1. EPA | Endocrine | Endocrine Disruptors Research Initiative endocrine disruptors Research Initiative. Determining the extent of the impact of endocrine disruptors on humans, wildlife, and the environment. http://www.epa.gov/endocrine/

Endocrine Disruptor Research Initiative Contact Us Print Version Search: NCER Advanced Search EPA Home EPA Endocrine Site being revised check back for updates Endocrine Disruptors Research Initiative Evidence suggests that environmental exposure to some anthropogenic chemicals may result in disruption of endocrine systems in human and wildlife populations. A number of the classes of chemicals suspected of causing endocrine disruption fall within the purview of the U.S. Environmental Protection Agency’s ( EPA ) mandates to protect both public health and the environment. Although there is a wealth of information regarding endocrine disruptors, many critical scientific uncertainties still remain. In 1996, EPA’s Office of Research and Development ( ORD ) identified endocrine disruption as one of its top six research priorities and developed a risk-based research approach to address some of these uncertainties. ORD’s research program is based on a peer-reviewed Research Plan published in 1998 ( www.epa.gov/ORD/WebPubs/final

2. EPA/OSCP: Endocrine Disruptor Screening Program This site provides you information about endocrine disruptors and EPA s approach and progress for screening and testing chemicals for potential endocrine http://www.epa.gov/scipoly/oscpendo/

Endocrine Disruptor Screening Program Recent Additions Contact Us Print Version Search: EPA Home Office of Prevention, Pesticides, and Toxic Substances Office of Science Coordination and Policy EDSP Overview ... Learn More About Endocrine Disruptors Welcome to the Office of Science Coordination and Policy's Endocrine Disruptor Screening Program (EDSP) web site. This site provides you information about endocrine disruptors and EPA's approach and progress for screening and testing chemicals for potential endocrine disruption. You will also find information about EDSP's program activities and upcoming meetings. In recent years, some scientists have proposed that certain chemicals might be disrupting the endocrine system of humans and wildlife. A variety of chemicals have been found to disrupt the endocrine systems of animals in laboratory studies, and compelling evidence shows that endocrine systems of certain fish and wildlife have been affected by chemical contaminants, resulting in developmental and reproductive problems. Based on this and other evidence, Congress passed the Food Quality Protection Act in 1996, requiring that EPA initiate EDSP to screen pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife.

3. WWF Endocrine Disruptor Information Pesticides as endocrine disruptors WWF Endocrine Disruptor Information. Dr. Theo Colborn, a leading scientist and expert on endocrine http://www.pmac.net/theos.htm

Pesticides as Endocrine Disruptors WWF Endocrine Disruptor Information Dr. Theo Colborn, a leading scientist and expert on endocrine disruptors, has co-authored Our Stolen Future with Dianne Dumanoski and John Peterson Myers. STATE OF THE WORLD FORUM Dr. Theo Colborn, November 6, 1997, San Francisco CA. Evolutionary differences between natural and synthetic estrogens are discussed in a fascinating November 16, 1997 post to the Sanet discussion group by Dr. Ann Clark, University of Guelph. Dr. Clark reflects upon information in Our Stolen Future and offers examples cropping-livestock systems of how animals respond differently to plant estrogenic compounds they have evovled with, in contrast to those introduced into their environment from an exogenous source. WWF - Hormone Disruptor site with information on how hormone disruptors interfere with bio-chemical processes, the wildlife- human connection, a known and suspected list of hormone disruptors and an audio clip from Dr. Theo Colburn as she explains endocrine disruption and it's hazards "Acceptance Speech" , Dr. Theo Colborn, delivered June 19, 1997, upon receipt of the

4. NRDC: Endocrine Disruptors FAQ Answers to these and other questions What are endocrine disruptors? How do we know endocrine disruptors are dangerous? 2. What is an endocrine disruptor? http://www.nrdc.org/health/effects/qendoc.asp

In Brief : FAQ Endocrine Disruptors What is the endocrine system? What is an endocrine disruptor? What are some likely routes of exposure to endocrine disruptors? How do we know that endocrine disruptors are dangerous? ... What can I do to reduce my risk of exposure? 1. What is the endocrine system? The endocrine system is a complex network of glands and hormones that regulates many of the body's functions, including growth, development and maturation, as well as the way various organs operate. The endocrine glands including the pituitary, thyroid, adrenal, thymus, pancreas, ovaries, and testes release carefully-measured amounts of hormones into the bloodstream that act as natural chemical messengers, traveling to different parts of the body in order to control and adjust many life functions. 2. What is an endocrine disruptor? An endocrine disruptor is a synthetic chemical that when absorbed into the body either mimics or blocks hormones and disrupts the body's normal functions. This disruption can happen through altering normal hormone levels, halting or stimulating the production of hormones, or changing the way hormones travel through the body, thus affecting the functions that these hormones control. Chemicals that are known human endocrine disruptors include diethylstilbesterol (the drug DES), dioxin, PCBs, DDT, and some other pesticides. Many chemicals, particularly pesticides and plasticizers, are suspected endocrine disruptors based on limited animal studies. 3. What are some likely routes of exposure to endocrine disruptors?

5. Low Dose Endocrine Disruptors Page Report evaluating the low dose effects and dose response relationships for endocrine disrupting chemicals in mammalian species that relate to human health. http://ntp-server.niehs.nih.gov/htdocs/liason/LowDoseWebPage.html

October 10 - 12, 2000 Sheraton Imperial Hotel and Convention Center Research Triangle Park, North Carolina Organized by the National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, NC FINAL Report of the Endocrine Disruptors Low-Dose Peer Review (Transmitted to the U.S. EPA 8/20/01. Includes Public comments.) Peer Review Program (pdf format) download a free copy of Adobe Acrobat Reader Selection and Organizing Committee Principal Investigators - Selected Studies Subpanel Members Reference Lists Selected Studies Background Information To receive hard copies please contact the EPA OPPTS docket-42208A, (202)260-7099. Federal Register Notices: May 16, 2001 (Vol. 66, No. 95) September 27, 2000 (Vol. 65, No. 188) April 17, 2000 (Vol. 65, No. 74 January 6, 2000 (Vol. 65, No. 4) Sponsored by the U.S. Environmental Protection Agency Washington, DC and the National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, NC NTP NIEHS Return to NTP Home Page

6. Endocrine Disruptors endocrine disruptors. IPCS HomePage / Activities / Emerging Issues main / Human Data Initiative http://www.who.int/pcs/emerg_site/edc/edc.html

ENDOCRINE DISRUPTORS IPCS HomePage Activities Emerging Issues main Human Data Initiative

7. ThreeFold Sensors: Biosensor Assay Systems TFS makes realtime biosensors which measure molecular interactions and binding kinetics and detect environmental endocrine disruptors. http://ic.net/~tfs/TFS_Default.html

ThreeFold Sensors (TFS) develops biosensor assays and biosensor instrumentation for research and environmental applications where rapid results are desirable. TFS BioSensors can be used in research settings to measure concentrations or to perform kinetic assay measurements of analytes in water, blood and urine. TFS BioSensors measurements can be made in 3-10 minutes with accuracies comparable to laboratory assays methods taking 4-24 hours. For researchers interested in developing biosensor assays or measuring the binding and dissociation rates of molecular interactions, TFS's provides development kits which allow researchers to sensitize their own fibers and assemble sensor cartridges for use with TFS BioSensor measurement systems. This platform is well suited to drug discovery research based upon molecular interaction analysis using receptor proteins. To learn more about TFS and available BioSensor products, click the appropriate button on the left. s="na";c="na";j="na";f=""+escape(document.referrer)

8. State Of The Science Of Endocrine Disruptors DESCRIPTION, KEYWOORDS, State of the Science of endocrine disruptors, UNEP / ILO / WHO, Location Main Section of EHP Online GLOBAL ASSESSMENT OF THE STATEOF-THE-SCIENCE OF. endocrine disruptors http://ehis.niehs.nih.gov/who

Advanced Search Become a Print Subscriber Subscribe online today! Subscriber Services Buy EHP Publications View Shopping Cart Advertising Information ... Search INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY GLOBAL ASSESSMENT OF THE STATE-OF-THE-SCIENCE OF ENDOCRINE DISRUPTORS These files are in Adobe PDF format. If you need information on how to view PDFs, you can find it here An assessment prepared by an expert group on behalf of the World Health Organization, the International Labour Organisation, and the United Nations Environment Programme. Edited by: Terri Damstra, Sue Barlow, Aake Bergman, Robert Kavlock, Glen Van Der Kraak The issue of this document does not constitute formal publication. It should not be reviewed, abstracted, or quoted without the written permission of the Director, International Programme on Chemical Safety, WHO, Geneva, Switzerland. Preface Abbreviations Chapter 1. Executive Summary Chapter 2. Introduction/Background ... References

9. Health Care Without Harm - Home Collaborative campaign for environmentally responsible health care made up of more than 250 organizations. Work to transform the health care industry so it is no longer a source of environmental harm by eliminating pollution in health care. Also info on endocrine disruptors. http://www.noharm.org/

Search: Sign up for the latest news from HCWH Enter email: What's New 2 PC makers favor bigger recycling roles , New York Times (May 19) DEHP-free trend in Philadelphia hospitals 5/11: Protesters at Stericycle shareholder meeting demand closure of massive incinerators HCWH press release Stericycle Investors Tip Sheet Stericycle's Med Waste Incineration Capacity CleanMed 2004 a huge success! CleanMed News Green by Design: Kathy Gerwig Robin Guenther AIA register here REACH update: government report HCWH letter Alternative Technologies Database medical waste website Health Care Without Harm is an international coalition of 436 organizations in 52 countries working to transform the health care industry so it is no longer a source of harm to people and the environment. More about HCWH Europe Canada Africa Tools for: Nurses Material Managers Communities with Incinerators Waste Handlers A partnership with American Hospital Association, U.S. EPA, American Nurses Association and HCWH Sitemap Contact Us

10. Endocrine Disruptors endocrine disruptors , Location Main Section of EHP Online Drinking Water. Quality. endocrine disruptors. Indoor Air Quality Environews by Topic endocrine disruptors. When PCBs Act Like Thyroid Hormone Mysterious Mimicry in the Fetal Brain. http://ehis.niehs.nih.gov/topic/endodisrupt.html

Advanced Search Become a Print Subscriber Subscribe online today! Subscriber Services Buy EHP Publications View Shopping Cart Advertising Information ... contact By Topic Air Pollution Arsenic Asthma/Other Respiratory Disease ... Medicine Section Environews by Topic: Endocrine Disruptors Origins of Obesity. Mead, M. Nathaniel. (112N6 FOR: A344) Estrogen Exposure and Metabolic Gene Expression. Phelps, Jerry. (112N6 NIEHS: A350) Forage Findings: Expanding the Definitions of EDCs. Barrett, Julia R. (112N6 SS: A368) When PCBs Act Like Thyroid Hormone: Mysterious Mimicry in the Fetal Brain. Renner, Rebecca. (111N5 SS: A300-A301) DDT and DDE: Effect on Second Generation Time to Pregnancy. Phelps, Jerry. (111N14 NIEHS: A759) NIEHS-Funded Research Pursues Thyroid Findings. Renner, Rebecca. (111N12 NIEHS: A638-A641) Disrupting a Delicate Balance: Environmental Effects on the Thyroid. Brown, Valerie. (111N12 FOC: A642-A649) EDCs in Singapore Seawaters: Mixtures May Multiply Effects. Freeman, Kris. (111N12 SS: A658) Pollutants Alter Play: Another Way PCBs Affect Children.

11. WWF | Toxic Chemicals Information from the World Wildlife Fund on toxic chemicals in the environment. Focus on endocrine disruptors, persistant organic pesticides (POP's) and agricultural pesticides. http://www.worldwildlife.org/toxics/

Worldwildlife.org Join WWF Member Login Take Action ... Donate Now Search Aquaculture and Agriculture Climate Change Conservation Finance Educating Future Leaders ... Wildlife Trade User Name: Password: Login Help Not a member? Get access Toxic Chemicals Polar bear in October. Churchill, Canada Modern society has developed an extensive array of synthetic chemicals over the last several decades - chemicals to control disease, increase food production, and to provide convenience in our daily lives. Ironically, many of these well-intentioned chemicals are now wreaking havoc around the world, threatening the health of wildlife and people. As WWF tracks the growing body of scientific research on chemical contamination and the effects of exposure, a sobering picture emerges. Wherever scientists look - the tropics, marine systems, industrial regions, the Arctic - they find the effects of toxic chemicals. Wildlife, people and entire ecosystems are threatened by chemicals that can alter sexual and neurological development, impair reproduction, and undermine immune systems. Today there is unequivocal evidence that a number of widely distributed synthetic chemicals have already caused serious damage to the health of wildlife and people and pose an ongoing danger. Wildlife as diverse as polar bears, whales, frogs, eagles, and fish are contaminated with pesticides and industrial chemicals. Many scientists have concluded that synthetic chemicals have damaged wildlife populations by causing decreased fertility, thyroid dysfunction, behavioral abnormalities, decreased hatching success, and feminization and demasculinization in males.

12. Questions About Endocrine Disruptors Questions about endocrine disruptors. Here are some of the most frequently asked questions about the endocrine system and endocrine disruptors http://ace.orst.edu/info/extoxnet/faqs/pesticide/endocrine.htm

Questions about Endocrine Disruptors Here are some of the most frequently asked questions about the endocrine system and endocrine disruptors: What is the endocrine system? What are hormones? How do hormones work? How do scientists study hormones? ... Links to more information about Endocrine Disruptors What is the endocrine system? The endocrine system is composed of ductless glands that secret hormones into the blood stream to act at distant sites. Together with the nervous system, the endocrine system is responsible for the integration of many different processes which allow complicated organisms to function as a unit (maintain homeostasis). What does the endocrine system look like? What are hormones? Hormones can be proteins, polypeptides, amino acids, or steroids. The most well known hormones are the sex steroids estrogen, produced in the ovaries, and testosterone, produced in the testes. Estrogen and testosterone are also produced in the adrenal glands of both sexes. Other hormones include thyroxin, produced in the thyroid, and insulin, produced in the pancreas. The pituitary and hypothalamus in the brain release a variety of hormones that affect other organs, including the sex glands. How do hormones work?

13. Pesticides As Endocrine Disruptors Pesticide Impacts on Human Health Pesticides as endocrine disruptors. RACHEL S Learn more about endocrine disruptors and their effects. Washington http://www.pmac.net/endodisr.htm

Pesticide Impacts on Human Health Pesticides as Endocrine Disruptors Series on "The Latest Hormone Science" Part 1 - Issue #750, August 22, 2002 Part 2 - Issue #751, September 5, 2002 Part 3 - Issue #752, September 19, 2002 Part 4 - Disrupting Life's Messages - Issue #753, October 3, 2002 Kids at risk Genes may solve hormone-disrupter debate , Robert Triendl, Toyko, Nature, Volumbe 209, January 28, 2001 Environmental Estrogens and Their Hormones "An educational service and an interactive forum where those interested in environmental estrogens and other environmental hormones can find accurate, timely information and can contribute to the ongoing public debate." Cause for Precautionary Action Pesticide, Fertilizer Mixes Linked to Range of Health Problems , Co-authors James W. Jaeger Univ. of Wisconsin, Madison, Department of Zoology, and Ian H. Carlson of the Edocrinology Laboratory, University of Wisconsin Hospital. Posted on the University of Wisconsin, Madison, Office of News and Public Affairs "Endocrine, Immune, and Behavioral Effects of Aldicarb (Carbamate), Atrazine (Triazine) and Nitrate (Fertilizer) Mixtures at Groundwater Concentrations"

14. OECD Endocrine Disruptors Assessment Part of the OECD Test Guidelines Programme, focused on reaching international agreement on the testing and assessment of chemicals with respect to their endocrine disrupting potential. http://www.oecd.org/EN/document/0,,EN-document-524-14-no-24-6685-524,00.html

15. Endocrine Disruptor Knowledge Base Home Page Welcome to the Endocrine Disruptor Knowledge Base. endocrine disruptors are chemicals that interfere with the endocrine systems, leading to adverse effects. http://edkb.fda.gov/

Health and Human Services Food and Drug Administration NCTR EDKB Home ... Publications Welcome to the Endocrine Disruptor Knowledge Base Go straight to the Database page The Endocrine Disruptor Knowledge Base (EDKB) website consists of a biological activity database, relevant literature citations, computational models, and ultimately, models for risk assessment. It is designed to help research and regulatory scientists, and other interested parties set priorities for testing of endocrine disrupting compounds, make use of the existing body of knowledge, and reduce dependency upon slow and expensive animal experiments. Legislation requiring the development and implementation of a strategy for screening and testing chemicals for estrogen, androgen and thyroid endpoints [ EDSTAC, #545 ] led to the definition of a two-tiered, multiple-endpoint strategy by EPA's Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) of which FDA is a participating member. This strategy incorporates more than 20 different in vitro and in vivo assays [ Gray, 1998 #250]

16. Endocrine Disruptors endocrine disruptors and the FQPA. EPA's Endocrine Disruptor Screening and Testing Advisory 1/24/97) on endocrine disruptors Screening and Testing Advisory Committee (EDSTAC http://www.ecologic-ipm.com/endocrin.html

EPA Actions and Position s Endocrine Disruptors and the FQPA EPA's Endocrine Disruptor Screening and Testing Advisory Committee Home Page (EDSTAC) Press Advisory (1/24/97) on Endocrine Disruptors Screening and Testing Advisory Committee (EDSTAC) Meeting. Other Views Dioxin Study is a Political Hot Potato for EPA Dioxin has gone from being a 'possible' to a 'known' human carcinogen , San Francisco Chronicle, March 12, 2001 Genes may solve hormone-disrupter debate , Robert Triendl, Toyko, Nature, Volume 409, January 18, 2001 Pesticides as Endocrine Disruptors Acceptance Speech , by Dr. Theo Colborn, World Wildlife Fund scientist, upon receipt of the Rachel Carson Leadership Award from Chatham College. WWF-Canada Hormone Disruptor Site The Weybridge Report , by Peter Montague, RACHEL'S ENVIRONMENT AND HEALTH WEEKLY #547, May 22, 1997. Evolutionary differences between natural and synthetic estrogens , November 16, 1997 SANET Post by Dr. Ann Clark. "Endocrine Disruptor Worries Here to Stay," by Dr. Allan Felsot, Washington Statue University. This article appeared in the September 1997 Agrichemical and Environmental News and includes the passage: "I've wondered a lot lately whether industry realizes what a potential mess it has gotten itself, and by association our farmers, into by its passive support of the FQPA last year."

17. EDKB What Are Endocrine Disruptors What are endocrine disruptors? Endocrine mechanisms. A comprehensive definition of endocrine disruptors, given in Kavlock, 1996 40 follows http://edkb.fda.gov/endodisrupt.html

Health and Human Services Food and Drug Administration NCTR EDKB Home ... Publications What are Endocrine Disruptors? Endocrine disrupting compounds (EDC's) are chemicals that either mimic endogenous hormones, interfere with pharmacokinetics or act by other mechanisms. A comprehensive definition of endocrine disruptors, given in [ Kavlock, 1996 #40 ] follows: "An exogenous agent that interferes with the production, release, transport, metabolism, binding, action or elimination of natural hormones in the body responsible for the maintenance of homeostasis and the regulation of developmental processes." This definition includes the general types of mechanisms for endocrine disruptors. Such adverse effects as compromised reproductive fitness, functional or morphological birth defects, cancer and altered immune functions, among others, have been reported in the scientific press for wildlife, in vitro, and in vivo studies. These findings have received considerable attention in the popular press, led to government regulatory actions and expanded research in Europe, Asia and the U.S. Many suspected endocrine disruptors (ED's) are high-volume, economically important chemicals, a factor that magnifies the need for resolution of the scientific issues [ Kavlock, 1996 #40

18. Endocrine Disruptors : Questions On Endocrine Disruptors Scientific Facts on endocrine disruptors. This study is a faithful summary of the External link Global Assessment of the stateof http://www.greenfacts.org/endocrine-disruptors/

alert("script not found"); Home Studies Scientific Facts on Endocrine Disruptors This is a preliminary Draft, published for review only. It has not yet been approved for publication by the GreenFacts Scientific Board. Do not copy or quote. This study is a faithful summary of the "Global Assessment of the state-of-the-science of Endocrine Disruptors" a leading scientific consensus report produced in 2002 by the IPCS (International Programme on Chemical Safety). The study is written in a language for non-specialists and structured in 3 levels of increasing detail. More info on our 3-level structure Questions on Endocrine Disruptors What are Endocrine Disruptors (EDCs) ? How do EDCs act ? Do EDCs affect wildlife ? Do EDCs affect human health ? ... Other views on Endocrine Disruptors GreenFacts 3-Levels Structure Our Endocrine Disruptors study is structured into 3 levels of increasing detail: the SUMMARY, the DETAILS and the SOURCE.

19. Endocrine Disruptors : Questions On Endocrine Disruptors More results from www.greenfacts.org Questions about endocrine disruptorsQuestions about endocrine disruptors. Here are some of the most frequently asked questions about the endocrine system and endocrine disruptors http://www.greenfacts.org/studies/endocrine_disruptors/

alert("script not found"); Home Studies Scientific Facts on Endocrine Disruptors This is a preliminary Draft, published for review only. It has not yet been approved for publication by the GreenFacts Scientific Board. Do not copy or quote. This study is a faithful summary of the "Global Assessment of the state-of-the-science of Endocrine Disruptors" a leading scientific consensus report produced in 2002 by the IPCS (International Programme on Chemical Safety). The study is written in a language for non-specialists and structured in 3 levels of increasing detail. More info on our 3-level structure Questions on Endocrine Disruptors What are Endocrine Disruptors (EDCs) ? How do EDCs act ? Do EDCs affect wildlife ? Do EDCs affect human health ? ... Other views on Endocrine Disruptors GreenFacts 3-Levels Structure Our Endocrine Disruptors study is structured into 3 levels of increasing detail: the SUMMARY, the DETAILS and the SOURCE.

20. EMS - Endocrine Disruptors Facts endocrine disruptors Fast Facts. Terminology endocrine disruptors, Environmental Estrogens and Phytoestrogens. Where to Get More Information? http://www.ems.org/endocrine_disruptors/facts.html

Wednesday, 26 May 2004 Website Overview Search for: Printer-friendly version Fast Facts Last update: February 24, 2003 In recent years, scientists have found that in addition to any known toxic effects, many industrial chemicals, pesticides and heavy metals can interfere with the endocrine systems of humans and wildlife by mimicking natural hormones. Endocrine disruptors can cause health problems at doses far below the threshold for acute toxicity. Numerous animal studies have found that extremely low doses of endocrine disruptors may contribute to abnormal sexual development, reproductive disorders, behavioral disorders and diseases affecting gland tissue, such as breast and prostate cancer. When endocrine disruptors enter the body, they disrupt the body's natural processes by sending false messages, blocking real messages, preventing synthesis of the body's own hormones, and accelerating the breakdown and excretion of hormones. Endocrine disruptors are now ubiquitous in the environment; they have even been found in the breast milk of Inuit women in the remote Arctic where known endocrine disrupting chemicals are neither used nor produced. A range of scientific studies have linked endocrine disruptors to: Reproductive disorders Immune system dysfunction Certain types of cancer Congenital birth defects of the penis (hypospadias) Neurological effects in humans and wildlife Attention deficit and poor short-term memory Low IQ Falling sperm counts Early onset of puberty in young girls

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