41. Frederick Sanger - Les Membres De L'Académie Des Sciences Translate this page sanger (frederick). Chercheur honoraire au Conseil de la recherche médicale deCambridge. Né le 13 août 1918, élu Associé étranger le 9 février 1981. http://www.academie-sciences.fr/membres/S/Sanger_Frederick.htm

Sanger ( Frederick C Section : Chimie Membre de la Royal Society (Grande-Bretagne) Accueil Membres Publications Prix ... Plan du site

42. MSN Encarta - Sanger, Frederick Translate this page sanger, frederick. sanger, frederick (*1918), britischer Biochemiker und zweifacherNobelpreisträger. Multimedia. Erfahren Sie mehr über sanger, frederick aus, http://de.encarta.msn.com/encyclopedia_761574882/Sanger_Frederick.html

MSN Home My MSN Hotmail Suche ... Upgrade auf Encarta Premium Encarta - Suche Abonnentenartikel MSN Encarta Premium: Holen Sie sich diesen Artikel, 47.000 weitere Artikel, einen interaktiven Atlas, W¶rterb¼cher und vieles mehr f¼r 29,95€/Jahr (zuz¼glich Steuern). Lernen Sie mehr. Dieser Artikel ist ausschlieŸlich f¼r Abonnenten von MSN Encarta Premium verf¼gbar. Sind Sie schon Abonennt? Melden Sie sich oben an. Sanger, Frederick Sanger, Frederick (*1918), britischer Biochemiker und zweifacher Nobelpreistr¤ger. Multimedia M¶chten Sie noch mehr von Encarta? Werden Sie noch heute Abonnent, und Sie erhalten Zugriff auf: 47.000 Artikel W¶rterb¼cher Interaktiver Atlas Lernstudio Erfahren Sie mehr ¼ber Sanger, Frederick aus Andere Features aus Encarta Suchen in Encarta nach Sanger, Frederick MSN Home My MSN ... Groups ©2004 Microsoft Corporation. Alle Rechte vorbehalten. TRUSTe-gepr¼fte Datenschutzbestimmungen Werbung Nutzungsbedingungen Impressum

43. Frederick Sanger --  Britannica Concise Encyclopedia Online Article Britannica Concise Encyclopedia, sanger, frederick Britannica Concise. To cite thispage MLA style frederick sanger. Britannica Concise Encyclopedia. 2004. http://concise.britannica.com/ebc/article?eu=402983

44. Frederick Sanger Road Accommodation There are 32 units in frederick sanger Road. . Independent heatingsystems. Office frederick sanger Road. frederick sanger Road. Typical Plans, http://www.surrey-research-park.com/fsroad.html

Home Overview Aerial view Communications ... Space to let Frederick Sanger Road Sites for development Faraday Court George Stephenson Place The Surrey Technology Centre ... Guildford Borough Council Frederick Sanger Road Accommodation There are 32 units in Frederick Sanger Road. The range of unit areas is as follows: 1,050 square feet 1,135 square feet 1,215 square feet 1,350 square feet These units have been designed to offer self-contained accommodation suitable for either small independent companies wishing to occupy high quality space or specialist sections of large companies wishing to locate on a Science/Research Park. Where units are adjacent they have been designed so that they may be interlinked offering a maximum of 4850 sq ft. Each unit is finished throughout to a high standard which includes a suspended ceiling with recessed lighting, carpeting throughout, a fitted kitchenette and the provision of 5 on-site car parking spaces per suite. Natural light is excellent and the accommodation is adaptable to either cellular or open plan format, creating an attractive, flexible and practical working environment.

45. Frederick Sanger Road frederick sanger Road. http://www.surrey-research-park.com/fredsanger.html

Frederick Sanger Road

46. Frederick Sanger - Reference Library frederick sanger. frederick sanger (1918 ) is a British molecular biologistwho was working on problems related to the determination http://www.campusprogram.com/reference/en/wikipedia/f/fr/frederick_sanger.html

Reference Library: Encyclopedia Main Page See live article Alphabetical index Frederick Sanger Frederick Sanger - ) is a British molecular biologist who was working on problems related to the determination of the structure of proteins . His studies resulted in the determination of the structure of insulin ; for this discovery he received Nobel Prize in Chemistry in In , he developed the chain termination method , also known as the "Sanger method." He later received another Nobel Prize in Chemistry in "for contributions concerning the determination of base sequences in nucleic acids." In 1992, the Sanger Centre in Cambridge, named after Frederick Sanger, was founded by the Wellcome Trust and the British Medical Research Council, the purpose of which is stated on their website as "to provide a major focus in the UK for mapping and sequencing the human genome, and genomes of other organisms." Links: A brief biography about the 1958 Nobel Prize About the 1980 Nobel Prize The Sanger Centre This article is from Wikipedia. All text is available under the terms of the GNU Free Documentation License

47. Caramba! - Nobelova Cena - Chemie (1943-1963) 1957. Todd, Alexander RI; Todd, Alexander R. II. 1958. sanger, frederickI. sanger, frederick II. sanger, frederick III. 1959. Heyrovský http://www.caramba.cz/page.php?PgID=953

48. Caramba! - Nobelova Cena - Chemie (1964-1984) 1980. Berg, Paul I. Berg, Paul II. Gilbert, Walter I. Gilbert, Walter II. sanger,frederick I. sanger, frederick II. 1981. Fukui, Kenichi I. Fukui, Kenichi II. http://www.caramba.cz/page.php?PgID=954

49. Frederick Sanger (1955) 1955. frederick sanger (Cambridge) determines the sequence of aminoacids in insulin (Nobel Prize for Chemistry 1958) Image reference. http://www.bioss.sari.ac.uk/~dirk/genomeOdyssey/go_1955.html

Frederick Sanger (Cambridge) determines the sequence of amino acids in insulin (Nobel Prize for Chemistry 1958) Image reference Comparison of the amino acid sequences from pig and sheep: first evidence that species differ at a molecular level. > Links Darwin's evolution theory to molecular biology. Next Previous Start

50. HighBeam Research: Search Results: Article sanger, frederick (1918 ). The Hutchinson Dictionary of ScientificBiography; 1/1/1998. Read the Full Article, Get a FREE Trial for http://www.highbeam.com/library/doc0.asp?DOCID=1P1:28910066&num=7&ctrlInfo=Round

51. HighBeam Research: ELibrary Search: Results 4. sanger, frederick (1918 ) The Hutchinson Dictionary of Scientific Biography;January 1, 1998 sanger, frederick (1918- ) is a British http://www.highbeam.com/library/search.asp?FN=AO&refid=ency_refd&search_thesauru

52. Frederick Sanger Definition Meaning Information Explanation frederick sanger definition, meaning and explanation and more about fredericksanger. FreeDefinition - Online Glossary and Encyclopedia, frederick sanger. http://www.free-definition.com/Frederick-Sanger.html

A B C D ... Contact Beta 0.71 powered by: akademie.de PHP PostgreSQL Google News about your search term Frederick Sanger Frederick Sanger - ) is a British molecular biologist who was working on problems related to the determination of the structure of protein s. His studies resulted in the determination of the structure of insulin ; for this discovery he received Nobel Prize in Chemistry in In , he developed the chain termination method , also known as the "Sanger method." He later received another Nobel Prize in Chemistry in "for contributions concerning the determination of base sequences in nucleic acids." In 1992, the Sanger Centre in Cambridge, named after Frederick Sanger, was founded by the Wellcome Trust and the British Medical Research Council, the purpose of which is stated on their website as "to provide a major focus in the UK for mapping and sequencing the human genome, and genomes of other organisms." Links: A brief biography about the 1958 Nobel Prize About the 1980 Nobel Prize The Sanger Centre Books about 'Frederick Sanger' at: amazon.com

53. Www.net-lexikon.de/Frederick-Sanger.html frederick sanger Online Encyclopedia Information Geniusfrederick sanger. Online Encyclopedia frederick sanger (1918 ) isa British molecular biologist who was working on problems related http://www.net-lexikon.de/Frederick-Sanger.html

54. The Sanger Institute : Information: Introduction To The Sanger Institute About frederick sanger. Fred sanger and his colleagues developed manyof the techniques still used in genomic biology to this day. http://www.sanger.ac.uk/Info/Intro/sanger.shtml

Sanger Home Acedb YourGenome Ensembl ... Publications Introduction Sanger Institute Major Publications Highly Cited Publications Prospectus ... John Sulston Campus WT-Conferences Sanger Scenes South Field Extension Sequencing Centre ... Printable version About Frederick Sanger Fred Sanger and his colleagues developed many of the techniques still used in genomic biology to this day. The fundamental method of 'reading' DNA using special bases called chain terminators, the use of very thin gel systems, the adaptation of efficient cloning methods to produce both DNA strands and the whole-genome shotgun were all developed by Fred and his group during the 1970s. Fred's group produced the first DNA whole genome sequence (for a virus called phiX174 that grows in bacteria) of just over 5000 base-pairs. They went on to sequence the first human genome (albeit that of the DNA in mitochondria - small energy factories in all our cells that have their own genome of about 16,000 base-pairs) and the genome of an important virus for molecular biology, bacteriophage lambda, in 1982. To sequence this virus genome - about 48,000 base-pairs - Fred developed the whole-genome shotgun method. The sequence of lambda was the first whole-genome shotgun. Fred was born towards the end of the First World War in Gloucestershire, UK. His father was a GP from whom he gained an interest in biology. Fred took his first degree at

55. Frederick Sanger (1918-), Biochemist National Portrait Gallery, list of portraits for frederick sanger including fredericksanger by Liam Woon, frederick sanger by Paula A. MacArthur, frederick http://www.npg.org.uk/live/search/person.asp?LinkID=mp06016

56. NPG 6151; Frederick Sanger NPG 6151 frederick sanger, NPG 6151 frederick sanger by Paula A. MacArthurDate 1991 Medium oil on canvas Measurements 53 7/8 in. x 53 7/8 in. http://www.npg.org.uk/live/search/portrait.asp?mkey=mw08253

57. Ôðåäåðèê Ñåíãåð (Frederick Sanger) The summary for this Russian page contains characters that cannot be correctly displayed in this language/character set. http://www.peoples.ru/science/chemistry/sanger/

a a b c ... z English German French Beartrap - Security Appliance SmartFunction.com - Dedicated Web Hosting SmartForex.com - Currency Trading (Forex) ÑÅÍÅÐ, ÔÐÅÄÅÐÈÊ (Sanger, Frederick), (ð.1919). Íîáåëåâñêàÿ ïðåìèè ïî õèìèè, 1958, Íîáåëåâñêàÿ ïðåìèÿ ïî õèìèè, 1980 (ñîâìåñòíî ñ Ï.Áåðãîì è Ó.èëáåðòîì). Òàê êàê èññëåäîâàíèÿ, ïðîâîäèìûå â ëàáîðàòîðèè ïðîôåññîðà ×èáíåëëà âûïîëíÿëèñü, â îñíîâíîì, ñ èíñóëèíîì, òî Ñåíãåð è çàíÿëñÿ ýòèì áåëêîì. Ïåðâîíà÷àëüíîå èçó÷åíèå èíñóëèíà ïîêàçàëî, ÷òî îí ñîäåðæèò äâå ðàçíûå N-êîíöåâûå àìèíîêèñëîòû. Ñëåäîâàòåëüíî, êàæäàÿ ìîëåêóëà èíñóëèíà ñîñòîèò èç äâóõ âèäîâ ïîëèïåïòèäíûõ öåïåé. Îíè ñîåäèíåíû ìåæäó ñîáîé äèñóëüôèäíûìè ìîñòèêàìè.  1949 Ñåíãåð îòêðûë ñïîñîá ðàçðóøåíèÿ ýòèõ äèñóëüôèäíûõ ìîñòèêîâ è, ñëåäîâàòåëüíî, ìåòîä ðàçäåëåíèÿ äâóõ öåïåé. Ñåíãåð è ïðèåõàâøèé èç Âåíû àíñ Òóïïè (Hans Tuppy) ðàçðàáîòàëè ïëàí óñòàíîâëåíèÿ ïîñëåäîâàòåëüíîñòè ÷åðåäîâàíèÿ àìèíîêèñëîò â êàæäîé ïîëèïåïòèäíîé öåïè èíñóëèíà. Ðàçáèâ öåïü íà îòðåçêè, ýòè ó÷åíûå ïëàíèðîâàëè óñòàíîâèòü àìèíîêèñëîòíóþ ïîñëåäîâàòåëüíîñòü êàæäîãî îòðåçêà è, èñõîäÿ èç ýòîé èíôîðìàöèè, àìèíîêèñëîòíóþ ïîñëåäîâàòåëüíîñòü âñåé ïîëèïåïòèäíîé öåïè. Ñåíãåð ïåðâîíà÷àëüíî èñïîëüçîâàë êèñëîòó äëÿ ðàçðûâà öåïè íà îòðåçêè, íî âñêîðå îáíàðóæèë, ÷òî ôåðìåíòû äåéñòâóþò íàìíîãî òî÷íåå. Òàêèì îáðàçîì, Ñåíãåð è Òóïïè ñðàâíèâàëè ðàçëè÷íûå ôðàãìåíòû öåïè, ïîëó÷åííûå â ðåçóëüòàòå ïðèìåíåíèÿ ðàçíûõ ôåðìåíòîâ, äëÿ ðàñøèôðîâêè àìèíîêèñëîòíîé ïîñëåäîâàòåëüíîñòè âñåé öåïè. Åùå äî ïîëó÷åíèÿ ïðåìèè îí çàíÿëñÿ èçó÷åíèåì ãåíåòèêè. Îò÷àñòè ýòî ïðîèçîøëî ïîä âëèÿíèåì äðóæáû ó÷åíîãî ñ Ôðåíñèñîì Õàððè Êîìïòîíîì Êðèêîì (Francis, Harry Compton Crick, ðîä. â 1916, Íîáåëåâñêèé ëàóðåàò ïî ôèçèîëîãèè èëè ìåäèöèíå, 1962).

58. Storia Della Chimica. Frederick Sanger E La Struttura Dell'insulina (I) http://www.minerva.unito.it/Storia/ChimicaClassica/Cromatografia/CROM5.htm

Frederick Sanger e la struttura dell'insulina (I) Fra gli scienziati l'ironia è una dote rara, rarissima nella versione dell'autoironia. Lungo i quaranta anni dedicati alla biochimica Frederick Sanger ne ha fatto abbondante uso (per se stesso) e dono (ai suoi collaboratori), giungendo ad un risultato accademico ineguagliato: due premi Nobel per la chimica, nel 1958 e nel 1980. L'incontro di Sanger con le proteine avvenne durante le ricerche per il PhD, condotte fra il 1940 e il 1943 nel Dipartimento di Biochimica di Cambridge. Secondo quanto ha scritto lo stesso Sanger, molto probabilmente non avrebbe mai potuto studiare in quella prestigiosa università se i suoi genitori "non fossero stati discretamente ricchi", perché il giovane non era "accademicamente brillante". In realtà gli mancava semplicemente ciò che noi chiamiamo 'parlantina', dato che i suoi insegnanti al termine di un anno supplementare di studi in biochimica gli diedero un first grade degree . Subito dopo (1940) Sanger fece due mosse fondamentali: si sposò - a ventidue anni - e fu accettato come allievo per il dottorato, aiutato in questo dalla duplice fortunata circostanza di essere esentato dagli obblighi militari in quanto obbiettore di coscienza, e di non aver bisogno di un aiuto finanziario in quanto benestante. Il lavoro per la tesi di dottorato, sul metabolismo della lisina, lo familiarizzò con la chimica degli amminoacidi, così che al momento dell'arrivo del nuovo direttore del Dipartimento Sanger potè inserisi nel filone di ricerca principale. Infatti A.C. Chibnall, il nuovo direttore e successore del grande Hopkins (premio Nobel per la scoperta delle vitamine), aveva portato con sé dall'Imperial College numerosi collaboratori ed una solida ricerca sull'insulina.

59. Storia Della Chimica. Frederick Sanger E La Struttura Dell'insulina (II) di questo mio racconto delle vicende legate alla determinazione http://www.minerva.unito.it/Storia/ChimicaClassica/Cromatografia/CROM6.htm

Frederick Sanger e la struttura dell'insulina (II) Tornato in Inghilterra Sanger si ritrovò al punto di partenza e si risolse a separare le due catene con i metodi collaudati della precipitazione frazionata. La frazione A, corrispondente al 'terminale' glicina risultò contenere circa 20 amminoacidi, mentre la frazione B, corrispondente all'altro 'terminale' fenilalaninico, ne conteneva circa 30. Contrariamente alle aspettative la catena B risultò di più facile soluzione, mediante l'uso abile della idrolisi acida e dell'FDNB. In effetti Sanger e i suoi inventarono e risolsero un geniale puzzle , basato sull'isolamento, l'analisi e la 'connessione' dei tanti frammenti ottenuti: venivano eseguiti dei frazionamenti preliminari (ionoforesi, cromatografia per scambio ionico, adsorbimento su carbone), poi le frazioni contenenti da 5 a 20 peptidi venivano sottoposte a cromatografia su carta bidimensionale. Le 'macchie' venivano ritagliate, il materiale eluito, sottoposto a idrolisi completa e analizzato negli aminoacidi costituenti. Vorrei fare un esempio semplice delle mosse tipiche di questo 'gioco'. In una certa frazione particolarmente acida erano presenti solo sei peptidi diversi, ciascuno dei quali conteneva acido cisteico; poiché a sua volta la catena B aveva solo due residui cisteici tutte le sequenze si dovevano ridurre a due soltanto. Due peptidi davano indicazioni immediate: Val.CySO

60. Frederick Sanger - InformationBlast frederick sanger Information Blast. frederick sanger. frederick sanger(born 1918) is a British molecular biologist who was working http://www.informationblast.com/Frederick_Sanger.html

Frederick Sanger Frederick Sanger OM (born August 13 ) is a British molecular biologist who was working on problems related to the determination of the structure of proteins . His studies resulted in the determination of the structure of insulin ; for this discovery he received Nobel Prize in Chemistry in In , he developed the chain termination method , also known as the "Sanger method." He later received another Nobel Prize in Chemistry in "for contributions concerning the determination of base sequences in nucleic acids." In 1992, the Sanger Centre in Cambridge, named after Frederick Sanger, was founded by the Wellcome Trust and the British Medical Research Council, the purpose of which is stated on their website as "to provide a major focus in the UK for mapping and sequencing the human genome, and genomes of other organisms." External links Categories: Nobel Prize in Chemistry winners Wikipedia is available under the terms of the GNU Free Documentation License

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