121. The Scientist - Gene Therapy--The Next Generation News. gene therapyThe Next Generation. Blaese also echoes many of his colleagues who say that the concept of gene therapy is too elegant not too work. http://www.the-scientist.com/yr1998/may/smaglik_p4_980511.html

The Scientist 12[10]:4, May. 11, 1998 News Gene TherapyThe Next Generation By Paul Smaglik Date: May 11, 1998 Author: Paul Smaglik Vectors in development seek to benefit from earlier trials The gene therapy field resembles a toolbox containing instruments researchers haven't quite mastered, and the number of devicesviral and nonviral vectorsin this toolbox keeps increasing. "There are all these different tools out there," notes A. Dusty Miller , researcher at Fred Hutchinson Cancer Research Center in Seattle. "People are still trying to figure out what tools to use for what diseases." Photo: Richard Lobell Photography BIOBYPASS: During a normal open-heart surgery, a surgeon injects an adenovirus carrying a molecule promoting endothelial cell growth into parts of the heart where a normal bypass can't be effective. Insulin syringes (inset) contain the vectors. Miller and other gene therapy investigators will report on the strengths and weaknesses of a host of vectors at the American Society of Gene Therapy's inaugural meeting in Seattle May 27-31. James M. Wilson

122. Www.noah.cuny.edu/pregnancy/march_of_dimes/genetics/genetest.html Betterhumans Alcoholic Rats Treated with gene therapygene therapy has been shown to reduce alcohol consumption in alcoholic rats, a finding that could help treat drug and alcohol addiction in humans. Fiction. http://www.noah.cuny.edu/pregnancy/march_of_dimes/genetics/genetest.html

123. Hadassah Medical Center gene therapy is an exciting frontier in medicine. The idea behind it is simple introducing corrective genetic material into cells http://www.hadassah.org.il/English/Eng_SubNavBar/Departments/Clinics and Institu

Home About Departments Medical Services Clinics Nursing profession ... Publications International Patient Contact Home Medical Services Clinics and Institutes Gene Therapy Gene Therapy Introduction Basic Research Facility GMP Production Facility Clinical Research Ward Scientific Activities Meet the Staff Contact Us Links Gene therapy is an exciting frontier in medicine. The idea behind it is simple: introducing corrective genetic material into cells to cure disease or alleviate the symptoms thereof. In practice, considerable obstacles still preclude its successful application in medicine. The Institute of Gene Therapy at the Hadassah Medical Organization was established in 1998 thanks to a generous contribution from Ms. Goldyne Savad , and is headed by Prof. Eithan Galun The mission of the Institute, as recommended by the scientific steering committee and adopted by the director of the Hadassah University Hospital, is to develop gene therapy for clinical applications. Our gene therapy perspective In an effort to expedite clinical application of gene therapy, the Institute has adopted a number of simple general guidelines: Recruiting principal investigators (PI) with high scientific achievements, each of whom is afforded full scientific independence, and is responsible for the development of her/his research group;

124. Octagen Corporation | Developing New Therapies For Hemophilia Privately held company developing therapies for hemophilia and other genetic disorders, using recombinant Factor VIII and gene therapy. Includes clinical trial status, licensing, corporate profile and contacts in Bala Cynwyd, Pennsylvania. http://www.octagen.com/

Octagen Corporation is a privately held biopharmaceutical company whose mission is to develop and commercialize improved therapies for hemophilia and other genetic disorders. Legal Notice

125. MSNBC - Gene Therapy Creates Super-muscles gene therapy creates supermuscles. Experts worry that athletes will take unfair advantage. Now gene therapy looms as an even more serious threat, he said. http://msnbc.msn.com/id/4282866/

MSN Home My MSN Hotmail Shopping ... Money document.write('') Web Search: logoImg("http://sc.msn.com"); MSNBC News Alerts Newsletters Help ... MSNBC Shopping Search MSNBC: Advanced Search   RESOURCE GUIDE Buy Life Insurance Yellow pages expedia.com Shopping ... Small Business Tips Genetics Gene therapy creates super-muscles Experts worry that athletes will take unfair advantage By Paul Recer Science Writer The Associated Press Updated: 11:39 p.m. ET Feb.16, 2004 SEATTLE - Gene injections in rats can double muscle strength and speed, researchers have found, raising concerns that the virtually undetectable technology could be used illegally to build super athletes. advertisement A University of Pennsylvania researcher seeking ways to treat illness said that studies in rats show that muscle mass, strength and endurance can be increased by injections of a gene-manipulated virus that goes to muscle tissue and causes a rapid growth of cells. “The things we are developing with diseases in mind could one day be used for genetic enhancement of athletic performance,” Lee Sweeney of the University of Pennsylvania said Monday at the national meeting of the American Association for the Advancement of Science. Betrayal of ideals Sports officials said the gene therapy has the potential of betraying the very essence of sport — athletes using their natural talents and training to compete.

126. MedlinePlus: Genes And Gene Therapy Search MEDLINE for recent research articles on Genes and gene therapy • gene therapy • Gene mapping. You gene therapy. Health http://www.nlm.nih.gov/medlineplus/genesandgenetherapy.html

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Other health topics: A B C D ... List of All Topics Genes and Gene Therapy Contents of this page: News From the NIH General/Overviews Anatomy/Physiology ... Teenagers Search MEDLINE for recent research articles on Genes and Gene Therapy: Gene therapy Gene mapping You may also be interested in these MedlinePlus related pages: Genetic Disorders Genetic Testing Genetics/Birth Defects Latest News HIV May Be Treated with Gene Therapy (05/25/2004, United Press International) Gene Therapy May Help Rheumatoid Arthritis (05/20/2004, United Press International) Johns Hopkins Identifies Leukemia Gene (05/17/2004, United Press International) Scientists Compare Rat Genome with Human, Mouse (03/31/2004, National Heart, Lung, and Blood Institute, National Human Genome Research Institute) NIH and FDA Launch New Human Gene Transfer Research Data System (03/26/2004, Food and Drug Administration, National Institutes of Health) International Sequencing Consortium Launches Online Resource: New Web Site Promotes Sharing of Large-Scale Sequencing Information (03/24/2004, National Human Genome Research Institute) More News on Genes and Gene Therapy From the National Institutes of Health Gene Therapy for Cancer: Questions and Answers (National Cancer Institute) Genetics Home Reference (National Library of Medicine) Human Genome Project (National Human Genome Research Institute) Learning about Genetics (National Human Genome Research Institute)

127. Aastrom Develops proprietary process technologies and devices for cell therapy applications, including stem cell therapies and gene therapy. (Nasdaq ASTM). http://www.aastrom.com/

Develops proprietary patient-specific cell therapeutics for stem cell tissue repair, and the treatment of cancer and infectious disease. AASTROM NEWS Read More... Aastrom Biosciences, Inc. Reports Third Quarter Fiscal Year 2004 Financial Results Read More... Aastrom Biosciences to Hold Investor Conference Call Tomorrow Read More... AASTROM EVENTS Read More... CEO Interview with The Wall Street Transcript Read More... 10th Int'l. Society for Cellular Therapy Meeting Read More...

128. American Scientist Online - Gene Therapy gene therapy. Investigators have been searching for ways to add corrective genes to cells harboring defective genes. A better strategy http://www.americanscientist.org/template/AssetDetail/assetid/15681

Home Current Issue Archives Bookshelf ... Subscribe In This Section Search Book Reviews by Issue Issue Index Topical Index ... Classics Site Search Advanced Search Visitor Login Username Password Help with login Forgot your password? Change your username see full issue: May-June 1999 Volume: Number: Page: DOI: Gene Therapy Investigators have been searching for ways to add corrective genes to cells harboring defective genes. A better strategy might be to correct the defects Eric B. Kmiec It has been the hope of biomedical researchers to find ways to fix the genes that cause disease. Over a decade ago, when researchers at MIT realized that viruses could be modified to carry corrective genes into cells, gene therapy seemed to be an eventuality. But to date, no one has found a way to reliably control the therapeutic genes to make them clinically useful. Our author surveys the history of this field and gives us a peek at the future of gene therapy, where the emphasis may be less on replacing defective genes and more on correcting them. Go to Article ADVERTISEMENTS About American Scientist Site Map Text Archive ... Contact Us

129. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: 1. Recruiting, Comparison of gene therapy With Chemotherapy in Treating Patients With Head and Neck Cancer Condition Head and Neck Cancer. http://www.clinicaltrials.gov/search/term=gene therapy

Home Search Browse Resources ... About Search results for gene therapy [ALL-FIELDS] are shown below. Include trials that are no longer recruiting patients. 158 studies were found. Here are studies 1 to 50. Recruiting Comparison of Gene Therapy With Chemotherapy in Treating Patients With Head and Neck Cancer Condition: Head and Neck Cancer Recruiting Chemotherapy With or Without Gene Therapy in Treating Patients With Unresectable Recurrent Head and Neck Cancer Condition: Head and Neck Cancer Recruiting Chemotherapy Combined With Gene Therapy in Treating Patients Who Have Stage III or Stage IV Breast Cancer Conditions: Male Breast Cancer; stage IIIA breast cancer; stage IIIB breast cancer; stage IIIC breast cancer; stage IV breast cancer Recruiting Gene Therapy Plus Chemotherapy in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma Conditions: adult brain tumor; adult non-Hodgkin's lymphoma; adult solid tumor Recruiting Gene Therapy to Improve Wound Healing in Patients With Diabetes Conditions: Wounds and Injuries; Diabetes; Diabetic Foot Ulcers; Foot wounds Recruiting Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx Conditions: lip and oral cavity cancer; Oropharyngeal Cancer; stage lip and oral cavity cancer; stage oropharyngeal cancer

130. Welcome To Tronolab Collection of protocols, maps and sequences regarding manipulation of lentiviral vectors, siRNA and transgenic animals. Applications in HIV, stem cell and gene therapy research at University of Geneva. http://www.tronolab.com/

@import "css/tronolab.css"; Tronolab Website Home Research Reagents Publications ... Credits Welcome to Tronolab Tronolab Website Currently, we mainly provide a support for our Lentiviral vector system: brief description of the vector system standard and bicistronic lentivectors constitutive and conditional siRNA lentivectors maps, sequences and protocols as well as clonning strategies and desing of siRNAs (including small siRNA database There are new sections coming soon about lentivector mediated transgenesis and stem cells. >>> NEW New layout, just because its fun...:) siRNA desgin extended New packaging plasmid - (2nd generation) >>> NEW Due to increasing number of support request we have organized an interactive Forum , a new section of tronolab.com dedicated for free exchange of information about lentivectors and siRNA. Please use the Forum to address questions, post comments, exchange useful and practical informations. Cooperation makes it happen ! If you have any questions or comments about this website please send me an email XHTML 1.0

131. Cancer Gene Therapy News Backgrounder: New Ideas Fuel Next Generation Gene Thera Cancer gene therapy news backgrounder New ideas fuel next generation gene therapy research. This nonviral aspect is very different in gene therapy. http://www.eurekalert.org/pub_releases/2004-05/uotm-cgt050504.php

Public release date: 5-May-2004 Contact: Nancy Jensen nwjensen@mdanderson.org University of Texas M. D. Anderson Cancer Center Cancer gene therapy news backgrounder: New ideas fuel next generation gene therapy research The concept seems straightforward. If, at its heart, cancer is a disease of genes, then giving patients new genes should disarm cancer. Such treatment would replace missing or faulty genes that keep cell growth in check, or would flush the body with "super genes" that could attack and destroy cancer. But as yet no such "gene therapy" for cancer has ever been approved by the United States Food and Drug Administration (FDA). Past attempts to inject therapeutic genes directly into solid tumors have shown promise, but researchers have stumbled over efforts to treat multiple tumors or cancer that has spread. That's because a patient's immune system reacts against the therapy, or the genes can't find their way to cancer cells. Albert Deisseroth, M.D., one of the first gene therapy researchers at The University of Texas M. D. Anderson Cancer Center, has said of numerous early attempts, "Our challenge to design gene therapy has been many times more complicated than finding the proverbial needle in a haystack." Still, new and ambitious approaches to gene therapy at M. D. Anderson are seen as encouraging to many of the researchers involved.

132. UNC Gene Therapy Center Working to translate gene therapy research from the laboratory bench into Phase I clinical trials for the treatment of hematologic and endocrine diseases. The center has a GMP facility for clinical grade gene vector production. http://www.med.unc.edu/genether/

Click here to learn more about our gene therapy research. Announcements March 2004 Drs. Stilwell and Samulski published a breakthrough study on the safety of AAV virion shells. They found that viral capsids may influence gene expression independent from their packaged DNA. AAV and adenovirus were compared using DNA microarrays for their effects on cellular gene expression. AAV was found to have minimal impact on gene expression in the cell, while adenovirus activated the expression of genes associated with toxicity and the immune response. These findings indicate that AAV may be a safer and more effective form of transduction. Click here for more information about this study Stilwell J and Samulski RJ. 2004. Role of Viral Vectors and Virion Shells on Cellular Gene Expression . Molecular Therapy, 9(3): 337-346. Fall 2003 - The UNC Gene Therapy Center was featured in Endeavors Magazine for our work with Canavan Disease. Click here to learn more and read the article New Publications Rabinowitz JE, Bowles DE, Faust SM, Ledford JG, Cunningham SE, Samulski RJ. 2004.

133. Radiologists Provide Safe Delivery Method For Gene Therapy Computed tomography (CT)guided injections offer a safe delivery method for gene therapy in patients with metastatic kidney cancer. http://www.eurekalert.org/pub_releases/2004-05/rson-rps042704.php

Public release date: 3-May-2004 Contact: Maureen Morley mmorley@rsna.org Radiological Society of North America Radiologists provide safe delivery method for gene therapy OAK BROOK, Ill. – Computed tomography (CT)-guided injections offer a safe delivery method for gene therapy in patients with metastatic kidney cancer, according to a study in the May issue of the journal Radiology. Gene therapy involves introducing genetic material directly into cells to fight disease. "The new gene therapies offer promise for controlling certain types of cancer, but delivering the agents directly into tumors poses its own set of challenges," said the study's lead author, Robert D. Suh, M.D., who is an assistant clinical professor of radiology and director of thoracic interventional services at the David Geffen School of Medicine at University of California, Los Angeles (UCLA). "As research in gene therapy, or immunotherapy, progresses, we need a good gene therapy delivery mechanism." Treatment of metastatic kidney cancer is difficult because the disease is largely resistant to chemotherapy. The only Food and Drug Administration (FDA)-approved immunotherapeutic treatment, recombinant interleukin-2 (IL-2), has a response rate of only 15 percent when administered intravenously, and its use is limited by significant and occasionally life-threatening side effects. Researchers have developed several gene therapy agents to improve the effectiveness and minimize the side effects of IL-2. UCLA's technique involves injecting an IL-2-encoded recombinant gene directly into cancer cells.

134. NEUROLAB Specializing in preclinical pharmacology testing of drugs targeting central nervous system diseases. Also provides CNS gene therapy research including transgene construction, characterization of transgene expression and in-vivo testing. http://neurolab.fr

NEUROLAB Biological Research Laboratory Your Research Partner In-Vivo Platform Functional Proteomics Platform Multiple Biomarkers Analysis NEW..... OUR ONGOING PROTEOMICS PLATFORM ...OUR NEW WEBSITE IS COMING SOON.Click Here l News l Company Profile l Services l Contact us l Job Opportunity l Last update: February 09th 2002 Best view on PC/Explorer

135. Gene Therapy Results Are "promising" In Fight Against HIV | Headlines | News | G gene therapy results are promising in fight against HIV Ben Townley, Gay.com UK Thursday 13 May, 2004 1115 More from this date Today s headlines. http://uk.gay.com/headlines/6250

@import url(http://uk.gay.com/css/uk.css); Home News Scene Multimedia ... Connect Now in News International Partnerships UK Headlines ... login have your say Should London have a Lesbian and Gay Museum? Headlines Previous story next story Gene therapy results are "promising" in fight against HIV Ben Townley, Gay.com UK Thursday 13 May, 2004 11:15 More from this date Today's headlines Research into using gene therapy as a way of fighting HIV has had promising results, according to a report in the New Scientist magazine. The results of trials using the technique suggest that introducing enhanced T-cells into the body is a safe and possibly effective way of containing the virus. According to the magazine, the therapy involves genetically engineering T-cells from HIV positive patients so that they can fight the virus more effectively. T-cells are the body's way of fighting infections, although HIV is able to destroy them and, consequently, their protection. By introducing the new cells back into the body, researchers hoped that the virus would be stopped from replicating around the body. The VIRxSYS company, which has been managing the trials, says the results prove the technique is safe to use on humans. It now hopes to expand the study to two new patients.

136. Research Interests Studies of Cystic Fibrosis gene therapy. From the University of Edinburgh in Scotland. http://www.ed.ac.uk/~pthorpe/research.htm

Research Interests Gene Correction of Cystic Fibrosis mutations (1999-) Cystic Fibrosis Gene Therapy Assays (1997-1999) Type I Restriction and Modification Systems (1990-1996) Cystic Fibrosis and Gene Therapy Cystic Fibrosis (CF) and our Gene Therapy research (including lab. Publications) are briefly summarised as part of the Medical Genetics Cystic Fibrosis group within the Medical Genetics Section . Note this site is still under development. Correction of Cystic Fibrosis Mutations 1999- Click here - our current research is detailed on a separate page Cystic Fibrosis Gene Therapy Assays 1997-1999 At the MRC Human Genetics Unit Edinburgh. My research was involved with developing and utilising a variety of assays to study the efficacy of gene delivery and expression of our Gene Therapy reagents. We used quantitative PCR in situ hybridisation to study gene delivery to the lungs; and epitope tagged versions of CFTR to study protein synthesis and localisation. The aim is to have available an array of assays which enable a thorough analysis of the efficiency of gene therapy reagents in all experimental systems, including potential clinical trials. References;

137. Gene Therapy Reduces Drinking In Rats With Genetic Predisposition To “Alco gene therapy Reduces Drinking in Rats with Genetic Predisposition to “Alcoholism”. Finding confirms earlier result using better http://www.bnl.gov/bnlweb/pubaf/pr/2004/bnlpr050504a.htm

Environment Newsroom Administration Directory ... Image Library Building 134 P.O. Box 5000 Upton, NY 11973-5000 phone 631 344-2345 fax 631 344-3368 www.bnl.gov managed for the U.S. Department of Energy by Brookhaven Science Associates, a company founded by Stony Brook University and Battelle News Release Number: 04-47 Released: May 5, 2004 Contact: Karen McNulty Walsh , 631 344-8350, or Peter Genzer Finding confirms earlier result using better model for human alcohol abuse previous work Genetically predisposed alcohol-preferring rats are a much better model for human alcoholism than the rats used previously, which the scientists had to train to prefer alcohol. Without any training, the genetic alcohol-preferring rats drink, on average, more than five grams of ethanol per kilogram of body weight per day when given a free choice between alcohol and plain water. Genetically non-preferring rats, in contrast, typically consume less than one gram of ethanol per kilogram of body weight per day. Brain scans showing fewer dopamine receptors (less red) in the nucleus acumbens, or "pleasure center," of alcohol-preferring (P) rats compared to nonpreferring (NP) rats.

138. PEGT: Introdcution To The Program Printable Version. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE. PROGRAMS OF EXCELLENCE IN gene therapy FOR HEART, LUNG, AND BLOOD DISEASES. http://www.med.cornell.edu/pegt/

Screen Reader/Printer Friendly Version NATIONAL HEART, LUNG, AND BLOOD INSTITUTE PROGRAMS OF EXCELLENCE IN GENE THERAPY FOR HEART, LUNG, AND BLOOD DISEASES Welcome to the NHLBI Programs of Excellence in Gene Therapy for Heart, Lung, and Blood Diseases Home Page The purpose of the PEGT Website is to provide information about the PEGTs' basic and clinical projects and their available resources (vector production cores, cell morphology core, hematopoietic stem cell processing core and primate stem cell transplantation core). The website will also include electronic versions of the applications that are necessary for requesting any available PEGT services or training. Applications may be filed electronically so as to expedite the process. The administrative organization of the PEGTs is a collaborative effort between the NHLBI staff and the supported investigators. To facilitate this, several committees have been established such as an Inter-Program Steering Committee, an External Scientific Panel and Internal Advisory Committees. A Data and Safety Monitoring Board has been appointed by the Director, NHLBI to provide overall monitoring of interim data and safety issues. In addition, a Data and Coordinating Center has been established to coordinate a range of functions that is common to NHLBI and all the PEGTs.

139. Charitable Medical Air Travel And Housing For Gene Therapy Patients Charitable medical air transportation and housing arrangements for gene therapy patients and their families through Angel Flight America and the National Association of Hospital Hospitality Houses. http://www.genetherapytravel.org/

www.GeneTherapyTravel.org Charitable travel and housing arrangements through Angel Flight America and the National Association of Hospital Hospitality Houses. There are two key challenges for many who must travel a long distance from home for specialized gene therapy evaluation, diagnosis or treatment. They are: Long-distance Travel. There is charitable long-distance medical air transportation available to help - whether it is just one trip or multiple round trips. Follow the link to go to www.PatientTravel.org or call their Helpline at Away from Home Guest Housing. There are hundreds of Hospital Hospitality Guest Houses able to provide assistance to patients and families. Follow the link to go to www.nahhh.org - the National Association of Hospital Hospitality Houses - for housing directory assistance, or call their Helpline at National Association Hospital Hospitality Houses, Inc Lodging Assistance for Persons Receiving Medical Treatment Away From Home CONTACTING THE ORGANIZATIONAL SPONSORS OF THIS SITE: Mercy Medical Airlift for: National Patient Travel Center (Serving Angel Flight America) 4620 Haygood Road, Ste. 1

140. Gene Therapy gene therapy Treatment of diseases through the transfer of a therapeutic gene into the cells of the patient to replace absent or defective genes or to http://www.crucell.com/glossary/item/gene therapy

Gene Therapy Treatment of diseases through the transfer of a therapeutic gene into the cells of the patient to replace absent or defective genes or to stimulate a cell into producing a therapeutic protein.

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