41. AstraZeneca - Our Commitment - Endocrine Disruptors endocrine disruptors. Endocrine disrupting chemicals are a group of compounds that can cause adverse effects on the hormone systems of animals. http://www.astrazeneca.com/article/11342.aspx

Skip to content Home News Investors ... Our commitment Endocrine disruptors Endocrine disruptors Endocrine disrupting chemicals are a group of compounds that can cause adverse effects on the hormone systems of animals. Some substances, such as natural and synthetic oestrogens have always been known to have such effects. However, in the 1990s, new, more sensitive test methods indicated that a much wider range of substances might be capable of acting as oestrogen mimics and having similar effects. This discovery was then immediately linked with a very wide range of problems being seen in humans and wildlife that appeared to be due to impacts on hormonal systems. The most often reported impact was the apparent decline in human male sperm count, with the associated concerns over human fertility. In the environment, a number of impacts were similarly attributed to endocrine disrupting chemicals, the most significant of which, was the feminisation of fish in lowland rivers of the United Kingdom. However, this link was only theoretical, and a very large amount of research work is currently being carried out, primarily to answer the following questions. What substances might have endocrine disrupting properties and how might they be identified?

42. Endocrine Disruptors The message that endocrine disruptors are present in the environment and have the potential to affect many people over a lifespan has not effectively reached http://www.naturodoc.com/library/women/endocrine_disruptors.htm

Site Index Natural Health Articles Health News About Us ... Links NaturoDoc Note: Be sure to read this report, or at least the Consensus Statement, Section 4 . The importance of these issues and the credibility of these scientists makes reading this report a priority for all of us. Statement from the Work Session on Environmental Endocrine-Disrupting Chemicals Neural, Endocrine and Behavioral Effects The Problem A multidisciplinary group of international experts gathered for a work session on "Environmental Endocrine-Disrupting Chemicals: Neural, Endocrine and Behavioral Effects" under the auspices of the International School of Ethology at the Ettore Majorana Centre for Scientific Culture in Erice, Sicily, November 5-10, 1995. The need for this work session grew out of evidence accumulated since the first consensus statement on endocrine disrupting chemicals was released in October, 1991. The first statement was framed as a product of a work session on "Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection." Research since 1991 has reinforced concerns over the scope of the problems posed to human health and ecological systems by endocrine-disrupting chemicals. New evidence is especially worrisome because it underscores the exquisite sensitivity of the developing nervous system to chemical perturbations that result in functional abnormalities. Moreover, the consequences of these perturbations depend upon the stage of development during which exposure occurs and are expressed in different ways at different times in life, from birth through to advanced age.

43. An Overview Of The Endocrine Disruptor Screening Program Some scientists have suggested that such harmful chemicals, known as endocrine disruptors, are prevalent among the chemicals with which we come into contact http://www.hsus.org/ace/11412

About Us Field Projects How You Can Help Publications ... An Overview of the Endocrine Disruptor Screening Program An Overview of the Endocrine Disruptor Screening Program The Environmental Protection Agency is developing a program to assess whether chemicals can cause harmful effects on people by disrupting their endocrine system, the hormone-secreting glands that regulate important bodily functions such as blood-sugar levels. Some scientists have suggested that such harmful chemicals, known as "endocrine disruptors," are prevalent among the chemicals with which we come into contact, and that they may cause problems such as low sperm count in mature males and premature sexual development in young girls. Congress took up this issue and enacted legislation that called upon the EPA to establish an endocrine disruptor (ED) screening program and to adhere to an ambitious timetable. The EPA established the now defunct Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) and charged it with coming up with an appropriate battery of tests for assessing pesticides, industrial chemicals, and environmental contaminants. Unfortunately, EDSTAC's proposed battery relies heavily on animal tests. Thousands of chemicals would be run through this battery, unproven in its relevance as an ED screen, making the Endocrine Disruptor Screening Program (EDSP) one of the largest animal testing exercises in history. Animal protectionists and sympathetic scientists have criticized EDSTAC's proposed battery on several grounds: It is based on an unproven hypothesis about widespread harm to people from endocrine disruptors; it has never been validated for the purpose of ED screening; and it ignores alternative approaches. Moreover, key meetings of the Endocrine Disruptor Standardization and Validation Task Force, formed to develop, standardize, and validate the EDSTAC-recommended screens and tests, took place behind closed doors and without adequate public input. A new panel has been created, including people from the animal protection community who have been involved in this issue.

44. Pesticides, Endocrine Disruptors, And Other Toxic Substances - National Center F Health Studies Branch. Pesticides, endocrine disruptors, and Other Toxic Substances. CDC is collaborating with the Texas Department http://www.cdc.gov/nceh/hsb/toxins.htm

Environmental Health Studies Content Home Churchill County (Fallon), Nevada Cancer Study Concentrated Animal Feeding Operations (CAFOs) Disaster Epidemiology and Assessment ... NCEH Brochures Health Studies Branch Pesticides, Endocrine Disruptors, and Other Toxic Substances CDC is collaborating with the Texas Department of Health and the United States Environmental Protection Agency (USEPA) on a pilot surveillance project to track acute, nonoccupational, pesticide-related health conditions. The purpose of this surveillance program is to evaluate the public health impact of nonoccupational pesticide exposures in Texas. It involves active case finding and follow-up activities, outbreak investigations, and intervention/prevention activities. A final component will evaluate the program for completeness and representativeness of the case-finding effort. CDC is assisting the New Mexico Department of Health to evaluate statewide 1998 poison control center reports of nonoccupational pesticide poisoning. CDC will then use a descriptive analysis of the data to identify intervention/ prevention activities that may help reduce nonoccupational pesticide poisoning in New Mexico. CDC is collaborating with USEPA, other government agencies, and industry representatives in developing specific interventions to reduce children’s exposures to rodenticide products. Interventions will include labeling changes and educational activities. Although adverse health effects are rare, thousands of children are exposed yearly, resulting in many unnecessary visits to emergency rooms and doctors' offices.

45. Bergeson & Campbell, P.C. -- Endocrine Disruptors endocrine disruptors. Endocrine Disruptor Screening Program Materials (August 16, 2000); NTP endocrine disruptors LowDose Peer Review (June 22, 2000); http://www.lawbc.com/endocrine.shtml

lawbc.com is now available in several languages. click on a flag for english, german, french or spanish Go to.... Monthly Updates FAQs FDA Federal/EPA Regulatory Policy EPA News/Transitions Info Quality Act Implementation Bioterrorism and Chemical Issues FIFRA TSCA HPV Children's Health Testing Endocrine Disruptors NTP EPCRA EIM Pesticide Regulation Proposition 65 Clean Air Act Clean Water Act RCRA CERCLA Toxic Tort OSHA International Issues HOME To subscribe to the private sections of our web site, please click here Most of the documents listed on this site are in Adobe PDF format. Endocrine Disruptors Overview EPA’s Semi-Annual Report Concerning the Status of Chemicals for Screening in the EDSP (August 27, 2003) EPA Issues Strategy for Selecting the First EDSP Priority List (December 31, 2002) Availability of Endocrine Disruptor Documents for Comment (October 28, 2002) Federal Court Approves Consent Decree Setting Deadlines for REDs and Risk Assessments (October 4, 2001) Endocrine Disruptor Screening Program Materials (August 16, 2000)

46. The Scientist :: Virtual Endocrine Disruptors Virtual endocrine disruptors. EPA seeking computational shortcuts to identify harmful hormone mimics By Charles Q Choi. To narrow http://www.biomedcentral.com/news/20030903/02

Previous Next Virtual endocrine disruptors By Charles Q Choi To narrow down the list of chemicals, among thousands in the environment, that pose risks to people or wildlife, the US Environmental Protection Agency (EPA) is turning to computational methods . The agency has $2.4 million in anticipated funding for innovative approaches to virtually mimicking the effects of compounds on living organisms. The specific problem the EPA is concerned with at the program's outset is endocrine disruption "There are 87,000 chemicals in the environment. There is a need for improved approaches for prioritizing which chemicals should be screened and tested," explained Elaine Francis, director of EPA's endocrine disruptors research program. "We would not have to test every chemical for effects, and make better informed decisions as a regulatory agency." Computational toxicology also could help cut animal testing, the original reason EPA began pursuing the approach 15 months ago, Francis told The Scientist "I'm very happy to see the EPA coming up with funding to stimulate research in this area. I think we'll be seeing a lot more of these initiatives, for instance, from in NIH," said Thomas Knudson of Thomas Jefferson University, editor of the journal

47. Endocrine Disruptors endocrine disruptors. All of the following examples represent animal populations that had extreme exposure to known endocrine disruptors http://www.ccaej.org/projects/endocrine.htm

Endocrine Disruptors Our Stolen Future: Are We Threatening Our Fertility, Intelligence ad Survival? by Theo Colborn, Diane Dumanoski and John Peterson Myers. The Endocrine System The endocrine system acts as the chemical messenger system for communication throughout our body. The main purpose of the endocrine system is to control and regulate body functions especially growth and development. This is accomplished through hormones, potent, biologically-active chemical messengers that in very small amounts can produce significant biological effects. Hormones are released from the brain, thyroid, ovaries, testes and other endocrine glands and then carries them through the bloodstream to the target cells and organs where they activate and regulate various functions. The system is made up of the pituitary gland which acts as a control center telling the ovaries or the thyroid when to send their signals and how much hormone to send. The pituitary gets its cues from another gland, the hypothalamus, which acts as a thermostat telling the pituitary to increase production, slow down or shut off. These messages travel back and forth continuously to keep all parts of the organism operating as one coordinated being. Hormones also guide the growth of a baby’s nervous system and immune system and "programs" organs and tissues such as the liver, blood, kidneys and muscles so they will function properly. During early development this regulation of growth and development is critical for a child. The thyroid hormone, for example, is essential for normal neurological function and development. Deficiencies of thyroid hormones during fetal development or during early infancy can lead to mental retardation, hearing loss and speech problems. Children with thyroid deficiencies, even those with normal IQ’s, can have language comprehension problems, impaired learning and memory and hyperactive behavior.

48. Phthalates Information Center -- Phthalates And Your Health -- Endocrine Disrupt Endocrineactive chemicals (sometimes called endocrine disruptors ) received wide publicity in 1996 with the publication of a book dramatizing the impact of http://www.phthalates.org/yourhealth/endocrine.asp

Search: Asthma Cancer Endocrine Disruptors Food Packaging ... Site Terms Background The endocrine system in humans and other animals has an important job. It produces the hormones that regulate the body's various processes, such as metabolism and reproduction, which are vital to the chemistry of life. One example of a hormone is insulin, which breaks down sugar. Another is adrenalin, which pumps us up so we can deal with stress or danger. Estrogens are hormones that impart female characteristics and androgens impart male characteristics. Endocrine-active chemicals (sometimes called "endocrine disruptors") received wide publicity in 1996 with the publication of a book dramatizing the impact of accidental chemical spills and other isolated incidents on wildlife - and hypothesizing that humans could also be harmed. What gave the book an added fear factor was its emphasis on potential effects on sexual development and reproduction. The book speculated that even extraordinarily low levels of some chemicals, delivered at just the wrong time, could have calamitous consequences on sexual structure, function, behavior and even identity. Some have coined a catchy phrase for such chemicals - "gender benders." The Issue Many things like diet, drugs, exercise, or exposure to beneficial or harmful substances, can alter the operation of the human body, including the endocrine system. The precise issue of how and when the endocrine system can be disrupted, however, is still very murky - as well as anxiety-inducing. Everyone agrees that a few chemicals and some natural substances (for example, soybeans are a weak estrogen mimic), can impact the endocrine system to some degree.

49. State Of Environment In Norway: Endocrine Disruptors Hazardous chemicals. endocrine disruptors. animals. The presence of endocrine disruptors can cause feminization of male animals. http://www.environment.no/templates/themepage____3167.aspx

ABOUT SOE NORWAY CONTACT US PICTURES NORWEGIAN A-Z directory Air pollution Hazardous chemicals Polar regions ... Data and statistics Hazardous chemicals Endocrine disruptors Hazardous chemicals List of Dangerous Substances Criteria for undesirable properties The Observation List ... Strict regulation of endocrine disruptors Hormones control a whole range of functions in people, animals and plants, and are particularly important for growth and development. We have known for a long time that some chemicals can interfere with the hormone balance in people and animals and have effects similar to those of hormones. They may disrupt the endocrine (hormone) system by mimicking, enhancing or inhibiting the effects of hormones. All types of hormones may be affected, but the focus has often been on possible effects on the functioning of sex hormones, and especially the female sex hormone oestrogen. Oestrogen controls sexual development in the fetuses and young of both people and animals. The presence of endocrine disruptors can cause "feminization" of male animals. 1.State

50. E/E Letter Links Research Project Inventory; IPCS Global Inventory of Research on endocrine disruptors; NIHS Database Receptor DB; SETACEurope; Society http://www.eeletter.com/links.htm

Word of Mouse Academic and Science Sites Endocrine Disrupter Sites Endocrine Disrupter Documents Environmental - Advocacy Groups ... Brominated Flame Retardants Academic and Science Sites Breast Cancer and Environmental Risk Factors in New York State The Endocrine Society Home Page Federal Endocrine Disrupter Research Project Inventory IPCS Global Inventory of Research on Endocrine Disruptors ... Tulane-Xavier Center for Bioenvironmental Research Endocrine Disrupter Sites CEFIC Endocrine Modulators Study Group Endocrine Disrupters (Maintained by Peter deFur last updated 5/96) Endocrine Disruptors Research Initiative (Committee on the Environment and Natural Resources) Environment Canada's National Strategy for Addressing Endocrine Disrupting Substances ... WWF Global Toxics Program Endocrine Disruptors Recent Findings Endocrine Disrupter Documents Comments on the European Commission's Endocrine Disrupter Strategy International Council of Chemical Associations (ICCA) CEFIC Position Paper on the EU Commission Communication on a Community Strategy for Endocrine Disrupters CEFIC Presentation to the European Parliament WWF comments ... WWF Letter to Comments on EPA's Proposed Endocrine Disrupter Screening Program American Crop Protection Association World Wildlife Fund (WWF) Chemical Manufacturers Association (CMA) Consultants in Toxicology, Risk Assessment and Product Safety (CTRAPS)

51. Endocrine Disruptors And Carcinogenic Risk Assessment endocrine disruptors and Carcinogenic Risk Assessment. Volume 340 NATO Science Series Life and Behavioural Sciences Edited by L http://www.iospress.nl/html/boek1635768026.html

Endocrine Disruptors and Carcinogenic Risk Assessment Volume 340 NATO Science Series: Life and Behavioural Sciences Edited by: L. Chyczewski J. Niklinski and E. Pluygers 2002, 372 pp., hardcover ISBN: Price: The book is devoted to the study of the endocrine-related effects on human health with special reference to carcinogenesis, and to the assessment of carcinogenic risk. After providing basic information at the general, cellular and molecular levels, the contents focus on the paradigm of Biologically Based Risk Assessment, as developed form Physiologically-Based Toxicokinetic Models. The analysis of this material is proposed as the novel parameters for developing Biologically Based Models of Carcinogenesis, considered to be more relevant to risk assessment than traditional approaches. This data appears unique in an important and rapidly developing field. IOS Press Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands +31 20 688 3355 phone, +31 20 620 3419 fax info@iospress.nl e-mail

52. Washington Free Press - #56 March/April 2002 endocrine disruptors and the Transgendered By Christine Johnson, contributor. New Findings on Global Warming. endocrine disruptors and the Transgendered. http://www.washingtonfreepress.org/56/EndocrineDisruptors.htm

#56 March/April 2002 Home Subscribe Back Issues The Organization ... Do Something Directory Regulars Reader Mail Envirowatch Urban Work Rad Videos ... Northwest Books Features Frankencorn Threatens Mexico’s Ancient Maize Stocks By Ronnie Cummins, Organic Consumers Association CANADA FISH FARMS ENDANGER MARINE ENVIRONMENT By Neville Judd PETA SUES ON BEHALF OF FARM ANIMALS FRANKENSOY REQUIRES MORE HERBICIDES WEIRD DNA FOUND IN ROUNDUP READY SOYBEANS by Cat Lazaroff DO NOT EAT VEAL EUROPE GOING ORGANIC PUSH FOR ORGANIC PROGRAMS AT WSU Why Airbus will Beat the Crap out of Boeing by Martin Nix, contributor Clinton on AIDS, War, Climate Change, Globalization The Eighth Lively Art: Conversations with Painters, Poets, Musicians, and the Wicked Witch of the West By Wesley Wehr Endocrine Disruptors and the Transgendered By Christine Johnson, contributor New Findings on Global Warming What Is a ‘Just’ War? Religious Leaders Speak Out by David Harrison, Contributor Local Vet Counters the Big Lie about Pearl Harbor By Captain O’Kelly McCluskey, WWII DAV Case Against John Walker Lindh is Underwhelming By Glenn Sacks, contributor

53. NRP50 Summary. The presence of endocrineactive chemicals ( endocrine disruptors ) in the biosphere has become a worldwide public health and environmental concern. http://www.nrp50.ch/

About NRP50 Job and Partner Market Links Contacts About NRP50 ... Position Papers Summary The presence of endocrine-active chemicals ("endocrine disruptors") in the biosphere has become a worldwide public health and environmental concern. In 1999, a report released by the Swiss Agency for the Environment, Forests and Landscape (BUWAL) concluded that such chemicals have already left a mark in the Swiss landscape and implicated them as a general cause of population changes in wildlife. Some of the chemicals involved (e.g. polychlorinated biphenyls (PCBs) and dibenzo-p-dioxins (dioxins)), have received wide media attention because of their negative health impact on humans. The potential contribution of endocrine disruptors to the increased incidence of a number of diseases and developmental disorders in humans and animals is alarming, but the establishment of solid cause-effect relationships requires scientific clarification. The National Research Programme aims to develop scientific strategies to assess the risks and hazards that arise when endocrine disruptors are processed through ecosystems to cause human and animal exposure. Major objectives to be addressed are: What is the magnitude of exposure of humans, domestic animals, wildlife and environment in Switzerland?

54. In-Vitro Recombinant Yeast Assay And In-vivo Uterotrophic Assay To Screen For Oe endocrine disruptors. http://www.safepharm.co.uk/Services/Toxicology/endocrine-disruptors.html

Endocrine Disruptors In Vitro Screening Test For Oestrogenic Activity The Background The Yeast Assay ... Endocrine Disruption Assay In Vitro Screening Test For Oestrogenic Activity The Department of Ecotoxicology has validated a sensitive and specific in vitro screening test for oestrogenic chemicals using a recombinant yeast assay. This assay allows for the generation of reproducible empirical biological data to be obtained in a cost-and-time-effective manner. A simple colour change from yellow to red, measured by a spectrophotometer, indicated the presence of an oestrogenic chemical. The intensity of the colour change is directly related to the oestrogenic activity. This assay has been shown to be suitable for both neat chemicals and environmental samples and complements the in vivo mammalian methods also available at SPL . A similar assay for androgenic activity has also been validated. The Department now offers a full range of oestrogen, androgen, anti-oestrogen and anti-androgen screens. The Background Widespread concern exists over environmental contaminants that can mimic the biological activities of the female hormone, oestrogen. A wide range of chemicals has been shown to be weakly oestrogenic. These include both natural chemicals, such as phytoestrogens and mycoestrogens, as well as synthetic chemicals such as pesticides, polychlorinated biphenols, plasticisizers and the degradation products of surfactants. The regulatory response to these concerns has been spearheaded by the US Environmental Protection Agency, which is mandated to screen some 15000 chemicals for endocrine disrupting effects.

55. E.hormone | Hormones And The Environment Third International Workshop on Brominated Flame Retardants in the Environment Environmental endocrine disruptors Reproductive Tract Biology XIII International http://e.hormone.tulane.edu/

Events e.hormone 2004 October 27-30, 2004 Third International Workshop on Brominated Flame Retardants in the Environment ... Books: The Greatest Experiment Ever Performed on Women Last updated: May 26, 2004 e.hormone Events Learning News and Views ... Center for Bioenvironmental Research at Tulane and Xavier Universities

56. Endocrine Disruptors. endocrine disruptors. What are endocrine disruptors ? Questions on Endocrine They claim that endocrine disruptors are a major threats for the humanity. http://www.clockarium.org/greenfacts/endocrine_disruptors/endocrine_disruptors.h

Endocrine Disruptors What are endocrine disruptors ? Questions on Endocrine: What are Endocrine Disrupters (EDCs) ? How do the EDCs act ? Do EDCs affect wildlife ? ... Other views on Endocrine Disruptors Provided by GreenFacts Regularly, the news spreads reports on the dangers of environmental chemicals aggressing men's virility and woman's fertility. These chemicals are called endocrine disruptors because they can interfere with our hormonal system, called "endocrine" by scientists. Some people believe that endocrine disruptors can ruin people's reproductive ability and cause lots of diseases and malformations. They claim that endocrine disruptors are a major threats for the humanity. In the other hand, some skeptics claim that that endocrine disruptors are "just another creation of fear mongering environmentalist leftists". So who's right, who's wrong? Who knows... except possibly for endocrine disruptor specialists. Regrouped under the WHO (World Health Organization) in a worldwide program called the IPCS (International Programme on Chemical Safety), they have published recently an extensive report giving the state of science on endocrine disruptors. It contains over a hundred pages written in a scientific jargon for endocrine disruptors specialists... nothing for you and me. Luckily

57. Endocrine Disruptor Page ICCVAM Evaluation of In Vitro Test Methods For Detecting Potential endocrine disruptors Estrogen Receptor and Androgen Receptor Binding and Transcriptional http://iccvam.niehs.nih.gov/methods/endocrine.htm

Home Contact Us Test Methods Documents ... Meetings (Click on poster to enlarge) In Vitro Endocrine Disruptor Screening Assays Updates and Announcements Request for Comments and Nominations for Validation Studies Nominations for Comment: Xenobiotic Detection Systems,Inc. IA, Inc. Please Submit Comments/Nominations by June 7, 2004 FR Notice (Vol. 69, No. 77, pp. 21564, 04/21/04) PDF or HTML At the request of the U.S. EPA, ICCVAM and NICEATM convened an independent panel of scientists, May 21-22, 2002, in Research Triangle Park, NC, to assess the validation status of four different types of in vitro assays proposed as screens to identify chemicals with potential hormonal activity. The assays, estrogen receptor (ER) and androgen receptor (AR) binding assays, and ER and AR transcriptional activation assays, were evaluated. The panel also developed proposed minimum performance standards (MPS) for future methods to achieve and proposed substances for validation of the methods. The Expert Panel report, final list of substances for validation, and ICCVAM recommendations have been compiled into a final ICCVAM evaluation report which will be forwarded to Federal agencies for their consideration. Responses from these agencies will be added to this web site and announced through the ICCVAM public mailing list (

58. Greencape endocrine disruptors endocrine disruptors For information about endocrine disruptors, go to the following links World Wildlife http://www.greencape.org/endocrine.html

Cape Alliance for Pesticide Education Home Pesticide Database The Precautionary Principle Pesticides in Schools ... GreenCAPE Newsletter Endocrine Disruptors Endocrine disruptors are synthetic chemicals that mimic or otherwise interfere with naturally produced hormones that control how an organism develops and functions. Wildlife and humans are constantly exposed to these pervasive and often persistent chemicals. They have been implicated in the rising levels of breast, testicular and prostate cancer. They cause reproducuctive abnormalities and infertility. There is strong evidence that they cause behavior and learning problems in children. For information about endocrine disruptors, go to the following links: World Wildlife Fund: Endocrine Disruptors: A superb introduction to the whole problem of endocrine disruptors, how they are related to Persistent Organic Pollutants (POP's) and the science that supports the growing concern over these chemicals. Introduction to Hormone Disrupting Chemicals: This site was created by Dr. A. Michael Warhurst, an Environmental chemist whop works for Friends of the Earth in London. Clear and Concise informatin, presented in an easy to understand way. EPA Endocrine Disruptor Page: This web site provides information aboout the endocrine system and why certain chemicals can affect it, how the EPA Endocrine Disruptor Screening Program was developed, and the current status of EPA's implementation activities.

59. The Regulatory Studies Program - Endocrine Disruptor Screening Program: Proposed Summary Research has demonstrated that some chemicals, dubbed endocrine disruptors, can interfere with animals’ hormone systems, potentially causing http://www.mercatus.org/regulatorystudies/article.php/213.html

Trans fats in foods are down but not out 05.26.2004 - The fight over the amount of trans fat in America's diet is hotter than ever both on supermarket shelves... Energy Department Plans a Push to Retrieve Nuclear Materials 05.26.2004 - In an effort to keep the raw materials for nuclear bombs out of the hands of terrorists, the Energy Department... S.E.C. Mutual Fund Inquiry Widens to Include Wellington More HOME ABOUT THE PROGRAM ... SITEMAP Environmental Protection Agency Endocrine Disruptor Screening Program: Proposed Chemical Selection Approach for Initial Round of Screening by Joel Schwartz March 17, 2003 RSP 2003-05 Summary Research has demonstrated that some chemicals, dubbed "endocrine disruptors," can interfere with animals’ hormone systems, potentially causing adverse health effects. EPA created the Endocrine Disruptors Screening Program (EDSP) to comply with a Food Quality Protection Act (FQPA) of 1996 requirement to screen all chemicals used in pesticides. Thus, EPA should limit the EDSP only to those chemicals for which testing is mandated, and include only those additional chemicals for which low-dose effects have been reported in at least one laboratory animal study in the peer-reviewed literature that used realistic routes of exposure. The first 50-100 chemicals should include a broad universe that samples a range of expected endocrine activity, biochemical modes of action, and toxicity. The selection process should also ensure inclusion of chemicals with widespread human exposure, but for which there are few or no toxicity data.

60. Regradar - Endocrine Disruptors Hot Regs Archive. endocrine disruptors. Research has demonstrated that some chemicals, dubbed “endocrine disruptors,” can interfere http://www.mercatus.org/regradar/article.php/227.html

Regulation Facts Trans fats in foods are down but not out 05.26.2004 - The fight over the amount of trans fat in America's diet is hotter than ever both on supermarket shelves... Energy Department Plans a Push to Retrieve Nuclear Materials 05.26.2004 - In an effort to keep the raw materials for nuclear bombs out of the hands of terrorists, the Energy Department... S.E.C. Mutual Fund Inquiry Widens to Include Wellington More HOME REGS. BY ISSUE AREA ... WHAT'S ON YOUR RADAR? Hot Regs Archive Endocrine Disruptors Research has demonstrated that some chemicals, dubbed “endocrine disruptors,” can interfere with animals’ hormone systems, potentially causing adverse health effects. EPA created the Endocrine Disruptors Screening Program (EDSP) to comply with a requirement in the Food Quality Protection Act (FQPA) of 1996 that EPA develop a program to determine “whether certain substances may have an effect in humans that is similar to an effect produced by a naturally occurring estrogen, or such other endocrine effect as the [EPA] Administrator may designate.” The FQPA requires screening of all chemicals used in pesticides. The EDSP would prioritize chemicals for screening, and initially screen them for ability to interact with the endocrine system using a set of short-term in vivo and in vitro assays. Chemicals that come up positive in these “Tier 1” assays would go on to “Tier 2” testing—longer-term tests to look for adverse reproductive and developmental effects.

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