1. Research Grant Awardees 1994 (Molecular) krebs edwin g. Dept. of Pharmacology Biochemistry, University ofWashington, Seattle USA Margolis Robert L. Institut de Biologie http://www.hfsp.org/awardees/AwardsRGM1994.htm

@import "/style/hfsp.css"; June 5, 2004 Home About HFSP How to Apply Awardees ... For Awardees Only AWARD YEAR 1994 - "Molecular" Research Grants The awards are listed alphabetically by principal applicant. You can use your browser's "find" function to locate specific keywords on this page. Return to Grant Awardees top page Cogdell Richard J. Dept. of Botany, University of Glasgow UK Lugtenburg Johan Dept. of Organic Chemistry, University of Leiden THE NETHERLANDS Koyama Yasushi Faculty of Science, Kwansei Gakuin University, Nishinomiya JAPAN Gillbro Tomas Dept. of Physical Chemistry, University of Umea SWEDEN Frank Harry Dept. of Chemistry, University of Connecticut, Storrs USA The molecular mechanisms of how carotenoids function in photosynthesis. Delidakis Christos GREECE Stifani Stefano Montreal Neurological Institute, McGill University, Montreal CANADA Artavanis-Tsakonas Spyridon Dept. of Cell Biology, Howard Hughes Medical Institute, New Haven USA Functions of the signalling proteins of the E(spl)-C in Drosophilia and mammals. Gergen J. Peter

2. Edwin G. Krebs - Autobiography edwin G. krebs – Autobiography. I was born in Lansing, Iowa on June6, 1918, the third of the four children of William Carl krebs http://www.nobel.se/medicine/laureates/1992/krebs-autobio.html

In the period from 1933 to 1940 in Urbana I completed the last three years of high school and carried out undergraduate work at the University of Illinois Urbana High School In 1936, I entered the University of Illinois with the idea of majoring in some branch of science related to chemistry, but I did not have a very clear idea of where I was headed. Taking advantage of an "individual curriculum" program that was available to those with reasonably good scholastic records - and for this reason presumably knew where they were going - I was relieved of the necessity of meeting many specific requirements and could pick and choose courses that I wanted. In this way I was able to take enough biology to meet premedical requirements but could also take the math, chemistry, and physics courses designed for professionals in these fields. By the beginning of my fourth year in college, I had narrowed my choices either to getting an advanced degree in organic chemistry or going to medical school. For the latter financial help would be required. This became available in the form of a scholarship to attend Washington University School of Medicine in St. Louis. At this point I assumed that the agony of indecision was over and my future was now defined. I would become a physician.

3. UW Dept Of Pharmacology--Dr. Edwin G. Krebs Emeritus Professor of Pharmacology and Biochemistry. Protein Phosphorylation and Signaling. This laboratory is concerned with the mechanisms involved in the intracellular transmission of hormone and http://depts.washington.edu/phcol/fac/krebs.html

FACULTY RESEARCH Faculty Research Research Groups ... Research Dr. Edwin G. Krebs Emeritus Professor of Pharmacology and Biochemistry Protein Phosphorylation and Signaling This laboratory is concerned with the mechanisms involved in the intra-cellular transmission of hormone and growth factor signals. Of particular interest are mechanisms that involve the phosphorylation and dephosphorylation of proteins. One specific area of research addresses the question of how growth factor receptors possessing protein tyrosine kinase activity, e.g. the insulin, epidermal growth factor, and the platelet-derived growth factor receptors, regulate the phosphorylation of cellular proteins on serine or threonine residues. How is this latter category of protein phosphorylation/dephosphorylation related to changes in cell functions? The laboratory is also interested in the mechanisms that are involved in programmed cell death or apoptosis. Through identification of the specific protein kinases involved in apoptosis it is hoped that some light can be shed on this process. Publications Graves JD, Gotoh Y, Draves KE, Ambrose D, Chernoff J, Clark EA, and Krebs EG. (1998) Caspase-mediated activation and induction of apoptosis by the mammalian Ste-20-like kinase Mst1.

4. Edmond H. Fischer 1920 - Edwin G. Krebs 1918 Proteins are involved in most cell functions, and in most body functions such as digestion and movement. Because of proteins' important and varied functions, they are closely regulated by the body through enzymes. returning to internal medicine." edwin G. krebs, Les Prix Nobel, 1992. edwin G. krebs, born in Lansing http://history.nih.gov/exhibits/rodbell/1_Fischer_Krebs.htm

P roteins are involved in most cell functions, and in most body functions such as digestion and movement. Because of proteins ' important and varied functions, they are closely regulated by the body through enzymes . The enzymes fine tune the working of a protein by attaching one or more phosphate groups to it. This is called "phosphorylation." Fischer and Krebs first purified and described an enzyme which regulates proteins by removing phosphate groups from the protein-"reversible protein phosphorylation." They did this by studying how muscles get energy to contract. Reversible protein phosphorylation affects nearly all bodily processes such as blood pressure, brain signals, and immune responses to several diseases, including cancer. For information about Fischer and Krebs' work, see www.nobel.se/medicine/laureates/1992/press.html

5. Krebs, Edwin. The Columbia Encyclopedia, Sixth Edition. 2001 Frost, R. Hopkins, G.M. Keats, J. Lawrence, D.H The Columbia Encyclopedia, Sixth Edition. 2001. krebs, edwin http://www.bartleby.com/65/kr/Krebs-Ed.html

Select Search All Bartleby.com All Reference Columbia Encyclopedia World History Encyclopedia Cultural Literacy World Factbook Columbia Gazetteer American Heritage Coll. Dictionary Roget's Thesauri Roget's II: Thesaurus Roget's Int'l Thesaurus Quotations Bartlett's Quotations Columbia Quotations Simpson's Quotations Respectfully Quoted English Usage Modern Usage American English Fowler's King's English Strunk's Style Mencken's Language Cambridge History The King James Bible Oxford Shakespeare Gray's Anatomy Farmer's Cookbook Post's Etiquette Bulfinch's Mythology Frazer's Golden Bough All Verse Anthologies Dickinson, E. Eliot, T.S. Frost, R. Hopkins, G.M. Keats, J. Lawrence, D.H. Masters, E.L. Sandburg, C. Sassoon, S. Whitman, W. Wordsworth, W. Yeats, W.B. All Nonfiction Harvard Classics American Essays Einstein's Relativity Grant, U.S. Roosevelt, T. Wells's History Presidential Inaugurals All Fiction Shelf of Fiction Ghost Stories Short Stories Shaw, G.B. Stein, G. Stevenson, R.L. Wells, H.G. Reference Columbia Encyclopedia PREVIOUS NEXT ... BIBLIOGRAPHIC RECORD The Columbia Encyclopedia, Sixth Edition. Krebs, Edwin

6. Edwin G. Krebs Winner Of The 1992 Nobel Prize In Medicine edwin G. krebs, a Nobel Prize Laureate in Physiology and Medicine, at the Nobel Prize Internet Archive. edwin G. krebs. 1992 Nobel Laureate in Medicine http://www.almaz.com/nobel/medicine/1992b.html

E DWIN G K REBS 1992 Nobel Laureate in Medicine for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism. Background Born: 1918 Residence: U.S.A. Affiliation: University of Washington, Seattle WA Featured Internet Links Prize co-recipient: Edmond H. Fischer Search WWW Search The Nobel Prize Internet Archive Links added by Nobel Internet Archive visitors Winner of The Gairdner Foundation Int'l Award Back to The Nobel Prize Internet Archive Literature Peace ... Medicine We always welcome your feedback and comments

7. Medicine 1992 Edmond H. Fischer, edwin G. krebs. 1/2 of the prize, 1/2 of the prize. edwinG. krebs Autobiography Nobel Lecture Other Resources. prev 1991, 1993 next. http://www.nobel.se/medicine/laureates/1992/

The Nobel Prize in Physiology or Medicine 1992 "for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism" Edmond H. Fischer Edwin G. Krebs 1/2 of the prize 1/2 of the prize Switzerland and USA USA University of Washington Seattle, WA, USA University of Washington Seattle, WA, USA b. 1920 (in Shanghai, China) b. 1918 The Nobel Prize in Physiology or Medicine 1992 Press Release Presentation Speech Illustrated Presentation ... Other Resources The 1992 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: SITE FEEDBACK CONTACT TELL A FRIEND Last modified June 16, 2000 The Official Web Site of The Nobel Foundation

8. Edwin G. Krebs Winner Of The 1992 Nobel Prize In Medicine edwin G. krebs, a Nobel Prize Laureate in Physiology and Medicine, at the NobelPrize Internet Archive. edwin G. krebs. 1992 Nobel Laureate in Medicine http://almaz.com/nobel/medicine/1992b.html

E DWIN G K REBS 1992 Nobel Laureate in Medicine for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism. Background Born: 1918 Residence: U.S.A. Affiliation: University of Washington, Seattle WA Featured Internet Links Prize co-recipient: Edmond H. Fischer Search WWW Search The Nobel Prize Internet Archive Links added by Nobel Internet Archive visitors Winner of The Gairdner Foundation Int'l Award Back to The Nobel Prize Internet Archive Literature Peace ... Medicine We always welcome your feedback and comments

9. Index Of Nobel Laureates In Medicine Koehler, Georges JF, 1984. Kornberg, Arthur, 1959. Kossel, Albrecht, 1910. krebs,edwin G. 1992. krebs, Sir Hans Adolf, 1953. Krogh, Schack August Steenberger, 1920. http://almaz.com/nobel/medicine/alpha.html

ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE Name Year Awarded Adrian, Lord Edgar Douglas Arber, Werner Axelrod, Julius Baltimore, David ... Medicine We always welcome your feedback and comments

10. University Of Washington Department Of Biochemistry Faculty - Edwin Krebs edwin krebs. Professor Emeritus. Faculty Research. New Faculty Positions. Graduate Program. Courses Course Websites. New Course Listings. Seminars. Directories. Nobel Laureates. Yeast Resource Center. DNA Sequencing Facility. General Information Fischer, E.H. and krebs, E.G., J. Biol. Chem http://depts.washington.edu/biowww/directories/faculty/krebs.html

Edwin Krebs Professor Emeritus Faculty Research New Faculty Positions Graduate Program New Course Listings Seminars Directories Nobel Laureates Yeast Resource Center ... Home Department of Biochemistry Box 357350 University of Washington Seattle, WA 98195 Telephone: 206-543-1660 FAX: 206-685-1792 Selected Publications "FGF, but not activin, activates mitogen-activated protein kinase in Xenopus explants", Graves, L.M., Northrop, J.L., Potts, B.C., Krebs, E.G. and Kimelman, D., Proc. Natl. Acad. Sci. USA, 91, 1662 (1993). "Overexpression of mitogen-actvated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells", Seger, R., Seger, D., Reszka, A., Munar, E.S., Eldar-Finkelman, H., Dobrowolska, G., Jensen, A.M., Campbell, J.S., Fischer, E.H. and Krebs, E.G., J. Biol. Chem., 269, 25699 (1994). "Inactivation of glycogen synthase kinase-3 by EGF is mediated by RSK-MAPK signaling pathway in NIH/3T3 cells", Eldar-Finkelman, H., Seger, R., Vandenheede, J.R., and Krebs, E.G., J. Biol. Chem., 270, 987 (1995). "Differential activation of mitogen-activated protein kinase in response to basic fibroblast growth factor in skeletal muscle cells", Campbell, J.S., Wenderoth, M.P., Hauschka, S.D., and Krebs, E.G., Proc. Natl. Acad. Sci. USA,92, 870 (1995).

11. EDWIN G edwin G. krebs, M.D. Dr. krebs laboratory works in the general area of growth factor signaling mechanisms http://www.pathology.washington.edu/labs/schwartz/cvp/cvp/Investigators_files/kr

12. Annual Krebs Lecture The edwin G. krebs Lectureship in Molecular Pharmacology. The SeventeenthAnnual edwin G. krebs Lecture in Molecular Pharmacology http://depts.washington.edu/phcol/cal/krebslec.html

Events Seminars Journal Club Annual Krebs Lecture Annual Retreat The Edwin G. Krebs Lectureship in Molecular Pharmacology The Seventeenth Annual Edwin G. Krebs Lecture in Molecular Pharmacology Sponsored by an endowment from Sterling Winthrop, Inc. The Control of Cell Cycle Transitions by: Tim Hunt, Ph.D. Principal Scientist, Cancer Research UK, Clare Hall Laboratories Tuesday, May 11, 2004 3:30 PM, Room T-625 HSC more information >> About the Lectureship The goal of research in molecular pharmacology is to understand the action of hormones and drugs on the molecular components of their target cells. Dr. Edwin G. Krebs Nobel Prize for Physiology or Medicine in 1992. During his outstanding career, Dr. Krebs has been Professor of Biochemistry at the University of Washington and Professor and Chairman of the Department of Biological Chemistry at the University of California, Davis from 1968 to 1977. As the second Chairman of the Department of Pharmacology at the University of Washington, from 1977 to 1984, Dr. Krebs led a major expansion of research in molecular pharmacology at this university. The Edwin G. Krebs Lectureship in Molecular Pharmacology is intended to recognize Dr. Krebs' major achievements in research and administration in the field of molecular pharmacology and to stimulate at the University further development of this area of excellence. List of Annual Lectures Seminars Journal Club Annual Krebs Lecture ... Annual Retreat

13. Krebs, Edwin Gerhard krebs, edwin Gerhard. ( b. June 6, 1918, Lansing, Iowa, U.S.), American biochemist, winner with Edmond H. Fischer of the 1992 Nobel Prize for Physiology or Medicine. krebs received a medical degree from Washington University (St During the 1950s krebs and Edmond Fischer began investigating the http://www.britannica.com/nobel/micro/329_3.html

Krebs, Edwin Gerhard (b. June 6, 1918, Lansing, Iowa, U.S.), American biochemist, winner with Edmond H. Fischer of the 1992 Nobel Prize for Physiology or Medicine . They discovered reversible protein phosphorylation, a biochemical process that regulates the activities of proteins in cells and thus governs countless processes that are necessary for life. Krebs received a medical degree from Washington University (St. Louis, Mo.) in 1943. From 1946 to 1948 he did research there under the biochemists Carl and Gerty Cori. In 1948 he joined the faculty of biochemistry at the University of Washington, Seattle, becoming full professor in 1957. In 1968 he moved to the University of California at Davis, returning to Washington University in 1977. During the 1950s Krebs and Edmond Fischer began investigating the process by which muscle cells obtain energy from glycogen (the form in which the body stores sugar). The Coris had previously demonstrated that cells use an enzyme called phosphorylase to release glucose (the source of energy in cell function) from glycogen. Krebs and Fischer showed that phosphorylase could be converted from an inactive to an active form by the addition of a phosphate group taken from the compound adenosine triphosphate (ATP). The enzymes that catalyze this process are called protein kinases. Krebs and Fischer also showed that phosphorylase is inactivated by the removal of a phosphate group; this process is catalyzed by enzymes called phosphatases. Malfunctions in protein phosphorylation have been implicated in the causation of diseases such as diabetes, cancer, and Alzheimer's disease.

14. MSN Encarta - Krebs, Edwin G. krebs, edwin G. krebs, edwin G. (1918 ), American biochemist and Nobel Prizewinner, born in Lansing, Iowa. Find more about krebs, edwin G. from, http://encarta.msn.com/encyclopedia_761582611/Krebs_Edwin_G.html

MSN Home My MSN Hotmail Shopping ... Money Web Search: logoImg('http://sc.msn.com'); Encarta Subscriber Sign In Help Home ... Upgrade to Encarta Premium Search Encarta Subscription Article MSN Encarta Premium: Get this article, plus 60,000 other articles, an interactive atlas, dictionaries, thesaurus, articles from 100 leading magazines, homework tools, daily math help and more for $4.95/month or $29.95/year (plus applicable taxes.) Learn more. This article is exclusively available for MSN Encarta Premium Subscribers. Already a subscriber? Sign in above. Krebs, Edwin G. Krebs, Edwin G. (1918- ), American biochemist and Nobel Prize winner, born in Lansing, Iowa. Krebs received an M.D. degree from the University of... Related Items work with Edmond H. Fischer Multimedia Selected Web Links Edwin G. Krebs [Nobel Foundation] 1 item Want more Encarta? Become a subscriber today and gain access to: Daily Math Help Literature Guides Researcher Tools Paper-Writing Guides 60,000 + articles Interactive Atlas Magazine Center Find more about Krebs, Edwin G.

15. MSN Encarta - Related Items - Physiology Kossel, Albrecht. krebs, edwin G. krebs, edwin G. – Fischer, Edmond H. krebs,Sir Hans Adolf. Krogh, (Schack) Augustus Steenberg. Landsteiner, Karl. http://encarta.msn.com/related_761577323_9/Nobel_Prize_in_physiology_or_medicine

var fSendSelectEvents = true; var fSendExpandCollapseEvents = true; var fCallDisplayUAText = false; MSN Home My MSN Hotmail Shopping ... Money Web Search: logoImg('http://sc.msn.com'); Encarta Subscriber Sign In Help Home ... Upgrade to Encarta Premium Search Encarta Related Items from Encarta Physiology Anatomy, structure of living things see also Comparative Anatomy William Harvey, English founder of physiology ... Feedback

16. National Academy Of Sciences - Members krebs, edwin G. University of Washington. Elected to NAS 1973. ScientificDiscipline Physiology and Pharmacology. Membership Type Member. http://www4.nationalacademies.org/nas/naspub.nsf/(urllinks)/NAS-58N47T?opendocum

17. National Academy Of Sciences Ignarro, Louis J. Jan, Lily Y. Karlin, Arthur. Kaziro, Yoshito. krebs, edwin G.Latorre, Ramon. Leeman, Susan E. MacLennan, David H. McCann, SM. Murad, Ferid. http://www4.nationalacademies.org/nas/naspub.nsf/urllinks/$$Section23?OpenDocume

18. Edmond H. Fischer 1920 And Edwin G. Krebs 1918 For more information about Fischer, see www.nobel.se/medicine/laureates/1992/fischerautobio.html.edwin G. krebs I became http://history.nih.gov/exhibits/rodbell/text/1_Fischer_Krebs.htm

Home The Nobel Prize and Hormones A Knowledge Revolution The First Step : Isolating Single Cells Robdell's Inspiration : Sutherland's Second Messenger A New Model for Message Transmission : Discovering the Role of GTP A Far-ranging Impact Cholera Inherited Night Blindness McCune Albrights Syndrome ... Acknowledgement Edmond H. Fischer: P roteins are involved in most cell functions, and in most body functions such as digestion and movement. Because of proteins' important and varied functions, they are closely regulated by the body through enzymes. The enzymes fine tune the working of a protein by attaching one or more phosphate groups to it. This is called "phosphorylation." Fischer and Krebs first purified and described an enzyme which regulates proteins by removing phosphate groups from the protein-"reversible protein phosphorylation." They did this by studying how muscles get energy to contract. Reversible protein phosphorylation affects nearly all bodily processes such as blood pressure, brain signals, and immune responses to several diseases, including cancer. For information about Fischer and Krebs' work, see www.nobel.se/medicine/laureates/1992/press.html

19. Edwin G. Krebs Translate this page Nobelpreis fuer Medizin 1992 (Nobel Prize Medicine 1992)edwin G. krebs, amerik. Biochemiker, geb. 6. Juni 1918. http://www.zuta.de/npmed/krebse.htm

Nobelpreis fuer Medizin 1992 (Nobel Prize Medicine 1992) Edwin G. Krebs, amerik. Biochemiker, geb. 6. Juni 1918 (links: Edmond H. Fischer)

20. Krebs krebs, edwin G. (szül. 1918. jún. 6. Lansing, Iowa, USA), amerikai biokémikus,a megfordítható fehérjefoszforiláció felfedezéséért http://www.mezgazd-koszeg.sulinet.hu/kemia/DATA/Tudosok/data/bh3/krebs.html

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