61. SRP cesar milstein, che scoprì la sequenzasegnale. La scoperta della sequenza segnale (cesar milstein) http://grup.bio.unipd.it/biomol2/biomolcellula/SRPintroduction.html

La scoperta della sequenza segnale e della Signal Recognition Particle (SRP) In questa parte del corso iniziamo ad analizzare il "sorting" intracellulare di proteine. Come sappiamo, la cellula eucariote è composta da molti compartimenti intracellulari, delimitati da membrana. Questo fatto ci conduce a porci diverse domande: Come fanno le proteine a localizzarsi nel giusto compartimento? A cosa servono tutti questi compartimenti? Quali sono le differenze tra i diversi eucarioti? E i procarioti hanno qualcosa di omologo? E come possiamo affrontare sperimentalmente questo settore di ricerca? Ricordiamoci che la Scienza deve sempre partire dall'osservazione e dalla descrizione oggettiva della natura: sia che si tratti dell'intero universo, di una particella subatomica o, naturalmente, di una cellula. Quindi dobbiamo prima osservare, scoprire e descrivere quello che troviamo, poi dobbiamo cercare di interpretare le osservazioni e capirne il senso, formulando ipotesi. Infine, con l'approccio sperimentale dobbiamo provare le nostre ipotesi. (Milstein et al. (1972) A possible precursor of immunoglobulin light chains. Nature New Biology 239, 117-120.)

62. Sica News.- 12/5/03 Translate this page cesar milstein Premio Nobel 1984 de Medicina por su trabajo para perfeccionarel sistema de defensa inmunológico a través del desarrollo de anticuerpos http://www.paginadigital.com.ar/articulos/2003/2003quint/tecnologia/sica20-6pl.a

Artículos Notas relacionadas Educación Cartas de Navegantes ... Imprimir SicaNews Año 4 - Número 114 20 de Junio de 2003 El Reporte Eléctrico Sumario de esta Edición: Editorial El Producto de la Semana Informaciones y Algo Más... Noticias de Nuestra Empresa ... Direcciones y Contactos Editorial Leyenda : La casa del trueno Cuentan los viejos que entre Totomoxtle y Coatzintlali existía una caverna en cuyo interior los antiguos sacerdotes habían levantado un templo dedicado al Dios del Trueno, de la lluvia y de las aguas de los ríos. Eran tiempos en los que aún no llegaban los hispanos ni las portentosas razas, conocidas hoy como totonacas, que poblaron el lugar de Veracruz que después llamaron Totonacan. Y siete sacerdotes se reunían cada tiempo en que era menester cultivar la tierra y sembrar las semillas y cosechar los frutos, siete veces invocaban a las deidades de esos tiempos y gritaban entonaban cánticos a los cuatro vientos o sea hacia los cuatro puntos cardinales, porque según las cuentas esotéricas de esos sacerdotes, cuatro por siete eran 28 y ventiocho días componen el ciclo lunar. Siguen diciendo las viejas crónicas que se han convertido en asombrosas leyendas, que esos viejos sacerdotes hacían sonar el gran tambor del trueno y arrastraban cueros secos de los animales por todo el ámbito de la caverna y lanzaban flechas encendidas al cielo. Y poco después atronaban el espacio furiosos truenos y los relámpagos cegaban a los animales de la selva y a las especies acuáticas que moraban en los ríos.

63. Sumarios Varios Catálogo de la Biblioteca Complutense de Madrid Autores milstein, cesar; Neuberger,Michael S; Staden, Rodger Revista Proceedings of the National Academy of http://europa.sim.ucm.es:8080/compludoc/AA?a=Rodger&donde=otras&zfr=0

64. Argentina: Como Somos Translate this page Para 1983, cesar milstein ya era un ciudadano y científico inglés, y había sidonombrado jefe director de la División de Química de Proteínas y Acidos http://www.surdelsur.com/somos/fuga/f_milste.htm

El Sur del Sur WEB SITE Como Somos LOS ARGENTINOS EN EL EXTERIOR Fuga de Cerebros: , provincia de Buenos Aires , el 8 de octubre de 1927 Universidad de Buenos Aires Medical Center Research de Cambridge Frederick Sanger , en 1984 por el desarrollo de los anticuerpos monoclonales Doctor Honoris Causa de la Universidad Nacional del Sur Precedente Bernardo Houssay Facultad de Medicina , miembro del Concejo Superior de la UBA , Presidente de la academia Nacional de Medicina Conicet . Obtuvo el Nobel en 1947 por su ciencia argentina Como Somos Tabla de contenidos Navegando el Sur - Todos los derechos reservados. webmaster@surdelsur.com

65. PNAS -- Abstracts: Milstein Et Al. 95 (15): 8791 Immunology Both DNA strands of antibody genes are hypermutation targets.cesar milstein * , Michael S. Neuberger, and Rodger Staden http://www.pnas.org/cgi/content/abstract/95/15/8791

Full Text of this Article PDF Version of this Article Similar articles found in: PNAS Online ISI Web of Science PubMed PubMed Citation This Article has been cited by: other online articles Search PubMed for articles by: Milstein, C. Staden, R. Search for citing articles in: ISI Web of Science (60) Alert me when: new articles cite this article Download to Citation Manager Vol. 95, Issue 15, 8791-8794, July 21, 1998 Immunology Both DNA strands of antibody genes are hypermutation targets Cesar Milstein Michael S. Neuberger, and Rodger Staden Medical Research Council Laboratory of Molecular Biology, MRC Centre, Hills Road, Cambridge CB2 2QH, United Kingdom During the maturation of the immune response, antibody genes are subjected to localized hypermutation. Mutations are not evenly distributed along the V gene; intrinsic hot spots exist that are correlated with primary sequence motifs. Although the mechanism of hypermutation remains unknown, it has been proposed to exhibit DNA strand polarity because purine residues on the coding strand are more frequently targeted for mutation than pyrimidines. However

66. Am Ha-Aretz / עם הארץ: Jewish Nobel Prize Wi metabolism USA 1985 Goldstein, Joseph L. for their discoveries concerning theregulation of cholesterol metabolism USA 1984 milstein, cesar for theories http://www.amhaaretz.com/2004/02/jewish_nobel_prize_winners.html

Judaism of the masses (the blog) Main February 08, 2004 Jewish Nobel Prize winners [ Israel Israel Science and Technology lists all the Jewish Nobel Prize laureates up to 2003. Though the list does not include prizes in Peace, according to another list , eight Jews won a prize in this category. Thus, according to these lists, a total of 149 Jews won the Nobel Prize. Here are the latest Jewish winners in each category: Physics Vitaly L. Ginzburg (2003): "for pioneering contributions to the theory of superconductors and superfluids". Chemistry Alan J. Heeger (2000): "for the discovery and development of conductive polymers". Physiology or Medicine Sydney Brenner and H. Robert Horvitz (2002) : "for their discoveries concerning 'genetic regulation of organ development and programmed cell death'". Literature Imre Kertész (2002): "for writing that upholds the fragile experience of the individual against the barbaric arbitrariness of history". Peace Shimon Peres and Yitzhak Rabin (1994): "for their efforts to create peace in the Middle East". Economic Sciences Daniel Kahneman (2002): "for having integrated insights from psychological research into economic science, especially concerning human judgment and decision-making under uncertainty".

67. Asociación Medica Argentina, Asociacion Medica Argentina Translate this page 5411 - 4814-2182. Usted está en Publicaciones Revistas. Volver.Académico Honorario Dr. cesar milstein. Su fallecimiento. La vida y http://www.ama-med.org.ar/publicaciones_revistas3.asp?id=34

68. SYDNEY MORNING HERALD OBITUARIES 09JAN1998 P17. MILNER,Christopher. Physicist. 19121998. 14MAR1998 P16. milstein,cesar.Scientist. 1927-2002. 08APR2002 P38. MINALE,Marcello. Designer. 1938-2000. http://www.rootsweb.com/~nswsdps/obits/smhom004.htm

THE RYERSON INDEX SYDNEY MORNING HERALD OBITUARIES Ryerson Index Home Page NAME OCCUPATION LIFE SPAN PUBLISHED MILLER,Edward Oehler (Rev.) US priest MILLER,Franklin Vietnam hero MILLER,Ingeborg (Inge) Photographer MILLER,James Cameraman MILLER,Jason Playwright and actor MILLER,Jim Dick Pearl Harbour survivor MILLER,Julia Film producer and author MILLER,Lily May Countess of Galloway MILLER,Mick Aboriginal Leader MILLIGAN,Terence Alan ("Spike") Comedian and author MILLS,Roy (Dr) Doctor,physician MILNE,George Hotelier MILNER,Christopher Physicist MILSTEIN,Cesar Scientist MINALE,Marcello Designer MINASSIAN,Armen MINCHIN,Helen Patricia Actress,broadcaster,beauty MIRALLES,Enric Architect MIRAMS,Roger Television producer MIRZAIAN,Aramais Armenian Priest MITCHELL,Barry Actor MITCHELL,Bessie Headmistress MITCHELL,Elma Poet MITCHELL,Francis Edward Dressmaker,character MITCHELL,Guy Singer MITCHELL,Isabella ("Pat") Wife of Forbes-Semphill MITCHELL,James Writer MITCHELL,Jean Fair Headmistress MITCHELL,Ken Special educator MITCHELL,Roma Flinders (Dame) Outstanding legal figure MITCHELL,Ruth

69. Biocompare - Looking For An Antibody? In 1975, George Kohler and cesar milstein developed a technology that allowed scientiststo generate unlimited quantities of antibodies all specific for one http://www.biocompare.com/spotlight.asp?id=123

70. BBC News | SCI/TECH | British Science Mourns Research Great Dr cesar milstein, whose work sparked an international billionpoundbiotechnology industry has died aged 74. http://news.bbc.co.uk/hi/english/sci/tech/newsid_1893000/1893932.stm

CATEGORIES TV RADIO COMMUNICATE ... INDEX SEARCH You are in: Sci/Tech Front Page World UK ... AudioVideo SERVICES Daily E-mail News Ticker Mobiles/PDAs Feedback ... Low Graphics Tuesday, 26 March, 2002, 09:04 GMT British science mourns research great Dr Cesar Milstein, one of the great post-war figures in British science, has died. He was 74. The researcher, who was born in Argentina, won the Nobel Prize for Medicine in 1984 for his pioneering work on the immune system. An outstanding contribution to Britain's science, health and wealth creation Prof Sir George Radda, MRC With Dr Georges Kohler, he found a way to make any required antibody in pure form, in the test tube. Although these monoclonal antibodies, as they are termed, have not quite lived up to the hype that once dubbed them "magic bullets", they have nonetheless found wide usage in medicine - from treating cancer and transplant rejection to diagnosing Aids and pregnancy. Dr Milstein died at Addenbrooke's Hospital in Cambridge on Sunday. The cause of death was not announced. 'Sorely missed' He will be remembered as key figure in the hothouse of scientific talent established in Cambridge at the Laboratory of Molecular Biology.

71. BBC News | SCI/TECH | Scientists Salute 25-year-old Discovery It is 25 years ago this summer that Cambridge researchers Drs cesar milstein andGeorge Kohler found a way to make any required antibody in pure form, in the http://news.bbc.co.uk/hi/english/sci/tech/newsid_833000/833042.stm

low graphics version feedback help You are in: Sci/Tech Front Page World UK ... AudioVideo Friday, 14 July, 2000, 02:09 GMT 03:09 UK Scientists salute 25-year-old discovery Specificity: A model of a monoclonal antibody By BBC News Online's John Newell Scientists have gathered in London to celebrate one of the great discoveries in modern medicine - monoclonal antibodies. It is 25 years ago this summer that Cambridge researchers Drs Cesar Milstein and George Kohler found a way to make any required antibody in pure form, in the test tube. It was a breakthrough that has brought science within touching distance of a "magic bullet" - a tailored weapon that can home in and destroy the causes of disease. Monoclonal antibodies still have some way to go to fulfil this dream but their obvious potential was sufficient to earn Milstein and Kohler a Nobel Prize in 1984. The UK's Medical Research Council, which funds the lab where the men did their pioneering work, paid its own tribute on Thursday by honouring Dr Milstein with its first Millennium Medal for outstanding scientific achievement. Sadly, Dr Kohler could not share the award - he died in 1995 aged just 49.

72. Roche In Deutschland - News Translate this page 1982 cesar milstein Georges JF Köhler Entwickelten eine Methode der Zellverschmelzungvon Antikörper produzierenden Lymphzellen mit Myelomzellen in vitro http://www.roche.de/presse/molbio_preis.htm

Home - Presse Preis Molecular Bioanalytics Hintergrund -informationen/ Pressemappe Fotos Preisverleihung Professor Sir Edwin Mellor Southern Stephen P. A. Fodor, Ph.D. Professor Andrei D. Mirzabekov Richard P. Haugland Lubert Stryer Franz Hillenkamp Michael Karas Arthur B. Pardee Peng Liang Mario R. Capecchi Rudolf Jaenisch David C. Ward Jeanne B. Lawrence Karry B. Mullis Henry A. Erlich David D. Schwartz Charles A. Cantor Alec J. Jeffreys Brigitte Wittmann-Liebold Michael W. Hunkapiller Leroy Hood Edwin M. Southern Cesar Milstein Walter Gilbert Allan M. Maxam Frederick Sanger Alan R. Coulson Jerker Porath Shmuel Shaltiel Eva Engvall Peter Perlmann Antonius H.W.M. Schuurs Bauke Klaas van Weemen Hans Massmann Norman G. Anderson Entwickelte das GeMSAEC-Schnell-Analysen-System (General Medical Sciences Atomic Energy Commission). Eric A. Newsholme Letzte Aktualisierung:

73. Welcome To Adobe GoLive 5 The 3rd Georges Koehler Lecture. Date, 18.01.1999. Speaker, cesar milstein.Title Hypermutation and the maturation of the immune response. http://www.immunbio.mpg.de/groups/reth/links/g_koehler/gkl_pages/gkl_3.html

Department of Molecular Immunology home research teaching members ... whats new The 3rd Georges Koehler Lecture Date Speaker Cesar Milstein Title: Hypermutation and the maturation of the immune response home research teaching members ... whats new last modified:

74. CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS cesar milstein se otorga por primera vez este año y será destinadoa los investigadores doctores Gabriel Rabinovich, José Mordoh, Osvaldo http://www.conicet.gov.ar/NOTICIAS/2002/octubre/premios_Dr_Housay.php

75. Detalle De La Noticia Translate this page EL 7 de agosto de 1975, dos científicos de Cambridge, cesar milstein y GeorgesKohler, publicaron los primeros datos sobre lo que se ha considerado el mayor http://www.ukinspain.com/NewsSC/UKSC_NEWS_detail.asp?IdNews=1759

76. Nat'l Academies Press, Biotechnology Unzipped: (1997), Index materialism 55 , 60 Medawar, Peter 57 58, 222 Mendel, Gregor 6 , 8 -9, 28 micropropagation182 -185, 183 Miescher, Johann 12 , 28 milstein, cesar 48 molecules http://books.nap.edu/openbook/0309057779/html/240.html

Read more than 3,000 books online FREE! More than 900 PDFs now available for sale HOME ABOUT NAP CONTACT NAP HELP ... ORDERING INFO Items in cart [0] TRY OUR SPECIAL DISCOVERY ENGINE Questions? Call 800-624-6242 Biotechnology Unzipped: Promises and Realities Joseph Henry Press ( JHP The views expressed in this book are solely those of the author(s) and do not necessarily reflect the views of the National Academies. CHAPTER SELECTOR: Openbook Linked Table of Contents Front Matter, pp. i-iv Contents, pp. v-x Preface, pp. xi-xvi Chapter 1: How Biotechnology Came About, pp. 1-30 Chapter 2: Tools in the Genetic Engineering Workshop, pp. 31-54 Chapter 3: Biotechnology and the Body, pp. 55-96 Chapter 4: Biotechnology on the Farm, pp. 97-132 Chapter 5: Biotechnology and the Environment, pp. 133-160 Chapter 6: Biotechnology in Seas and Trees, pp. 161-190 Chapter 7: Ethical Issues, pp. 191-224 Postscript, pp. 225-230 Glossary, pp. 231-234 Further Reading, pp. 235-237 Internet Resources, pp. 238-239 Index, pp. 240-247 GO TO PAGE: TABLE OF CONTENTS PAGE PRINTABLE PDF PAGE CHAPTER PAGE SEARCH THIS BOOK: The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the

77. Sciforums.com - Jewish Laureates Of Nobel Prizes factors Italy 1985 Goldstein, Joseph L. for their discoveries concerning theregulation of cholesterol metabolism USA 1984 milstein, cesar for theories http://www.sciforums.com/showthread.php?t=3820

78. César Milstein - Autobiography César milstein – Autobiography. My father was Philadelphia, USA(1984). From Les Prix Nobel 1984. César milstein died in 2002. http://www.nobel.se/medicine/laureates/1984/milstein-autobio.html

My father was a Jewish immigrant who settled in Argentina, and was left to his own devices at the age of 15. My mother was a teacher, herself the daughter of a poor immigrant family. For both my mother and my father, no sacrifice was too hard to make sure that their three sons (I was the middle one) would go to university. I wasn't a particularly brilliant student, but on the other hand I was very active in Student Union affairs and in student politics. It was in this way that I met my wife, Celia. After graduation, we married, and took a full year off in a most unusual and romantic honeymoon, hitch-hiking our way through most countries in Europe, including a couple of months working in Israel kibbutzim. As we returned to Argentina, I started seriously to work towards a doctoral degree under the direction of Professor Stoppani, the Professor of Biochemistry at the Medical School . My PhD thesis work was done with no economic support. Both Celia and I worked part-time doing clinical biochemistry, between us earning just enough to keep us going. My thesis was on kinetics studies with the enzyme aldehyde dehydrogenase. When that was finished, I was granted a British Council Fellowship to work under the supervision of Malcolm Dixon. There, in the Department of Biochemistry at the University of Cambridge , I started a project on the mechanism of metal activation of the enzyme phosphoglucomutase. It was through that enzyme that I started to collaborate with

79. César Milstein (1927 - ) César milstein (1927 ) Born in Bahía Blanca, Argentina, César milstein graduated from Buenos Aires University with an undergraduate degree in chemistry in 1945. http://www.accessexcellence.org/AB/BC/Cesar_Milstein.html

Milstein conducted groundbreaking work into the synthesis of antibodies, proteins that are produced by the cells of the immune system in response to attacks by foreign bodies called antigens. His work was instrumental in the development of monoclonal antibody technology . By fusing antibody-producing B lymphocyte cells with tumor cells that are "immortal," his lab was able to produce a "hybridoma," which could continuously synthesize antibodies. All of the antibodies produced by this type of hybridoma cell were identical, the same as those produced by the B cell before it was fused. Because the antibodies that are produced by this process all come from a single clone of hybridoma cells, they are called monoclonal antibodies. This technique of monoclonal antibody production, developed in 1975 with Georges Kohler, has been used extensively in the commercial development of new drugs and diagnostic tests. For his efforts, Milstein was awarded the Nobel Prize for Physiology or Medicine with Georges Kohler and Niels Jerne in 1984. Go to next profile: Kary B. Mullis

80. Milstein, César milstein, César. ( b. Oct. 8, 1926, Bahía Blanca, Arg milstein and Köhler, who was at Cambridge on a fellowship, made their discovery of the technique for producing http://www.britannica.com/nobel/micro/394_71.html

and Niels K. Jerne , received the Nobel Prize for Physiology or Medicine for his work in the development of monoclonal antibodies. Milstein attended the universities of Buenos Aires and Cambridge (Ph.D., 1960) and was on the staff of the National Institute of Microbiology in Buenos Aires (1957-63). Thereafter he was a member of the Medical Research Council Laboratory of Molecular Biology, Cambridge, Eng., and held dual Argentine and British citizenship. the cells of a myeloma, a type of tumour that can be made to reproduce indefinitely. The resulting hybrid cells retained the two desired properties: like the lymphocytes, they secreted a single species of antibody molecules, and, like myeloma cells, they perpetuated themselves, providing potentially unlimited amounts of any desired antibody. This technique enabled the production of large quantities of pure, uniform antibodies that are able to recognize single antigenic determinants ( i.e., a single characteristic of a particular microbial invader in the body). ( See also antibody In 1994 Milstein was made a Companion of Honour.

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