81. Genome Biology | Research News The newly discovered molecular switch the riboswitch involves an RNA moleculewith enzymatic activity the ribozyme, explained thomas R. cech, from the http://genomebiology.com/researchnews/default.asp?arx_id=gb-spotlight-20040319-0

82. Ribosomes Reveal Their RNA Secrets: Science News Online, Aug. 12, 2000 It s just RNA at the center, comments thomas R. cech, president of the HowardHughes Medical Institute in Chevy Chase, Md. That s pretty exciting. . http://www.sciencenews.org/20000812/fob1.asp

Math Trek Art of the Grid Food for Thought Science Safari Chip Collection TimeLine 70 Years Ago in Science News Week of Aug. 12, 2000; Vol. 158, No. 7 , p. 100 Ribosomes Reveal Their RNA Secrets Jessica Gorman Ribosomes, the cell's protein factories, have been tough targets for researchers aiming to see them close up. Now, for the first time on the atomic scale, scientists know what most of the ribosome looks like. The large ribosomal subunit shows RNA (gray), proteins (gold), and a molecule in the active site (green at center). Nenad Ban et a l./ Science A new map reveals most of the structures of the two RNA molecules and 31 proteins that make up the larger of the two subunits of a bacterial ribosome. The map suggests where and how the ribosome chemically stitches amino acids into a protein. The new details confirm suspicions that ribosomes' RNA molecules, and not their proteins, make peptides. That result adds to evidence that an RNA-based biochemistry preceded today's DNA-based biology (SN: 8/10/96, p. 93). The results also will help researchers tease out further details of the ribosome's structure and function, information that may be useful in the design of new antibiotics. For decades, the ribosome's unwieldy size has made it a challenge to study. Yet in recent years, researchers around the world have produced maps of increasingly higher resolution using a battery of tools—X-ray crystallography, electron microscopy, and computers.

83. The Real Moment Of Science Episode Guide Seventeen Catalysis, Chemical, and Biochemical, Part I, Dr. thomas R. cech.Eighteen Catalysis, Chemical, and Biochemical, Part II, Dr. thomas R. cech. http://casa.colorado.edu/~kachun/mos/epguide.html

The Real Moment of Science Episode Guide: Episode Subject Guest One: Life on Mars Dr. Bruce Jakosky Two: Black Holes Dr. Mitch Begelman Three: Chaos Dr. John Cary Four: Arithmetic, Population, and Energy, Part I Dr. Albert Bartlett Five: Arithmetic, Population, and Energy, Part II Dr. Albert Bartlett Six: Arithmetic, Population, and Energy, Part III Dr. Albert Bartlett Eight: Arithmetic, Population, and Energy, Part IV, LIVE Dr. Albert Bartlett Seven: Microbes! Dr. Steve Schmidt Nine: Bose-Einstein Condensate, Part I Dr. Carl Wieman Ten: Bose-Einstein Condensate, Part II Dr. Carl Wieman Eleven: Venus Revealed Dr. David Grinspoon Twelve: Ozone Depletion Dr. Susan Solomon Thirteen: Evolution Dr. Michael Grant Fourteen: Airborne Astronomy and Galapagos Tortoises , a talk on Science Education John Keller Fifteen: Forensic Anthropology Katherine Hoff Sixteen: Comet Hale-Bopp Mary Urquhart and Niescja Turner Seventeen: Catalysis, Chemical, and Biochemical, Part I

84. Biochem. Soc. Trans (2002) 30, 1162-1166 - R. Cech - Ribozymes And RNA Catalysis Xray crystallography. Abbreviation used IGS, internal guide sequence.1 E-mail thomas.cech@colorado.edu. Abstract. In 1982 we reported http://www.biochemsoctrans.org/bst/030/bst0301162.htm

About the journal Subscriptions Authors Users ... Download to Citation Matcher Biochem. Soc. Trans. (2001) (Printed in Great Britain) Ribozymes, the first 20 years T. R. Cech Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789, U.S.A., and University of Colorado, Boulder, CO 80309-0215, U.S.A. Key words: catalytic RNA, group I intron, RNA structure, splicing, X-ray crystallography. Abbreviation used: IGS, internal guide sequence. Abstract In 1982 we reported the first catalytic RNA or ribozyme: the self-splicing intron of the Tetrahymena pre-rRNA. Additional examples of natural ribozymes were soon found, and research in the field focused on their enzymic mechanism and secondary and tertiary structure. Ribozymes identified through in vitro selection extended the repertoire of RNA catalysis. Two directions of current and future interest are the determination of atomic-resolution structures of large ribozymes by X-ray crystallography and the structural and mechanistic analysis of complexes of ribozymes with protein facilitators of their activity. Search... Whole site

85. Biochem. Soc. Trans (2002) 30, 1162-1166 - R. Cech - Ribozymes And RNA Catalysis 1 Email thomas.cech@colorado.edu. 3 cech, TR (1990) Annu 15 van der Veen, R., Arnberg,AC, van der Horst, G., Bonen, L., Tabak, HF and Grivell, LA (1986) Cell 44 http://www.biochemsoctrans.org/bst/030/1162/bst0301162.htm

About the journal Subscriptions Authors Users ... Download to Citation Matcher Biochem. Soc. Trans. (2001) (Printed in Great Britain) Ribozymes, the first 20 years T. R. Cech Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789, U.S.A., and University of Colorado, Boulder, CO 80309-0215, U.S.A. Key words: catalytic RNA, group I intron, RNA structure, splicing, X-ray crystallography. Abbreviation used: IGS, internal guide sequence. Abstract In 1982 we reported the first catalytic RNA or ribozyme: the self-splicing intron of the Tetrahymena pre-rRNA. Additional examples of natural ribozymes were soon found, and research in the field focused on their enzymic mechanism and secondary and tertiary structure. Ribozymes identified through in vitro selection extended the repertoire of RNA catalysis. Two directions of current and future interest are the determination of atomic-resolution structures of large ribozymes by X-ray crystallography and the structural and mechanistic analysis of complexes of ribozymes with protein facilitators of their activity. Introduction Although progress in any given research project always seems excruciatingly slow, with little advance from week to week, it still amazes me to see how far a field can move in 20 years, when good laboratories around the world contribute. Such has been the case with 'ribozymes': 20 years ago this word was first used to describe catalytic RNA in a paper published in Cell [

86. Chemistry International Prof. Dr. thomas R. cech. Eight plenary lecturers, including fourNobel Prize winners, headlined an array of leading chemists from http://www.iupac.org/publications/ci/1999/november/37thcongress.html

Chemistry International Vol. 21, No. 6, November 1999 1999, Vol. 21 No. 6 (November) .. 40th Council Highlights .. IUPAC: 2000 and Beyond ... CI Homepage Chemistry International Vol. 21, No. 6 November 1999 th IUPAC Congress-27 th GDCh General Meeting 14-19 August 1999, Berlin, Germany This extremely successful event, held at Berlin's International Congress Center (ICC) with the general theme "Frontiers in Chemistry: Molecular Basis of the Life Sciences", celebrated the 80 th anniversary of the founding of IUPAC and the 50 th anniversary of the refounding of the Gesellschaft Deutscher Chemiker (GDCh) after World War II. More than 2 400 participants (most from outside Germany) from 55 countries had the opportunity to attend about 350 talks (in up to 12 parallel sessions) and to view about 1 200 posters. Over 250 attendees from developing or economically disadvantaged countries were sponsored, at least in part, by substantial reductions in registration fees. Prof. Dr.

87. 50/50 Reflections On The Double Helix - News 03/28/03 Hunkapiller, Michael W. President, Applied Biosystems 03/28/03 cech, ThomasR. President, Howard Hughes Medical Institute Nobel Prize Laureate in http://www.bio-itworld.com/news/reflections_index_date.html

More Information About Home > 50/50 Reflections on the Double Helix To mark the 50th anniversary of the double helix and the genomic revolution it inspired, Bio-IT World presents in this Special Report the personal views of 50 luminaries from the world of genomics and biomedicine on the future of DNA research. These exclusive interviews were conducted by Senior Editor Malorye Branca and other Bio-IT World staff. The April 2003 issue of Bio-IT World also includes these articles about the Double Helix: Beyond the Blueprint First Base Debating DNA in Monterey Get into the Groove View by Date / View By Name *Collins, Francis Director National Human Genome Research Institute **Venter, J. Craig President The Center for the Advancement of Genomics Snyder, Michael Director of Yale Center of Genomics and Proteomics Yale University Eisen, Jonathan Investigator The Institute for Genomic Research Nicholson, Jeremy Head of Biological Chemistry Imperial College, University of London Nadeau, Joseph Co-Director, Center for Computational Genomics Case Western Reserve University Brookes, Anthony

88. The Scientist - Hot Papers In Telomerase Oct. 11, 1999 Robert A. Weinberg of Massachusetts Institute of Technology and ThomasR. cech of the University of Colorado Health Sciences Center discuss the http://www.the-scientist.com/yr1999/oct/hot1_991011.html

The Scientist 13[20]:14, Oct. 11, 1999 Hot Papers Hot Papers In Telomerase By None Edited by: Paul Smaglik Thomas R. Cech T.M. Nakamura, G.B. Morin, K.B. Chapman, S.L. Weinrich, W.H. Andrews, J. Lingner, C.B. Harley, T.R. Cech, "Telomerase catalytic subunit homologs from fission yeast and human," Science :955-9, Aug. 15, 1997. (Cited in more than 220 papers since publication) Comments by Thomas R. Cech , professor of biochemistry, biophysics, and genetics at the University of Colorado Health Sciences Center, Boulder This paper is "a derivative," laughs Thomas Cech. The "real breakthrough" paper that made it (and its companion, see below) possible came months earlier, but has received less citation attention than either of its successors. That earlier paper reported the purification of the telomerase enzyme's catalytic subunitthe first such subunit cloned. "That paper was the result of four years in the cold room by Joachim Lingner ," Cech recalls, adding that the skill and diligence of the then-University of Colorado at Boulder postdoc beat the odds. "There were industrial companies that had a dozen people working full time to purify the human enzyme and had been unsuccessful. And he did it all by himself." Key to the success of that first cloning was the use of Euplotes , rather than human. The ciliated protozoan has an abundance of short chromosomes and consequently, more telomeres, resulting in a higher concentration of telomerase than human.

89. PNAS -- Search Result BIOCHEMISTRY Tracy M. Bryan, Jamie M. Sperger, Karen B. Chapman, and ThomasR. cech Telomerase reverse transcriptase genes identified in Tetrahymena http://www.pnas.org/cgi/search?qbe=pnas;252396199&journalcode=pnas&minscore=5000

90. Alexander R. Thomas Books Books Alexander R. thomas. Entheogens and the Future of Religion. By AlexanderR. thomas, Polly J. Smith 13 September, 2002 More Info? International Ethics. http://www.iriepeople.com/cgi-bin/amazon/amazon_products_feed-mode-books-search_

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