[P&S Journal:Sp:95] Taxol-Mimicking Antibodies Assemble Microtubules A poignant note about the paper is that Dr. niels K. jerne, the major reviewerand submitter of Dr. Erlanger s paper to PNAS, died last year at age 83. http://cumc.columbia.edu/news/journal/journal-o/archives/jour_v15n2_0006.html
Extractions: Taxol-Mimicking Antibodies Assemble Microtubules Dr. Bernard Erlanger has isolated a novel monoclonal antibody that mimics the anti-cancer drug taxol and has the ability to assemble a large supramolecular structure, a behavior never seen in antibodies. Further research on how the unusual antibody works might lead to the development of new taxol-like tumor-killing agents. In the October 1994 issue of the Proceedings of the National Academy of Sciences, Dr. Erlanger, professor emeritus of microbiology, reports this first example of an antibody that can build a macromolecule from its biochemical subunits. The unique antibody, which is called an anti-idiotypic antibody, is in the construction business because Dr. Erlanger generated it to imitate taxol. Like taxol, which stops tumor cell growth by irreversibly stabilizing cellular components known as microtubules that normally break down when cells divide, the antibody can assemble microtubules from tubulin components. Dr. Erlanger suggests that new taxol-like drugs could be created based on further research leading to an understanding of how the antibody, a protein, is able to do what taxol, an organic compound, does. Antibodies normally do not assemble molecules. Antibodies are proteins made by the immune system, as part of its humoral response, to neutralize foreign antigens, such as bacteria or viruses. The immune system has evolved to be able to recognize essentially any antigen that confronts it, including biomolecules made by the organism itself. Hundreds of millions of immune cells, called B cells, continually make low levels of all the possible antibodies a person might need. Antigens, such as bacteria, for example, induce certain clones of B cells-those that make antibodies that recognize the bacteria-to grow selectively. After the antibacterial antibodies fight the infection, secondary antibodies shut off their production. The immune system maintains a balance between antibodies and these anti-antibodies, which are called anti-idiotypic antibodies.
Extractions: Laureati dall'anno 1969 fino ai giorni nostri. Italiano>Nobel Overview Name Fisica Chimica Medicina e fisiologia Letteratura Pace Economia Murray Gell-Mann Derek H. R. Barton Odd Hassel Max Delbr¼ck ... Heinrich B¶ll non assegnato John R. Hicks Kenneth J. Arrow Leo Esaki Ivar Giaever ... Henry A. Kissinger Le Duc Tho Wassily Leontief Sir Martin Ryle Antony Hewish Paul J. Flory ... Claude Simon International Physicians for the Prevention of Nuclear War (IPPNW) Franco Modigliani Ernst Ruska Gerd Binnig Heinrich Rohrer ... Naguib Mahfouz United Nations Peacekeeping Forces Maurice Allais Norman F. Ramsey Hans G. Dehmelt Wolfgang Paul ... Joseph Rotblat - Pugwash Conferences on Science and World Affairs Robert E. Lucas Jr.
Thomas Söderqvist Hvilken kamp for at undslippe? En biografi over immunologen og nobelpristagerenNiels K. jerne. Copenhagen Borgen, 1998. View the coverpage here. http://www.pubhealth.ku.dk/amh/staff/mhthso-e.htm
Extractions: Books Om biologi: en introduktionsbog, Copenhagen: Reitzel, 1979 (with P. Agger, G. Mathiasen and J. Haraldsdottir). View the coverpage here View the coverpage here Hvilken kamp for at undslippe? En biografi over immunologen og nobelpristageren Niels K. Jerne. Copenhagen: Borgen, 1998. View the coverpage here What Struggle to Escape: the Life and Work of Niels K. Jerne. New Haven: Yale University Press (in press 2003).
Søren Rieck DanskAmr. Particle movements TopNiels K. jerne (1911-1994). The immune systemof the body TopJens Christian Skou (1918- ). Molecular enzym pump. http://home1.stofanet.dk/rieck/d-nobel-001e.htm
Extractions: Johannes V. Jensen. Alfred Nobel was born in 1833 in Stockholm, Sweden to a family of engineers. On December 10, 1901 the Nobel Prize one of the world's most prestigious prizes was awarded for the first time. Year 2001 wee are celebrating the five prizes in physics, chemistry, physiology or medicine, literature and peace, which have now been awarded for one hundred years. The Swedish medals were designed by master engraver Erik Lindberg (1873-1966) and the Norwegian Peace medal by the Norwegian artist Gustav Vigeland (1869-1943). In 1968, "Sveriges Riksbank" instituted the "Bank of Sweden Prize in Economic Sciences in Memory of Alfred Nobel" in time for the bank's tercentenary celebrations. Danish Winners
CAPLEX Nettleksikon Www.caplex.no Translate this page Sverige. John R. Vane. Storbritannia. 1983. Barbara McClintock. USA. 1984. NielsK. jerne. Danmark. Georges JF Köhler. Vest-Tyskland. César Milstein. Storbritannia.1985. http://www.caplex.net/web/tabeller/tabeller.asp?art_id=t-npris4
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Extractions: SPERRY Roger W. (1913-1994) Estados Unidos, HUBEL, David H. (n. 1926) Estados Unidos, WIESEL, Torsten N (n. 1924) Suecia BERGSTROM, Sune K. (n. 1916) Suecia, SAMUELSSON, Bengt I. (n. 1934) Suecia, VANE, John R por sis descubrimientos sobre las prostaglandinas McCLINTOCK, Barbara (1902-1992) Estados Unidos JERNE, Niels K (1911-1994) Dinamarca; (1946-1995) Alemania; MILSTEIN, Cesar (n. 1927) Argentina por sus descubrimientos sobre los anticuerpos monoclonales BROWN, Michael S. (n. 1941) Estados Unidos, GOLDSTEIN, Joseph L. (n. 1940) Estados Unidos por sus descubrimientos sobre los factores que regulan el metabolismo del colesterol COHEN, Stanley (n. 1922) Estados Unidos, LEVI-MONTALCINI Rita (n. 1909) Italia por sus descubrimientos sobre los factores de crecimiento TONEGAWA, Susumu BLACK, Sir James W ELION, Gertrude B.
Nobel Prize In Medicine Since 1901 JF; Milstein, Cesar. 1985, Brown, Michael S.; Goldstein, Joseph L. http://www.planet101.com/nobel_medi_hist.htm
Extractions: Nobel Prize in Medicine since 1901 Year Prize Winners Behring, Emil Adolf Von Ross, Sir Ronald Finsen, Niels Ryberg Pavlov, Ivan Petrovich Koch, Robert Cajal, Santiago Ramon Y.; Golgi, Camillo Laveran, Charles Louis Alphonse Ehrlich, Paul; Mechnikov, Ilya Ilyich Kocher, Emil Theodor Kossel, Albrecht Gullstrand, Allvar Carrel, Alexis Richet, Charles Robert Barany, Robert Bordet, Jules Krogh, Schack August Steenberger Hill, Sir Archibald Vivian; Meyerhof, Otto Fritz; Banting, Sir Frederick Grant; Macleod, John James Richard; Einthoven, Willem; Fibiger, Johannes Andreas Grib Wagner-Jauregg, Julius Nicolle, Charles Jules Henri Eijkman, Christiaan; Hopkins, Sir Frederick Gowland Landsteiner, Karl Warburg, Otto Heinrich Adrian, Lord Edgar Douglas; Sherrington, Sir Charles Scott Morgan, Thomas Hunt Minot, George Richards; Murphy, William Parry; Whipple, George Hoyt Spemann, Hans Dale, Sir Henry Hallett; Loewi, Otto Nagyrapolt, Albert Szent-Gyorgyi Von Heymans, Corneille Jean Francois Domagk, Gerhard Dam, Henrik Carl Peter; Doisy, Edward Adelbert Erlanger, Joseph; Gasser, Herbert Spencer
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Glossary The summary for this Japanese page contains characters that cannot be correctly displayed in this language/character set. http://homepage2.nifty.com/sakino/glossary.htm
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Extractions: Fibiger, Johannes Andreas Grib Wagner-Jauregg, Julius Nicolle, Charles Jules Henri Eijkman, Christiaan Hopkins, Sir Frederick Gowland Landsteiner, Karl Warburg, Otto Heinrich Sherrington, Sir Charles Scott Adrian, Lord-Edgar Douglas Morgan, Thomas Hunt Whipple, George Hoyt Minot, George Richards Murphy, William Parry Spemann, Hans Dale, Sir Henry Hallett Domagk, Gerhard Dam, Henrik Carl Peter Doisy, Edward Adelbert ºñŸ¹Î K ¹ß°ß ºñŸ¹Î KÀÇ ÈÇÐÀû º»¼º ¹ß°ß Erlanger, Joseph Gasser, Herbert Spencer Fleming, Sir Alexander Chain, Sir Ernst Boris Florey, Lord(Howard Walter) Muller, Hermann Joseph X¼±¿¡ ÀÇÇÑ Àΰø µ¹¿¬º¯ÀÌ ¿¬±¸ Houssay, Bernardo Alberto
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Extractions: m[xãwE¶wÜ Nx ãwE¶wÜ E.A.vonx[O hCc Emil Adolf von Behring R.X CMX Ronald Ross N.tBZ Niels Ryberg Finsen I.P.put VA Ivan Petrovich Pavlov R.Rbz hCc Robert Koch C.SW C^A Camillo Golgi S.ECEJn XyC Santiago Ramon y Cajal C.L.A.u tX Charles Louis Alphonse Laveran P.G[q hCc Paul Ehrlich E.`jRt VA Ilya Ilyich Mechnikov E.T.Rbq[ XCX Emil Theodor Kocher A.RbZ hCc Albrecht Kossel A.OXgh XEF[f Allvar Gullstrand A.J tX Alexis Carrel C.R.VF tX Charles Robert Richet R.oj[ I[XgA Robert Barany xM[ Robert Barany A.N[ Schack August Steenberg Krogh A.V.q CMX Archibald Vivian Hill hCc Otto Fritz Meyerhof F.oeBO Ji_ Frederick Grant Banting CMX John James Richard Macleod W.ACgz[tF I_ Willem Einthoven J.tB[rK[ Johannes Andreas Grib Fibiger J.W.vonEbO I[XgA Julius Wagner-Jauregg C.J.H.jR tX Charles Jules Henri Nicolle F.G.zvLY