1. Phillip A. Sharp Phillip A. Sharp studies the control of gene expression, which affects all major activities at all levels and stages of development in the brain. Phillip A. Sharp's work focuses on mechanisms controlling gene expression in human http://web.mit.edu/mcgovern/html/Principal_Investigators/sharp.shtml

@import url(../../stylesheets/int_ie.css); Key terms Contact us Career opportunities For the media ... Home Phillip A. Sharp who we are areas of research principal investigators events and seminars news and publications support the McGovern Institute Bizzi Constantine- Paton DiCarlo Fee ... Poggio Sharp Phillip A. Sharp studies the control of gene expression, which affects all major activities at all levels and stages of development in the brain. Director, McGovern Institute; Institute Professor, MIT Sharp lab site Contact phone: 617 253 6421 fax: 617 253 3867 MIT Bldg E17-529 email: sharppa@mit.edu Phillip A. Sharp's work focuses on mechanisms controlling gene expression in human cells. Both development of the brain and its normal functions depend upon these processes. In 1993, Sharp received the Nobel Prize in Physiology or Medicine for the discovery that genes contain nonsense segments that are edited out by cells in the course of utilizing genetic information. Sharp joined the MIT faculty in 1974 and in 1999 was named Institute Professor, the highest honor bestowed on a faculty member. From 1991 to 1999, he chaired the Department of Biology and was Director of the Center for Cancer Research from 1985-1991. In 2000, he was named Founding Director of the McGovern Institute for Brain Research. Sharp received his Ph.D. in 1969 from the University of Illinois at Urbana. He is an elected member of the National Academy of Sciences, the Institute of Medicine, the American Philosophical Society, the American Academy of Arts and Sciences, and an Honorary Fellow of the Royal Society of Edinburgh, Scotland.

2. WIEM: Sharp Phillip Allen sharp phillip allen (1944), biolog amerykanski. Biologia, Stany Zjednoczone SharpPhillip Allen (1944-). sharp phillip allen (1944-), biolog amerykanski. http://wiem.onet.pl/wiem/001e84.html

WIEM 2004 - zobacz now± edycjê encyklopedii! Kup abonament i encyklopediê na CD-ROM, sprawd¼ ofertê cenow±! Oferta specjalna abonamentów dla szkó³ i instytucji! Uwaga! Przedstawione poni¿ej has³o pochodzi z archiwalnej edycji WIEM 2001! Prace redakcyjne nad edycj± 2001 zosta³y zakoñczone. Zapraszamy do korzystania z nowej, codziennie aktualizowanej i wzbogacanej w nowe tre¶ci edycji WIEM 2004 Biologia, Stany Zjednoczone Sharp Phillip Allen Sharp Phillip Allen (1944-), biolog amerykañski. Od 1974 profesor Massachusetts Institute of Technology w Cambridge, od 1985 dyrektor Center for Cancer Research tego¿ instytutu, od 1991 kierownik jego Departamentu Biologii. W 1977 odkry³ tzw. geny nieci±g³e (split genes), sk³adaj±ce siê z eksonów i  intronów transkrypcja ), obalaj±c teoriê ci±g³ej budowy genu Nagroda Nobla w 1993 (z R.J. Robertsem ) za niezale¿ne odkrycie genów nieci±g³ych. WIEM zosta³a opracowana na podstawie Popularnej Encyklopedii Powszechnej Wydawnictwa Fogra zobacz wszystkie serwisy do góry

3. Phillip Allen Sharp Phillip Allen Sharp. Phillip Allen Sharp (1944) American molecularbiologist, awarded the 1993 Nobel Prize for Physiology or Medicine http://www.nobel-winners.com/Medicine/phillip_allen_sharp.html

Phillip Allen Sharp Phillip Allen Sharp American molecular biologist, awarded the 1993 Nobel Prize for Physiology or Medicine, along with Richard J. Roberts, for his independent discovery that individual genes are often interrupted by long sections of DNA that do not encode protein structure. Sharp received a doctorate in chemistry from the University of Illinois at Urbana-Champaign in 1969. In that year he began working at the California Institute of Technology, moving to the Cold Spring Harbor Laboratory in New York in 1971. In 1974 he went to the Massachusetts Institute of Technology, where he did his prize-winning research. In 1977 Sharp helped found Biogen Ltd., a biotechnology company. In 1977 Sharp and his team discovered that the messenger RNA (mRNA) of an adenovirus corresponded to four separate, discontinuous segments of DNA. They found that the segments of DNA that coded for proteins, now called exons, were separated by long stretches of DNA, now called introns, that did not contain genetic information. At the same time, a team working independently under Roberts came up with the same finding. Previously biologists had believed that genes were continuous stretches of DNA that served as direct templates for mRNA in the assembly of proteins; this model was based on studies of prokaryotic organisms such as bacteria. Following the discovery of Sharp and Roberts, it was demonstrated that the discontinuous gene structure is the most common one found in eukaryotes, among which are all higher organisms, including human beings.

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5. UWeek Vol.16, No.20 March, 11, 1999 Memorial service for Dodge. RNA splicing is topic for Nobel LaureateSharp’s lecture. Phillip A. sharp phillip a. Sharp. Scientists http://depts.washington.edu/~uweek/archives/1999.03.MAR_11/article20.html

Wilson named to chair Immunology Sir Michael Berridge to speak on discoveries in calcium signaling Perfusionists to present John Gibbon Award to cardiothoracic chief Poll Scholar to present public lecture on new approaches to a cure for diabetes ... Memorial service for Dodge Phillip A. Sharp Scientists work around the clock trying to understand precisely how RNA segments are spliced in the subregions of our cells. All our hereditary data, including genetic disease, is passed on at this level. What chemical reactions take place? Can the process be regulated? How is the RNA itself formed? In light of recent cloning and gene therapy advances, it may be surprising to hear investigators say that little is known about this process. The fact is that what knowledge there is has come rapidly and dramatically. In the early 1970s, biotechnology companies did not exist. Genetic research was conducted primarily in academic labs. The first biotech company, Genentech Inc., was founded in 1976. Today, there are hundreds of biotech companies around the world. Working independently, Sharp and Roberts were attempting to identify the location of genes on the DNA molecule in the adenovirus nucleus. Using electron microscopy, they found that single RNA segments corresponded to separate segments of DNA in the larger molecule. In other words, they found that genes exist as discontinuous segments on a DNA molecule.

6. Sharp, Phillip A. sharp, phillip A., Copyright Brooks Kraft/Sygma. in full phillip ALLEN sharp (b. June 6, 1944, Falmouth, Ky., U.S.), American molecular biologist, awarded the 1993 Nobel Prize for Physiology or Medicine, along with Richard J. http://www.britannica.com/nobel/micro/541_28.html

Sharp, Phillip A., Phillip A. Sharp, 1993 in full PHILLIP ALLEN SHARP (b. June 6, 1944, Falmouth, Ky., U.S.), American molecular biologist, awarded the 1993 Nobel Prize for Physiology or Medicine , along with Richard J. Roberts , for his independent discovery that individual genes are often interrupted by long sections of DNA that do not encode protein structure. Sharp received a doctorate in chemistry from the University of Illinois at Urbana-Champaign in 1969. In that year he began working at the California Institute of Technology, moving to the Cold Spring Harbor Laboratory in New York in 1971. In 1974 he went to the Massachusetts Institute of Technology, where he did his prize-winning research. In 1977 Sharp helped found Biogen Ltd., a biotechnology company. In 1977 Sharp and his team discovered that the messenger RNA (mRNA) of an adenovirus corresponded to four separate, discontinuous segments of DNA. They found that the segments of DNA that coded for proteins, now called exons, were separated by long stretches of DNA, now called introns, that did not contain genetic information. At the same time, a team working independently under Roberts came up with the same finding. Previously biologists had believed that genes were continuous stretches of DNA that served as direct templates for mRNA in the assembly of proteins; this model was based on studies of prokaryotic organisms such as bacteria. Following the discovery of Sharp and Roberts, it was demonstrated that the discontinuous gene structure is the most common one found in eukaryotes, among which are all higher organisms, including human beings.

7. Sharp, Phillip Allen. The American Heritage® Dictionary Of The English Language American Heritage® Dictionary. sharp. sharpe, William Forsyth Heritage® Dictionary of the English Language Fourth Edition. 2000. sharp, phillip Allen. PRONUNCIATION shärp http://www.bartleby.com/61/7/S0320725.html

Select Search All Bartleby.com All Reference Columbia Encyclopedia World History Encyclopedia Cultural Literacy World Factbook Columbia Gazetteer American Heritage Coll. Dictionary Roget's Thesauri Roget's II: Thesaurus Roget's Int'l Thesaurus Quotations Bartlett's Quotations Columbia Quotations Simpson's Quotations Respectfully Quoted English Usage Modern Usage American English Fowler's King's English Strunk's Style Mencken's Language Cambridge History The King James Bible Oxford Shakespeare Gray's Anatomy Farmer's Cookbook Post's Etiquette Bulfinch's Mythology Frazer's Golden Bough All Verse Anthologies Dickinson, E. Eliot, T.S. Frost, R. Hopkins, G.M. Keats, J. Lawrence, D.H. Masters, E.L. Sandburg, C. Sassoon, S. Whitman, W. Wordsworth, W. Yeats, W.B. All Nonfiction Harvard Classics American Essays Einstein's Relativity Grant, U.S. Roosevelt, T. Wells's History Presidential Inaugurals All Fiction Shelf of Fiction Ghost Stories Short Stories Shaw, G.B. Stein, G. Stevenson, R.L. Wells, H.G. Reference American Heritage Dictionary sharp ... BIBLIOGRAPHIC RECORD The American Heritage Dictionary of the English Language: Fourth Edition.

8. MIT Department Of Biology: Phillip A. Sharp HomeFaculty and Areas of Research phillip A. sharp. Institute Professor. Director, McGovern Institute for. Brain Research. Ph.D. 1969, University of Illinois. Room E17529B. Phone (617) 253-6421. Fax (617) 253-3867. Email sharppa@mit.edu http://web.mit.edu/biology/www/facultyareas/facresearch/sharp.shtml

Home Faculty and Areas of Research Phillip A. Sharp Institute Professor Director, McGovern Institute for Brain Research Ph.D. 1969, University of Illinois Room E17-529B Phone: (617) 253-6421 Fax: (617) 253-3867 Email: sharppa@mit.edu Sharp Lab Website McGovern Institute for Brain Research Overview Regulation of gene expression in vertebrates: RNA interference, RNA splicing, and control of transcription by RNA polymerase II. Research Summary RNA Interference (RNAi): Recent results suggest that siRNAs transfected into mammalian cells are recognized by the endogenous pathway responsible to the activities of microRNAs (miRNAs). Theses latter 21-22 nt RNAs are processed from hairpin RNAs encoded by cellular DNA and are thought to regulate gene expression primarily by inhibiting translation. Other laboratories have predicted the existence of 200-250 different miRNA genes in humans. An indication that siRNAs function through the miRNA-pathway is the observation that siRNAs will inhibit the translation of a reporter gene, which contains multiple partially complementary target sites. We are exploiting this finding to study the mechanism of translational inhibition by miRNAs and to develop a purification protocol for identifying the targets of miRNAs.

9. Sharp. The American Heritage® Dictionary Of The English Language: Fourth Editio Sharon, Plain of. sharp, phillip Allen. CONTENTS · INDEX · ILLUSTRATIONS · BIBLIOGRAPHIC RECORD Inflected forms sharp·er, sharp·est. 1. Having a thin edge or a fine point http://www.bartleby.com/61/7/S0320700.html

Select Search All Bartleby.com All Reference Columbia Encyclopedia World History Encyclopedia Cultural Literacy World Factbook Columbia Gazetteer American Heritage Coll. Dictionary Roget's Thesauri Roget's II: Thesaurus Roget's Int'l Thesaurus Quotations Bartlett's Quotations Columbia Quotations Simpson's Quotations Respectfully Quoted English Usage Modern Usage American English Fowler's King's English Strunk's Style Mencken's Language Cambridge History The King James Bible Oxford Shakespeare Gray's Anatomy Farmer's Cookbook Post's Etiquette Bulfinch's Mythology Frazer's Golden Bough All Verse Anthologies Dickinson, E. Eliot, T.S. Frost, R. Hopkins, G.M. Keats, J. Lawrence, D.H. Masters, E.L. Sandburg, C. Sassoon, S. Whitman, W. Wordsworth, W. Yeats, W.B. All Nonfiction Harvard Classics American Essays Einstein's Relativity Grant, U.S. Roosevelt, T. Wells's History Presidential Inaugurals All Fiction Shelf of Fiction Ghost Stories Short Stories Shaw, G.B. Stein, G. Stevenson, R.L. Wells, H.G. Reference American Heritage Dictionary Sharon, Plain of ... BIBLIOGRAPHIC RECORD The American Heritage Dictionary of the English Language: Fourth Edition.

10. Phillip A. Sharp Winner Of The 1993 Nobel Prize In Medicine phillip A. sharp, a Nobel Prize Laureate in Physiology and Medicine, at the NobelPrize Internet Archive. phillip A. sharp. 1993 Nobel Laureate in Medicine http://almaz.com/nobel/medicine/1993b.html

P HILLIP A S HARP 1993 Nobel Laureate in Medicine for discovery of split genes. Background Born: 1944 Residence: U.S.A. Affiliation: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA Featured Internet Links Prize co-recipient Richard J. Roberts Search WWW Search The Nobel Prize Internet Archive Nobel News Links Let Nobelists Inspire, Menino Says Two from Mass. Win Nobel for Medicine Latest Nobel Affirms MIT Leadership in Biology Sharp Jolts MIT, Rejects Top Post (1990) Links added by Nobel Internet Archive visitors Home town reaction Biogen Winner of The Gairdner Foundation Int'l Award Phillip A. Sharp - Autobiography (submitted by Daike) Phillip A. Sharp - Nobel Lecture (submitted by Davis Brown) Back to The Nobel Prize Internet Archive Literature Peace Chemistry ... Medicine We always welcome your feedback and comments

11. Phillip A. Sharp Winner Of The 1993 Nobel Prize In Medicine phillip A. sharp, a Nobel Prize Laureate in Physiology and Medicine, at the Nobel Prize Internet Archive. phillip A. sharp. 1993 Nobel Laureate in Medicine The Gairdner Foundation Int'l Award. phillip A. sharp Autobiography( submitted by Daike) phillip A. sharp - Nobel Lecture http://www.almaz.com/nobel/medicine/1993b.html

P HILLIP A S HARP 1993 Nobel Laureate in Medicine for discovery of split genes. Background Born: 1944 Residence: U.S.A. Affiliation: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA Featured Internet Links Prize co-recipient Richard J. Roberts Search WWW Search The Nobel Prize Internet Archive Nobel News Links Let Nobelists Inspire, Menino Says Two from Mass. Win Nobel for Medicine Latest Nobel Affirms MIT Leadership in Biology Sharp Jolts MIT, Rejects Top Post (1990) Links added by Nobel Internet Archive visitors Home town reaction Biogen Winner of The Gairdner Foundation Int'l Award Phillip A. Sharp - Autobiography (submitted by Daike) Phillip A. Sharp - Nobel Lecture (submitted by Davis Brown) Back to The Nobel Prize Internet Archive Literature Peace Chemistry ... Medicine We always welcome your feedback and comments

12. Index Of Nobel Laureates In Medicine Sakmann, Bert, 1991. Samuelsson, Bengt I. 1982. Schally, Andrew V. 1977. sharp,phillip A. 1993. Sherrington, Sir Charles Scott, 1932. Smith, Hamilton O. 1978. http://almaz.com/nobel/medicine/alpha.html

ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE Name Year Awarded Adrian, Lord Edgar Douglas Arber, Werner Axelrod, Julius Baltimore, David ... Medicine We always welcome your feedback and comments

13. Phillip A. Sharp - Autobiography phillip A. sharp – Autobiography. A sense of place was and remainsan important part of my life. I was born in a rural community http://www.nobel.se/medicine/laureates/1993/sharp-autobio.html

A sense of place was and remains an important part of my life. I was born in a rural community in the northern hill country of Kentucky. My earliest memories are those of a child playing around the house on our family farm, located in a bend of the Licking River near McKinneysburg. My mother, Kathrin Colvin Sharp, had grown up in that same house and her family had been part of this community for many generations. My father, Joseph Walter Sharp, grew up nearby within walking distance of the nearest town and county-seat, Falmouth. Both parents came from large families and I was surrounded by grandparents, aunts, uncles, siblings and cousins. My formal education was entirely in the public schools of Pendleton County: McKinneysburg Elementary, Butler Elementary and High School and Pendleton County High School. Even though my studies never interfered with sports or fun, I managed to gain an appreciation of math and science. All through my childhood, my parents strongly encouraged me to attend college. With that in mind, they taught me to save my money for college tuition, and, even more important, they allowed me to earn it by raising cattle for the market and growing tobacco. The rural background of my childhood made me feel more comfortable attending a small institution in a familiar environment. Therefore, I entered a small liberal arts school, Union College, in the foothills of eastern Kentucky. Union is in Barbourville, the county-seat of Knox County, and in those days it was one of the gateways for the youth from the mountains in the eastern part of the state to emerge into a larger world. While at Union, I majored in chemistry and mathematics and decided that I wanted to continue to study and learn about science, particularly chemistry. I also met and married a lovely girl from New Jersey, Ann Holcombe (Sharp).

14. Medicine 1993 Richard J. Roberts, phillip A. sharp. 1/2 of the prize, 1/2 of the prize. UnitedKingdom, USA. phillip A. sharp Autobiography Nobel Lecture Interview Other Resources. http://www.nobel.se/medicine/laureates/1993/

The Nobel Prize in Physiology or Medicine 1993 "for their discoveries of split genes" Richard J. Roberts Phillip A. Sharp 1/2 of the prize 1/2 of the prize United Kingdom USA New England Biolabs Beverly, MA, USA Massachusetts Institute of Technology (MIT), Center for Cancer Research Cambridge, MA, USA b. 1943 b. 1944 The Nobel Prize in Physiology or Medicine 1993 Press Release Presentation Speech Illustrated Presentation ... Other Resources The 1993 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: SITE FEEDBACK CONTACT TELL A FRIEND Last modified June 30, 2003 The Official Web Site of The Nobel Foundation

15. Phillip A Sharp Middle School, Butler, Kentucky phillip A sharp Middle School, Butler, Kentucky. Compare phillip A sharp Middle School, track phillip A sharp Middle performance http://rdre1.inktomi.com/click?u=http://www.greatschools.net/modperl/browse_scho

16. Sharp, Phillip --  Britannica Student Encyclopedia sharp, phillip Britannica Student Encyclopedia. MLA style sharp, phillip. BritannicaStudent Encyclopedia. 2004. Encyclopædia Britannica Premium Service. http://www.britannica.com/ebi/article?eu=338089&query=borsos, phillip&ct=ebi

17. Search Results For Sharp - Encyclopædia Britannica sharp, Cecil James (Br. mus.) sharp, phillip A. ( Am. physiol.) sharp, phillip A. American molecular biologist, awarded the 1993 Nobel Prize for Physiology or Medicine, along with http://www.britannica.com/search?ref=B04319&query=sharp&submit=Find

18. SHARP, PHILLIP A. - CIRS sharp, phillip A. Email sharppa@mit.edu Institute Professor and Directorof the McGovern Institute for Brain Research, Center for Cancer Research http://www.cirs-tm.org/Chercheurs/chercheurs1.php?id=393

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Book ISBN 0697050300 new and used Author Robert Phillip Sharp . Home Contact Geology: field guide to Southern California; Robert Phillip Sharp Geometric Galois Actions: Around Grothendieck s Esquisse D Un Programme Geology of Construction Materials Geometriia diskretnykh grupp i mnogoobrazii Coastal Southern California: Field Guide [K/H Geology Field Guide Series , 19] ... Geology: field guide to Southern California ; Phillip, Robert Robert Phillip Sharp Geology for Engineers 5ed F G H Blyth Geology for Engineers and Environmental Scientists ... John Edward Prentice

20. MSN Encarta - Sharp, Phillip A. sharp, phillip A. sharp, phillip A. (1944 ), American chemist and Nobel laureateborn in Falmouth, Kentucky. Find more about sharp, phillip A. from, http://encarta.msn.com/encyclopedia_761582680/Sharp_Phillip_A.html

MSN Home My MSN Hotmail Shopping ... Money Web Search: logoImg('http://sc.msn.com'); Encarta Subscriber Sign In Help Home ... Upgrade to Encarta Premium Search Encarta Subscription Article MSN Encarta Premium: Get this article, plus 60,000 other articles, an interactive atlas, dictionaries, thesaurus, articles from 100 leading magazines, homework tools, daily math help and more for $4.95/month or $29.95/year (plus applicable taxes.) Learn more. This article is exclusively available for MSN Encarta Premium Subscribers. Already a subscriber? Sign in above. Sharp, Phillip A. Sharp, Phillip A. (1944- ), American chemist and Nobel laureate born in Falmouth, Kentucky. Sharp received a Ph.D. degree from the University of... Multimedia Selected Web Links Phillip A. Sharp [Nobel Foundation] 1 item Want more Encarta? Become a subscriber today and gain access to: Daily Math Help Literature Guides Researcher Tools Paper-Writing Guides 60,000 + articles Interactive Atlas Magazine Center Find more about Sharp, Phillip A. from Other Features from Encarta Search Encarta for Sharp, Phillip A.

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