61. Stensland The Neuropathology of AIDS aids dementia complex. David S. Stensland. Navia, BA, Cho, E., Petito, CK Price, RW The aids dementia complex II. Neuropathology. http://www.indstate.edu/thcme/anderson/DSS.html

The Neuropathology of AIDS: AIDS Dementia Complex David S. Stensland Staining methods which differentiate microglial and cholinergic neurons have shown a close physical relationship between the two in the basal forebrain. In vitro studies suggest that microglia may express mRNA for nerve growth factor by which basal forebrain cholinergic neurons are known to be stimulated. It has been hypothesized that alterations in microglia, which have been shown to occur by HIV-1 infection, may have profound functional effects on neurons by disrupting the normal microglial-neuronal interaction. Normal function of cholinergic basal forebrain neurons is essential for normal cognitive function and may therefore be responsible for the cognitive dementia associated with AIDS Dementia Complex. The single most difficult factor to explain in association with HIV infection and the subsequent appearance of AIDS Dementia Complex is how neurological disease can result from relatively few infected cells with a low copy number of virus per infected cell. Some patients have very low levels of active viral infection and yet clinically apparent neuronal dysfunction. For example, children less than 3 years old with HIV encephalopathy have very low levels of active viral infection while children older than three years old have antigen levels comparable to adults. Low or absent active viral infection indicates the existence of an alternative mechanism involved in neuronal dysfunction. BIBLIOGRAPHY Gene Therapy of Immune System

62. Peters AIDS AND THE NERVOUS SYSTEM A FOCUS ON THE aids dementia complex. Tom Peters. The pathology of the aids dementia complex is complicated and variable. http://www.indstate.edu/thcme/anderson/TP.html

AIDS AND THE NERVOUS SYSTEM: A FOCUS ON THE AIDS DEMENTIA COMPLEX Tom Peters Infection by the human immunodeficiency virus (HIV), the biologic agent of the AIDS syndrome, has emerged as one of the most important threats to public health in the United States and its incidence is rapidly increasing. A highly lethal disease with over 70% of AIDS patients dying within 2 years of diagnosis. This disease has already become the leading cause of death in men aged 25-44 and women aged 25-34. The Centers for Disease Control have for the purpose of epidemiological surveillance, defined AIDS as a "reliably diagnosed disease that is at least moderately indicative of an underlying cellular immunodeficiency in a person who has no underlying cause of cellular immunodeficiency nor any other cause of reduced resistance reported to be associated with that disease." [5] The pathophysiology of HIV is indicative of a retrovirus. At the cellular level the most distinct feature of AIDS is the depletion of the helper-inducer lymphocytes or T-helper cells. The specific antigen CD4 present on these lymphocytes appears to be the target of the AIDS retrovirus. HIV does not usually cause disease as soon as it is acquired and therefore in most cases, has a latency period which may be variable. The ultimate problem in this disease is the progressive immunosuppresslon due to the lack of lymphocytes. There has been issues raised about cognitive impairment and early AIDS infection. Questions have been raised about Public safety being at risk if infected individuals were in safety-sensitive jobs. The American Academy of Neurology supports the conclusion that "there is no justification for HIV-1 serological screening as a strategy for detecting functional impairment in asymptomatic persons, because at present, there is no evidence for an increase of clinically significant neuropsychiatric abnormalities"[2]. This conclusion was also supported by the fact that impaired job performance can be caused by a number of more common problems ,such as alcoholism.

63. AIDS Dementia Complex aids dementia complex. This is an illness that affects the brain in people who have HIV or AIDS. People with it can have trouble http://www.livepositive.ca/library/aidsd.html

AIDS Dementia Complex This is an illness that affects the brain in people who have HIV or AIDS. People with it can have trouble with coordination, have mood swings, have a bad memory and have trouble thinking in general. This is a very common problem in people with HIV/AIDS and it gets worse as time passes once you have it.

64. Penn State Faculty Research Expertise Database (FRED) , AIDS Encephalopathies, AIDS Related Dementia Complex. Complex......Faculty Research Expertise Database. aids dementia complex. http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D015526

65. HIV Treatment Neurological Conditions aids dementia complex (ADC) What is it? aids dementia complex (ADC), sometimes called HIVassociated dementia http://www.planetout.com/health/hiv/treatment/?sernum=2518

66. ScienceDaily -- Browse Topics: Health/Conditions_and_Diseases/Neurological_Disor Click Here. Top Health Conditions and Diseases Neurological Disorders Dementia aids dementia complex (3 links). News about aids dementia complex http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Neurologica

Match: sort by: relevance date Free Services Subscribe by email RSS newsfeeds PDA-friendly format loc="/images/" A A A Find Jobs In: Healthcare Engineering Accounting College Contract / Freelance Customer Service Diversity Engineering Executive Healthcare Hospitality Human Resources Information Tech International Manufacturing Nonprofit Retail All Jobs by Job Type All Jobs by Industry Relocating? Visit: Moving Resources Moving Companies Mortgage Information Mortgage Calculator Real Estate Lookup Front Page Today's Digest Week in Review Email Updates ... Dementia AIDS Dementia Complex (3 links) See Also: Health: Conditions and Diseases: Immune Disorders: Immune Deficiency: AIDS News about AIDS Dementia Complex NIAID Announces Contracts To Develop Vaccine Against H5N1 Avian Influenza (June 1, 2004) full story Mouse Study Could Aid Vaccine Designers (May 31, 2004) full story Hormone Therapy May Still Offer Important Health Benefits To Postmenopausal Women (May 31, 2004) full story Yerkes Researchers Discover Combination Of Drug Therapies Reduces Cocaine Use In Primates (May 28, 2004) full story Researchers Explore Gene Treatment To Obliterate HIV Before It Does Damage (May 26, 2004)

67. Goodhealth N You All about aids dementia complex Research has now proved that HIV affects the brain directly through a condition called the aids dementia complex (ADC). http://www.goodhealthnyou.com/hot/aids1.php3?id=1207

68. Goodhealth N You All about aids dementia complex Date 200102-09 Research has now proved that HIV affects the brain directly through a condition called the AIDS Dementia http://www.goodhealthnyou.com/features/features1.php3?id=1207

69. Conditions And Diseases - AIDS Dementia Complex Top Links aids dementia complex Web Site Links. aids dementia complex This article is from the Dec. 96 Bulletin of Experimental Treatments for AIDS. http://www.disease-resources.com/Top_Health_Conditions_and_Diseases_Neurological

Sub Categories Related Healthcare Subjects Disabilities Environmental Health Fitness Health Insurance ... Men's Health AIDS Dementia Complex Web Site Links AIDS Dementia Complex This article is from the Dec. 96 Bulletin of Experimental Treatments for AIDS. In depth and covers the symptoms, classifications, diagnosis, treatment and prevention. AIDS Knowledge Base AIDS Dementia Complex: An introduction, definitions and terminology, incidence and natural history, pathogenesis, clinical presentation, differential diagnosis, diagnostic studies and treatment. AIDS Dementia Complex A comprehensive guide to this condition called ADC, dementia, sub acute encephalitis or HIV encephalitis from AEGIS. MedicineNet A brief article about AIDS dementia complex. Other Useful Health Web Links National Institutes of Health (NIH) US Government department in charge of medical research. AHRQ: Clinical Information Clinical information on evidence-based practice, clinical guidelines, medical effectiveness, pharmaceutical therapy, new technology, screening and preventive services, outcomes research, and the National Guideline Clearinghouse. The UK Health Technology Assessment Programme Site contains details of program's many projects and publications; an NHS national research and development initiative.

70. Conditions And Diseases: Neurological Disorders: Dementia: AIDS Dementia Complex Information on Conditions and Diseases, Neurological Disorders, Dementia, aids dementia complex and much more Treasure Coast Health. http://treasurecoasthealth.com/treasurecoasthealth.php/Health/Conditions_and_Dis

Home Doctor Directory Health Resources Resources for Women Newsletter Sign Up ... Advertise with Us ** Buy text Ads! About Us Conditions and Diseases: Neurological Disorders: Dementia: AIDS Dementia Complex Canadian Pharmacies See also: Health: Conditions and Diseases: Immune Disorders: Immune Deficiency: AIDS AIDS Dementia Complex - A comprehensive guide to this condition called ADC, dementia, sub acute encephalitis or HIV encephalitis from AEGIS. AIDS Dementia Complex - This article is from the Dec. 96 Bulletin of Experimental Treatments for AIDS. In depth and covers the symptoms, classifications, diagnosis, treatment and prevention. MedicineNet - A brief article about AIDS dementia complex. Sponsors: Oral Chelation Therapy - Oral Chelation Therapy PCA-Rx is an alternative treatment for and mercury toxicity. The result of years of rigorous research and development.PCA-Rx English Pharmacy - Save up to 80% on England drugs British Pharmacies - Save up to 80% on Britain drugs Discount Pharmacy Online Get prescription drugs online today at our pharmacy.

71. Entrez PubMed Click here to read Metabolic characterization of aids dementia complex by spectroscopic imaging. Moller HE, Vermathen P, Lentschig http://www.biomedcentral.com/pubmed/10030645

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order J Magn Reson Imaging. 1999 Jan;9(1):10-8. Related Articles, Links Metabolic characterization of AIDS dementia complex by spectroscopic imaging. Moller HE, Vermathen P, Lentschig MG, Schuierer G, Schwarz S, Wiedermann D, Evers S, Husstedt IW. Westfalische Wilhelms-Universitat Munster, Institut fur Physikalische Chemie, Germany. moeller@uni-muenster.de

72. Entrez PubMed Proton MR spectroscopy of the brain in aids dementia complex. MeSH Terms aids dementia complex/metabolism*; Adult; Aspartic Acid/analogs derivatives; http://www.biomedcentral.com/pubmed/1629410

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order J Comput Assist Tomogr. 1992 Jul-Aug;16(4):538-42. Related Articles, Links Proton MR spectroscopy of the brain in AIDS dementia complex. Menon DK, Ainsworth JG, Cox IJ, Coker RC, Sargentoni J, Coutts GA, Baudouin CJ, Kocsis AE, Harris JR. NMR Unit, Hammersmith Hospital, London, U.K.

73. Los Angeles Caregiver Resource Center - Fact Sheet: HIV Associated Dementia Definition HIVAssociated Dementia Complex (also known as aids dementia complex) is a progressive neurological disorder that can affect persons who are http://geroweb.usc.edu/lacrc/Diseases/FactSheets/hiv.htm

Los Angeles Caregiver Resource Center 3715 McClintock Avenue Los Angeles, CA 90089-0191 www.usc.edu/lacrc Email: lacrc@usc.edu Fact Sheet: HIV-Associated Dementia Complex Definition HIV-Associated Dementia Complex (also known as AIDS Dementia Complex) is a progressive neurological disorder that can affect persons who are infected with the Human Immunodeficiency Virus (HIV). HIV-Associated Dementia Complex (HAD) is thought to be a subcortical dementia and is characterized by cognitive, motor and behavioral impairments severe enough to interfere with an individual's ability to function occupationally or socially. Facts Although the precise incidence and prevalence of HIV-Associated Dementia Complex is uncertain, it has been estimated that as many as two-thirds of individuals with AIDS will develop dementia or related neurological disorders. The leading hypothesis regarding HAD is that it is caused by direct infection of the brain by the Human Immunodeficiency Virus (HIV), the cause of AIDS. In 1987 the Centers for Disease Control included HIV-Associated Dementia Complex as a primary diagnostic condition that warrants a diagnosis of AIDS. Symptoms The early manifestations of HIV-Associated Dementia Complex may include: • Cognitive: Memory loss (difficulty recalling appointment times, telephone numbers, or names), impaired concentration (trouble keeping track of conversations or completing thoughts), and mental slowing (not as "quick" as usual, slower at responding to questions).

74. Scout Report Archives Archives Browse Resources. Browse Resources. aids dementia complex. (1 classification). Classifications. Research (1). Andrew W Mellon http://scout.cs.wisc.edu/Archives/SPT--BrowseResources.php?ParentId=14025

75. Publications CYTOKINES AND AIDS DEMENTIA COMPLEX Cancer Control Research Grant Publications. 1R01MH05042601 null, null null CYTOKINES AND aids dementia complex. Publication Title (click for Abstract)*. http://cancercontrol.cancer.gov/grants/publications.jsp?phs=MH&serial=50426&appl

76. Automated Web Directory: AIDS Dementia Complex Snowfox Home. Automated Web Directory. Powered by the Snowfox Relevance Engine. http://www.snowfox.com/topictrees/English/root/health/medicine/branches_of_medic

Snowfox Home Automated Web Directory Powered by the Snowfox Relevance Engine root health medicine AIDS Dementia Complex Snowfox alphabetic index

77. Alexa Web Search - Subjects > Health > ... > Neurological Disorders > Dementia > aids dementia complex Subjects Health Neurological Disorders Dementia aids dementia complex. Sort by Most Popular. http://www.alexa.com/browse/general?catid=594543&mode=general

78. Zidovudine To Treat And Prevent AIDS Dementia Complex Use Zidovudine in Combination to Treat and Prevent aids dementia complex. from Drugs Therapy Perspectives. Introduction. In the advanced http://www.medscape.com/viewarticle/406332

79. Greater Lafayette Health Services, Inc. Procedures InMotion. Health Information Education. Back to Index, aids dementia complex. by Robin Brett Parnes, MS, MPH. What is aids dementia complex? http://www.glhsi.org/DesktopDefault.aspx?ID=43788&tabid=178

80. 61. Factors Associated With AIDS Dementia Complex 1000 61. Factors Associated with aids dementia complex B. Brew* 1 , M. Fulham 2 , and R. Garsia 2 1 St. Vincent s Hosp. and 2 Royal http://63.126.3.84/2002/Abstract/13381.htm

Abstract E-mail Abstract Author Add To Itinerary Session Search Abstracts ... Program Session 15 Oral Abstract Session Neuropathogenesis Session Time: Tuesday, 10 am - 12:30 pm Room 606-609 Factors Associated with AIDS Dementia Complex B. Brew* , M. Fulham , and R. Garsia St. Vincent's Hosp. and Royal Prince Alfred Hosp., Sydney, Australia Background: Recently, the incidence of AIDS dementia complex (ADC) has been found to have halved as a consequence of the introduction of highly active antiretroviral therapy (HAART) but it is unknown whether this can be maintained with long-term HAART. Moreover, it is not clear what factors are important in ADC development in patients who are taking HAART and who have plasma HIV viral suppression. Methods: HIV-infected patients who were well and without clinical evidence of ADC were enrolled in a 4-year prospective study to determine the factors that govern involvement of the brain by HIV. Plasma HIV viral load was 400 copies/ mL At entry all were assessed neurologically and neuropsychologically with a standard battery.

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