41. Entrez PubMed Click here to read Acquired activated protein c resistance in myeloma patients with venous thromboembolic events. Deitcher SR, Choueiri http://www.biomedcentral.com/pubmed/14632794

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Br J Haematol. 2003 Dec;123(5):959. Related Articles, Links Acquired activated protein C resistance in myeloma patients with venous thromboembolic events. Deitcher SR, Choueiri T, Srkalovic G, Hussein MA.

42. RCPA - The Manual - Activated Protein C (APC) Resistance Test - Plasma Home Activated protein C (APC) resistance test plasma. activated protein c resistance is associated with an increased risk of venous thromboembolism. http://www.rcpamanual.edu.au/sections/pathologytest.asp?s=33&i=226

43. ARUP Activated Protein C Resistance search. activated protein c resistance, , Allergens, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, Search UG. 0030127 activated protein c resistance. http://www.aruplab.com/guides/ug/tests/0030127activated_20protein_20c_20resistan

44. The GUCH Message Board activated protein c resistance factor five leiden. The GUCH Message Board General Discussion Group activated protein c resistance factor five leiden http://cgi.aghorner.force9.co.uk/discus/messages/8/1030.html?1080207643

45. Entrez PubMed Click here to read activated protein c resistance and factor V Leiden in patients with hemolysis, elevated liver enzymes, low platelets syndrome. http://www.rbej.com/pubmed/9721789

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Obstet Gynecol. 1998 Sep;92(3):457-60. Related Articles, Links Activated protein C resistance and factor V Leiden in patients with hemolysis, elevated liver enzymes, low platelets syndrome. Krauss T, Augustin HG, Osmers R, Meden H, Unterhalt M, Kuhn W.

46. Entrez PubMed Click here to read Factor V Leiden and acquired activated protein c resistance among 1000 women with recurrent miscarriage. Rai http://www.rbej.com/pubmed/11331645

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Hum Reprod. 2001 May;16(5):961-5. Related Articles, Links Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage. Rai R, Shlebak A, Cohen H, Backos M, Holmes Z, Marriott K, Regan L.

47. ACTIVATED PROTEIN C RESISTANCE (APCR) activated protein c resistance (APCR). Test Performed At BarnesJewish Hospital Laboratory. Specimen Required Draw a full, light http://webserver01.bjc.org/labtestguide/APCR.htm

ACTIVATED PROTEIN C RESISTANCE (APCR) Test Performed At: Barnes-Jewish Hospital Laboratory Specimen Required: Draw a full, light blue-top (citrate) tube(s) AND 3 mL whole blood in a purple-top (EDTA) tube. Avoid hemolysis and heparin contamination of specimen. NOTE: Draw a discard tube prior to light blue-top (citrate) tube. Tube should remain stoppered. Blood should not be obtained through an indwelling catheter or an A-V shunt. Laboratory Notes: DO NOT CENTRIFUGE. (CLOTTED BLOOD OR AN INSUFFICIENT SPECIMEN IS NOT ACCEPTABLE.) Send citrated whole blood. Forward promptly at ambient temperature only. Reference Values: Day(s) Test Set Up: Monday – Thursday Turn Around Time: 7 days CPT Code: Care Manager Order Name: Activated Protein C Resistance V Assay Cerner Order Name: APCR Last Updated 04/03

48. Activated Protein C Resistance/with TIA's Message Boards on Health Related Topics. stroke message board. activated protein c resistance/with TIA s. http://www.healthboards.com/stroke/727.html

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49. Factor V Leiden - Information / Diagnosis / Treatment / Prevention Web Directory ? activated protein c resistance Discusses the thrombotic risks of this inherited disorder, also known as Factor V Leiden. http://www.healthcyclopedia.com/blood-disorders/blood-coagulation/factor-v-leide

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... blood coagulation > factor v leiden Factor V Leiden Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Health News Web Directory: Related Topics: Cardiovascular Disorders/Vascular Disorders/Thrombosis Genetic Disorders Health News: Search millions of published articles for news on Factor V Leiden Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Activated Protein C Resistance Discusses the thrombotic risks of this inherited disorder, also known as Factor V Leiden. Factor Five Leiden Support Support for sufferers of the Factor Five Leiden blood clotting disorder, an inherited blood condition discovered in 1995. History, glossary, and meeting information (Oregon). Living with Factor V Leiden Factor V Leiden is the most common hereditary blood coagulation disorder in the United States. It is present in 5% of the American population.

50. RESISTANCE TO ACTIVATED PROTEIN C AS PATHOGENIC FACTOR OF VENOUS Key words activated protein c resistance A chromogenic assay for activated protein c resistance has been introduced by Varadi et al. (97). http://www.lfhk.cuni.cz/periodik/actamed/39_2/anchroba.htm

51. Activated Protein C Resistance Test Menu activated protein c resistance, Primary Name, activated protein c resistance. Synonym, Screen for factor V Leiden. Synonym, . Contraction, APC resistance. http://peir.path.uab.edu/coag/article_19.shtml

Front Page Announcements Contact Us Clinical Conditions ... Test Order Form Search All Categories Front Page Announcements Contact Us Clinical Conditions Guidelines Links Patient Information Test Menu Test Order Form Test Menu Activated protein C resistance Email this article Printer friendly page Primary Name Activated protein C resistance Synonym Screen for factor V Leiden Synonym Contraction APC resistance Contraction APCR Contraction UAB Procedure Number CPT Code Specimen Collect one (1) blue-stopper tube (3.2% sodium citrate), filled to specified volume. Do not underfill or overfill. * If follow-up factor V Leiden mutation test is indicated, collect one (1) lavender-stopper tube (EDTA) whole blood. Specimen Management Centrifuge blue-stopper tube within 1 hour of collection, separate plasma and test or quick-freeze at -70°C. The lavender-stopper tube may be refrigerated up to 72 hours before shipping. Ship overnight at ambient temperature or on wet ice. Specimen Accepted Daily including weekends Times Available Test Performed Twice weekly Available Stat?

52. Factor V Leiden Factor 5 Leiden. APC Resistance. activated protein c resistance. Labs Activated Protein C (APC) resistance Can not be anticoagulated when this lab run. http://www.fpnotebook.com/HEM26.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Hematology and Oncology Coagulopathy Assorted Pages Coagulation Bleeding Disorders Dysfibrinogenemia Hemophilia A Factor IX Deficiency ... Perioperative Anticoagulation Factor V Leiden Factor 5 Leiden APC Resistance Activated Protein C resistance Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Hematology and Oncology Index Anemia Cancer Coagulopathy Cardiovascular Medicine Dermatology Endocrinology Otolaryngology Examination Gastroenterology Hemoglobin Hemolysis Histiocytosis HIV Infectious Disease Laboratory Leukemia General Pulmonology Lymph Marrow Neurology Obstetrics Orthopedics Pediatrics Pharmacology Platelet Prevention Procedure Psychiatry Rheumatology Sarcoma Surgery Symptom Evaluation Vascular Page Coagulopathy Index Bleeding Bleeding Dysfibrinogenemia Bleeding Hemophilia A Bleeding Hemophilia B Bleeding Von Willebrands Clotting Pathway Background Clotting Pathway Common Clotting Pathway Extrinsic Clotting Pathway Inhibition Clotting Pathway Intrinsic DIC Hypercoagulable Hypercoagulable Antithrombin III Hypercoagulable APC resistance Hypercoagulable Fibrinolysis Hypercoagulable Protein C-S Epidemiology

53. Disease Directory : Activated Protein C Resistance Diseases Blood Disorders Blood Coagulation Factor V Leiden activated protein c resistance. Directory Listing. Title Activated http://www.diseasedirectory.net/detailed/8708.aspx

Wednesday, June 02, 2004 Blood Disorders Blood Coagulation Factor V Leiden Diseases ... Factor V Leiden : Activated Protein C Resistance Directory Listing Title: Activated Protein C Resistance Description: Discusses the thrombotic risks of this inherited disorder, also known as Factor V Leiden. Date Added: 2/4/2004 1:24:36 PM URL: http://www.beckmancoulter.com/Coulter/Techpubs/coagulation/APC.asp

54. Disease Directory : The Role Of Activated Protein C Resistance In The Pathogenes Diseases Blood Disorders Blood Coagulation Factor V Leiden The Role of activated protein c resistance in the Pathogenesis of Venous Thrombosis. http://www.diseasedirectory.net/detailed/8709.aspx

Wednesday, June 02, 2004 Blood Disorders Blood Coagulation Factor V Leiden Diseases ... Factor V Leiden : The Role of Activated Protein C Resistance in the Pathogenesis of Venous Thrombosis Directory Listing Title: The Role of Activated Protein C Resistance in the Pathogenesis of Venous Thrombosis Description: Center for Disease Control's page discussing the background of this disorder including study results, testing, and complications. Date Added: 2/4/2004 1:24:36 PM URL: http://www.cdc.gov/genetics/info/reports/research/protein_C.html

55. Resistance To Activated Protein C As A Pathogenic Factor Of Thrombophilia of identifiable causes of familial thrombophilia has increased from 510% to 60-70% since the identification of activated protein c resistance (aPCR) in http://www.imbiomed.com/Innsz/Nnv48n3/english/Znn63-07.html

Ruiz-Argüelles GJ Resistencia a la proteína C activada como causa de trombofilia Rev Invest Clin Resistance to activated protein C as a pathogenic factor of thrombophilia ABSTRACT The proportion of identifiable causes of familial thrombophilia has increased from 5 10% to 60 70% since the identification of activated protein C resistance aPCR in February 1993 by Dahlbäck et al. A mutation in the factor V gene G A, 1691 leads to the so called Leiden mutation R 506 Q that produces a mutated factor V resistant to the catalytic action of activated protein C aPC , yet normal in its procoagulant properties. This recently identified aPCR is in Nordic populations the most prevalent and well defined genetic defect associated with disease so far described. Its prevalence in the general population ranges from 0% to up to 15% and suggests that a positive genetic selection pressure has been involved. The aPCR phenotype can be assessed in vitro by measurement of the prolongation of the activated partial thromboplastin time in the presence of aPC, whereas the aPCR genotype is studied using polymerase chain reaction searching for the Arg to Gln mutation in the coagulation factor V gene. Some acquired conditions such as the presence of lupus anticoagulants, antiphospholipid antibodies, pregnancy, liver disease and contraceptives may lead into the aPCR phenotype. The aPCR search must be the initial step in the study of a patient with thrombophilia, either inherited or acquired; aPCR together with protein C, protein S and antithrombin III explain 60 to 70% of cases of familial thrombophilia.

56. ACTIVATED PROTEIN C RESISTANCE activated protein c resistance. Test performed by the Haematology laboratory. For results, use ward computer or phone Lablink 5995 http://www.adhb.govt.nz/LabPlusHandbook/handbook/ManualACTIVATED_PROTEIN_C_RESIS

ACTIVATED PROTEIN C RESISTANCE Test performed by the Haematology laboratory. For results, use ward computer or phone Lablink : 5995 or (09) 307-8995 or 0800 522 758. SPECIMEN: 4.5 mL blood. Citrate tube . Tube must be completely filled, or,1.8 mL blood in a paediatric citrate tube . Fill to the blue line. Lab Note: Specimens should preferably be filtered, and must be sent frozen to LabPlus. Minimum volume 0.5 mL. RANGE This test is included in a Thrombophilia Screen Result available within 2 weeks. DIAGNOSTIC USE: Activated Protein C (APC) is an important natural anticoagulant which cleaves and inhibits activated factors V and VIII. Resistance to APC reduces this activity leading to an increased tendency to thrombosis. The most common cause of APC resistance (APCR) is factor V Leiden. The APCR index is an assay based on the APTT (and is invalid if baseline APTT is prolonged). Interpretation: See Factor V Mutation Analysis For further information contact the laboratory or: Dr George Chan, Haematologist: Ext 2015 Loc 93-4711 Dr Paul Harper, Haematologist: Ext 7565 Loc 93-5188

57. Biochem. J. (1996) 313, 467-472 - C. Aparicio And B. Dahlba~Dck - Factor V:Q506 Biochem. J. (1996) 313 (467–472) (Printed in Great Britain). Molecular mechanisms of activated protein c resistance Properties http://www.biochemj.org/bj/313/bj3130467.htm

About the journal Subscriptions Authors Users ... Download to Citation Matcher Biochem. J. (1996) Molecular mechanisms of activated protein C resistance Properties of factor V isolated from an individual with homozygosity for the Arg to Gln mutation in the factor V gene Abbreviations used: APC, activated protein C; FV, factor V; FVa, activated factor V; FV:Q , factor V with glutamine (Q) at position 506 ; FV:R , factor V with arginine (R) at position 506; FXa, activated factor X; mAb, monoclonal antibody; HPC4, mAb against protein C; HPS54, mAb against protein S; HFV30, mAb against factor V; EGF, epidermal growth factor; PPACK, D -phenylalanyl- L -prolyl- L -arginine chloromethyl ketone; PEG, polyethylene glycol; APTT, activated partial thromboplastin time. * To whom correspondence should be addressed. Resistance to activated protein C (APC), which is the most prevalent pathogenetic risk factor of thrombosis, is linked to a single point-mutation in the factor V (FV) gene, which predicts replacement of Arg (R) at position 506 with a Gln (Q). This mutation modifies one of three APC-cleavage sites in the heavy chain of activated FV (FVa), suggesting that mutated FVa (FVa:Q ) is at least partially resistant to APC-mediated degradation. To elucidate the molecular mechanisms of APC-resistance and to investigate the functional properties of FV in APC resistance, FV:Q

58. Factor V Leiden a genetically acquired trait that can result in a thrombophilic (hypercoaguable) state resulting in the phenomenon of activated protein c resistance (APCR) as http://www-admin.med.uiuc.edu/hematology/PtFacV2.htm

University of Illinois - Urbana/Champaign Carle Cancer Center Hematology Resource Page Patient Resources Factor V Leiden Home Factor V Leiden Antiphospholipid Syndrome General Clotting Information ... Protein S deficiency Factor V Leiden is a genetically acquired trait that can result in a thrombophilic (hypercoaguable) state resulting in the phenomenon of activated protein C resistance (APCR) as described below. Associated with factor V Leiden, APCR was first described in 1993; factor V Leiden was subsequently discovered in 1994. Over 95% of patients with APCR have factor V Leiden. Factor V Leiden's overall impact on the coagulation cascade described below. Mechanism of Action of Factor V Leiden: Factor V Leiden is characterized by a phenomenon called APCR where a genetic mutation in the factor V gene causes a change in the factor V protein making it resistant to inactivation by protein C. Epidemiology of Factor V Leiden: Factor V Leiden is seen more commonly in the northern European populations. About 4-7% of the general population is heterozygous (see * below) for factor V Leiden. About 0.06 to 0.25% of the population is homozygous (see * below) for factor V Leiden. The factor V Leiden mutation is relatively uncommon in the native populations of Asia, Africa and North America. In contrast, in Greece and southern Sweden, rates above 10% have been reported.

59. Hereditary Resistanace To APC In 1993 a new defect in the response to activated Protein C (activated protein c resistance) was reported as a cause of recurrent thrombosis. http://www.coagcenter.com/coag_ed_apcresistance.htm

Introduction Tests / CPT Codes / Samples Special Collection / Processing Guidelines ... Home E D U C A T I O N A L N O T E B O O K Hereditary Resistance to Activated Protein C / APC Resistance Individuals with a suspected inherited predisposition to thrombosis usually have recurrent juvenile or familial thrombotic events in usual sites (i.e. axillary vein, mesenteric vein, sagittal vein). Arterial thromboses are less common but do occur. Until now, approximately 30% of these disorders have been diagnosed as a deficiency of Antithrombin III, Protein C or Protein S. In 1993 a new defect in the response to activated Protein C (activated Protein C resistance) was reported as a cause of recurrent thrombosis. This Resistance to APC is seen in 21-64% of patients with a history of thrombotic events and appears, in part, to be due to an abnormal Factor V (Leiden) mutation. The most common test for this defect is an APTT-based assay that incorporates activated Protein C into the reagent. At this time, the test is still considered investigational and should not be used as the sole basis for diagnosis. However, this risk factor should be considered when evaluating a patient with a history of thrombosis. SPECIAL NOTE: Because the patient's APTT must be within normal range for valid results to be obtained, a screening APTT will be run by the Coagulation Center. If an abnormal APTT result is obtained, the report will state "abnormal APTT result obtained; test could not be performed."

60. PT 20210 V Leiden and PT 20210. Also known as Factor V Leiden activated protein c resistance (APC) resistance, Factor V R506Q; PT 20210 PT G20210A Formally known as http://www.labtestsonline.org/understanding/analytes/pt_20210/glance.html

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