressive behavioural changes. The first evidence of neurological involvement in four patients was dysaesthesiae in the limbs and/or face. Development of a cerebellar syndrome with problems with gait and limb muscle coordination after a period of weeks or months. Development of forgetfulness and memory disturbance, often late in the clinical course, which progressed to severe cognitive impairment and a state of akinetic mutism

75. Agricultural And Biosystems Engineering @ Iowa State Univeristy Tremor * Speech disturbances * Epilepsy * Abdominal cramps * Mimics flulike viralillness * Paraesthesiae * Parkinsonism * akinetic mutism * Acidosis of http://www.abe.iastate.edu/human_house/conditions.asp

College of Agriculture College of Engineering Iowa State University ABE Home ... Search ISU Extension Pub # none: electronic file only Author: Thomas H. Greiner, Extension Agricultural Engineer Department of Agricultural and Biosystems Engineering, Iowa State University. September, 1997 TWO CONDITIONS FOR A CARBON MONOXIDE HAZARD 1. Carbon monoxide must be produced 2. Combustion gases must be released into the structure. If either one or two is present, 50% of the hazard exists. One factor of safety is gone. If both exist, THERE IS A SEVERE PROBLEM 1. Complete combustion does NOT produce carbon monoxide Check for complete combustion 1. Measure gas flow 2. Measure air/fuel/dilution 3. Measure CO in combustion products 4. Check venting 2. Combustion gases must be released into the structure. Common causes: Vent failure Unvented appliances Internal combustion engines CARBON MONOXIDE PROBLEMS ARE SUBTLE Carbon monoxide is a deadly, lethal poison. It is called the "Quiet Killer" and "The Great Imitator."

76. C-NET_ADULTNEURO Archives - February 2001 akinetic mutism akinetic mutism (27 lines) From Laurie Sheehy lsheehy@MCO.EDU Date Tue, 27 Feb 2001 141432 0500; Re Akinetic http://listserv.arizona.edu/cgi-bin/wa?A1=ind0102&L=c-net_adultneuro

77. C-NET_ADULTNEURO Archives - July 2001 Search. akinetic mutism akinetic mutism (18 lines) From Carol Wilkins cwilkins@SKYNET.CA Date Wed, 18 Jul 2001 212306 0400; http://listserv.arizona.edu/cgi-bin/wa?A1=ind0107&L=c-net_adultneuro

78. Virtual Naval Hospital: United States Naval Flight Surgeon Manual: Third Edition These conditions include (1) locked in syndrome, (2) psychogenic coma, (3) persistentvegetative state, (4) akinetic mutism,(5) hypersomnolence (exaggerated http://www.vnh.org/FSManual/07/07ManagementComa.html

United States Naval Flight Surgeon's Manual: Third Edition 1991: Chapter 7: Neurology Management of Coma and Unresponsiveness Naval Aerospace Medical Institute Peer Review Status: Internally Peer Reviewed The degree of drowsiness is often misrepresented on the patient'srecord. The terms obtundation, stupor, and coma are often used interchangeably. It is best to note the response the patient makes to his environment (i.e. responds to soft verbal stimuli, loud verbal stimuli,physical stimuli such as shaking, or deep painful stimuli to theextremities). Coma or absence of arousal to any external stimuli is mimicked by several other clinical conditions which should not be diagnosed as coma. These conditions include: (1) locked in syndrome, (2) psychogenic coma, (3) persistent vegetative state, (4) akinetic mutism,(5) hypersomnolence (exaggerated sleep response), and (6) brain death. All of these conditionswill look like coma and should be considered in the differential diagnosis. Locked-in syndrome is seen in brain stem infarction or metabolic conditions which cause paralysis of all four extremities without loss ofconsciousness. Generally there is preservation of eye movements and the blink reflex, and communication may be established in this manner. This may alsooccur in acute motor paralysis due to peripheral nerve or neuromuscularjunction blockade. Psychogenic coma should be considered if the patient has intact brainstem reflexes including calorics, pupillary reactions, and optokinetic nystagmus. In psychogenic coma there is an active resistance to eyelidopening and the eyes will tend to avoid looking at the examiner.

79. University Of Miami School Of Medicine - Glossary - Akinetic For example, a person in coma is akinetic. For another example, akineticmutism is a condition in which a person is both mute and akinetic. http://www.med.miami.edu/patients/glossary/art.asp?articlekey=6989

80. Complexity Digest Forum: RE: The Neurology Of Impaired Consciousness: Global Dis Global disorders of consciousness include stupor and coma, vegetative states, akineticmutism, absence and partial complex seizures, hyperkinetic mutism, and http://www.comdig.org/topic2.php?id_topic=64&sort=1&haction=add&id_msgboard=65

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