81. SignOnSanDiego > News > Science -- Research Is Breakthrough K. barry sharpless, a San Diego chemist whose research led to new methods for makingdrugs and other compounds shared the Nobel Prize in chemistry yesterday. http://www.uniontrib.com/news/science/20011011-9999_7m11sharp.html

Advertising Info About Us Contact SignOn Membership ... AP Wire Research is breakthrough Scripps scientist shares award; work led to new manufacturing techniques By Bruce V. Bigelow UNION-TRIBUNE STAFF WRITER October 11, 2001 K. Barry Sharpless, a San Diego chemist whose research led to new methods for making drugs and other compounds shared the Nobel Prize in chemistry yesterday. Sharpless, a scientist at The Scripps Research Institute, shared the prestigious award with William S. Knowles of St. Louis and Ryoji Noyori of Japan's Nagoya University. The three were honored for discovering new types of chemical reactions that could be used to duplicate the highly specific way that nature makes molecules. Nobel winner's enthusiasm is intoxicating Nobel is awesome, but also carries a price Their research led to manufacturing techniques that didn't exist before the 1970s, enabling scientists to produce new types of medicine such as L-dopa, a now-standard treatment for Parkinson's disease. Their work, which dates to the 1960s, also allowed other industries to create purer, more-effective compounds from perfumes and pheromone-based pesticides to flavorings and sweeteners. From the archives: Scripps scientist cited for molecular work Scripps, UCSD top influence list in chemistry

82. Learn More About K. Barry Sharpless In The Online Encyclopedia. Visit the Online Encyclopedia and learn more and get your questions answeredabout K. barry sharpless. see previous page. K. barry sharpless. http://www.onlineencyclopedia.org/k/k_/k__barry_sharpless.html

You are here: Online Encyclopedia Enter a phrase or search word in the box below. You can enter multiple phrases at a time by putting a comma between each word.(e.g. cat ,dog ,lion ) Press the search button to start your search. Hint: Play with putting spaces before and after your words to see the different results you get. see previous page K. Barry Sharpless K. Berry Sharpless (born ) won the Nobel Prize in Chemistry in for his work on chirally catalysed oxidation reactions ( Sharpless epoxidation Sharpless bishydroxylation ). This prize was shared with William S. Knowles and Ryoji Noyori for their study of chirally catalyzed hydrogenations. Sharpless was born in Philadelphia . He began his studies in Dartmouth College and earned his PhD from Stanford University in . He continued post-doctoral work at Stanford University and Harvard University Sharpless became professor at the Massachusetts Institute of Technology Stanford University , and the Scripps Research Institute, where currently holds the W. M. Keck professorship in chemistry. This article is from Wikipedia. All text is available under the terms of the

83. C&EN: JACS AT 125 - A PRACTICAL REACTION asymmetric epoxidation J. Am. Chem. Soc., 102, 5974 (1980) evokesvivid memories for K. barry sharpless. Also called the sharpless http://pubs.acs.org/cen/science/8143/8143jacs125.html

Table of Contents cen-chemjobs.org Today's Headlines Cover Story ... What's That Stuff? Back Issues Safety Letters Chemcyclopedia ACS Members can Join ACS October 27, Volume 81, Number 43 CENEAR 81 43 p. 42 ISSN 0009-2347 JACS AT 125 A PRACTICAL REACTION Titanium-catalyzed asymmetric epoxidation paved the way to a Nobel Prize in Chemistry MAUREEN ROUHI T he paper titled "The First Practical Method for Asymmetric Epoxidation," which reports the discovery of titanium-catalyzed asymmetric epoxidation [ J. Am. Chem. Soc. ] evokes vivid memories for K. Barry Sharpless tert CHEERS Katsuki (left) and Sharpless, in 1980, celebrate the discovery of titanium-catalyzed asymmetric epoxidation. COURTESY OF THE SHARPLESS LAB The paper is one of the 125 most cited papers in the history of the Journal of the American Chemical Society but it might never have been published there. Sharpless, a chemistry professor at Scripps Research Institute and winner of the Nobel Prize in Chemistry in 2001 for his work on asymmetric oxidations, says one reviewer rejected the paper on the grounds that it was merely an incremental improvement over previous work. The paper was published only after Barry M. Trost

84. Fiftieth Annual NSTA Convention Underway In San Diego But two undisputed highlights were presentations from a pair of the most respectedleaders in the scientific community Dr. K. barry sharpless, a 2001 Nobel http://www.nsta.org/main/news/stories/nsta_story.php?news_story_ID=46832

85. SPIN - µpe? µe?a? 2001 - ?atate? http//wwwnoyori.os.chem.nagoya-u.ac.jp/. K. barry sharpless. ?µe?a?,60 et (?e. 1941). ?p? t? 1990 http://www.spin.gr/spin/story.jsp?id=152

86. 65th Anniversary K. barry sharpless, WM Keck Professor of Chemistry at the Scripps Research Institutein the US; and Dr William Knowles, previously with Monsanto Company in the http://www.polyu.edu.hk/cpa/anniversary/news_04.htm

Event Highlight Lectures by Nobel Laureates Dr Sir Gordon Wu presented the Certificate of Appointment to Prof. K. Barry Sharpless (right). Dr Sir Gordon Wu presented the Certificate of Appointment to Prof. Ryoji Noyori (left) Interviewing Dr William Knowles (left) by Prof. Albert Chan Sun-chi. PolyU conferred the title of Distinguished Honorary Professorship, the highest academic honour of the University, to the winners of the 2001 Nobel Prize in Chemistry at a special ceremony held on campus on 29 April. The association with the three top scholars will be a strong boost to the further development of the University's Area of Excellence "The Hong Kong Institute of Molecular Technology for Drug Discovery and Synthesis". The esteemed academic honour was conferred by Council Chairman Dr Sir Gordon Wu upon the three Nobel Laureates. They are Prof. Ryoji Noyori, Director of the Research Centre for Materials Science of Nagoya University in Japan; Prof. K. Barry Sharpless, W.M. Keck Professor of Chemistry at the Scripps Research Institute in the US; and Dr William Knowles, previously with Monsanto Company in the US.

87. Science Box K. barry sharpless, on the other hand, is awarded half of the Prize for developingchiral catalysts for another important type of reaction – oxidation. http://science.box.sk/?newsid=1065

88. News Of Interest To The Catalytic Community, ParísSur París, Francia, Ryoji Noyori Universidad de Nagoya Nagoya, Japón, K.barry sharpless Instituto Scripps de Investigación La Jolla, California, USA. http://www.icp.csic.es/secat/news.html

Spanish Catalysis Society NEWS: 2003 Eugene J. Houdry Award of the North American Catalysis Society which, in the words of its president Dr. John N. Armor, "it is a very high honor, often considered the most important award in heterogeneous industrial catalysis in the USA and probably in the world". More information about the nature and previous recipients of this award can be found at the address: http://www.nacatsoc.org "FLUID/SOLID KINETICS" From: bohdanw@aol.com Date sent: Thu, 27 June 2002 Subject: Fluid/Solid Kinetics To: Dear Juan, I am writing to let you know that Prof. Rice and I have developed an interesting method of doing solid/fluid kinetics of the sort that may be of benefit to people doing fluid/solid reactions, desorption studies or TPD work in general. Our initial work in this area was introduced at the Adsorption Conference in Lyon in 2000 and the following year in our book "Experimental Methods in Kinetic Studies" . We have further developed this aspect of temperature scanning applications and are now able to calculate from a single TPD-like adsorption/desorption run: the "effective" void volume of the reactor

89. International: Italiano: Scienze: Chimica: Chimici_e_Ricercatori: Sharpless,_K._ Translate this page In tutta la Directory. http://open-site.org/International/Italiano/Scienze/Chimica/Chimici_e_Ricercator

Open Site The Open Encyclopedia Project Pagina Principale Aggiungi Contenuti Diventa Editore In tutta la Directory Solo in Chimici_e_Ricercatori/Sharpless,_K._Barry Top International Italiano Scienze ... Chimici e Ricercatori : Sharpless, K. Barry Vedi anche: International: Italiano: Societ : Strutture Sociali: Persone: Biografie: Premio Nobel K. Barry Sharpless ¨ stato insignito del premio Nobel per la chimica, nel 2001, per gli studi sulle reazioni di ossidazione catalizzate chiralmente. Questa Categoria ha bisogno di un Editore - Richiedila Open Site Code 0.5.3 JVDS.com Visit our sister sites dmoz.org mozilla.org chefmoz.org musicmoz.org ... modifica

90. Les Informations http://www.sfc.fr/Informations.htm

SFC info en ligne Liste des manifestations en chimie Prix Nobel 2001 William S. Knowles Ryoji Noyori (Université de Nagoya, Chikusa, Nagoya, Japon), pour "leurs travaux sur les réactions d'hydrogénation catalysées par chiralité", K. Barry Sharpless (Institut de recherche Scripps, La Jolla, Californie, Etats-Unis),pour "ses travaux sur les réactions d'oxydation catalysées par chiralité". Robert J. P. Corriu Jean-Claude Bernier http://nobel.sdsc.edu/announcement/2001/chemfr.html http://www.nobelprizes.com/ Documentation Prix Nobel 2001 Le Prix Nobel de Chimie William S. KNOWLES Ryoji NOYORI K. Barry SHARPLESS Institut de Recherche Scripps (La Jolla, Californie, USA) http://nobel.sdsc.edu/announcement/2001/chemfr.html http://www.nobelprizes.com/ Ce 10 octobre 2001, l'Académie Royale des Sciences de Suède a décidé d'attribuer le Prix Nobel de Chimie de l'année 2001 pour le développement de la synthèse asymétrique catalytique, pour moitié collectivement à William S. Knowles (Saint-Louis, Missouri, USA), et à Ryoji Noyori (Université de Nagoya, Chikusa, Nagoya, Japon), pour "leurs travaux sur les réactions d'hydrogénation catalysées par chiralité"

91. SunSITE India : 2001 Nobel Chemistry Prize 2001 Nobel Prize. 2001 Nobel Prize in Chemistry. William S.Knowles Ryoji Noyori K.BarrySharpless Biography. William S. Knowles, 84 years, born 1917 (US citizen). http://sunsite.iisc.ernet.in/nobel2001/che2001_bio.html

2001 Nobel Prize 2001 Nobel Prize in Chemistry William S.Knowles Ryoji Noyori K.Barry Sharpless Biography William S. Knowles , 84 years, born 1917 (US citizen). PhD 1942 at Columbia University. Previously at Monsanto Company, St Louis, USA. Retired since 1986. Ryoji Noyori , 63 years, born 1938 Kobe, Japan (Japanese citizen). PhD 1967 at Kyoto University. Since 1972 Professor of Chemistry at Nagoya University and since 2000 Director of the Research Center for Materials Science, Nagoya University, Nagoya, Japan. http://www-noyori.os.chem.nagoya-u.ac.jp K. Barry Sharpless , 60 years, born 1941 Philadelphia, Pennsylvania, USA (US citizen). PhD 1968 at Stanford University. Since 1990 W.M. Keck Professor of Chemistry at the Scripps Research Institute, La Jolla, USA. http://www.scripps.edu/chem/sharpless/kbs.html Comments/Suggestions to Webmaster, SunSITE

92. Direct AnaLyse ses travaux sur les réactions d oxydation catalysées par chiralité . http://www.directanalyse.com/nobel.htm

Communiqué de presse Le Prix Nobel de Chimie 2001 10 octobre 2001 L'Académie Royale des Sciences de Suède a décidé d'attribuer le Prix Nobel de Chimie de l'année 2001 pour le développement de la synthèse asymétrique catalytique, pour moitié collectivement à : William S. Knowles Saint-Louis, Missouri, USA, et à Ryoji Noyori Nagoya University, Chikusa, Nagoya, Japon, "pour leurs travaux sur les réactions d'hydrogénation catalysées par chiralité", et pour l'autre moitié à : K. Barry Sharpless The Scripps Research Institue, La Jolla, Californie, USA, "pour ses travaux sur les réactions d'oxydation catalysées par chiralité". La catalyse inverse optique Un grand nombre de molécules existent sous deux formes inverses optiques – comme le sont nos mains. Elles sont dites chirales. Les chercheurs ont constaté que, dans la nature, l'une des deux formes est souvent plus fréquente que l'autre. Dans nos cellules, l'une des formes inverses optiques "va comme un gant" à l'opposé de l'autre qui peut même s'avérer nocive. Les produits pharmaceutiques sont souvent composés de molécules chirales et la différenciation des deux formes peut se révéler vitale – ce que prouva la catastrophe provoquée par le Neurosedyn dans les années 60. Il est donc important de pouvoir produire les deux formes chirales séparément.

93. »þÇø®½º The summary for this Korean page contains characters that cannot be correctly displayed in this language/character set. http://preview.britannica.co.kr/spotlights/nobel/list/chem0103.html

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94. Tom.com The summary for this Chinese (Simplified) page contains characters that cannot be correctly displayed in this language/character set. http://www.scitom.com.cn/history/event/evt095.html

SCITOMÊ×Ò³ TOMÍƼö ¡¡¡¡2001Äê10ÔÂ10ÈÕÈðµä»Ê¼ÒѧԺÕýʽÐû²¼£¬½«2001Äêŵ±´¶û»¯Ñ§½±ÁªºÏÊÚÓèWilliam S. Knowles¡¢Ryoji NoyoriºÍK. Barry SharplessÈýλ¿Æѧ¼Ò£¬ÒÔ±íÕËûÇÔÚ¡°ÊÖÐÔ´ß»¯Ñõ»¯·´Ó¦¡±ÁìÓòÖеÄÍ»³ö¹±Ïס£ Knowles ¡¡¡¡William S. Knowles£¬À¹úÈË£¬ÏÖÄê84Ëê¡£1942ÔÚ¸çÂ×±ÈÑÇ´óѧ»ñµ²©Ê¿Ñ§Î»£¬ºóÖ÷ÒªÔÚÀ¹úµÄMonsanto¹«Ë¾¹¤×÷¡£1986ÄêÍËÐÝÖÁ½ñ¡£ ¡¡¡¡±¾ÊÀ¼Í50Äê´ú£¬¿ÆѧÇÈÔ²»÷È·´ß»¯¼Á¶ÔÊÖÐÔ·Ö×ӵķǶԳƺϳÉÊÇ·ñÓÐ×÷Ó¡£Ö±µ½1968ÄêÔÚÀ¹úMonsanto¹«Ë¾¹¤×÷µÄWilliam S. Knowles·¢ÏÖʹÓÒ»ÖÖ¹ý¶É½ðÊôîÉ¿ÉÒԺϳÉÒ»ÖÖÊÖÐÔ´ß»¯¼Á½«ÊÖÐÔ·Ö×Óת±ä³É·ÇÊÖÐÔ·´Ó¦ÎïºÏ³ÉÊÖÐÔ²úÎï¡£·´Ó¦ÖÐÐèÒªÇ⻯×÷Ó£¬Ò»¸ö´ß»¯¼Á·Ö×Ó¿É´ß»¯ºÏ³ÉÉÏÒÚ¸öÊÖÐÔ·Ö×ÓÄ¿±ê½á¹¹¡£ËûµÄÄ¿±êÊÇ·¢÷Ò»ÖÖL-DOPA°±»ùËᣨ¿ÉÓÓÚÖÎÁÆÅÁ½ô˹×ÛºÏÖ¢£©µÄ¹¤ÒµºÏ³É·½·¨¡£Í¨¹ý¶Ô²»Í¬½á¹¹PH3·Ö×ÓµÄʵÑ飬KnowlesºÍËûµÄͬÊÂǺܿì±ãÑÐÖƳɹ¦ÁËÓÓڷǶԳƺϳÉL-DOPA°±»ùËáµÄ´ß»¯¼Á£¬ÕâÒ²Êǵ±Ê±µÚÒ»¸öÓÓڷǶԳƺϳɵĴ߻¯¼Á¡£ Noyori ¡¡¡¡Ryoji Noyori£¬ÈÕ±¾ÈË£¬ÏÖÄê63Ëê¡£1967ÄêÔÚ¾©¶¼´óѧȡµ²©Ê¿Ñ§Î»¡£1972Äê³ÉΪÈÕ±¾û¹ÅÎÝ´óѧµÄ»¯Ñ§½ÌÊÚ£¬2000Äê³ÉΪ¸´óѧ²ÄÁÏ¿ÆѧÑо¿ÖÐÐĵÄÖ÷ÈΡ£ ¡¡¡¡ÈÕ±¾¿Æѧ¼ÒRyoji NoyoriΪÁËÑÐÖƸüº¡¢¸üͨӵķǶԳƺϳɴ߻¯¼Á½øÐÐÁË´óÁ¿µÄÑо¿¹¤×÷£¬²¢È¡µÁËÓÅÒìµÄ³É¹û¡£ÔçÔÚ1980ÄêNoyori¾ÍºÍËûµÄͬÊÂÇ·¢±íÁ˹ØÓÚBINAPµÄÁ½ÖÖ¶ÔÓ³½á¹¹ºÏ³ÉµÄÂÛÎÄ¡£×÷Ϊһ¸ö³öÉ«µÄ¿Æѧ¼ÒËû²¢»ÓÐÂú×ãÒÑ»ñµµÄ³É¾Í£¬¶øÊÇ¿´µ½ÆÕÊÊ´ß»¯¼ÁµÄ¹ãÀ«Ó¦Óǰ;¡£Ëû³¢ÊÔ×ÅÓîÉ£¨Rh£©´úÌæ³£ÓµÄï©(Ru)£¬½á¹ûÖ¤÷ÊǶԵģ¬Ê¹·Ç¶Ô³ÆºÏ³ÉµÄÓÐӽṹ²úÎïËùÕ¼·Ý¶î´ó´óÌá¸ß¡£Ä¿Ç°Noyori·¢÷µÄRu-BINAPÒѹ㷺ÓÓÚ¿¹ÉúËØ¡¢×óÐýÆÏÌÑÌǵĹ¤ÒµºÏ³É£¬Í¬Ê±ÔÚеĻ¯Ñ§ÊÔ¼Á¡¢Ò©Æ·ºÍ¸ßÐËÄܲÄÁϵĺϳɷ½æÒ²Óй㷺Ӧӡ£ Sharpless ¡¡¡¡K. Barry Sharpless£¬À¹úÈË£¬ÏÖÄê60Ëê¡£1968ÄêÔÚ˹̹¸£´óѧȡµ²©Ê¿Ñ§Î»¡£1990ÄêÖÁ½ñÒ»Ö±ÊÇÀ¹úScrippsÑо¿ÔºµÄ»¯Ñ§½ÌÊÚ¡£

95. Nobel Prize Winner Puts Trust In Nature - ExpressNews - University Of Alberta Dr. John Vederas (front left) with Dr. K. BarrySharpless (front right) on campus Monday http://www.expressnews.ualberta.ca/expressnews/articles/news.cfm?p_ID=2483&s=a

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