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         Adrenoleukodystrophy:     more books (16)
  1. Peroxisomal Disorders: An entry from Gale's <i>Gale Encyclopedia of Medicine, 3rd ed.</i> by Judith Sims, Teresa Odle, 2006
  2. Lorenzo's oil - more than just a great movie.: An article from: Medical Update

21. Adrenoleukodystrophy
Click on small image to see full size. adrenoleukodystrophy. Findings Axial CT images show patchy diffuse posterior white matter hypodensity.
http://www.med.uc.edu/neurorad/webpage/fda.html
Click on small image to see full size. Adrenoleukodystrophy Findings:
Axial CT images show patchy diffuse posterior white matter hypodensity. Multiple MR images show predominant signal abnormalities in the parieto-occipital white matter and splenium of corpus callosum with symmetric enhancement along the periphery. The signal abnormalities extend into the brainstem. Differential Diagnosis:
The signal characteristics are most consistent with ADL. Globoid cell leukodystrophy may also have predominant abnormalities in the parietal regions, but this characteristic enhancement pattern would be unusual. MS and ADEM could rarely have this appearance, and would not likely be this symmetric. Discussion:
ADL represents a deficiency of lignoceroyl CoA ligase, with accumulation of very long chain fatty acids in brain, adrenals, and blood elements. It is inherited as x-linked recesive or autosomal recessive. Pathologically, there is demyelination which advances in zones, with the peripheral zone showing no inflammatory response. The intermediate zone has active demyelination and inflammatory response, with the inner zone showing necrosis, gliosis, and possible calcification. Numerous phenotypes exist, the most common of which has clinical onset between 5-10 years, with rapidly progressive neurologic decline and death. Imaging features include symmetric posterior white matter involvement including the splenium, with a rind of enhancement along the advancing edges. reference: Osborn, A; Tong, K. Handbook of Neuroradiology: Brain and Skull. 1996: Mosby Year Book. pp. 521-523.

22. ALD Family Support Trust
To Drive a Train. But all our dreams were over before they began, the only thing we all have in common now is that we have adrenoleukodystrophy.
http://www.aldfst.org.uk/

WELCOME YOU TO OUR WEB SITE
We Had A Dream To be Football Players in the Premier League. To Fly a Plane. To Drive a Train. But all our dreams were over before they began, the only thing we all have in common now is that we have Adrenoleukodystrophy. Adrenoleukodystrophy Family Support Trust is a national registered charity, specifically for children like us who are victims of the life threatening genetic disease called Adrenoleukodystrophy, better known as ALD for short. Please use the following pages and links to find out more about the work of the ALD Family Support Trust, and for information on how you can help us.
Thank You So Much. Home Home

23. Adrenoleukodystrophy (ALD): A Case Study Using The Film "Lorenzo's Oil"
**Sorry, WWNFF LPT can not answer questions regarding the film Lorenzo s Oil. ** We DO NOT have information on Lorenzo s condition.
http://www.woodrow.org/teachers/bi/1994/adreno.html
**Sorry, WWNFF - LPT can not answer questions regarding the film "Lorenzo's Oil."**
We DO NOT have information on Lorenzo's condition.
You may want to visit
The Internet Movie Database

for more information on the movie.
The information we do have is
here

The Woodrow Wilson National Fellowship Foundation
CN 5281, Princeton NJ 08543-5281 Tel:(609)452-7007 Fax:(609)452-0066

24. Adrenoleukodystrophy - Information / Diagnosis / Treatment / Prevention
home neurological disorders demyelinating diseases leukodystrophy adrenoleukodystrophy adrenoleukodystrophy. Information
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Related Topics: Genetic Disorders Rare Disorders Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "adrenoleukodystrophy" Health News: Search millions of published articles for news on Adrenoleukodystrophy Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Adrenoleukodystrophy Offers a summary of the disorder, possible treatments and links. Adrenoleukodystrophy (ALD) Foundation A non-profit organization created to educate about ALD by providing educational materials and links to information associated with the disease. Human and Scientific Story of Adrenoleukodystrophy Description, discussion of treatments, and links.

25. Adrenoleukodystrophy (ALD)
Search. Rare / Orphan Diseases, adrenoleukodystrophy Guide picks. An inherited progressive degenerative myelin disorder in which fats
http://rarediseases.about.com/cs/ald/
zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') About Rare / Orphan Diseases Home Essentials ... Rare cancers zau(256,152,145,'gob','http://z.about.com/5/ad/go.htm?gs='+gs,''); Is it a Rare Disease? Rare Diseases A - B Rare Diseases C - D Rare Diseases E - H ... Help zau(256,138,125,'el','http://z.about.com/0/ip/417/0.htm','');w(xb+xb);
Stay Current
Subscribe to the About Rare / Orphan Diseases newsletter. zau(256,152,100,'hs','http://z.about.com/5/ad/hs.htm?zIhsid=00',''); Search Rare / Orphan Diseases Adrenoleukodystrophy
Guide picks An inherited progressive degenerative myelin disorder in which fats are not metabolized properly, leading to permanent nerve and adrenal gland damage.
Adrenoleukodystrophy (ALD) and Lorenzo's Oil

Article explains the disease, its symptoms, diagnosis, and treatments, and what new therapies are being explored. From the About.com Guide to Rare/Orphan Diseases. Association Europeenne contre les Leucodystrophies
Addresses of support groups in France, Switzerland, Belgium, and comprehensive information on the disorder in French. The British Trust for the Myelin Project
Facts, research news, support, and links to international support groups.

26. NORD - National Organization For Rare Disorders, Inc.
adrenoleukodystrophy. View Cart/Checkout. Copyright 1985, 1986, 1988, 1989, 1990, 1993, 1994, 1997, 1998, 1999 Synonyms of adrenoleukodystrophy
http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Adrenoleukody

27. Adrenoleukodystrophy
adrenoleukodystrophy. adrenoleukodystrophy (ALD) is a member of a group of diseases, leukodystrophies, that cause damage to the myelin sheath of nerve cells.
http://www.ehendrick.org/healthy/000033.htm
MAIN SEARCH INDEX
Adrenoleukodystrophy
Definition
Adrenoleukodystrophy is a rare genetic disease characterized by a loss of myelin surrounding nerve cells in the brain and progressive adrenal gland dysfunction.
Description
Adrenoleukodystrophy (ALD) is a member of a group of diseases, leukodystrophies, that cause damage to the myelin sheath of nerve cells. Approximately one in 100,000 people is affected by ALD. There are three basic forms of ALD: childhood, adult-onset, and neonatal. The childhood form of the disease is the classical form and is the most severe. Childhood ALD is progressive and usually leads to total disability or death . It affects only boys because the genetic defect is sex-linked (carried on the X chromosome). Onset usually occurs between ages four and ten and can include many different symptoms, not all of which appear together. The most common symptoms are behavioral problems and poor memory. Other symptoms frequently seen are loss of vision, seizures, poorly articulated speech, difficulty swallowing, deafness, problems with gait and coordination, fatigue , increased skin pigmentation, and progressive dementia The adult-onset form of the disease, also called adrenomyeloneuropathy, is milder, progresses slowly, is usually associated with a normal life span, and usually appears between ages 21-35. Symptoms may include progressive stiffness, weakness, or

28. What Is Adrenoleukodystrophy?
adrenoleukodystrophy (ALD) falls into a group of disorders known as leukodystrophies. This disease is diagnosed with a plasma test
http://www.ikm.jmu.edu/Buttsjl/ISAT493/Adrenoleukodystrophy/aldintro.html
Main X-linked page Symptoms Incidence Severity ... "Lorenzo's Oil" Adrenoleukodystrophy (ALD) falls into a group of disorders known as leukodystrophies This disease is diagnosed with a plasma test to determine the level of very long chain fatty acids, regardless of symptomatology. It is a very specialized test, so it is only performed in a few laboratories worldwide. These very long chain fatty acids accumulate, due to absence of peroxisomes in the liver, and damage the ability of the adrenal gland to convert cholesterol to steroid hormones. The characteristic of the disease is progressive cognitive and behavioral impairment. This impairment is due to the myelin degeneration that occurs within these patients' central nervous system. Without the myelin sheath, nerve fibers are damaged and cease to function properly. Click the above graphic to hear the pronunciation of the disease. When prompted, choose 'open from current location.' The figure above shows the location of the Adrenoleukodystrophy gene on the x chromosome. It was borrowed from

29. Inidence Of Adrenoleukodystrophy
Incidence of adrenoleukodystrophy. adrenoleukodystrophy is an extremely rare disease, affecting only 175,000 live male births. The
http://www.ikm.jmu.edu/Buttsjl/ISAT493/Adrenoleukodystrophy/aldincidence.html
Incidence of Adrenoleukodystrophy Main X-linked page What is it? Symptoms Severity ... "Lorenzo's Oil" Adrenoleukodystrophy is an extremely rare disease, affecting only 1:75,000 live male births. The disease affects all races equally. There have been no known female sufferers of the childhood onset form of the disease, so the incidence in girls does not exist. It is estimated that 1:42,000 females in the United States carries the defective gene that causes Adrenolekodystrophy. The graph shown above illustrates the incidence of Adrenoleukodystrophy as well as carrier frequency. The graph was created in MS Excel v2000 by the Microsoft Corporation. previous next This page created by: Jennifer Butt

30. Kennedy Krieger Institute Adrenoleukodystrophy (ALD)
KKI Logo. Print this page. adrenoleukodystrophy (ALD). adrenoleukodystrophy (ALD) is a rare, genetic disorder characterized by the breakdown or loss of the myelin
http://www.kennedykrieger.org/kki_diag.jsp?pid=1069

31. AllRefer Health - Adrenoleukodystrophy (Melanodermic Leukodystrophy, NALD, Neona
adrenoleukodystrophy (Melanodermic Leukodystrophy, NALD, Neonatal Adrenoleukodyrstophy, XLinked adrenoleukodystrophy) information center covers causes
http://health.allrefer.com/health/adrenoleukodystrophy-info.html
AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia
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Alternate Names : Melanodermic Leukodystrophy, NALD, Neonatal Adrenoleukodyrstophy, X-Linked Adrenoleukodystrophy Definition Adrenoleukodystrophy describes any of several closely related inheritable disorders of the breakdown ( metabolism ) of certain fats (long chain fatty acid) that affects the adrenal glands , nervous system, and testes
Neonatal Adrenoleukodystrophy Adrenoleukodystrophy is transmitted as an X-linked trait (the neonatal form is by autosomal recessive transmission). Its

32. EMedicine - Peroxisomal Disorders : Article By Aziza Chedrawi, MD
Synonyms and related keywords metabolic disorders, metabolic diseases, peroxisome disorders, peroxisome diseases, adrenoleukodystrophy, ALD, neonatal
http://www.emedicine.com/neuro/topic309.htm
(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Neurology Pediatric Neurology
Peroxisomal Disorders
Last Updated: April 28, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: metabolic disorders, metabolic diseases, peroxisome disorders, peroxisome diseases, adrenoleukodystrophy, ALD, neonatal adrenoleukodystrophy, adrenomyeloneuropathy, infantile Refsum disease, hyperpipecolic acidemia, rhizomelic chondrodysplasia punctata, RCPD, pseudo–neonatal adrenoleukodystrophy, acyl CoA oxidase deficiency, metabolic kinase deficiency, hyperoxaluria type I, alanine glyoxylate aminotransferase deficiency, bifunctional enzyme deficiency, pseudo-Zellweger syndrome, peroxisome thiolase deficiency, acatalasemia, catalase deficiency, dihydroxy acetone phosphate acyltransferase deficiency, DHAP-AT, alkyl-DHAP synthase deficiency, glutaric aciduria, adult Refsum disease, classic Refsum disease, phytanoyl CoA hydroxylase deficiency, Zellweger syndrome, ZWS AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography
Author: Aziza Chedrawi, MD

33. FSP Syndromes
Adrenomyeloneuropathy l adrenoleukodystrophy protein (ALDP) ; Chromosome Xq28; Recessive Genetics phenotype; Allelic with adrenoleukodystrophy; ?
http://www.neuro.wustl.edu/neuromuscular/spinal/fsp.html

Front
Search Index Links ... Patient Info
FAMILIAL SPINAL CORD SYNDROMES
General principles
Familial Spastic Paraplegia ( SPG

Dominant

: Atlastin; 14q11
: Spastin; 2p22
SPG 12q

Recessive

: Paraplegin; 16q24
(Troyer): Spartin; 13q12.3
(Mast): Maspardin; 15q22 Infantile onset : Alsin; 2q33 X-linked : Proteolipid protein; Xq22 Other: Deafness Familial Spastic Paraplegia +... Ataxia CNS Ocular PNS ... Systemic Disorders Leukodystrophies Adrenomyeloneuropathy : ALDP; Xq28 Adult-onset Krabbe : GalC; 14q31 MLD : Arylsulfatase A; 22q13 Other spinal cord syndromes Syndromes AAA syndrome : Aladin; 12q13 Adrenomyeloneuropathy : ALDP; Xq28 Alexander : GFAP; 17q21; Dominant Alzheimer's : Presenilin 1; 14q24; Dominant Arnold-Chiari Malformation (SPG9): 10q23; Dominant Cavanagh's Cerebral palsy-Symmetrical Cerebrotendinous xanthomatosis : Cytochrome 450; 2q33 Charlevoix-Saguenay : Sacsin; 13q11 Deafness : X-linked DOPA-responsive dystonias DRPLA : DRPLA protein; 12p13; Dominant Episodic ataxia : 1p; Dominant Evans Fitzsimmons syndrome Friedreich ataxia : FRDA; 9q13 Hereditary Motor Syndromes HHH syndrome HMSN 5 : Dominant : ARX; Xp22

34. Adrenoleukodystrophy
HOME. adrenoleukodystrophy (AddisonSchilder syndrome, Fanconi-Prader syndrome, Siemerling-Creutzfeldt syndrome, bronze Schilder disease).
http://www.bdid.com/adrenoleukodystrophy.htm

HOME
Adrenoleukodystrophy (Addison-Schilder syndrome, Fanconi-Prader syndrome, Siemerling-Creutzfeldt syndrome, bronze Schilder disease)

35. MedFriendly.com: Adrenoleukodystrophy
provides an easy to understand definition for the medical term, adrenoleukodystrophy. TM, adrenoleukodystrophy MedFriendly.com TM TM
http://www.medfriendly.com/adrenoleukodystrophy.html
TM Adrenoleukodystrophy
MedFriendly.com
TM
TM
A B C D ...
  • What is the origin of the term, adrenoleukodystrophy?
    The Official Parent's Sourcebook on Adrenoleukodystrophy: A Revised and Updated Directory for the Internet Age WHAT IS IT? Adrenoleukodystrophy (abbreviated as ALD) is a rare disorder that is characterized by a buildup of saturated, very long chain fatty acids (abbreviated VLCFA) in the tissues of the body. Saturated means to be filled up with something. In the case of fats, saturated refers to how much hydrogen (a type of element) is contained in it. Saturated fats are filled with hydrogen. Fatty acids are types of chemicals in the body that are necessary for many bodily functions. Very long chain fatty acids are called "very long" because they have greater amounts of carbon in them. Carbon is a type of element that is essential to normal bodily functioning. In ALD, very long chain fatty acids are found in especially high numbers in the brain, blood, and the adrenal cortex (the outer part of the adrenal glands). The adrenal glands are a pair of glands that play an important role in metabolism and help the body respond to physical and emotional stress by releasing certain hormones. A gland is an organ in the body made of special cells that form and release materials such as fluid. Metabolism is the chemical actions in cells that release energy from nutrients or use energy to create other substances. Hormones are natural chemicals produced by the body and released into the blood that have a specific effect on tissues in the body.
  • 36. Adrenoleukodystrophy
    adrenoleukodystrophy. What is adrenoleukodystrophy? adrenoleukodystrophy (ALD) is a rare, genetic disorder characterized by the breakdown
    http://www.clevelandclinic.org/health/health-info/docs/1200/1242.asp?index=6030&

    37. HealthCentral - General Encyclopedia - Adrenoleukodystrophy
    General Health Encyclopedia, adrenoleukodystrophy. Alternative names Xlinked adrenoleukodystrophy; melanodermic leukodystrophy Definition
    http://www.healthcentral.com/mhc/top/001182.cfm
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    38. HealthCentral - Pediatrics Encyclopedia - Adrenoleukodystrophy
    Introduction adrenoleukodystrophy WrongDiagnosis.comIntroduction to adrenoleukodystrophy as a medical condition including symptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis.
    http://www.healthcentral.com/peds/top/001182.cfm
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    39. Health Library -
    adrenoleukodystrophy. Synonyms atrophy). adrenoleukodystrophy that is inherited as an Xlinked genetic trait may begin in childhood or adulthood.
    http://yalenewhavenhealth.org/library/healthguide/IllnessConditions/topic.asp?hw

    40. Adrenoleukodystrophy - Medical Dictionary Definitions Of Popular Medical Terms
    adrenoleukodystrophy A rare genetic (inherited) disorder characterized by the breakdown or loss of the myelin sheath surrounding nerve cells in the brain and
    http://www.medterms.com/script/main/art.asp?articlekey=11567

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