1. OI: Dementia -- ÆGIS aids dementia complex (ADC) is not a true opportunistic infection. It is one of the few conditions caused directly by the HIV virus. aids dementia complex. http://www.aegis.com/topics/oi/oi-adc.html

AIDS Dementia Complex "ADC" "dementia" "sub acute encephalitis" "HIV encephalitis" This is part of a series on Opportunistic Infections . Please note that This Page Is Just A Starting Point: who specializes in treating HIV. Finding The Latest Information: Advances in treating opportunistic infections can happen at any time, so the material on this page may be outdated. Some links in the see also section at the bottom of this page are actually special database links. They may contain information published after this page was written. Classification AIDS Dementia Comples (ADS) is not a true opportunistic infection. It is one of the few conditions caused directly by the HIV virus. Description The central nervous system can be damaged by a number of things opportunistic infections; direct effects of HIV in the brain; toxic effects of drug treatments. Those with ADC have HIV-infected macrophages in the brain. That means HIV is actively infecting brain cells. Symptoms: Early symptoms of AIDS Dementia can be confused with general manifestations of clinical depression. These include apathy, loss of interest in one's surroundings and the like. Later symptoms involve cognitive and motor problems. Memory loss, as well as mobility problems, come into the picture. ( Being Alive The US Centers For Disease Control considers HIV encephalopathy (dementia) an AIDS-defining condition Danger Zone A.D.C. can happen at

2. SF AIDS Fdn: BETA 12/96 -- AIDS Dementia Complex This article is from the Dec. 96 Bulletin of Experimental Treatments for AIDS. In depth and covers the symptoms, classifications, diagnosis, treatment and prevention. http://www.sfaf.org/treatment/beta/b31/b31adc.html

Published in the Bulletin of Experimental Treatments for AIDS December 1996 issue, by the San Francisco AIDS Foundation. December 1996 Table of Contents Main Page beta@sfaf.org AIDS Dementia Complex by Mark Bowers HIV is known to affect most if not all systems in the body. A member of the subfamily of retroviruses that causes a variety of neurological and immunological diseases, HIV has been found in the brain as early as 2 days after initial infection. A type of dementia usually referred to as AIDS dementia complex (ADC), but also known as HIV-1-associated dementia or HIV-associated cognitive/motor complex, has been estimated to affect up to one-third of adults and one-half of all children with AIDS. It remains unclear exactly how and where HIV enters the brain. However, newly devised methods of measuring HIV in the cerebrospinal fluid (CSF) that bathes the spinal cord and the brain may be predictive of the risk of developing ADC and may help gauge efforts to prevent or treat it. The availability of antiretroviral drugs from 2 new classes, protease inhibitors and non-nucleoside reverse transcriptase inhibitors (NNRTI), potentially increases the number of options for preventing and treating ADC. New and better understanding of how HIV causes disease in the brain opens the door for testing novel therapies, including anti-inflammatory drugs, antioxidants, cytokine regulators and calcium channel blockers.

3. AIDS Dementia Complex - HIV: Health And Medical Information About HIV And AIDS A brief article about aids dementia complex. http://www.medterms.com/script/main/art.asp?articlekey=8700

4. Project Inform's AIDS Dementia Complex (ADC) [ HIV / AIDS Treatment Information] Site Map. aids dementia complex. April 2002 impact his or her daily activities. aids dementia complex (ADC)dementia caused by HIV infectionis a complicated http://www.projinf.org/fs/dementia.html

Search Contact Us Feedback Calendar ... Site Map AIDS Dementia Complex April 2002 View PDF (Spanish Translation) Table of Contents Possible Symptoms of Early Stage ADC Possible Symptoms of Middle Stage ADC Possible Symptoms of Late Stage ADC What Is ADC? ... Conclusion ADC consists of many conditions that can be of varying degrees and may progressively worsen. These conditions can easily be mistaken for symptoms of other common HIV-associated problems including depression, drug side effects or opportunistic infections that affect the brain like toxoplasmosis or lymphoma. Symptoms of ADC may include poor concentration, forgetfulness, loss of short- or long-term memory, social withdrawal, slowed thinking, short attention span, irritability, apathy (lack of caring or concern for oneself or others), weakness, poor coordination, impaired judgment, problems with vision and personality change. Because ADC varies so much from person to person, it is poorly understood and has been reported and described in many conflicting ways. This publication will shed light on some of these issues as well as the available treatments for ADC. Possible Symptoms of Early Stage ADC Difficulty concentrating Difficulty remembering phone numbers or appointments Slowed thinking Longer time needed to complete complicated tasks Reliance on list keeping to help track daily activities Mental status tests and other mental capabilities may be normal Irritability Unsteady gait (walk) or difficulty keeping balance Poor hand coordination and change in writing

5. AIDS Dementia Complex-The Neurologic AIDS Research Consortium, Washington Univer Neurologic AIDS Research Consortium. aids dementia complex. aids dementia complex (ADC) is characterized by cognitive dysfunction http://www.neuro.wustl.edu/narc/adc.html

Neurologic AIDS Research Consortium AIDS Dementia Complex Recently completed experimental studies include the following: Open studies include the following: A5090 opened in the fall of 2001. It is a trial using transdermal selegiline for treatment of HIV related motor cognitive disorder. This study is jointly sponsored by NARC and the ACTG system, and will test the safety and efficacy of selegiline (deprenyl) patches for this disorder. It follows up an earlier small study that suggested efficacy for this agent in the setting of AIDS dementia. The study will be placebo controlled for the first 24 weeks, then open label for an additional 24 weeks. The Protocol Chair is Dr. Giovanni Schifitto, University of Rochester. Approximately twelve NARC sites are conducting this study. As of October 2002, thirty-seven subjects had been enrolled, with a target sample size of 120. To contact a site near you, please refer to the list of centers with NeuroAIDS expertise. ACTG 736 is an observational longitudinal study to evaluate the relationships among HIV virus in the blood and the CSF, immune status, and the development of cognitive impairment in subjects receiving potent antiretroviral therapy. The protocol is available to individuals beginning a potent antiretroviral regimen or switching regimens due to virologic failure. In order to enroll, subjects must have a CD4 count less than 200 cells and plasma HIV-1 RNA level greater than 2,000 copies OR any CD4 count with plasma level greater than 50,000 copies. Dr. Christina Marra, University of Washington, is the protocol chair. The target accrual is 100.

6. AIDS Dementia Complex The aids dementia complex (ADC) is one of the most common and clinically important CNS components of the term, aids dementia complex embody central features of the condition http://hivinsite.ucsf.edu/InSite.jsp?page=kb-04&doc=kb-04-01-03

7. Promising Treatment For AIDS Dementia Complex Highlights Of Promising Treatment for aids dementia complex Highlights of Neurological Research from the VIII International Conference on AIDS, Amsterdam, July 1924, 1992 http://www.aegis.com/pubs/step/1992/STEP4313.html

Promising Treatment for AIDS Dementia Complex: Highlights of Neurological Research from the VIII International Conference on AIDS, Amsterdam, July 19-24, 1992 Seattle Treatment Education Project: STEP Perspective - Volume 4, Number 3 - October 1992 Lyn Frumkin, M.D., Ph.D. Dementia is a progressive deterioration of intellectial function in areas such as language and memory, and it has many causes. The dementia associated with AIDS (termed AIDS dementia complex or ADC ) occurs as the result of direct HIV infection of the brain in the absence of brain opportunistic infections or cancers, and affects a large percentage of those with AIDS. There is no treatment to reverse ADC, although zidovudine ( AZT ) may slow the intellectual deterioration and in many cases may improve mental function. Peculiarly, HIV does not infect brain neurons, the cells intimately involved in the process of thinking. Although it is not known how HIV disturbs barin neurons and contributes to dementia, one theory is that gp120 (the outer protein coat of HIV) is toxic and disrupts the function of these cells. A group led by Dr. Candace Pert (Peptide Design, Rockville, MD) reported to the amsterdam conference that Peptide T, an experimental gp120 receptor blocker, improved some of the weakness and problems in thinking associated with ADC. Fifty-six persons with CDC Group IV HIV disease were tested at the beginning of the study and at 12 weeks following intranasal administration of Peptide T. No toxicity was reported and improvement in neuropsychological test performance occurred in most patients.

8. EMedicine - HIV-1 Encephalopathy And AIDS Dementia Complex : Article By Lauren J HIV1 Encephalopathy and aids dementia complex - aids dementia complex (ADC) is one of several neurologic conditions that may be caused by HIV itself. http://www.emedicine.com/neuro/topic447.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Neurology Neurological Infections HIV-1 Encephalopathy and AIDS Dementia Complex Last Updated: May 1, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: AIDS dementia complex, ADC, HIV-1–associated cognitive/motor complex, AIDS encephalopathy, HIV encephalopathy, subacute HIV encephalitis, HIV-associated dementia complex, AIDS-related dementia, HIV dementia, acquired immunodeficiency syndrome, AIDS, human immunodeficiency virus, HIV, minor cognitive motor disorder, MCMD, highly active antiretroviral therapy, HAART AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Lauren J Schaben, MD , Staff Physician, Department of Neurology, Saint Louis University School of Medicine Coauthor(s): Florian P Thomas, MD, PhD, Drmed

9. Neuro AIDS aids dementia complex. ACTG301 A randomized controlled trial of memantine for the treatment of aids dementia complex. All patients http://www.neuro.wustl.edu/clinical_trials/neuroAIDS.html

WASHINGTON UNIVERSITY neuro AIDS OPEN TRIALS PML ACTG363 A treatment trial for progressive multifocal leukoencephalopaty (PML) testing the adition of cidofovir to best antiretroviral therapy. The study will provide close follow-up and treatment through the AIDS Clicical Trial Unit and the Neurologic AIDS Research Consortium. To refer a patient contact: David Clifford MD AIDS Dementia Complex ACTG301 A randomized controlled trial of memantine for the treatment of AIDS dementia complex. All patients receive mazimally effctive HIV theray. The trial has a randomized, placebo controlled 16 week trial of memantine, a putative neuroprotective agent. This is followed by a period of open access to memantine for all participants. To refer a patient contact: David Clifford MD Motor Cognitive Disorder NARC003 A randomized, placebo controlled trial of CPI-1189, a tumor necrosis factor, alpha antagonist, for treatment of motor-cognitive disorder in HIV. This twelve week controlled trial is followed by 12 weeks of open label access to this novel agent. To refer a patient contact: David Clifford MD RETURN TO NEUROLOGY DEPARTMENT HOME PAGE

10. AIDS Dementia Complex aids dementia complex. broader Dementia; HIV Infections Patient Education; HIV; Brain; Acquired Immunodeficiency Syndrome; aids dementia complex; Facts about dementia what is http://omni.ac.uk/browse/mesh/detail/C0001849L0001849.html

low graphics AIDS Dementia Complex broader: Dementia HIV Infections other: AIDS-Related Opportunistic Infections Acquired Immunodeficiency Syndrome Alzheimer Disease Creutzfeldt-Jakob Syndrome ... Brain briefings : HIV's brain assault This is one of the Brain Briefing newsletters produced by the Society for Neuroscience specifically for a lay audience. The aim of these patient-oriented documents is "to explain how basic neuroscience discoveries lead to clinical applications". This document titled "HIV's Brain Assault" covers HIV-associated dementia, HIV and acquired immunodeficiency syndrome (AIDS), HIV's relationship with the brain and current therapy being tested with patients. Written in December 1999, this document contains illustrations and images. Patient Education HIV Brain Acquired Immunodeficiency Syndrome ... Facts about dementia: what is Aids-related cognitive impairment? This fact sheet, one of a series from the Alzheimer's Society intended for patients and carers, describes briefly how HIV may affect the brain. It outlines the symptoms, diagnosis and treatment of the condition. The document is also available here as a PDF, requiring Adobe Acrobat Reader. Patient Education Handout [Publication Type] AIDS Dementia Complex Last modified: 27 May 2004

11. AIDS Dementia Complex - Information / Diagnosis / Treatment / Prevention home neurological disorders dementia aids dementia complex aids dementia complex. aids dementia complex This article is from the Dec. http://www.healthcyclopedia.com/neurological-disorders/dementia/aids-dementia-co

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... dementia > aids dementia complex AIDS Dementia Complex Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Medical Definition Health News Web Directory: Related Topics: Immune Disorders/Immune Deficiency/AIDS Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "AIDS dementia complex" Health News: Search millions of published articles for news on AIDS Dementia Complex Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: AIDS Dementia Complex A comprehensive guide to this condition called ADC, dementia, sub acute encephalitis or HIV encephalitis from AEGIS. AIDS Dementia Complex This article is from the Dec. 96 Bulletin of Experimental Treatments for AIDS. In depth and covers the symptoms, classifications, diagnosis, treatment and prevention.

12. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: Behaviors and Mental Disorders aids dementia complex. Include trials that are no longer recruiting patients. http://clinicaltrials.gov/ct/screen/BrowseAny?path=/browse/by-condition/hier/BXM

13. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: Alphabetically A aids dementia complex. Include trials that are no longer recruiting patients. http://clinicaltrials.gov/ct/gui/c/a1b/screen/BrowseAny?recruiting=true&path

14. NeuroGate.com Search results for "aids dementia complex" Cardioguide Matches 1 2 of 2 Search AltaVista for more on 'aids dementia complex' http://www.neurogate.com/neuro/result.php3?search=AIDS Dementia Complex&sele

15. AIDS SA - AIDS Dementia Complex characteristics of the dementia associated with HIV infection was first described by Navia in 1986 who coined the term aids dementia complex (ADC) . http://www.niv.ac.za/virussa/aidsa/v7_3.htm

Pathogenesis Diagnosis Clinical Features Management The neuropathological characteristics of the dementia associated with HIV infection was first described by Navia in 1986 who coined the term "AIDS dementia complex (ADC)" . The disease has also been referred to by the WHO as well as the American Academy of Neurology by the rather cumbersome and seldom used alternate term, "HIV-associated cognitive/motor complex" Initially, ADC was seen in 15 to 30% of HIV infected patients, virtually always in the advanced stage of AIDS, and usually accompanied by a profound immunosuppression as well as other signs of AIDS. In developed countries, the incidence of ADC has dropped dramatically because of the widespread use of zidovudine and it is now a rare disease in those patients who are on zidovudine treatment. ADC is a diffuse CNS disorder, charac-terized clinically as a subcortical dementia which manifests itself by slowness of mental function and by disturbances of cognitive and motor functions. The disease, if untreated, is progressive with patients ultimately reaching a vegetative state before death. The mortality rate for ADC is 3 times that of Pneumocystis pneumonia. Replication of HIV in the CNS plays a key role in the pathogenesis and therefore the disease is treatable by antiretroviral agents, especially zidovudine, which penetrates readily into the CNS, and much of the neurological damage is reversible. PATHOGENESIS The pathogenesis of ADC is marked by the following features:-

16. AIDS Dementia Complex aids dementia complex Dementia in HIV. Book, Home Page. http://www.fpnotebook.com/HIV46.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement HIV Neurology Assorted Pages Neurologic manifestations of HIV AIDS Dementia Complex Focal Brain Lesion in HIV HIV related Myelopathy ... HIV related Neuropathy AIDS Dementia Complex Dementia in HIV Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter HIV Index Cardiovascular Medicine Dentistry Dermatology Endocrinology Otolaryngology Examination Ophthalmology Gastroenterology Gynecology Hematology and Oncology Infectious Disease Laboratory General Pulmonology Neurology Obstetrics Pediatrics Pharmacology Prevention Nephrology Rheumatology Page Neurology Index Approach Dementia Lesion Brain Myelopathy Neuropathy Epidemiology Common complication in late AIDS Pathophysiology Cognitive, behavioral, and motor dysfunction

17. AIDS Dementia Complex aids dementia complex. The aids dementia complex (ADC) is one of the most common and clinically important CNS complications of late HIV1 infection. http://hivinsite.ucsf.edu/InSite?page=kb-authors&doc=kb-04-01-03

18. AIDS Dementia Complex: Related Resources aids dementia complex Related Resources. Inc. January 2002. Images. Brain MRI from Patient with aids dementia complex. Links. National http://hivinsite.ucsf.edu/InSite?page=kbr-04-01-03

19. AIDS Dementia Complex aids dementia complex. http://omni.ac.uk/browse/mesh/C0001849L0001849.html

low graphics AIDS Dementia Complex broader: Dementia HIV Infections other: AIDS-Related Opportunistic Infections Acquired Immunodeficiency Syndrome Alzheimer Disease Creutzfeldt-Jakob Syndrome ... Brain briefings : HIV's brain assault This is one of the Brain Briefing newsletters produced by the Society for Neuroscience specifically for a lay audience. The aim of these patient-oriented documents is "to explain how basic neuroscience discoveries lead to clinical applications". This document titled "HIV's Brain Assault" covers HIV-associated dementia, HIV and acquired immunodeficiency syndrome (AIDS), HIV's relationship with the brain and current therapy being tested with patients. Written in December 1999, this document contains illustrations and images. Patient Education HIV Brain Acquired Immunodeficiency Syndrome ... Facts about dementia: what is Aids-related cognitive impairment? This fact sheet, one of a series from the Alzheimer's Society intended for patients and carers, describes briefly how HIV may affect the brain. It outlines the symptoms, diagnosis and treatment of the condition. The document is also available here as a PDF, requiring Adobe Acrobat Reader. Patient Education Handout [Publication Type] AIDS Dementia Complex Last modified: 27 May 2004

20. Entrez PubMed aids dementia complex evaluation with proton MR spectroscopic imaging. MeSH Terms aids dementia complex/diagnosis*; aids dementia complex/metabolism; Adult; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstra

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