21. THE MERCK MANUALSECOND HOME EDITION, Acromegaly And Gigantism In acromegaly and Gigantism. Overproduction growth. In children, the condition is called gigantism; in adults, it is called acromegaly. http://www.merck.com/mrkshared/mmanual_home2/sec13/ch162/ch162e.jsp

22. Acromegaly A look at this disorder, its causes, how common it is, diagnosis, and treatment. http://neurosurgery.mgh.harvard.edu/neuroendocrine/acromeg.htm

Acromegaly To the MGH Pituitary Tumor Center Homepage for links to more information on acromegaly Acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone (GH). It most commonly affects middle-aged adults and can result in serious illness and premature death. Once recognized, acromegaly is treatable in most patients, but because of its slow and often insidious onset, it frequently is not diagnosed correctly. The name acromegaly comes from the Greek words for "extremities" and "enlargement" and reflects one of its most common symptoms, the abnormal growth of the hands and feet. Soft tissue swelling of the hands and feet is often an early feature, with patients noticing a change in ring or shoe size. Gradually, bony changes alter the patient's facial features: the brow and lower jaw protrude, the nasal bone enlarges, and spacing of the teeth increases. Overgrowth of bone and cartilage often leads to arthritis. When tissue thickens, it may trap nerves, causing carpal tunnel syndrome, characterized by numbness and weakness of the hands. Other symptoms of acromegaly include thick, coarse, oily skin; skin tags; enlarged lips, nose and tongue; deepening of the voice due to enlarged sinuses and vocal cords; snoring due to upper airway obstruction; excessive sweating and skin odor; fatigue and weakness; headaches; impaired vision; abnormalities of the menstrual cycle and sometimes breast discharge in women; and impotence in men. There may be enlargement of body organs, including the liver, spleen, kidneys and heart.

23. HTML REDIRECT acromegaly is a hormonal disorder that most commonly occurs in middleaged men and women. Current government trials on acromegaly What is acromegaly? http://acromegaly.org/

24. EMedicine - Acromegaly : Article By Santiago A Centurion, MD acromegaly Excess secretion of growth hormone (GH) induces gigantism in prepubertal children and acromegaly in adults. acromegaly. Last Updated April 9, 2003, http://www.emedicine.com/derm/topic593.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Dermatology Internal Medicine Acromegaly Last Updated: April 9, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: growth hormone, GH, gigantism, GH-secreting pituitary adenomas, somatomedins, SMs, somatotropin-mediating hormones, insulinlike growth factors, IGFs AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Santiago A Centurion, MD , Staff Physician, Department of Dermatology, UMDNJ-New Jersey Medical School Coauthor(s): Robert A Schwartz, MD, MPH , Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, UMDNJ-New Jersey Medical School Santiago A Centurion, MD, is a member of the following medical societies: Alpha Omega Alpha American Academy of Dermatology American Medical Association , and Sigma Xi Editor(s): Shyam Verma, MBBS, DVD, FAAD

25. UpToDate Patient Resource Center Pituitary Gland Discusses the signs and symptoms of acromegaly along with other useful information for patients on treatments,diagnosis, and longterm menagement. http://www.uptodate.com/patient_info/topicpages/PituitaryGlandHome.htm

26. The Pituitary Society - Information For The Public Patient's guide to acromegaly diagnosis therapy http://pituitarysociety.med.nyu.edu/patients_guide.htm

Information for the Public THIS INFORMATION WAS DEVELOPED BY DAVID M. COOK, M.D. IT IS NOT INTENDED TO SUBSTITUTE FOR A FULL AND FRANK CONSULTATION WITH QUALIFIED MEDICAL PERSONNEL, WHICH IS THE PRIMARY MEANS FOR A PATIENT TO OBTAIN CARE AND TREATMENT. THE INFORMATION WAS BELIEVED TO BE CURRENT ON MAY 15, 2001, AND WITH THE LAPSE OF TIME, CERTAIN OF THIS MATERIAL WILL BE OUTDATED. by David M. Cook, M.D. Oregon Health Sciences University What is Acromegaly? What happens when there is too much growth hormone secreted? Because the pituitary tumor may be large enough to put pressure on the eye nerves, which are near by, there may be visual changes or headache, which might prompt an opthalmologic or neurologic exam. Specialists in these latter two disciplines are often the first to consider the patient may have acromegaly. The neurologist may also be involved because of the development of entrapment of the nerve that runs through the carpal tunnel and the development of carpal tunnel symptoms- a frequent development in acromegaly. Lastly, the presence of the pituitary tumor may cause decreased pituitary function, especially the cells which control the testes and ovaries resulting in symptoms of decreased sexual function. As the reader can appreciate, there are a number of body systems which can be involved when a patient develops acromegaly and it is up to the physician who sees the patient to think of the diagnosis. Because the signs and symptoms develop so slowly this diagnosis is often missed or overlooked.

27. Pituitary Network Association - Disorders - Acromegaly Facts, diagnosis, and treatment information about acromegaly, a serious systemic condition caused in over 98% of cases by an adenoma (i.e., benign tumor) of the pituitary gland that secretes excessive growth hormone (GH). http://www.pituitary.org/disorders/acromegaly.php

Acromegaly Please click onto www.acromegaly.org for further information Acromegaly is a serious systemic condition caused in over 98% of cases by an adenoma (i.e., benign tumor) of the pituitary gland that secretes excessive growth hormone (GH). The clinical features associated with acromegaly include the effects of GH over-production, and in some instances by the tumor compressing and injuring the normal pituitary gland, optic nerves and optic chiasm. Untreated acromegaly results in marked bony and soft tissue changes including an altered facial appearance (frontal bossing, prognathism), enlargement of the hands and feet, sleep apnea, and carpal tunnel syndrome. More serious problems may include accelerated cardiovascular disease, hypertension, diabetes mellitus and possibly an increased risk of colon cancer. If the tumor develops before bone growth is completed in adolescence, the result will be gigantism. Because of the serious systemic changes resulting from GH excess, treatment is essential, typically with transsphenoidal surgery. Symptoms and signs may include: Soft tissue thickening of the palms of the hands and soles of the feet Enlargement of hands (ring size), feet (shoe size) and head (hat size)

28. The Pituitary Foundation | Disorders | Acromegaly acromegaly is caused when a tumour on the pituitary gland produces too much growth hormone (GH). These tumours acromegaly. acromegaly is http://www.pituitary.org.uk/disorders/acromegaly.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links DISORDERS Acromegaly Adult GH Deficiency ... Disorders Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Acromegaly Acromegaly is caused when a tumour on the pituitary gland produces too much growth hormone (GH). These tumours are almost always benign (i.e. not cancerous) and therefore do not spread to other areas of the body. Acromegaly is a very rare condition and usually develops between the ages of 30 and 50. If the condition develops before a person has stopped growing (which usually occurs between the ages of 15 to 17 years of age), it causes gigantism because growth hormone promotes growth of bones in the body. Typical symptoms coarsening of facial features enlarged hands and feet thickening of the soft tissue in the palms and soles of the feet carpal tunnel syndrome (tingling feeling or pains in the hands) excessive sweating and oily skin headaches vision disturbance sleep apnoea general tiredness irregular periods (oligomenorrhoea) or loss of normal menstrual function (amenorrhoea) - adult females impotence - adult males reduced fertility decrease in sex drive All these symptoms tend to develop gradually and the changes may not be noticed for some time.

29. The Pituitary Foundation | Patient Leaflet | Acromegaly Online version of the patient information leaflet on acromegaly produced by The Pituitary Foundation. acromegaly. What is acromegaly? http://www.pituitary.org.uk/resources/acromegaly.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links RESOURCES The Pituitary Gland and its Hormones Acromegaly Adult GH ... Resources Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Acromegaly What is acromegaly? What does it feel like to have acromegaly? Coping with the stress of acromegaly How is acromegaly diagnosed? ... What acromegaly has meant to me What is acromegaly? Acromegaly is a disease of the pituitary gland . Your pituitary gland is a small, but very important, gland at the base of your brain behind the bridge of your nose. Sometimes it can be affected by a tumour. These are almost invariably benign rather than cancerous and therefore do not spread anywhere else. Acromegaly is caused when your pituitary gland has a tumour which produces too much growth hormone Acromegaly is a very rare condition and only four new cases per million of population are diagnosed each year. It usually develops in adults between the ages of 30 and 50, but you can be affected at any age. If acromegaly develops before you have stopped growing (which usually occurs around 15 to 17 years of age), it causes gigantism because growth hormone promotes growth of legs and arms.

30. History Of Acromegaly And Gigantism Statistics. The statistics section has been updated. (Well it now has content instead of being empty!). Early medical descriptions of acromegaly 1526 1885. http://www.cladonia.co.uk/acromegaly/

Introduction Guide to the physical features of acromegaly Acromegaly through the ages Giants: Fact and fiction ... Published papers David Bryson BSc CertEd MIMI RMIP ILTM Medical, Medicolegal and Scientific Photographer D.Bryson@cladonia.co.uk Site changes - last update 16/5/04 Statistics The statistics section has been updated. (Well it now has content instead of being empty!) Early medical descriptions of acromegaly 1526 - 1885 This part of the site is now up and running there is still work to be done as some of then original papers are rather long and some writing needs to be added but the complete set of links are up including scans of most of the original papers or illustrations. Illustrations from one of the papers that Piere Marie referred to in his paper of 1886 by Henrot, H in 1882. You can see the large coarse features of the face and the increased size of the hand typical features of acromegaly. For help and support please follow the Pituitary Foundation link above

31. History Of Acromegaly And Gigantism D.Bryson@cladonia.co.uk. acromegaly, Mr Punch and caricature. What is the reason for the hump on his back and large paunch? Physical features of acromegaly. http://www.cladonia.co.uk/acromegaly/ampc.html

Introduction Guide to the physical features of acromegaly Acromegaly through the ages Giants: Fact and fiction ... Published papers David Bryson BSc CertEd MIMI RMIP ILTM Medical, Medicolegal and Scientific Photographer D.Bryson@cladonia.co.uk Acromegaly, Mr Punch and caricature David Bryson BSc(Anatomy) CertEd AIMI RMIP, Programme Leader - Biological Imaging, University of Derby, School of Art and Design, Green Lane, Derby, DE1 1RX. E-mail D.Bryson@derby.ac.uk Reference for this paper Bryson D. Acromegaly, Mr Punch and caricature. Journal of Audiovisual Media in Medicine 1996; 19 (3): 119-122 pdf file on-line Outline Abstract Introduction Physical features of acromegaly Origin of Mr Punch ... References Abstract The origin of Mr Punch from the Italian Pulcinella of the Commedia dell'arte is well known but his features, large hooked nose, protruding chin, kyphosis and sternal protrusion all in an exaggerated form also suggest the caricature of an acromegalic. This paper looks at the physical characteristics of acromegaly, the origin of Mr Punch and the development of caricature linking them together into the acromegalic caricature that now has a life of it's own. Introduction Punch and Judy Shows are common entertainments at the seaside, fairs and for children's parties. We laugh at Mr Punch's antics without thinking about his origin. Why does he have a large nose and prominent chin? What is the reason for the hump on his back and large paunch?

32. Acromegaly acromegaly,. Print this article, acromegaly can result in periosteal bone formation, leading to widening of osseous structures and enlargement of soft tissue. http://www.amershamhealth.com/medcyclopaedia/Volume III 1/ACROMEGALY.asp

Amershamhealth.com Search for: Type a word or a phrase. All forms of the word are searchable. Browse entry words starting with: A B C D ... Other characters Acromegaly, an endocrine disorder caused by hypersecretion of growth hormone and characterized by enlargement of many skeletal parts. Endochondral bone formation is reactivated and periosteal bone formation is stimulated, with concurrent proliferation of connective tissue. Radiographic features of skeletal involvement include changes in skin thickness and abnormalities of the skull, hand, foot, vertebral column, thoracic cage, pelvis and other sites. Hypertrophy of cartilage and degeneration of both cartilage and bone also are seen (Table 1) ( Fig.1 Although accurate diagnosis of acromegaly is not difficult, particularly in advanced cases, some of the individual radiographic signs may be noted in other disorders. An acromegaly-like syndrome has been associated with pachydermoperiostosis . Radiographic findings are similar to those of acromegaly, with enlarged sinuses, prominent supraorbital ridges, and thickening of the phalanges. However, the sella turcica is not enlarged, and severe prominence of the phalangeal tufts and enlargement of articular space are not observed. Acromegaly, Table 1. Radiographic features in acromegaly.

33. Acromegaly Note All links within content go to MayoClinic.com. Diseases and Conditions. acromegaly. From MayoClinic.com Special to CNN.com. Overview. http://www.cnn.com/HEALTH/library/DS/00478.html

International Edition MEMBER SERVICES The Web CNN.com Home Page World U.S. Weather ... Special Reports SERVICES Video E-mail Services CNNtoGO Contact Us SEARCH Web CNN.com In association with: DIABETES AND ENDOCRINE SYSTEM Endocrine System Graves' disease Goiter Male hypogonadism Hyperthyroidism ... Prolactinoma INFORMATION CENTERS: Pick a category Health Centers Family Health Men's Health Women's Health Children's Health Seniors' Health Working Life Pain Management Condition Centers Immune System Allergy Alzheimer's Arthritis Respiratory System Cancer Endocrine System Digestive System Heart and Blood Infectious Disease Mental Health Note: All links within content go to MayoClinic.com Diseases and Conditions Acromegaly From MayoClinic.com Special to CNN.com Overview Acromegaly is an uncommon hormonal disorder that develops when your pituitary gland produces too much growth hormone. When this happens, your bones increase in size, including those of your hands, feet and face. The term acromegaly is derived from the Greek words for "extremities" and "enlargement." Because acromegaly is so uncommon, and the physical changes occur so gradually, doctors often don't recognize it immediately. If not treated promptly, this condition can lead to serious illness and even become life-threatening.

34. Acromegaly -- ECureMe.com acromegaly, more about acromegaly, acromegaly is the excessive production of growth hormone, which continues to be produced well into adulthood. http://www.ecureme.com/emyhealth/data/Acromegaly.asp

DisplayAd("468","60"); Select a Health Topic ADD/ADHD Allergy Alternative Medicine Arthritis Asthma Beyond Dieting Body Aches and Pains Breast Cancer Cancer Awareness Cardio Health Children's Health Colon Cancer Contraception COPD/Emphysema Dental Health Diabetes Elder Care Emergency Room Epilepsy Erectile Dysfunction Eye Care Fertility Fitness Gastrointestinal Health Glands and Hormones Gynecologic Health Hair Loss Headache Healthcare Today Healthy Aging HIV and AIDS Infectious Diseases Kidney Health Leukemia Liver Health Lung Cancer Lymphoma Multiple Sclerosis Men's Health Mental Health Nutrition Osteoporosis Parkinson's Disease Sexual Health Skin Health Sleep Disorders Special Events Stroke Surgeries and Procedures Teen Health Thyroid Health Urologic Health Vascular Disease Women's Health Workplace Health June 1, 2004 Resource Links Physician Search Your Questions, E-mail Doctor ... Hospital Directory Acromegaly more about Acromegaly Gigantism and hyperpituitarism Acromegaly is the excessive production of growth hormone, which continues to be produced well into adulthood. In adults it is involved in regulatory functions in the body, but since the growth plates are closed, excessive levels cause abnormal growth of hands, feet, and internal organs. Since pituitary tumors are the most common cause of this condition, other areas controlled by the pituitary are often affected (such as

35. Xray2000 acromegaly is caused by prolonged overproduction of GH by the pituitary gland. Many men with acromegaly also develop erectile dysfunction (impotence). http://www.xray2000.f9.co.uk/radpath/a/acromegaly.htm

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36. Introduction Acromegaly - WrongDiagnosis.com Introduction to acromegaly as a medical condition including symptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis. Introduction acromegaly. http://www.wrongdiagnosis.com/a/acromegaly/intro.htm

37. Acromegaly - Wikipedia, The Free Encyclopedia acromegaly. From Wikipedia, the free encyclopedia. acromegaly (from medication. Pituitary gigantism and acromegaly in children. This http://en.wikipedia.org/wiki/Acromegaly

Acromegaly From Wikipedia , the free encyclopedia. Acromegaly (from Greek akros "high" and megalos "large" - extremities enlargement) is a hormonal disorder that results when the pituitary gland produces excess growth hormone (hGH). Most commonly it is a benign hGH producing tumor derived from a distinct type of cells (somatotrophs) and called pituitary adenoma Acromegaly most commonly affects middle-aged adults and can result in serious illness and premature death. Because of its insidious onset and slow progression, the disease is hard to diagnose in the early stages and is frequently missed for many years. Features that result from high level of hGH or expanding tumor include: Soft tissue swelling of the hands and feet (early sign) Brow and lower jaw protrusion (enlarging jaw and hat size) Enlarging hands (ring size) Enlarging feet (shoe size) Arthritis and carpal tunnel syndrome Teeth spacing increase Heart failure (major medical problem). Compression of the optic chiasm leading to loss of vision in the outer visual fields. diabetes mellitus hypertension Table of contents 1 Causes 2 Treatment 2.1 Surgery

38. Acromegaly Basic Information (advertentie). acromegaly basic information, Solitaire. acromegaly is a rare disease caused by a noncancerous tumour on the pituitary. http://www.nvacp.nl/page.php?main=5&sub=37

39. Novartis Pharmaceutical- A Through Z - Acromegaly Change Text Size, make text smaller, make text larger. Diseases Conditions / A through Z / acromegaly acromegaly acromegaly (akro-MEG-aly) is a rare disease. http://www.pharma.us.novartis.com/conditions/az/acromegaly.jsp

40. Novartis Pharmaceutical- Men S Health - Acromegaly Change Text Size, make text smaller, make text larger. Diseases Conditions / Men s Health / acromegaly acromegaly acromegaly (akro-MEG-aly) is a rare disease. http://www.pharma.us.novartis.com/conditions/mens/acromegaly.jsp

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