81. JW Women's Health -- Sign In Summary and Comment. Screen for activated protein c resistance Isn t CostEffective. activated protein c resistance assay when applied in the general population. http://womens-health.jwatch.org/cgi/content/full/1997/401/10

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82. NEJM -- Resistance To Activated Protein C Correspondence from The New England Journal of Medicine resistance to activated protein C Number 2. Next. resistance to activated protein C. Since this article has no abstract, we have provided an by Svensson and Dahlback on resistanceto activated protein C (APC) (Feb http://www.nejm.org/cgi/content/short/331/2/129

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 331:129-130 July 14, 1994 Number 2 Next Resistance to Activated Protein C Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text Add to Personal Archive Add to Citation Manager E-mail When Cited ... PubMed Citation To the Editor: The article by Svensson and Dahlback on resistance to activated protein C (APC) (Feb. 24 issue) postulates that there is a genetically determined defect in anticoagulation characterized by resistance to APC. The authors subsequently found the anticoagulant cofactor that corrects inherited APC resistance to be identical to unactivated factor V. I believe that these findings could also be due to hyperhomocysteinemia. It has been demonstrated that hyperhomocysteinemia is an independent risk factor for vascular disease . It was previously demonstrated that homocysteine induced a vascular-endothelial-cell activator that led to the activation of factor Full Text of this Article References HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Comments and questions? Please

83. Protein C (resistance To Activated Protein C) - General Practice Notebook protein C (resistance to activated protein C). Mutation in blood coaulation factor V associated with resistance to activated protein C. Nature, 369, 647. http://www.gpnotebook.co.uk/cache/1711669304.htm

protein C (resistance to activated protein C) Resistance to the anticoagulant effects of activated protein C (APC) (Factor V Leiden heterozygous*) is common (1): 5% of the general population 25-50% of patients with venous thromboembolism 50% of patients with thrombosis who have a family or personal history of thrombosis APC resistance is usually due to a single point mutation in one or both of the protein C genes. The mutation reduces the susceptibility of factor V to cleavage by APC. There is increasing evidence that individuals with two or more laboratory characterisable thrombophilic abnormalities (or who are homozygous for either factor V Leiden or prothrombin G20210A) are at a greater risk of thrombosis than those in whom there is a single gene abnormality (1). * Factor V Leiden homozygous individuals have an 80x risk of venous thromboembolism Reference: (1) British Heart Foundation (Factfile 2/2002). Thrombophilia (2) Rogier, MB. et al. (1994). Mutation in blood coaulation factor V associated with resistance to activated protein C. Nature, 369, 64-7. (3) Drugs and Therapeutics Bulletin (1995), 33 (1), 6-8.

84. Resistance To Activated Protein C - General Practice Notebook resistance to activated protein C. et al. (1994). Mutation in blood coaulation factor V associated with resistance to activated protein C. Nature, 369, 647. http://www.gpnotebook.co.uk/cache/1731526712.htm

resistance to activated protein C Resistance to the anticoagulant effects of activated protein C (APC) (Factor V Leiden heterozygous*) is common (1): 5% of the general population 25-50% of patients with venous thromboembolism 50% of patients with thrombosis who have a family or personal history of thrombosis APC resistance is usually due to a single point mutation in one or both of the protein C genes. The mutation reduces the susceptibility of factor V to cleavage by APC. There is increasing evidence that individuals with two or more laboratory characterisable thrombophilic abnormalities (or who are homozygous for either factor V Leiden or prothrombin G20210A) are at a greater risk of thrombosis than those in whom there is a single gene abnormality (1). * Factor V Leiden homozygous individuals have an 80x risk of venous thromboembolism Reference: (1) British Heart Foundation (Factfile 2/2002). Thrombophilia (2) Rogier, MB. et al. (1994). Mutation in blood coaulation factor V associated with resistance to activated protein C. Nature, 369, 64-7. (3) Drugs and Therapeutics Bulletin (1995), 33 (1), 6-8.

85. NEJM -- Resistance To Activated Protein C Correspondence from The New England Journal of Medicine resistance to activated protein C. Next Next. resistance to activated protein C. http://content.nejm.org/cgi/content/short/331/2/129

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 331:129-130 July 14, 1994 Number 2 Next Resistance to Activated Protein C Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text Add to Personal Archive Add to Citation Manager E-mail When Cited ... PubMed Citation To the Editor: The article by Svensson and Dahlback on resistance to activated protein C (APC) (Feb. 24 issue) postulates that there is a genetically determined defect in anticoagulation characterized by resistance to APC. The authors subsequently found the anticoagulant cofactor that corrects inherited APC resistance to be identical to unactivated factor V. I believe that these findings could also be due to hyperhomocysteinemia. It has been demonstrated that hyperhomocysteinemia is an independent risk factor for vascular disease . It was previously demonstrated that homocysteine induced a vascular-endothelial-cell activator that led to the activation of factor Full Text of this Article References HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Comments and questions? Please

86. Procedure Activated Protein C Resistent FV also known as APC Resistant Factor V, protein C resistance Assay, Factor V Leiden, APCFV , activated protein C Resistant FVA, Blood. SPECIAL COAGULATION LAB, http://health.ucsd.edu/labref/P321.html

UNIVERSITY OF CALIFORNIA, SAN DIEGO CLINICAL LABORATORIES Activated Protein C Resistent FV Specimen Type: also known as APC Resistant Factor V, Protein C Resistance Assay, Factor V Leiden, APCFV , Activated Protein C Resistant FVA Blood SPECIAL COAGULATION LAB specimen requirements: Blue Top normal or reference ranges: Category LOW HIGH UNITS Normal unit of measure: Normal/Abnormal ideal sample: 2.7 mL Whole Blood, 5.0 mL blue top absolute minimum amount: 2.4 mL Whole Blood The following substances can adversely affect the results: Clots in Specimen, Improper Line Draw request test on form: Hematology Test Request ( 151-204 ) Miscellaneous ( 151-858 ) order/entry screen(s): Hematology/Coagulation method: Optical Clot Detection stat frequency : Monday - Friday, 0830-1630 routine turn around time: 1 Week For Hillcrest deliver to: SCRAP : Specimen Central Receiving and Processing, room 2-117 For Thornton deliver to: Hematology : Processing Desk, 1st floor, Hospital, room 1-013 Special Instructions: Assay is not affected by heparin, coumadin, or lupus anticoagulant.

87. Entrez PubMed Error occurred Document internals (TXmlObj) retrieval error 4 http://www.biomedcentral.com/pubmed/10574639

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Eur J Contracept Reprod Health Care. 1999 Sep;4(3):135-44. Related Articles, Links Increased resistance to activated protein C and factor V Leiden in recurrent abortions. Review of other hypercoagulability factors. Hatzis T, Cardamakis E, Drivalas E, Makatsoris K, Bevan D, Pantos C, Malliopoulou V, Tsagaris N, Kreatsa O, Antoniadi T, Petersen MB, Karageorgiou H, Mantouvalos H.

88. Activated Protein C (APC) Resistance activated protein C (APC) resistance. . REQUESTING AND COLLECTING. Collection Tube MUST be full. Place on ice if unable to deliver to laboratory within. http://www.sydpath.stvincents.com.au/spec_db/SydPathTestDetailsPage17.html

Activated Protein C (APC) Resistance REQUESTING AND COLLECTING Collection: Tube MUST be full. Place on ice if unable to deliver to laboratory within 2 hours of collection. Container(s): Citrate tube (4.5 mL blue-top) - required GENERAL INFORMATION Availability: Test performed weekly. Reference Intervals: Laboratory: Haemostasis and Special Haematology (8382-9145) Synonyms: APC resistance INSTRUCTIONS FOR REFERRING LABORATORIES Handling and and send frozen plasma. If separated must be double spun. INSTRUCTIONS FOR HANDLING AT SYDPATH SydPath Handling: SPRO: Processing by laboratory only. Mnemonic: APC Date Published: Friday, 14 May 2004 Reference intervals and availability data is for general guidance only. For specific details contact laboratory or see specific patient reports. Database managed by Dr Graham Jones at S YD P ATH . For questions, comments or suggestions please call via 8382-9100 or e-mail on gjones@stvincents.com.au

89. CLR [ Index Of Tests/rare Tests ] Tests/Rare Tests. Below are the results from your search activated protein Cresistance (APCR). ARUP Inc 500 Chipeta Way Salt Lake http://www.clr-online.com/cgi-bin/2003/testlisting.asp?ID=1495&Test=Activated pr

90. American Red Cross Blood Services, New England Region, Maine, Massachusetts, New conversion of protein C, present in the plasma, by thrombin to activated protein C. laboratory testing and an occasional diagnosis of APCresistance in some http://www.newenglandblood.org/professional/APCguide.htm

Home to Professional Resource Center American Red Cross Blood Services - New England Region Maine, Massachusetts, New Hampshire, Vermont Where Tradition and the New Millennium Meet Activated Protein C Transfusion Guidelines American Red Cross Blood Services - New England Region Name: Activated Protein C Major Products Available: Drotrecogin alpha (activated) Description/Contents Drotrecogin alpha (activated) is a recombinant form of human activated protein C (APC) that is manufactured as an inactive zymogen and is enzymatically activated by cleavage with thrombin, then purified using monoclonal antibodies. APC exerts an anticoagulant effect, along with its co-factor protein S, by inactivating Factors Va and VIIIa, two critical pro-coagulants that lead to thrombin formation. Thrombin binds to thrombomodulin on endothelial cells at – and adjacent to – the site of vascular injury which stimulated the coagulation process. Thrombomodulin serves as a cofactor for the conversion of protein C, present in the plasma, by thrombin to activated protein C. APC also inhibits tumor necrosis factor production by monocytes, blocks leukocyte adhesion to selectins and limits thrombin-induced microvascular damage. Discovery of an APC-resistant state, hereditary Factor V Leiden, which leads to increased susceptibility to thrombosis, has led to extensive laboratory testing and an occasional diagnosis of APC-resistance in some cases of thrombophilia or venous thrombosis.

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