41. Tonegawa, Susumu Site Map. encyclopediaEncyclopedia tonegawa, susumu. tonegawa, susumu, 1939–,Japanese molecular biologist, Ph.D. Univ. of California at San Diego, 1969. http://www.factmonster.com/cgi-bin/id/A0849023.hmtl

Encyclopedia Tonegawa, Susumu Tonegawa, Susumu, The Columbia Electronic Encyclopedia, tone tone poem Print this page Cite this page AD AD AD ADS Link to Fact Monster Add Fact Monster search to your site ... Privacy Brought to you by:

42. International: Italiano: Salute: Medicina: Medici_e_Ricercatori - Open Site Tinbergen, Nikolaas (0); tonegawa, susumu (0); Vane, John (0); Varmus,Harold (0); WagnerJauregg, Julius (0); Waksman, Selman Abraham http://open-site.org/International/Italiano/Salute/Medicina/Medici_e_Ricercatori

Open Site The Open Encyclopedia Project Pagina Principale Aggiungi Contenuti Diventa Editore In tutta la Directory Solo in Medicina/Medici_e_Ricercatori Top International Italiano Salute ... Medicina : Medici e Ricercatori Adrian, Edgar Douglas Arber, Werner Axelrod, Julius Baltimore, David ... Zinkernagel, Rolf Vedi anche: International: Italiano: Societ : Strutture Sociali: Persone: Biografie Questa Categoria ha bisogno di un Editore - Richiedila Open Site Code 0.5.3 JVDS.com Visit our sister sites dmoz.org mozilla.org chefmoz.org musicmoz.org ... modifica

43. HHMI News: Researchers Find Enzyme Crucial To Preservation Of Memories of these signal transduction pathways, and how they contribute to this very complexmechanism of memory consolidation, said HHMI investigator susumu tonegawa. http://www.hhmi.org/news/tonegawa.html

RESEARCH NEWS RESEARCH NEWS GRANT ANNOUNCEMENTS SCIENCE EDUCATION NEWS INSTITUTE NEWS ... HHMI HOME ALSO OF INTEREST Scientists Discover Memory-Enhancing Switch Researchers Trace Roots of Vivid Memories Learning and Memory Download this story in Acrobat PDF format. (requires Acrobat Reader Researchers Find Enzyme Crucial to Preservation of Memories "We believe that further studies using this technique will allow us to dissect in greater detail the differential roles and interactions of these signal transduction pathways, and how they contribute to this very complex mechanism of memory consolidation," said HHMI investigator Susumu Tonegawa. Using a technique to eliminate the function of one enzyme in a restricted memory-related region in the brains of mice, researchers have shown that the enzyme is important in consolidating long-term memories. In an article published in the September 21, 2001, issue of Cell , Howard Hughes Medical Institute investigator Susumu Tonegawa and colleagues at the Massachusetts Institute of Technology and the Vollum Institute reported that elimination of the enzyme, calcium-calmodulin dependent kinase (CaMKIV), in the forebrains of mice had profound effects on signaling pathways in the brain and learning behavior. Tonegawa said that other research groups had attempted to knock out a protein called CREB, which is involved in turning on gene transcription in L-LTP, and which was believed to be activated by CaMKIV. The results of these studies were inconclusive, Tonegawa said, because there appeared to be multiple forms of CREB that could compensate for any knockout.

44. National Academy Of Sciences - Members tonegawa, susumu Massachusetts Institute of Technology. tonegawa hasmade pioneering discoveries in the rearrangement of gene segments http://www4.nationalacademies.org/nas/naspub.nsf/(urllinks)/NAS-58N2VR?opendocum

45. National Academy Of Sciences Taylor, Edwin W. Tilghman, Shirley M. Tilney, Lewis G. Tjian, Robert. tonegawa, susumu.Vale, Ronald D. Waelsch, Salome G. Wieschaus, Eric F. Yamamoto, Keith R. http://www4.nationalacademies.org/nas/naspub.nsf/urllinks/$$Section22?OpenDocume

46. Essays Page RELATED ESSAYS •, Nobel Prize. tonegawa, susumu Citation Text Oakes,Elizabeth H. tonegawa, susumu. Encyclopedia of World Scientists. http://www.fofweb.com/Subscription/Science/Helicon.asp?SID=2&iPin=eworldsci0340

47. Club Biotech Lecture With SUSUMU TONEGAWA (April 9th 2003) About the Club Biotech Guest Lecture on April 9th 2003 with Nobel Laureate SusumuTonegawa. A New Integrative Approach for the Study of Memory Mechanisms. . http://www.clubbiotech.at/Images/tonegawa_www/

About t he Club Biotech Guest Lecture on April 9th 2003 with Nobel Laureate Susumu Tonegawa "A New Integrative Approach for the Study of Memory Mechanisms." The 9th of April was without a doubt a big day for us - the members of the Club Biotech . We were pleased to welcome Susumu Tonegawa, Whitehead Professor of Biology and Neuroscience at the famous Massachusetts Institute of Technology in Boston (USA), as a featured speaker. At first glance this name will be unfamiliar to many readers, however, those of you that have studied immunology have been confronted with his work. He provided the answer to the $64.000-question: "How does the genome, consisting of only about 30.000 genes, determine the specificity of billions of different antibodies"? While working in Basel in the 70s, Prof. Tonegawa recognized that the virtually unlimited antibody-diversity is generated through somatic recombination of different gene-segments. The Nobel Prize in Physiology or Medicine was the logical outcome of this research. Club Biotech Lecture concerned on something completely different. It was hosted by the "Lord of the Fly's nervous system", Prof. Barry Dickson from the Research Institute of Molecular Pathology, Vienna. A press conference was planned to precede the lecture, but unfortunately none of the journalists that had previously expressed an interest to interview Prof. Tonegawa showed up.

48. Club Biotech Lecture With SUSUMU TONEGAWA (April 9th 2003) Club Biotech Lecture with susumu tonegawa (April 9th 2003) All rights belong to ClubBiotech (http//www.clubbiotech.at, office@clubbiotech.at) IV/03(PH) 10.04 http://www.clubbiotech.at/Images/tonegawa_www/index_3.htm

Club Biotech Lecture with SUSUMU TONEGAWA (April 9th 2003) All rights belong to Club Biotech ( http://www.clubbiotech.at, office@clubbiotech.at ) IV/03(PH) page 3 of 4

49. BBC NEWS | World | Asia-Pacific | Moving Stories: Susumu Tonegawa Moving stories susumu tonegawa. WATCH AND LISTEN. susumu tonegawa I have alreadytaken the view, since I was young, that science is totally international http://news.bbc.co.uk/1/hi/world/asia-pacific/3322387.stm

Home TV Radio Talk ... Programmes LANGUAGES Last Updated: Wednesday, 24 December, 2003, 00:58 GMT E-mail this to a friend Printable version Moving stories: Susumu Tonegawa BBC World Service's The World Today programme is asking migrants who have been successful in their adopted countries how they got to the top of their field. Susumu Tonegawa is a professor at the Massachusetts Institute of Technology. He won the 1987 Nobel Prize for Medicine. He was born and grew up in Japan. At the age of 22 I left Japan to do graduate study at the University of California, San Diego. My philosophy has always been that I choose the best environment in order to get my work done I wanted to become a so-called molecular biologist - this is many years ago, 1963 - and at that time there were no real molecular biology laboratories in Japan, and my professor told me I should go abroad to get the proper training. 1987 - I was awarded the Nobel Prize for Physiology and Medicine for my research in immunology. If I had stayed in Japan, probably I could not have done the work that I did.

50. Susumu Tonegawa Translate this page susumu tonegawa Susuma tonegawa Nació en Nagoya, Japón en 1939.Estudió la licenciatura de Medicina en Japón, trabajando en http://www.guajara.com/wiki/es/wikipedia/s/su/susumu_tonegawa.html

Susumu Tonegawa Susuma Tonegawa Nació en Nagoya, Japón en . Estudió la licenciatura de Medicina en Japón, trabajando en el departamento de Química de la Universidad de Kyoto . En se traslada a Estados Unidos comenzando a trabajar en el departamento de Biología de la Universidad de San Diego, California . Fue nombrado miembro del Instituto de Basilea y profesor de Biología en el Centro de Investigación del Cáncer del Instituto de Tecnología de Massachusetts. Descubrió que ciertos elementos de la masa genética( ADN ) podían trasferirse y reagruparse en el trascurso del desarrollo al pasar de la célula embrionaria al estado del linfocito B .Demostró que cada linfocito es capaz de formar el anticuerpo necesario, es decir el anticuerpo que el organismo necesita en cada momento. Ante una agresión por un antígeno determinado, se produce una respuesta celular del organismo y produce la recombinación adecuada de genes para formar el anticuerpo específico contra ese antígeno. Ante estos hallazgos Tonegawa llegó a formular la teoria de que la cantidad y calidad de la respuesta inmulógica está condicionada genéticamente. Gracias a sus trabajos se ha podido conocer cuántos genes de inmunoglobulinas tiene el ser humano, y como dan lugar a multitud de anticuerpos espcíficos.

51. AllRefer Encyclopedia - Susumu Tonegawa (Biochemistry, Biographies) - Encycloped AllRefer.com reference and encyclopedia resource provides complete information onSusumu tonegawa, Biochemistry, Biographies. Includes related research links. http://reference.allrefer.com/encyclopedia/T/Tonegawa.html

AllRefer Channels :: Health Yellow Pages Reference Weather SEARCH : in Reference June 05, 2004 You are here : AllRefer.com Reference Encyclopedia Biochemistry, Biographies ... Susumu Tonegawa By Alphabet : Encyclopedia A-Z T Susumu Tonegawa, Biochemistry, Biographies Related Category: Biochemistry, Biographies Susumu Tonegawa Encyclopedia U com Check out around 175,000 brief encyclopedia articles on almost all topics. Related Categories: Medicine Biographies People Medicine ... Biochemistry More articles from AllRefer Reference on Susumu Tonegawa Encyclopedia U com Check out around 175,000 brief encyclopedia articles on almost all topics. Content on this web site is provided for informational purposes only. We accept no responsibility for any loss, injury or inconvenience sustained by any person resulting from information published on this site. We encourage you to verify any critical information with the relevant authorities. About Us Contact Us Privacy Links Directory ... AllRefer.com

52. AllRefer Encyclopedia - Encyclopedia Topics T : Tog - Transu - Reference Thumb • tomtom • ton • tonality • Tonawanda • Tonbridge and Malling •Tonder • Tone, Theobald Wolfe • tone • tonegawa, susumu • tone poem http://reference.allrefer.com/encyclopedia/topics-a-z/T4.html

AllRefer Channels :: Health Yellow Pages Reference Weather SEARCH : in Reference June 05, 2004 You are here : AllRefer.com Reference Encyclopedia Encyclopedia Topics A-Z ... com Check out around 175,000 brief encyclopedia articles on almost all topics. Content on this web site is provided for informational purposes only. We accept no responsibility for any loss, injury or inconvenience sustained by any person resulting from information published on this site. We encourage you to verify any critical information with the relevant authorities. About Us Contact Us Privacy Links Directory ... AllRefer.com

53. —˜ªìi,tonegawasusumu Biographie.net Buchstabe T - Tonke, Laura www.prisma-online.de/tv/person.html?pid=laura_tonke; http://www1.odn.ne.jp/manganigaoekobo/scientist/tonegawa,susumu.htm

—˜ªì@i Tonegawa, Susumu .1939`i‚Š‚‚‚‚Žj R‘ÌŽY¶‚Ì‚µ‚­‚݁v1987”Nƒm[ƒxƒ‹¶—ŠwEˆãŠwÜŽóÜ ŠO“G‚©‚çg‚ðŽç‚éR‘̂́C ‚³‚Ü‚´‚܂ȍ׋ۂȂǂɑΉž‚·‚邽‚߁C ”ñí‚É‘½‚­‚ÌŽí—Þ‚ª•K—v‚É‚È‚éB ‚±‚̂悤‚É‘½—l‚ȍR‘Ì‚ð‚‚­‚èo‚·ˆâ“`Žq‚Ì‚µ‚­‚Ý‚ð‰ð–¾‚µ‚½B ˆâ“`ŽqHŠw‚̐¬‰Ê‚Å‚ ‚éÅV‚Ì‹Zp‚ðŽg‚Á‚āC ‚Þ‚¸‚©‚µ‚¢‚Æ‚³‚ê‚Ä‚¢‚½‚È‚¼‚ð‰ð–¾‚µ‚½B ‚±‚̐¬‰Ê‚ÆŽè–@‚Í•ªŽq¶•¨Šw‚ɐV‚µ‚¢Žž‘ã‚ðØ‚èŠJ‚¢‚½B ‚»‚ÌŒãCˆâ“`Žq‘€ì‹Zp‚ðŽg‚Á‚āC ”]‚ÌŒ¤‹†‚É‚àV‚½‚ȍvŒ£‚ð‚µ‚Ä‚¢‚é

54. Susumu Tonegawa: Awards Won By Susumu Tonegawa 123Awards hardwork is paid in form of awards. The biggest english dictionary RealDictionary.com. Awards of susumu tonegawa. OTHER-NOBEL, 1987, MEDICINE. http://www.123awards.com/artist/7250.asp

hardwork is paid in form of awards The biggest english dictionary - RealDictionary.com Awards of Susumu Tonegawa OTHER-NOBEL MEDICINE Enter Artist/Album Partner Sites Stardose.com RealLyrics.com OnlyHitLyrics.com Real Dictionary ... Add 123Awards to Favourites Please select the appropriate Shopping Category Auctions Search Engines Charity Dutch ... Stationery

55. Geschiedenis 1978-Nu - Roche Nederland B.v. 1987, Nobelprijs voor susumu tonegawa. susumu tonegawa. 1987, Productlancering Anexate, anesthesie; Tilcotil, antiontstekingsmiddel. http://www.roche.nl/geschiedenis/geschiedenisnu.htm

Geschiedenis 1978 - Nu H E D e acquisitie in 1990 van een meerderheidsaandeel in Genentech, een leider in het veld van genetische engineering en de overname van de Syntex Corporation, een sterk onderzoeksgericht bedrijf maakten deel uit van de strategie van Roche om een sterkere positie in de gezondheidsindustrie te krijgen. Met de aankoop van Nicholas, een producent van receptvrije geneesmiddelen versterkte Roche haar portofolio aangezien met deze producten een steeds belangrijker wordend gebied in de groeiende trend van zelfmedicatie gaan innemen. Door Boehringer Mannheim over te nemen werd Roche de wereldleider op de diagnostica markt voor wat betreft de unieke reeks van innovatieve producten, diepte en breedte van de technologie, even als de wereldomvattende geografische aanwezigheid. R Tijd van Fritz Gerber Product lancering: Rocaltrol, osteodystrofie (groeistoornis van het beenweefsel) medicijn. Product lancering: Cobas Bio, eerste analytische instrument voor klinische laboratoria.

56. Re: Resulting Effects Of Susumu Tonegawa's Nobel Prize For P. And M. MadSci Network Immunology. Re Resulting effects of susumu tonegawa sNobel Prize for P. and M. Area Immunology Posted By Brian http://www.madsci.org/posts/archives/dec97/879706838.Im.r.html

MadSci Network : Immunology Re: Resulting effects of Susumu Tonegawa's Nobel Prize for P. and M. Area: Immunology Posted By: Brian Edelson, MD/PhD Student Date: Sun Nov 16 12:55:43 1997 Area of science: Immunology ID: 878256597.Im Message: Current Queue Current Queue for Immunology Immunology archives Try the links in the MadSci Library for more information on Immunology MadSci Home Information Search ... Join Us! MadSci Network webadmin@www.madsci.org

57. Resulting Effects Of Susumu Tonegawa's Nobel Prize For P. And M. Subject Resulting effects of susumu tonegawa s Nobel Prize for P. and M. Thankyou. Re Resulting effects of susumu tonegawa s Nobel Prize for P. and M. http://www.madsci.org/posts/archives/dec97/879706838.Im.q.html

MadSci Network : Immunology Subject: Resulting effects of Susumu Tonegawa's Nobel Prize for P. and M. Date: Thu Oct 30 18:09:57 1997 Posted by Kevin Grade level: School: Sharon High City: Sharon State/Province: MA Country: USA Area of science: Immunology ID: 878256597.Im Message: Can you please tell me what kinds of changes Mr. Tonegawa's research have had on the scientific and medical communities Thank you. Re: Resulting effects of Susumu Tonegawa's Nobel Prize for P. and M. Current Queue Current Queue for Immunology Immunology archives Try the links in the MadSci Library for more information on Immunology MadSci Home MadSci Home Information ... Join Us! MadSci Network webadmin@www.madsci.org

58. Roche Unsere Geschichte 1978 - 2001 Translate this page 1987. Nobelpreis an susumu tonegawa. susumu tonegawa, der von 1972 bis 1981 am Institutfür Immunologie Basel tätig gewesen ist, erhält den Nobelpreis für http://www.roche.com/de/home/company/com_hist/com_hist_1978.htm

Home Konzern Geschichte Mitteilung des CEO ... Kontakte Produkteinführung: Rocaltrol, gegen Knochenabbau Rocaltrol, ein Medikament gegen Knochenabbau vor allem bei Niereninsuffizienz und Dialysepatienten, wird eingeführt. Produkteinführung: Cobas Bio, erstes Analysengerät für klinische Labors Die Division Diagnostics führt den Cobas Bio, das erste vollständig von Roche entwickelte Analysengerät für klinische Labors, ein. Beginn der Zusammenarbeit mit Genentech, USA Am Roche Institute of Molecular Biology wird ein reines Alfa-Interferon isoliert. Roche Nutley und Genentech, ein Biotech-Unternehmen in South San Francisco, beginnen ein gemeinsames Projekt zur Produktion einer gentechnisch hergestellten Version der Substanz. Produkteinführungen: Pretuval, Erkältungs- und Grippemittel; Benical, Hustensirup Pretuval, ein Mittel gegen Erkältungen und Grippe, sowie Benical, ein Hustensirup, werden eingeführt. Produkteinführung: Rocephin, Cephalosporinantibiotikum Rocephin, ein Antibiotikum aus der Familie der Cephalosporine, wird bereits vier Jahre nach seiner Entdeckung in der Schweiz eingeführt. Bereits 1987 wird Rocephin weltweit umsatzmässig an der Spitze aller Roche-Produkte stehen. Produkteinführung: Enzym-immunologischer Test zur Überwachung von Krebstherapien Ein enzym-immunologischer Test auf der Basis monoklonaler Antikörper zur Überwachung der Therapie bestimmter Krebskrankheiten wird eingeführt.

59. Roche Our History 1978 - 2001 1987. Nobel Prize for susumu tonegawa. susumu tonegawa, who worked at the Basel Institutefor Immunology from 1972 to 1981, receives the Nobel Prize for medicine http://www.roche.com/home/company/com_hist/com_hist_1978.htm

Home Company History CEO Message ... Contacts The move towards creating separate business units, begun in the mid- 70s, continued and resulted in the creation of autonomous divisions. Accounting and reporting practices were standardised groupwide, and comprehensive reorganisation, rationalisation and modernisation measures were implemented in all areas. The sale of Maag in 1990 and the spin-off of Givaudan in 2000 left Roche with three divisions: pharmaceuticals, vitamins and fine chemicals, diagnostics. A wide range of pharmaceutical products were introduced over the years to come, and some represented real medical breakthroughs. The acquisition in 1990 of a majority interest in Genentech, a leader in the field of genetic engineering, and the takeover of Syntex Corporation, a strongly research-oriented company, were part of a strategy for strengthening Roche's position in the global healthcare market. With the purchase of Nicholas, a producer of non-prescription medicines, Roche strengthens its portfolio of over-the-counter medicines, an increasingly important area because of the growing trend towards self-medication. By acquiring Boehringer Mannheim, Roche became the world leader in the area of diagnostic market in terms of a unique range of innovative products, depth and breadth of technologies as well as overall geographical presence. Roche intends to continue developing innovative, cost-effective advances in drug therapy, diagnostics, prevention and biomedical research to the ultimate benefit of patients.

60. Featured Lesson- Main susumu tonegawa won the Nobel Prize in Physiology or Medicine in 1987 for hisexperiments demonstrating how a small number of genes can produce the vast http://www.nobelchannel.com/learningstudio/featured_lesson.sps?id=685

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