61. HRLMP - Service - Newsletters - Spring, 1995 Issue No. 39, QUARTERLY NEWSLETTER, Spring, 1995. activated protein c resistance AND THROMBOSIS. What tests are used to detect activated protein c resistance? http://www.fhs.mcmaster.ca/hrlmp/service/news3995.htm

Administrative Office St. Joseph's Hospital Site, L301-10 50 Charlton Avenue East HAMILTON, Ontario, CANADA L8N 4A6 PHONE: (905) 521-6141 FAX: (905) 521-6142 http://www.fhs.mcmaster.ca/hrlmp/ Issue No. 39 QUARTERLY NEWSLETTER Spring, 1995 ACTIVATED PROTEIN C RESISTANCE AND THROMBOSIS In the last two years, a new coagulation disorder, termed "activated protein C resistance" or "APC resistance" has been identified as an important cause of inherited thrombotic disease. Most individuals with APC resistance have been shown to have a mutation in the factor V gene that causes the coagulation factor V protein to escape regulation by the protein C anticoagulant pathway. This results in a disturbance in the normal balance between hemostasis and clot promotion. Because the mutation associated with this abnormality occurs in many parts of the world, APC resistance has become recognized as one of the most frequent causes of inherited, prothrombotic disease. In health, clot formation is balanced by a natural anticoagulant system, the protein C pathway. The coagulation factors Va and VIIIa are key non-enzymatic components of the hemostatic pathway. Together, they accelerate coagulation 300,000 fold by promoting the assembly of procoagulant enzyme complexes. When coagulation occurs, protein C is activated, and, together with protein S, it inactivates factors Va and VIIIa by proteolytic cleavage. Although defects in the protein C anticoagulant pathway, due to deficiencies in protein C or protein S, have been recognized for many years; these disorders occur infrequently in patients with inherited thrombotic disease. Similarly, defects in antithrombin, another important natural anticoagulant, are also rare. Together, protein C, protein S and antithrombin deficiencies are found in only 10-15% of patients with thrombophilia or inherited thrombotic disease.

62. PROGEN GMBH --- Diagnostics --- Research Products --- Point-of-Care --- Translate this page activated protein c resistance Control Kit. Kontrollsatz für das activated protein c resistance Sensitivity Kit, enthält je 5 x http://www.progen.de/index_D.php?a=diagnostik_home&b=einzelprodukt&c=876

63. PROGEN GMBH --- Diagnostics --- Research Products --- Point-of-Care --- Translate this page activated protein c resistance Sensitivity Kit. Reagenziensatz zum funktionellen Nachweis der hereditären und erworbenen Resistenz http://www.progen.de/index_D.php?a=diagnostik_home&b=einzelprodukt&c=879

64. :: Ez2Find :: Factor V Leiden activated protein c resistance Site Info - Translate - Open New Window Discusses the thrombotic risks of this inherited disorder, also known as Factor http://ez2find.com/cgi-bin/directory/meta/search.pl/Health/Conditions_and_Diseas

Guide : Factor V Leiden Global Metasearch Any Language English Afrikaans Arabic Bahasa Melayu Belarusian Bulgarian Catala Chinese Simplified Chinese Traditional Cymraeg Czech Dansk Deutsch Eesti Espanol Euskara Faroese Francais Frysk Galego Greek Hebrew Hrvatski Indonesia Islenska Italiano Japanese Korean Latvian Lietuviu Lingua Latina Magyar Netherlands Norsk Polska Portugues Romana Russian Shqip Slovensko Slovensky Srpski Suomi Svenska Thai Turkce Ukrainian Vietnamese Mode All Words Any Word Phrase Results Timeout Depth Adult Filter Add to Favorites Other Search Web News Newsgroups Images Guides Factor V Leiden ez2Find Home Directory Health Conditions and Diseases ... Blood Coagulation : Factor V Leiden Related Categories Health: Conditions and Diseases: Cardiovascular Disorders: Vascular Disorders: Thrombosis Health: Conditions and Diseases: Genetic Disorders Web Sites Activated Protein C Resistance [Site Info] [Translate] [Open New Window] Discusses the thrombotic risks of this inherited disorder, also known as Factor V Leiden. URL: http://www.beckmancoulter.com/Coulter/Techpubs/coagulation/APC.asp Factor Five Leiden Support [Site Info] [Translate] [Open New Window] Support for sufferers of the Factor Five Leiden blood clotting disorder, an inherited blood condition discovered in 1995. History, glossary, and meeting information (Oregon).

65. AKU-AKUH Clinical Laboratories HOSPITAL SERVICES. Clinical Laboratories. LABRAD. activated protein c resistance A COMMON RISK FACTOR FOR THROMBOSIS Muhammad Salman. http://www.aku.edu/akuh/hs/cl/labrad-23-th9.shtml

Clinical Services Nursing Services Support Services Executive Clinic ... Physicians' Referral Guide AKU Main Site AKUH Home Search Site Map Contact H OSPITAL S ERVICES Clinical Laboratories LABRAD ACTIVATED PROTEIN C RESISTANCE: A COMMON RISK FACTOR FOR THROMBOSIS Muhammad Salman Introduction Clinical Manifestations Of APCR The penetration of clinical manifestations among APCR individuals is variable, and a majority of heterozygous carriers of FV:Q506 actually never experience any symptoms. In fact, not even homozygous carriers will necessarily be affected by thrombosis during their life time. FV:Q506 is a mild risk factor per se and that the probability of APCR individual developing thrombosis is dependent on the co-existence of other risk factors. About 60% of APCR patients have their first thrombotic event in combination with pregnancy, oral contraceptives, trauma or surgery. The clinical manifestations of inherited, heterozygous protein defects in familial thrombophilia involving antithrombin, protein C, protein S and factor V are fairly similar, Mutations affecting the qualitative or quantitative function of these proteins often results in venous thromboembolism at a young age (before the age of 45 years) and are followed by a tendency towards recurrent thrombotic episodes.

66. Ingenta: Article Summary -- Reactions To Awareness Of Activated Protein C Resist Reactions to awareness of activated protein c resistance carriership a descriptive study of 270 women Acta Obstetricia et Gynecologica Scandinavica May 2003 http://www.ingenta.com/isis/searching/ExpandTOC/ingenta?issue=pubinfobike://mksg

67. Griffin Laboratory - Publications activated protein c resistance caused by Arg506Gln mutation in factor Va. Lancet 34313611362, 1994. 5. Greengard JS, Eichinger S, Griffin JH, Bauer KA. http://www.scripps.edu/mem/eht/griffin/publications.html

Laboratory Home Research Publications Personnel Selected publications (from 233 total) Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 68:1370-1373, 1981. Branson HE, Katz J, Marble R, Griffin JH. Inherited protein C deficiency and a coumarin-responsive chronic relapsing purpura fulminans syndrome in a neonate. Lancet November 19, 1165-1168, 1983. Schwarz HP, Fischer M, Hopmeier P, Batard MA, Griffin JH. Plasma protein S deficiency in familial thrombotic disease. Blood 64:1297-1300, 1984. Greengard JS, Sun X, Xu X, Fernandez JA, Evatt B, Griffin JH. Activated protein C resistance caused by Arg506Gln mutation in factor Va. Lancet 343:1361-1362, 1994. Greengard JS, Eichinger S, Griffin JH, Bauer KA. Variability of thrombosis among homozygous siblings resistant to activated protein C due to Arg506Gln-Factor V. N Engl J Med 331:1559-1562, 1994. Heeb MJ, Kojima Y, Greengard JS, Griffin JH. Activated protein C resistance: Molecular mechanisms based on studies using purified Gln506-factor V.

68. Health, Conditions And Diseases, Blood Disorders, Blood Coagulation: Factor V Le Factor V Leiden, also known as activated protein c resistance, is a hereditary blood disorder that causes hypercoagulability and an increased risk of thrombosis http://www.combose.com/Health/Conditions_and_Diseases/Blood_Disorders/Blood_Coag

Top Health Conditions and Diseases Blood Disorders ... Factor V Leiden Related links of interest: Health:Conditions and Diseases:Genetic Disorders Health:Conditions and Diseases:Cardiovascular Disorders:Vascular Disorders:Thrombosis Activated Protein C Resistance - Discusses the thrombotic risks of this inherited disorder, also known as Factor V Leiden. Factor Five Leiden Support - Support for sufferers of the Factor Five Leiden blood clotting disorder, an inherited blood condition discovered in 1995. History, glossary, and meeting information (Oregon). Living with Factor V Leiden - Factor V Leiden is the most common hereditary blood coagulation disorder in the United States. It is present in 5% of the American population. The Role of Activated Protein C Resistance in the Pathogenesis of Venous Thrombosis - Center for Disease Control's page discussing the background of this disorder including study results, testing, and complications. University of Illinois Patient Resources - Description of factor V Leiden, its risks and treatment options. Also discusses the impact of other conditions on this disease. Yahoo! Groups: Leiden Factor V Support

69. Descripteur : Activated Protein C Resistance = RESISTANCE PROTEINE C ACTIVEE Translate this page Descripteur activated protein c resistance = RESISTANCE PROTEINE C ACTIVEE Définition NLM A hemostatic disorder characterized by a poor anticoagulant http://www.saphirdoc.ch/Thesaurus.htm&numrec=051913024919580

SAPHIR : Accueil Identifiant : Mot de passe : Dossiers Publications OMS (Europe) Bibliographies Index Auteurs Types de document Recherche Simple Expert Revues Recherche rapide Descripteur : Activated Protein C Resistance = RESISTANCE PROTEINE C ACTIVEE A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance. C - Diseases : Hemic and Lymphatic Diseases: Hematologic Diseases: Thrombophilia: Activated Protein C Resistance C - Diseases : Congenital, Hereditary, and Neonatal Diseases and Abnormalities: Genetic Diseases, Inborn: Blood Coagulation Disorders, Inherited: Activated Protein C Resistance C - Diseases : Hemic and Lymphatic Diseases: Hematologic Diseases: Blood Coagulation Disorders: Blood Coagulation Disorders, Inherited: Activated Protein C Resistance C - Diseases : Hemic and Lymphatic Diseases: Hematologic Diseases: Blood Coagulation Disorders: Coagulation Protein Disorders: Activated Protein C Resistance Synonymes : APC Resistance ; Resistance, APC ; C15.378.100.141.036 ; C15.378.100.425.037 ; C15.378.925.050 ; C16.320.099.037

70. Scripta Academica Lundensis Dissertations From mutation; APC resistance Abstract activated protein c resistance (APC resistance) is the most common hereditary condition associated with venous thrombosis. http://www.lub.lu.se/cgi-bin/show_diss.pl?db=global&fname=med_167.html

71. MP Forum - Medyczna Lista Dyskusyjna Serwisu MP OnLine RE MPForum activated protein c resistance. To mp-forum@medprakt.pl ; Subject RE MP-Forum activated protein c resistance; http://www.mp.pl/mp-forum/archiwum/index.php?dir=200202&wysw=msg00002.html

72. MP Forum - Medyczna Lista Dyskusyjna Serwisu MP OnLine MPForum activated protein c resistance. Subject MP-Forum activated protein c resistance; Nastepny wg watku RE MP-Forum activated protein c resistance; http://www.mp.pl/mp-forum/archiwum/index.php?dir=200202&wysw=msg00001.html

73. Coagulation And Transfusion Medicine Coagulation and Transfusion Medicine / Original Article. activated protein c resistance Assay Detects Thrombotic Risk Factors Other Than Factor V Leiden. http://www.ajcp.com/previews/abstracts/202180artoc.html

Coagulation and Transfusion Medicine / Original Article Activated Protein C Resistance Assay Detects Thrombotic Risk Factors Other Than Factor V Leiden Laurie L. Graf, CLSp(MB), Carolyn H. Welsh, MD, Zainab Qamar, and Richard A. Marlar, PhD Key Words: Activated protein C resistance; Case-control study; Factor V Leiden; Factor VIII; HR2 haplotype; Venous thromboembolism DOI: 10.1092/LX9E6Y043P58YVCL Abstract Activated protein C (APC) resistance is a common risk factor for venous thromboembolism (VTE) attributed to various mechanisms, including factor V Leiden (FVL) polymorphism. FVL is considered responsible for up to 95% of APC resistance; however other factor V polymorphisms and elevated factor VIII levels also have been implicated. We value your input... If you have something to say regarding this article or ajcp.com in general, share it with us. If you would like to give us feedback on the Web site in general or make corrections to this article, click on Feedback below. To write correspondence to the editor regarding this article, please click on Comment below. Thank you. more abstracts Order full text article Comment American Society for Clinical Pathology 2100 West Harrison Street Chicago, Illinois 60612

74. AMS Reference Lab: Search Results Search Again . activated protein c resistance. Test Number 7500485. Component(s) APCR2/APCR1 RATIO, ACT PROT C RESIST INTERP, ACTIVATED PROTEIN C RES. 1, 85307. http://www.amsreferencelab.com/cgi-bin/test-directory?page=details&item=7500485-

75. MedlinePlus Medical Encyclopedia: Congenital Protein C Or S Deficiency Mutations in protein C can cause a syndrome of activated protein c resistance similar to factor V Leiden (a mutation in factor V). http://www.nlm.nih.gov/medlineplus/ency/article/000559.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Congenital protein C or S deficiency Contents of this page: Illustrations Definition Causes, incidence, and risk factors Symptoms ... Prevention Illustrations Blood clot formation Blood clots Definition Return to top These inherited disorders of blood coagulation are caused by deficiency of the Vitamin K-dependent plasma proteins C or S that are naturally occurring anticoagulants. The disorder results in an increased tendency for intravascular blood clot formation. Causes, incidence, and risk factors Return to top Congenital protein C or S deficiency is an inherited disorder that causes abnormal blood clotting. Normal blood coagulation is a complex process involving as many as 20 different plasma proteins which are known as blood coagulation factors. A series of complex chemical reactions using these factors takes place very rapidly to form an insoluble protein called fibrin that stops bleeding . Other plasma proteins, such as proteins C and S, inhibit or reverse the cascade to prevent excessive clotting.

76. Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Activated+Protein+C+Resistance American Journal of Critical Care Role of activated protein C in alfa (activated), a recombinant form of human activated protein C, in patients increases in nosocomial infections and antimicrobial resistance to antibiotic http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Activated Protein C Resistance

77. FACTOR V LEIDEN SCREEN molecular weight heparin therapy. Methods activated protein c resistance, functional clotting test. Clinical Utilities Screening test http://www.mgh.org/lab/CATALOG/TESTS/5434.HTM

FACTOR V LEIDEN SCREEN Marquette General Health System General Info Alpha Code MGH LIS Test No Schedule Monday, Wednesday, Friday Testing Time 1 day Testing Lab Marquette General Hospital Specimen Info Type 1 Blue Top (Citrate) Volume 1.0 mL plasma Temperature Frozen Preservative Collection Info Platelet poor plasma required. Spin specimen with a Sure-Sep II or double spin by first spinning and removing plasma, then spin plasma again, removing and freezing immediately. Test may be performed on patients on stabilized oral anticoagulant, heparin and low molecular weight heparin therapy. Methods Activated Protein C resistance, functional clotting test. Clinical Utilities Screening test for Factor V Leiden defect which is the most common cause of inherited thrombophilia. An abnormal test should be followed up with Factor V Leiden R506Q gene mutation. CPT Codes Reference Range Ratio of: 2.2 - 6.0 Component Information Collection Notes Additional Comments Initial oral anticoagulation treatment before stabilization and levels of Protein C below 50% may give low Factor V Leiden Assay ratios. Questions or Comments email support@mgh.org

78. ALCOHOL, URINE activated protein c resistance. Synonyms Factor V Leiden Screen. Lab Test Code APCRE. Test Performed In Hematology. Test Methodology Clotting Assay. http://www.ucihs.uci.edu/com/pathology/PathologyServicesManual/..\Pathology Serv

ACTIVATED PROTEIN C RESISTANCE Synonyms: Factor V Leiden - Screen Lab Test Code: APCRE Test Performed In: Hematology Test Methodology: Clotting Assay Availability: Varies (once per week) Patient Preparation: Specimen Requirements: Draw blood in light blue-top (3.2% or 3.8% sodium citrate) tube(s). Immediately centrifuge at 1,500 G for 10 minutes to remove platelets, and send 2.0 mL of citrate platelet-poor plasma frozen in a plastic vial on dry ice. THE CORRECT RATIO OF BLOOD TO ANTICOAGULANT (9:1) IS CRITICAL. If the tubes are under filled, specimen must be recollected as results will not be accurate. A CLEAN VENIPUNCTURE IS ESSENTIAL TO AVOID SPECIMEN ACTIVATION. Reference Values: Additional Information: CPT Code(s):

79. JW (General) -- Sign In activated protein c resistance Is a Risk Factor for VTE. Comment It appears that resistance to activated protein C is an independent risk factor for VTE. http://general-medicine.jwatch.org/cgi/content/full/1999/511/8

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80. Faculty At The Department Of Pediatrics Sensitivity, Specificity and Predictive Value of Modified Assays for activated protein c resistance in Children Thrombosis and Hemostasis 79(3) 567-70 http://www.siumed.edu/peds/brandt.htm

Home Faculty Gregory Brandt, M.D. GREGORY P. BRANDT, M.D. ADDRESS: SIU School of Medicine Department of Pediatrics 800 E. Carpenter Street PO Box 19658 Springfield, IL 62794-9658 FAX: (217) 545-4117 EDUCATION: College of St. Thomas St. Paul, Minnesota Summa Cum Laude St. Louis University School of Medicine St. Louis, Missour TRAINING: Hematology/Oncology/Bone Marrow Transplant Children's Hospital Medical Center Cincinnati, Ohio St. Louis University Cardinal Glennon Children's Hospital St. Louis, Missouri i LICENSURE: Missouri, Illinois AWARDS AND HONORS: 1992 - 1993 American Cancer Society Fellowship Training Grant 1987 Near Honors in OB/Gyn 1985 Honors in Gross Anatomy 1983 Graduated Summa Cum Laude 1979 - 1983 Dean's List Delta Epsilon Sigma National Scholastic Honor Society FACULTY APPOINTMENTS: 1995 - Present Assistant Professor Southern Illinois University School of Medicine Department of Pediatrics 1991 - 1992 Instructor St. Louis University

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