1. Cech, Thomas R. ,cech thomas r. (1947). Grandfather Josef, a shoemaker, immigratedto the US from Bohemia in 1913. My other grandparents, also of http://www.cartage.org.lb/en/themes/Biographies/MainBiographies/C/Cech/Cech.htm

Cech Thomas R. Grandfather Josef, a shoemaker, immigrated to the U.S. from Bohemia in 1913. My other grandparents, also of Czech origin, were first-generation Americans. My father was and is a physician, my mother the homemaker. I was born in Chicago on December 8, 1947. The safe streets and good schools of Iowa City, Iowa provided the backdrop for the childhood years of my sister Barbara,my brother Richard and myself. My father, who loved physics as much as medicine, interjected a scientific approach and point of view into most every family discussion. I discovered science for myself in fourth grade, collecting rocks and minerals and worrying about how they were formed. By the time I was in junior high school, I would knock on Geology professors' doors at the University of Iowa, asking to see models of crystal structures and to discuss meteorites and fossils. In 1966 I entered Grinnell College, where I was to derive as much enjoyment studying Homer's Odyssey

2. WIEM: Cech Thomas R. Chemia, Biologia, Stany Zjednoczone. cech thomas r.( 1947) cech thomas r. ( 1947-), chemik amerykaski, profesor Uniwersytetu Colorado oraz Instytutu Bada Medycznych http://www.encyklopedia.pl/wiem/0115db.html

WIEM 2004 - zobacz now± edycjê encyklopedii! Kup abonament i encyklopediê na CD-ROM, sprawd¼ ofertê cenow±! Oferta specjalna abonamentów dla szkó³ i instytucji! Uwaga! Przedstawione poni¿ej has³o pochodzi z archiwalnej edycji WIEM 2001! Prace redakcyjne nad edycj± 2001 zosta³y zakoñczone. Zapraszamy do korzystania z nowej, codziennie aktualizowanej i wzbogacanej w nowe tre¶ci edycji WIEM 2004 Chemia, Biologia, Stany Zjednoczone Cech Thomas R. Cech Thomas R. (1947-), chemik amerykañski, profesor Uniwersytetu Colorado oraz Instytutu Badañ Medycznych Hughes w Boulder (Colorado). Prace nad w³a¶ciwo¶ciami katalitycznymi kwasów rybonukleinowych RNA ( kwasy nukleinowe ). Wykaza³, i¿ RNA obok roli spe³nianej podczas transkrypcji kwasu dezoksyrybonukleinowego (DNA) dzia³a tak¿e jako enzym katalizuj±cy reakcje w komórce. Nagroda Nobla w 1989. WIEM zosta³a opracowana na podstawie Popularnej Encyklopedii Powszechnej Wydawnictwa Fogra zobacz wszystkie serwisy do góry

3. WIEM: Cech Thomas R. cech thomas r. (1947), chemik amerykanski, profesor Uniwersytetu Coloradooraz Instytutu Badan Medycznych Hughes w Boulder (Colorado). Prace http://wiem.onet.pl/wiem/0115db.html

WIEM 2004 - zobacz now± edycjê encyklopedii! Kup abonament i encyklopediê na CD-ROM, sprawd¼ ofertê cenow±! Oferta specjalna abonamentów dla szkó³ i instytucji! Uwaga! Przedstawione poni¿ej has³o pochodzi z archiwalnej edycji WIEM 2001! Prace redakcyjne nad edycj± 2001 zosta³y zakoñczone. Zapraszamy do korzystania z nowej, codziennie aktualizowanej i wzbogacanej w nowe tre¶ci edycji WIEM 2004 Chemia, Biologia, Stany Zjednoczone Cech Thomas R. Cech Thomas R. (1947-), chemik amerykañski, profesor Uniwersytetu Colorado oraz Instytutu Badañ Medycznych Hughes w Boulder (Colorado). Prace nad w³a¶ciwo¶ciami katalitycznymi kwasów rybonukleinowych RNA ( kwasy nukleinowe ). Wykaza³, i¿ RNA obok roli spe³nianej podczas transkrypcji kwasu dezoksyrybonukleinowego (DNA) dzia³a tak¿e jako enzym katalizuj±cy reakcje w komórce. Nagroda Nobla w 1989. WIEM zosta³a opracowana na podstawie Popularnej Encyklopedii Powszechnej Wydawnictwa Fogra zobacz wszystkie serwisy do góry

4. Tom Cech For more information on Dr. cech thomas r. Cech Autobiography. Howard HughesMedical Institute. Thomas R. Cech, University of Colorado. http://research.osu.edu/TomCech.htm

UNIVERSITY RESEARCH LECTURE SERIES Thomas Cech October 1, 2003 LECTURE BEGINS AT 5:00PM RECEPTION IMMEDIATELY FOLLOWING LECTURE IS FREE AND OPEN TO THE PUBLIC From Catalytic RNA to Howard Hughes From a simple pond organism, Professor Thomas Cech discovered one of the secrets of RNA: the first example of a biochemical reaction catalyzed by RNA. His discovery led to an explosion of RNA research in the biological sciences and a Nobel Prize in chemistry in 1989. Now, Professor Cech has two professional lives: still a professor of biochemistry at the University of Colorado , Boulder and since 2000, president of the Howard Hughes Medical Institute (HHMI) in Chevy Chase, MD. In these two positions , Cech has been able to continue to pursue his passions: improving undergraduate education and carrying out RNA research. As president of HHMI, he oversees researchers who attempt to explain how the human body functions and why disease occurs. In addition to winning the Nobel Prize in Chemistry, Cech is a member of the U.S. National Academy of Sciences and the American Academy of Arts and Sciences. Professor Cech's lecture will provide a glimpse into the mind, the vision, and the stamina of this world-recognized researcher and leader.

5. Thomas R. Cech - Autobiography thomas R. cech – Autobiography. Grandfather Josef, a shoemaker,immigrated to the US from Bohemia in 1913. My other grandparents http://www.nobel.se/chemistry/laureates/1989/cech-autobio.html

Grandfather Josef, a shoemaker, immigrated to the U.S. from Bohemia in 1913. My other grandparents, also of Czech origin, were first-generation Americans. My father was and is a physician, my mother the homemaker. I was born in Chicago on December 8, 1947. The safe streets and good schools of Iowa City, Iowa provided the backdrop for the childhood years of my sister Barbara,my brother Richard and myself. My father, who loved physics as much as medicine, interjected a scientific approach and point of view into most every family discussion. I discovered science for myself in fourth grade, collecting rocks and minerals and worrying about how they were formed. By the time I was in junior high school, I would knock on Geology professors' doors at the University of Iowa , asking to see models of crystal structures and to discuss meteorites and fossils. In 1966 I entered Grinnell College , where I was to derive as much enjoyment studying Homer's Odyssey, Dante's Inferno, and Constitutional History as Chemistry. I met Carol over the melting point apparatus in a make-up Organic Chemistry lab, starting the partnership of our lives that is now more than 20 years old. The Chemistry I appreciated the most from textbooks was physical chemistry. However, undergraduate research experiences at

6. Thomas R. Cech Tom cech and his group are working to understand the structure and function of catalytic RNA molecules and the activity and regulation of telomerase. HHMI INVESTIGATORS / thomas R. cech. HHMI INVESTIGATORS Enzymatic RNA Molecules and the Replication of Chromosome Ends. thomas R. cech, Ph.D. http://www.hhmi.org/research/investigators/cech.html

HHMI INVESTIGATORS / Thomas R. Cech HHMI INVESTIGATORS HHMI INVESTIGATOR ALUMNI INTERNATIONAL RESEARCH SCHOLARS HHMI-NIH RESEARCH SCHOLARS ... HHMI HOME ALSO OF INTEREST Search PubMed The Cech Lab 1989 Nobel Prize in Chemistry Nobel Autobiography ... The Double Life of RNA Enzymatic RNA Molecules and the Replication of Chromosome Ends Thomas R. Cech, Ph.D. President, Howard Hughes Medical Institute, University of Colorado at Boulder Biography... Summary: Tom Cech and his group are working to understand the structure and function of catalytic RNA molecules and the activity and regulation of telomerase. A cell must orchestrate thousands of chemical reactions in order to live, to grow, and to respond to its environment. These chemical reactions rarely happen spontaneously but are usually catalyzed by macromolecules called enzymes. It was long thought that all enzymes were proteins. More recently we and others have found that RNA can in some cases act as an enzyme. The finding of RNA catalysis has several implications. First, it means that RNA is not solely a passive carrier of genetic information but can participate actively in directing cellular biochemistry. In particular, many RNA-processing reactions, as well as protein synthesis on ribosomes, are at least in part catalyzed by RNA. Second, the study of how RNA enzymes work may reveal hitherto unknown mechanisms of biologic catalysis. Third, RNA enzymes (ribozymes) have the potential to provide new therapeutic agents. For example, ribozymes efficiently cleave and thereby destroy viral RNAs under controlled laboratory conditions, making it plausible that ribozymes might be able to inactivate viruses in animals, including people.

7. Remarks By Thomas R. Cech From Research Universities and the Academic Disciplines. AAU Centennial Meeting. October 16, 2000. University of Chicago " Biology's Revolution Opportunities and Challenges for Universities" thomas http://www.aau.edu/aau/Cech10.00.html

From: Research Universities and the Academic Disciplines AAU Centennial Meeting October 16, 2000 University of Chicago "Biology's Revolution: Opportunities and Challenges for Universities" Thomas R. Cech President, Howard Hughes Medical Institute Good morning. It is a special pleasure to be back in Chicago, the city where I was born, and at the University of Chicago, where I have enjoyed many fine events through the years and have many colleagues. In fact, two former students from my laboratory became tenured faculty members here at the university. It is also a thrill for me to be able to talk about the future of education and research at universities with the people who are guiding these great institutions in the twenty-first century. We are already into this century, of course, but we still have ninety-nine years to make good on whatever we decide to do. Our invitation requested that we each talk about the past, present, and future of our own research disciplines. I was asked to speak before I had become president of the Howard Hughes Medical Institute, so I planned to give you a view "from the trenches," drawing on my twentythree years of carrying out research, teaching general chemistry and biochemistry to undergraduates, and teaching graduate students at the University of Colorado at Boulder. Now, having taken on the Howard Hughes position, I feel inclined also to address some higher-level issues. So this is going to be a discussion of what biological research is like and how it is changing, mixed in with a look at some of the ways that institutions might respond to new challenges.

8. Thomas R. Cech RNA was long thought to function solely as a carried out by Professor cech and his research group is J. and cech, T. R. Structural Basis of the Enhanced http://www.colorado.edu/Chemistry/grad/faculty/Cech/Cech.html

9. Chemistry 1989 Sidney Altman, thomas R. cech. 1/2 of the prize, 1/2 of the prize. thomasR. cech Autobiography Nobel Lecture Other Resources. prev 1988, 1990 next. http://www.nobel.se/chemistry/laureates/1989/

The Nobel Prize in Chemistry 1989 "for their discovery of catalytic properties of RNA" Sidney Altman Thomas R. Cech 1/2 of the prize 1/2 of the prize Canada and USA USA Yale University New Haven, CT, USA University of Colorado Boulder, CO, USA b. 1939 b. 1947 The Nobel Prize in Chemistry 1989 Press Release Presentation Speech Illustrated Presentation ... Other Resources The 1989 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: SITE FEEDBACK CONTACT TELL A FRIEND Last modified June 23, 2003 The Official Web Site of The Nobel Foundation

10. Thomas R. Cech Winner Of The 1989 Nobel Prize In Chemistry thomas R. cech, a Nobel Prize Laureate in Chemistry, at the Nobel Prize Internet Archive. thomas R. cech. 1989 Nobel Laureate in Chemistry submitted by Brig Klyce) thomas R. cech's HHMI Research in Progress http://www.almaz.com/nobel/chemistry/1989b.html

T HOMAS R C ECH 1989 Nobel Laureate in Chemistry for their discovery of catalytic properties of RNA. Background Born: 1947 Residence: U.S.A. Affiliation: University of Colorado, Boulder, CO Featured Internet Links Prize Co-recipient: Sidney Altman The Cech Laboratory page current research Search WWW Search The Nobel Prize Internet Archive Nobel News Links Thomas R. Cech receives Nobel Prize for Chemistry Links added by Nobel Internet Archive visitors Winner of The Gairdner Foundation Int'l Award (submitted by glengair@inforamp.net Modern or "strong" version of panspermia (submitted by Brig Klyce Thomas R. Cech's HHMI Research in Progress The Cech Lab Home Page Thomas R. Cech – Autobiography (submitted by Chinnappan Baskar Dr. Cech's Research Background (submitted by Thomas Thomas R. Cech - Nobel Lecture (submitted by Linda) Remarks by Thomas R. Cech (submitted by Jackson) Back to The Nobel Prize Internet Archive Literature Peace Chemistry ... Medicine We always welcome your feedback and comments

11. Thomas R. Cech Winner Of The 1989 Nobel Prize In Chemistry thomas R. cech, a Nobel Prize Laureate in Chemistry, at the Nobel Prize InternetArchive. thomas R. cech. Remarks by thomas R. cech (submitted by Jackson). http://almaz.com/nobel/chemistry/1989b.html

T HOMAS R C ECH 1989 Nobel Laureate in Chemistry for their discovery of catalytic properties of RNA. Background Born: 1947 Residence: U.S.A. Affiliation: University of Colorado, Boulder, CO Featured Internet Links Prize Co-recipient: Sidney Altman The Cech Laboratory page current research Search WWW Search The Nobel Prize Internet Archive Nobel News Links Thomas R. Cech receives Nobel Prize for Chemistry Links added by Nobel Internet Archive visitors Winner of The Gairdner Foundation Int'l Award (submitted by glengair@inforamp.net Modern or "strong" version of panspermia (submitted by Brig Klyce Thomas R. Cech's HHMI Research in Progress The Cech Lab Home Page Thomas R. Cech – Autobiography (submitted by Chinnappan Baskar Dr. Cech's Research Background (submitted by Thomas Thomas R. Cech - Nobel Lecture (submitted by Linda) Remarks by Thomas R. Cech (submitted by Jackson) Back to The Nobel Prize Internet Archive Literature Peace Chemistry ... Medicine We always welcome your feedback and comments

12. Thomas Cech Waiting For More Protozoan Genomes - News Click and fold proteins a bioinformatics dream waiting to come true. 03/27/03). thomas R. cech. President, Howard Hughes Medical Institute http://rdre1.inktomi.com/click?u=http://www.bio-itworld.com/news/032703_report22

13. Thomas Cech: Waiting For More Protozoan Genomes - News thomas R. cech President, Howard Hughes Medical Institute Professor, Univ.of Colorado at Boulder Nobel Prize Laureate in Chemistry, 1989. http://www.bio-itworld.com/news/032703_report2235.html

More Information About Home News > Thomas Cech: Waiting for More Protozoan Genomes Thomas Cech: Waiting for More Protozoan Genomes By Malorye Branca Bio-IT World (online) Thomas R. Cech President, Howard Hughes Medical Institute Professor, Univ. of Colorado at Boulder Nobel Prize Laureate in Chemistry, 1989 To my mind, the most important new advance is the RNA [interference] approach for using information from the genome sequence to knock out particular gene products. That advance gets into functional genomics, which is a critical area. Just knowing the sequence can be tantalizing, but how is one going to understand whether a gene product is important and in what process? This is especially true in the human genome, where there are multiple, similar genes. You can find ten kinases that look highly related. The question becomes, are they redundant? Are some expressed in some tissues and not others? After all, beyond being able to use bioinformatics to find related genes, the next thing you want to know is how does their function differ and how is it similar? And RNAi is vastly more powerful than anything we have had. People who don’t even know how to spell RNA are able to use this successfully in diverse biological systems! Everything else is a rather impressive continuation of things that have been going on for the past decade. Clearly we have not peaked in appreciating the true value of the genome project. And we will see a rapid upswing, particularly in the bioinformatics tools that enable one to mine the genome sequences. These tools are still improving, and in the future they will be a lot better than they are now.

14. Cech Lab Home Laboratory homepage of thomas R. cech cech Laboratory. Howard Hughes Medical Institute. Department of Chemistry and Biochemistry. University of Colorado at Boulder. Boulder CO 803090215. Welcometo the cech http://cechlab.colorado.edu/

The Cech Laboratory Howard Hughes Medical Institute Department of Chemistry and Biochemistry University of Colorado at Boulder Boulder CO 80309-0215 Welcome to the Cech Lab Web Page! Research Publications Members Alumni ... Local Links This site was designed by Toru M. Nakamura. It is now maintained by: Art Zaug

15. HHMI's BioInteractive - Thomas R. Cech, Ph.D. Photo Paul Fetters. thomas R. cech, Ph.D. Dr. cech became presidentof the Howard Hughes Medical Institute in January 2000. When http://www.hhmi.org/biointeractive/rna/cech.html

Photo: Paul Fetters Thomas R. Cech, Ph.D. HHMI.org Order Materials Send Feedback Help ... Search

16. Letter To Editor From Bob Harrison, Harpers Ferry, WV --Leesburg2Day-- The Journ Editor, Leesburg Today Our mission at the Howard Hughes Medical Institute is to conduct basic biomedical research aimed at improving human health. Locally, our goal is to be good Loudoun citizens http://www.leesburg2day.com/current.cfm?catid=32&newsid=8077

17. Nobel Laureates In Chemistry By Alphabetical Order Buchner, Eduard, 1907. Butenandt, Adolf Friedrich Johann, 1939. Calvin, Melvin,1961. cech, thomas R. 1989. Corey, Elias James, 1990. Cornforth, Sir John Warcup,1975. http://www.cartage.org.lb/en/themes/Sciences/Chemistry/Aboutchemistry/AlphaNobel

Themes Science Chemistry About Chemistry Generalities Name Year Awarded Alder, Kurt Altman, Sidney Anfinsen, Christian B. Arrhenius, Svante August Aston, Francis William Baeyer, Johann Friedrich Wilhelm Adolf Von Barton, Sir Derek H. R. Berg, Paul Bergius, Friedrich Bosch, Carl Boyer, Paul D. Brown, Herbert C. Buchner, Eduard Butenandt, Adolf Friedrich Johann Calvin, Melvin Cech, Thomas R. Corey, Elias James Cornforth, Sir John Warcup Cram, Donald J. Crutzen, Paul Curie, Marie Curl, Robert F., Jr. Debye, Petrus Josephus Wilhelmus De Hevesy, George Deisenhofer, Johann Diels, Otto Paul Hermann Eigen, Manfred Ernst, Richard R. Euler-chelpin, Hans Karl August Simon Von Fischer, Ernst Otto Fischer, Hans Fischer, Hermann Emil Flory, Paul J. Fukui, Kenichi Giauque, William Francis Gilbert, Walter Grignard, Victor Haber, Fritz Hahn, Otto Harden, Sir Arthur Hassel, Odd Hauptman, Herbert A. Haworth, Sir Walter Norman Heeger, Alan J. Herschbach, Dudley R. Herzberg, Gerhard Heyrovsky, Jaroslav Hinshelwood, Sir Cyril Norman Hodgkin, Dorothy Crowfoot Hoff, Jacobus Henricus Van't

18. Thomas R. Cech - CIRS Distinguished Professor and Investigator at the Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, USA. cech, thomas R. thomas.cech@Colorado.EDU http://www.cirs-tm.org/Chercheurs/Chemistry/CECH.htm

CECH, THOMAS R. thomas.cech@Colorado.EDU President of the Howard Hughes Medical Institute Distinguished Professor and Investigator at the Cech Laboratory , Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, USA. Research interests : Cech discovered that the intron in rRNA catalyzes its own excision. The discovery that RNA can function as an enzyme has changed the traditional concept of an enzyme and is of major importance in our understanding of RNA functions. His work has already led to fundamentally new ideas about the origin and evolution of cell genetics. Tom Cech and his group are working to understand the structure and function of catalytic RNA molecules and the activity and regulation of telomerase. Awards and Prizes : USPHS Research Career Development Award, 1980 Pfizer Award in Enzyme Chemistry, 1985 U.S. Steel Award in Molecular Biology, 1987 Heineken Prize, 1988 Nobel Prize in Chemistry, 1989 National Medal of Science, 1995

19. Cech, Thomas R. (1947- ) A B C D E F G H I J K L M N O P Q R S T U V W X Y Z this site WWW. cech, thomas R. (1947 ) http://www.daviddarling.info/encyclopedia/C/Cech.html

The Encyclopedia of Astrobiology, Astronomy, and Spaceflight FRONT PAGE NEWS ARCHIVE NEWSLETTER ... Z this site WWW Cech, Thomas R. (1947- ) American biochemist at the University of Colorado who shared the 1989 Nobel Prize for Medicine with Sidney Altman at Yale University for their discovery of ribozymes Further biographical details to follow. var site="s13space1234"

20. CECH, THOMAS R. - CIRS cech, thomas R. Email thomas.cech@Colorado.EDU President of theHoward Hughes Medical Institute. Distinguished Professor and http://www.cirs-tm.org/Chercheurs/chercheurs1.php?id=192

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