81. M. D. Anderson Cancer Center - W. M. Keck Center For Cancer Gene Therapy Welcome to the WM Keck Center for Cancer gene therapy website. gene therapy is the transfer of normal or redesigned genes into a http://www.mdanderson.org/departments/genetherapy/

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82. CNN.com - Gene Therapy For Parkinson's Disease Begins - Aug. 19, 2003 CNN http://cnn.com/2003/HEALTH/conditions/08/19/gene.therapy.ap/index.html

The Web CNN.com Home Page World U.S. Weather ... Special Reports SERVICES Video E-Mail Services CNNtoGO SEARCH Web CNN.com Gene therapy for Parkinson's disease begins Story Tools RELATED Painkillers may cut Parkinson's risk HEALTH LIBRARY Health Library What is Parkinson's disease? NEW YORK (AP) Researchers slipped billions of copies of a gene into the brain of a Parkinson's disease patient Monday, marking the first attempt to test gene therapy in a person with that disease. The patient, 55-year-old Nathan Klein of Port Washington, New York, said he was "feeling fine" in a telephone interview a few hours after the surgery. Klein said the disease gave him a tremor in his right arm, and made him shuffle and have to catch himself sometimes from falling. Medicines offer some relief, he said, but when he heard about the new study he decided to volunteer. With the disease, "you don't want to go out," Klein said. "It's embarrassing when you're shaking a lot and you walk like an old man." Klein is the first of a planned 12 patients for the study, said the surgeon, Dr. Michael Kaplitt of Weill Cornell Medical College. The research is focused on the procedure's safety, rather than whether or not it relieves symptoms. "Our whole goal here is to prove this is safe before we move on," Kaplitt said.

83. Center For Gene Therapy And Molecular Medicine - Mount Sinai School Of Medicine The Center for gene therapy and Molecular Medicine of Mount Sinai School of Medicine aims to employ novel scientific discoveries and developments in the use of http://www.mssm.edu/genetherapy/

Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, Box 1496, One Gustave L. Levy Place, New York, NY 10029 Tel: (212) 659-8288, Fax: (212) 849-2667, oneida.cintron@mssm.edu mssm education mssm research mssm directory ... search mssm Questions? Contact the Web Development Office

84. Parkinson's Patients Look To Gene Therapy CNN http://cnn.com/2002/HEALTH/conditions/10/11/parkinsons.genes.ap/index.html

85. Hospital Practice: Gene Therapy The Prospects for gene therapy STEPHEN L. ECK University of Pennsylvania. gene therapy will probably not be inordinately complex. Eck SL (Ed) gene therapy. http://www.hosppract.com/genetics/9910mmc.htm

The Prospects for Gene Therapy STEPHEN L. ECK University of Pennsylvania Gene therapy will probably not be inordinately complex. Although extremely high-tech in its design and manufacture, it is likely to be easy to administer in most practice settings. It will be widely used for classic genetic and common diseases alike. Dr. Eck is the Ann B. Young Assistant Professor of Medicine and Director of Cancer Gene Therapy Programs, University of Pennsylvania Medical Center, Philadelphia. Ever since DNA was first confirmed to be genetic material in the early 1950s, researchers have been wondering whether it might be altered, as a new kind of intervention against disease. After four decades, the knowledge and tools with which to do so are in hand. Indeed, we are already at the end of a decade of initial clinical trials. Among the strategies being pursued, perhaps the most prominent and straightforward is gene therapy. The fundamental idea is to administer a functional gene, so as to give targeted cells what amounts to a new protein-manufacturing capacity, one that would have been present but is missing or defective, or sometimes one never meant to be there. In the first instance, the treatment addresses single-gene, or mendelian, disease; in the second, it becomes applicable especially to acquired illnesses, including heart disease and cancer (Figure 1), where ultimately gene therapy may have its greatest public-health impact. In all cases, success is measured by how well an added gene functions. The major problems lie in delivering the gene to the correct destination and in having it act with a useful duration, producing sufficient amounts of the desired protein.

86. Gene Therapy Cures 4 With 'bubble Boy Disease' CNN http://cnn.com/2002/HEALTH/conditions/04/18/bubble.boy.disease.ap/index.html

87. Txt001jfo: Gene Therapy: Potential Applications In Clinical Transplantation gene therapy potential applications in clinical transplantation. Jeremy W. Fry and Kathryn J. Wood. Gene What is gene therapy? A http://www-ermm.cbcu.cam.ac.uk/99000691h.htm

Expert Reviews in Molecular Medicine: http://www-ermm.cbcu.cam.ac.uk Accession information: (99)00069-1h.htm (shortcode: txt001jfo); 8 June 1999 Request PDF version Discussion Group How to cite this article Gene therapy: potential applications in clinical transplantation Jeremy W. Fry and Kathryn J. Wood Author contact details In this review, we have discussed the basic principles of gene therapy and described the various vectors that are currently used both in research and in the clinic to deliver introduced genes (transgenes) to target tissues. The implications of gene transfer strategies to transplantation and potential future applications have also been reviewed. Allograft rejection and immunological tolerance For the foreseeable future, patients will continue to be transplanted with allogeneic organs which, by definition, are not identical at the major histocompatibility complex (MHC) locus. Without any other treatment, such as the administration of immunosuppressive drugs, the immune response generated by the recipient, which is mainly T-cell mediated, will reject such a graft (Fig. 1; What is gene therapy?

88. Gene Therapy Restores Vision To Dogs CNN http://cnn.com/2001/HEALTH/conditions/04/27/vision.restored.ap/index.html

89. Gene Therapy gene therapy. Many human diseases are caused by defective genes. A few common examples Disease, Genetic defect. gene therapy requirements. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/G/GeneTherapy.html

Index to this page Severe Combined Immunodeficiency (SCID) Treatment Options: Gene Therapy: requirements Packaging Cells ... Gene Therapy for X-linked SCID Gene Therapy Many human diseases are caused by defective genes. A few common examples: Disease Genetic defect hemophilia A absence of clotting factor VIII cystic fibrosis defective chloride channel protein muscular dystrophy defective muscle protein (dystrophin) sickle-cell disease defective beta globin hemophilia B absence of clotting factor IX severe combined immunodeficiency (SCID) any one of several genes fail to make a protein essential for T and B cell function All of these diseases are caused by a defect at a single gene locus . (The inheritance is recessive so both the maternal and paternal copies of the gene must be defective.) Is there any hope of introducing functioning genes into these patients to correct their disorder? Probably. Other diseases, also have a genetic basis, but it appears that several genes must act in concert to produce the disease phenotype . The prospects of gene therapy in these cases seems far more remote. Case study: severe combined immunodeficiency (SCID) SCID is a disease in which the patient has neither cell-mediated immune responses nor is able to make antibodies It is a disease of young children because, until recently, the absence of an immune system left them prey to infections that ultimately killed them.

90. Fiona Gilchrist : University Of Cambridge : Bioscience Engineering : Slater Grou CV, thesis and links to current research in novel gene therapy technologies at Cambridge, England. http://www.cheng.cam.ac.uk/research/groups/biosci/fg.html

BioScience Engineering Group University of Cambridge Department of Chemical Engineering BioScience Group Front Page ... University of Cambridge Dr Fiona Gilchrist Post Doctoral Researcher in BioScience Engineering Use of FRET polymers for Tumour Imaging Details of current research can be found here Dr Gilchrist's Thesis and CV are are available to download as PDF files via the links on the left of this page. Dr Gilchrist left the group in November 2003. Department of Chemical Engineering, University of Cambridge, New Museums Site, Cambridge, CB2 3RA, UK Telephone +44 (0)1223 334777 Fax +44 (0)1223 334796 Page Maintained by: Richard Taylor May 2004

91. Online NewsHour: Gene Therapy -- December 8, 1999 gene therapy. December 8, 1999. SUSAN DENTZER Ever since the notion of gene therapy first surfaced in the 1980s, the prospects have been tantalizing. http://www.pbs.org/newshour/bb/health/july-dec99/gene_therapy.htm

GENE THERAPY December 8, 1999 The National Institutes of Health and the Food and Drug Administration opened hearings to explore the safety of gene therapy treatment after a teen died while receiving the experimental care. Susan Dentzer reports on the procedure and its controversy. The Health Unit is a partnership with the Henry J. Kaiser Family Foundation. Health Spotlight on Gene Therapy Dec. 2, 1999 Breaking the Code Nov. 30, 1999 Medical Errors Focus: Internet Rx Nov. 11, 1999 Hope for the Heart Nov. 9, 1999 What the Doctor Ordered Nov. 1, 1999 Patient Privacy Browse the NewsHour's coverage of health. American Society of Gene Therapy Dr. W. French Anderson Human Gene Therapy ... UPenn The Institute for Human Gene Therapy RAY SUAREZ: Now, an inquiry into the developing science of gene therapy, reported by Susan Dentzer of our health unit, a partnership with the Henry J. Kaiser Family Foundation.

92. Biotechnology Resources Lists high tech companies in such fields as bioinformatics, gene therapy and immunology. http://www.biotechnologycompany.org/

93. Cancer Gene Therapy Publishes original laboratory and clinical research papers, case reports and review articles covering developments in gene transfer and gene therapy as applied to cancer research. Full articles available by subscription . http://www.naturesj.com/cgt/

nature.com about npg nature science update naturejobs ... site index SEARCH my account e-alerts subscribe register ... Journal home For readers Content Advance online publication Online sample issue E-alerts ... Society publishing NPG Subject areas Access material from all our publications in your subject area: Biotechnology Cancer Chemistry Clinical Medicine ... Microbiology NEW! Molecular Cell Biology Neuroscience Pharmacology Physics ISSN 0929-1903 2004 Volume 11 Publishes 12 issues a year ISI 2002 Impact Factor 2.929 Rank 42/115 Genetics and Heredity, 32/114 Oncology, View tables of contents The essential gene therapy resource for cancer researchers and clinicians Pertinent and practical, the Journal keeps its readers up to date with the latest developments in gene therapy for cancer Presents diverse viewpoints from academic, industry, and regulatory perspectives Publishes original laboratory and clinical research papers, case reports and review articles Topics covered include: antisense technology; drug resistance; hematopoietic gene transfer; homologous recombination; ribozyme technology; tumor immunotherapy; tumor suppressors

94. All The Virology On The WWW - Viral Vectors And Gene Therapy An up to date index of gene therapy and Viral Vector site, from All the Virology on the WWW. Please visit our sponsor! Viral Vectors and gene therapy. http://www.virology.net/garryfavwebgenether.html

Please visit our sponsor! Viral Vectors and Gene Therapy: General Sites Gene Therapy Related Sites Clinical Trials E-Journals Conferences Related Resources: Scientific Meetings Scientific Journals ATV Home ATV Table of Contents ... Graffiti Wall David M. Sander, Ph.D. (david.sander@virology.net ) If you are interested in developing a WWW site for your lab or organization, please feel free to contact me for any needed advice and/or assistance. Viral Vectors and Gene Therapy General Sites Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy - Dr. Harold Varmus, Director, National Institutes of Health (NIH), appointed an ad hoc committee to assess the current status and promise of gene therapy and provide recommendations regarding future NIH-sponsored research in this area. The Panel was asked specifically to comment on how funds and efforts should be distributed among various research areas and whatfunding mechanisms would be most effective in meeting research goals. Biotechnology and Gene Therapy Web 'Cite' - a large index of Gene Therapy information on the net.

95. TKT - Transkaryotic Therapies Develops and commercializes gene activation and nonviral gene therapy products for long term treatment of a broad range of human diseases. (Nasdaq TKTX). http://www.tktx.com/

TKT to Present at Banc of America's 2004 Health Care Conference...May 13, 2004 Massachusetts Court Dismisses TKT Derivative Lawsuit...May 10, 2004 PDF of Opinion TKT to Present at Deutsche Bank Securities 29th Annual Healthcare Conference...April 30, 2004 TKT to Present at Banc of America's 2004 Health Care Conference...May 13, 2004 Massachusetts Court Dismisses TKT Derivative Lawsuit...May 10, 2004 PDF of Opinion TKT to Present at Deutsche Bank Securities 29th Annual Healthcare Conference...April 30, 2004

96. The Gene Therapy Center At UAB THE SIXTH ANNUAL MEETING of the American Society of gene therapy (ASGT) took place June 4–8 in Washington, DC UAB researchers including James Markert, MD http://www.uab.edu/genetherapy/

oldHnav = null; HOME INTRODUCTION NEWS Cervical Cancer SPORE Initiative ... CONTACT US TUMOR-BUSTING VIRUSES A new technique called virotherapy harnesses viruses, those banes of humankind, to stop another scourge—cancer! Read the complete article by Dirk M. Nettelbeck and David T. Curiel, the feature article in the October issue of Scientific American magazine. Vector Ventures : News and Announcements from Members THE SIXTH ANNUAL MEETING of the American Society of Gene Therapy (ASGT) took place June 4–8 in Washington, D.C. UAB researchers including James Markert, M.D., Richard Whitley, M.D., John Mountz, M.D., Donald Buchsbaum, Ph.D., Kurt Zinn, D.V.M., Ph.D., and Tandra Chaudhuri, Ph.D., chaired sessions or made oral presentations of their research. As in years past, UAB had among the largest number of accepted abstracts and posters at the conference. The meeting also created an opportunity for former GTC postdocs to gather together again and catch up on each other’s work. GTC director David T. Curiel hosted an “alumni” breakfast reception, which was attended by 32 researchers from more than a dozen countries. The ASGT was established in 1996 to foster the exchange and diffusion of research and ideas relating to gene therapy, and to encourage professional and public education in all areas of gene therapy. This year some 2,000 researchers, academicians, and investigators from around the world gathered in Washington to discuss the latest in gene-therapy research.

97. Cystic Fibrosis Clinical And Research Center - Children's Hospital And RegionalM University of Washington CF Center. Information on Cf Research Development Program, Core Center for gene therapy, Clinic, Research Trials, current events and staff. http://depts.washington.edu/cfcenter

Site Under Construction Children's Hospital and Regional Medical Center Cystic Fibrosis Center (Pediatrics) 4800 Sand Point Way NE, 3D-2 Phone: 206-987-2024 Fax: 206-987-2639 University of Washington Cystic Fibrosis Clinic (Adults) Nurse Coordinator: Gwen McDonald, RN (206) 598-8446 Clinic Days/Hours: Mondays 8:30-12:30 Appointments: Rebecca Larson (206) 598-4615 Cystic Fibrosis Research Center - Adult and Pediatric Research Studies: Sharon McNamara, (206) 987-3921 Research Funding: Emily Sasnett, (206) 987-3861 General Information: Molly Andrina, (206) 987-1208 Cystic Fibrosis Therapeutics Development Network Coordinating Center Suites 90, 122 and 228 2611 NE 125th St. Seattle, WA 98125 Phone: 206-527-5725 Fax: 206-527-5767

98. Gene Therapy Under The Microscope CNN http://www.cnn.com/2000/HEALTH/mayo/03/31/gene.therapy/index.html

99. CNN - St. Jude Says Gene Therapy Experiment Not Tainted - February 17, 2000 CNN http://www.cnn.com/2000/HEALTH/02/17/gene.therapy/index.html

health Editions myCNN Video ... Feedback CNN Sites CNN CNN Europe CNNfn CNNSI myCNN CNNfyi AllPolitics Languages Search CNN.com CNNSI.com CNNfn.com The Web HEALTH TOP STORIES New treatments hold out hope for breast cancer patients MORE TOP STORIES Thousands dead in India; quake toll rapidly rising Israelis, Palestinians make final push before Israeli election Davos protesters confront police MORE ... MORE MARKETS 4:30pm ET, 4/16 DJIA NAS SPORTS Jordan says farewell for the third time ... LOCAL EDITIONS: CNN.com Europe change default edition MULTIMEDIA: video video archive audio multimedia showcase ... more services E-MAIL: Subscribe to one of our news e-mail lists Enter your address: DISCUSSION: chat feedback CNN WEB SITES: CNNfyi.com CNN.com Europe AsiaNow Spanish ... Korean Headlines TIME INC. SITES: Go To ... Time.com People Money Fortune EW CNN NETWORKS: CNN anchors transcripts Turner distribution SITE INFO: help contents search ad info ... jobs WEB SERVICES: St. Jude says gene therapy experiment not tainted February 17, 2000 Web posted at: 11:03 p.m. EST (0403 GMT) In this story: Trials closed pending results Concern first raised last year RELATED STORIES, SITES

100. CNN.com - Your Health -- Gene Therapy Shows Promise Against Cancer - August 4, 2 CNN http://www.cnn.com/2000/HEALTH/08/04/your.health.cancer/index.html

cancer Editions myCNN Video ... Feedback CNN Sites CNN CNN Europe CNNfn CNNSI myCNN CNNfyi AllPolitics Languages Search CNN.com CNNSI.com CNNfn.com The Web HEALTH TOP STORIES New treatments hold out hope for breast cancer patients MORE TOP STORIES Thousands dead in India; quake toll rapidly rising Israelis, Palestinians make final push before Israeli election Davos protesters confront police MORE ... MORE MARKETS 4:30pm ET, 4/16 DJIA NAS SPORTS Jordan says farewell for the third time ... LOCAL EDITIONS: CNN.com Europe change default edition MULTIMEDIA: video video archive audio multimedia showcase ... more services E-MAIL: Subscribe to one of our news e-mail lists Enter your address: DISCUSSION: chat feedback CNN WEB SITES: CNNfyi.com CNN.com Europe AsiaNow Spanish ... Korean Headlines TIME INC. SITES: Go To ... Time.com People Money Fortune EW CNN NETWORKS: CNN anchors transcripts Turner distribution SITE INFO: help contents search ad info ... jobs WEB SERVICES: Overview Genome guide Glossary Related sites ... Video Archive Gene therapy shows promise against cancer Early results promising August 4, 2000

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