81. Internet Links - Medicinal Chemistry (CHM 4790) - Dr. Howard Black Medical Matrix A good links site for Internet clinical medicine resources. ACSDivision of medicinal chemistry - the usual ACS divisional info meetings http://www.ux1.eiu.edu/~cfthb/classes/4790/links.htm

Chemistry 4790 - Dr. Howard Black Eastern Illinois University Important: The information on this page is for informational purposes only, and is not intended to replace medical consulation with your doctor. The aim is to help people become more informed health care consumers and to illustrate what vast data are available on the internet; it should never be construed as a substitute for consultation with your health care professional. Inclusion of a site does not imply any endorsement of the site, its stated positions, or its sponsor. Table of Contents Drug Information Resources on Diseases/Disorders Most Useful Medical Websites Drug Development ... Databases/Misc. Drug Information Clinical Pharmacology Online - a listing of hundreds of drugs, contains much pharmacological data on each drug, even in combined-product formulations. Includes mechanism of action and pharmacokinetics, including metabolism. CVS On-Line Pharmacy Store - A true on-line pharmacy providing wholesale pricing information; this particular page lists their top-selling several hundred products. Very informative, especially for comparing the retail price of a drug you or a friend may take with the wholesale price.

82. Chemistry, Clinical chemistry, clinical. Glossary of terms used in medicinal chemistry. Glossary of terms used in medicinal chemistry provides the 1998 http://bioresearch.ac.uk/browse/mesh/C0008000L0008000.html

low graphics Chemistry, Clinical broader: Chemistry other: Biochemistry Chemistry, Organic Chemistry, Physical Glossary of terms used in medicinal chemistry "Glossary of terms used in medicinal chemistry" provides the 1998 Recommendations of the International Union of Pure and Applied Chemistry's (IUPAC) Chemistry and Human Health Division and Medicinal Chemistry Section. The glossary is indexed alphabetically, and an abstract and a note on the entries is provided. Made available on the Web by the Department of Chemistry, Queen Mary University of London. Terminology [Publication Type] Chemistry, Clinical Last modified: 03 Jun 2004

83. Medicinal Chemistry Phase II clinical trials are expected to begin in the near future. Prof. His Medicinalchemistry Division in the Department of chemistry is unique in Israel. http://www.biu.ac.il/Spokesman/scholar/nudelma2.html

Scholar News Magazine Jewish ... Archeology Medicinal Chemistry Biophysics Geography Fertility Commercial ... Publishers A new potentially life-saving drug developed by a Bar-Ilan professor has received a green light for further development from the American Food and Drug Administration (FDA). Tests show that Prof. Abraham Nudelman's prodrug AN-9 demonstrates significant effectiveness in the war on cancer. It's not surprising that Prof. Abraham Nudelman's pharmaceutical lab has drawn the attention of major chemical and drug companies throughout the world. Through joint-research with Beilinson Medical Center's Dr. Ada Raphaeli, the Bar-Ilan University chemist has developed a drug-delivery system (or prodrug) whereby the cancer-fighting substance Butyric Acid can be delivered to the site of disease before breaking down. Nudelman's prodrug (called AN-9) has been tested using the strict procedures of the American National Cancer Institute, and was found to display promising anti-cancer properties in lung, pancreatic, colon cancers and melanoma. Prof. Nudelman connected with U.S.-based Titan

84. VC2: Careers: Medicinal Chemistry drugs because many different aspects of a molecule must be defined to identifya candidate for clinical studies. He adds, medicinal chemistry is the drug http://www.chemistry.org/portal/a/c/s/1/acsdisplay.html?DOC=vc2\3wk\wk3_med.html

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in entire NodeWorks Directory in Science in Chemistry Top Science Chemistry American Association for Clinical Chemistry An international scientific/medical society of clinical laboratory professionals, physicians, research scientists and other individuals involved with clinical chemistry and other clinical lab oratory science-related disciplines. American Association of Blood Banks An international association of blood banks that supports high standards of medical, technical and administrative performance, scientific investigation, clinical application and education. American Board of Clinical Chemistry Incorporated to provide a program of certification of competence in clinical chemistry. American Society for Clinical Laboratory Science The American Society for Clinical Laboratory Science (ASCLS). American Society of Clinical Pathologists ASCP, membership, Board of Registry, programs, publications and general information. Association of Clinical Biochemists (UK) Organization dedicated to promoting the advancement of clinical biochemistry in the United Kingdom and the Republic of Ireland. Canadian Society of Clinical Chemists The CSCC provides leadership in the practice of clinical biochemistry and clinical laboratory medicine through service, education and research. Contains a Virtual Chemist's Library, the society's position papers, membership information and links.

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88. U-M College Of Pharmacy: Regular Faculty of medicinal chemistry Julie A. Golembiewski, Pharm.D., clinical Assoc. of medicinalchemistry, College of Pharmacy Michael D. Kraft, Pharm.D., clinical Asst. http://www.umich.edu/~pharmacy/faculty/faculty_regular.html

A B C D ... Y A , Pharm.D., Clinical Assoc. Prof., College of Pharmacy* Gordon L. Amidon , Ph.D., Charles R. Walgreen Jr. Professor of Pharmaceutical Sciences Frank J. Ascione , Ph.D., Assoc. Dean for Academic Affairs, Prof. of Social and Administrative Sciences B Rosemary R. Berardi , Pharm.D., Prof. of Pharmacy* Barry E. Bleske , Pharm.D., Assoc. Prof. of Pharmacy * Eddie L. Boyd , Pharm.D., M.S., Assoc. Prof. of Pharmacy* Imad F. Btaiche , Pharm.D., Clinical Asst. Prof.* C Heather A. Carlson , Ph.D., John Gideon Searle Asst. Prof. of Medicinal Chemistry; Asst. Prof. of Chemistry College of LSA Peggy L. Carver , Pharm.D., Assoc. Prof. of Pharmacy * Hae Mi Choe , Pharm.D., Clinical Asst. Prof.* Catherine Christen , Pharm.D., Clinical Asst. Prof.* James K. Coward , Ph.D., Chair and Prof., Dept. of Medicinal Chemistry, College of Pharmacy; Prof. of Chemistry, College of LSA Ronald M. Cresswell , Ph.D., Prof. of Medicinal Chemistry Gordon M. Crippen

89. U-M MEDICINAL CHEMISTRY: Leroy B. Townsend, Ph.D. to a benzimidazole derivative which is currently in Phase II clinical trials against GraduateCourse, Med Chem 533, Survey of medicinal chemistry A general http://www.umich.edu/~pharmacy/MedChem/faculty/townsend/

Welcome Admissions PhD Curriculum Graduate Courses ... Medicinal Chemistry Gateway Leroy B. Townsend, Ph.D. Albert B. Prescott Professor Emeritus of Medicinal Chemistry, College of Pharmacy University of Michigan The University of Michigan College of Pharmacy 428 Church St. Ann Arbor, Michigan 48109-1065 Phone: (734) 764-7547 Fax: (734) 763-5633 ltownsen@umich.edu Education New Mexico, Highlands University, Las Vegas, NM, M.S., Chemistry Arizona State University, Tempe, AZ, Ph.D., Chemistry Research: Design and Synthesis of Heterocycles and Nucleosides Our research group is involved in the design, synthesis and development of structurally and mechanistically diverse biological and chemotherapeutic agents. The majority of this research effort is expended in one of the most successful areas for the development of potentially active chemotherapeutic agents, antimetabolites. The antimetabolite approach has been used with considerable success in the search for effective antiviral, antibacterial, antiparasitic, and anti-cancer agents. The design, synthesis and evaluation of the tricyclic nucleoside 5'-phosphate (TCN-P) is an excellent example of the success which can be achieved by using this approach since TCN-P has been recently placed on Phase II clinical trials as an anti-cancer agent. Human cytomegalovirus (HCMV) is a major cause of sickness and death among AIDS victims, infants and organ transplant patients. Our research group has designed and synthesized a number of compounds in diverse heterocyclic systems (e.g., pyrrolo[2,3-d]pyrimidine, benzimidazole, and purine) as part of a national cooperative drug discovery group supported by NIAID. Several compounds are currently undergoing evaluation for HCMV activity in animal and pre-clinical studies, in addition to a benzimidazole derivative which is currently in Phase II clinical trials against HCMV infections.

90. Current Medicinal Chemistry–Immunology, Endocrine & Metabolic Agents Volume 2, Current medicinal chemistry–Immunology, Endocrine Metabolic Agents Volume 2,No the prevalence of PAI, advances in the procedure for the clinical testing of http://www.bentham.org/cmciema/cmciema2-4.htm

[Back to Contents Page] [Back to Home Page] C Contents Endostatin: Preclinical Development as an Anticancer Agent Pp. 233-243 T. Bachelot, R. Pawliuk, E. Jouanneau and P. Leboulch [Abstract] Genetic Lipodystrophies: Models for Insulin Resistance Pp. 245-250 Robert A. Hegele [Abstract] Recent Advances in the Diagnosis and Therapy of Primary Adrenal Insufficiency Pp.251-272 Stefano Laureti, Fausto Santeusanio and Alberto Falorni [Abstract] Cerebral Hemorrhage Produced by Thrombolytic and Anti-Thrombotic Agents: A Review Pp. 273-278 Y. Suzuki, B.Q. Zhao and K. Umemura [Abstract] Inhibitor at the Gates, Inhibitor in the Chamber: Allosteric and Competitive Inhibitors of the Proteasome as Prospective Drugs Pp. 279-301 M. Gaczynska and P.A. Osmulski [Abstract] Abstracts [Back to top] Endostatin: Preclinical Development as an Anticancer Agent T. Bachelot, R. Pawliuk, E. Jouanneau and P. Leboulch Advances in angiogenesis research have shed a new light on the growth and metastasic spread of solid tumors, allowing to define new paradigms for cancer treatment. These studies have highlighted the dramatic therapeutic potential of natural inhibitors of angiogenesis, which were found capable of maintaining tumors in a state of dormancy. One of the most promising of these recently described natural inhibitors of angiogenesis is endostatin, a C-terminal fragment of collagen XVIII. In-vitro, endostatin strongly inhibits endothelial cell proliferation and migration. Initial in-vivo studies were impressive, recombinant endostatin was shown to induce regression and prevent the growth of experimental tumors in mice. Several studies by independent teams were published thereafter, they either described different forms of the

91. Current Medicinal Chemistry - Anti-Cancer Agents, Vol. 4, No. 2, 2004 been tested against human cancers in the early 1980s, but the clinical trials showed 1stands as the most promising lead of a medicinal chemistry program aimed http://www.bentham.org/cmcaca/cmcaca4-2.htm

[Back to Contents Page] [Back to Home Page] Current Medicinal Chemistry - Anti-Cancer Agents, Vol. 4, No. 2, 2004 Contents Thymidine Phosphorylase and Fluoropyrimidines Efficacy: A Jekyl and Hyde Story Pp.71-81 Joseph Ciccolini , Alexandre Evrard and Pierre Cuq [Abstract] Design of Novel Antitumor DNA Alkylating Agents: The Benzacronycine Series Pp.83-92 Marie-Helene David-Cordonnier , William Laine , Thomas Gaslonde , Sylvie Michel , Francois Tillequin , Michel Koch , Stephane Leonce , Alain Pierre and Christian Bailly [Abstract] Recent Anticancer Cytotoxic Agents Pp.93-121 Paolo Cozzi, Nicola Mongelli and Antonino Suarato [Abstract] Farnesylated Proteins as Anticancer Drug Targets: From Laboratory to the Clinic Pp.123-138 Patrizia Russo, Maura Loprevite, Alfredo Cesario and Andrea Ardizzoni [Abstract] Epidermal Growth Factor Receptor Inhibitors: A New Prospective in the Treatment of Lung Cancer Pp.139-148 M. Tiseo, M. Loprevite and A. Ardizzoni [Abstract] Extending Nature’s Leads: The Anticancer Agent Ellipticine Pp.149-172

92. Medicinal Chemistry The Practice of medicinal chemistry) Camille Wermuth, Camille Georges WermuthMedical Medical / Nursing Pharmacology clinical chemistry chemistry http://topics.practical.org/039692/040764/040838

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94. Avalon Pharmaceuticals: Science: Innovation: Accelerated Drug Optimization: Medi Lead Explosion Avalon s medicinal chemistry programs focus on rapid optimizationof leads to identify promising candidates for clinical development. http://www.avalonrx.com/science/innovation_5_2.html

Molecular Genetics Systems Biology Chemical Genomics Robotics ... Accelerated Drug Optimization Medicinal Chemistry Core Genes TSAR: Transcriptional Structure Activity Relationships RACETRACK - Rapid Assessment in Vivo Medicinal Chemistry Compound Libraries Small molecule compounds are the starting point of our drug discovery process. Our corporate collection contains high quality libraries and individually synthesized molecules from a variety of sources including internal combinatorial and medicinal chemistry programs and external compound collections, combinatorial libraries and natural products. Applying state-of-the-art chemoinformatics tools and our medicinal chemistry expertise our scientists select compounds and libraries emphasizing structural diversity, purity and drug-like character. The Company applies the same selection process to the design and synthesis of Avalon's proprietary compound libraries. Parallel Synthesis Lead optimization involves the design and synthesis of novel analogs, and the speed of this process has a direct impact on the overall time it takes to discover a new drug candidate. Parallel synthesis allows for preparation of many analogs at the same time. Avalon is applying these technologies to accelerate the discovery process. Based on its in-house expertise in both solution- and solid-phase parallel synthesis the Company prepares small and focused libraries for rapid investigation of transcriptional structure-activity relationships (T-SAR). Avalon is also developing proprietary chemistries to produce diverse libraries based on privileged structures.

95. Blackwell Synergy - Cookie Absent To cite this article Jeffrey, P. (2004) The Practice of medicinal chemistry.British Journal of clinical Pharmacology 57 (5), 662662. http://www.blackwell-synergy.com/links/doi/10.1111/j.1365-2125.2004.02080.x/full

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96. Annual Reports In Medicinal Chemistry (Volume 32) Annual Reports in medicinal chemistry (Volume 32) A title in the Annual Reportsin medicinal chemistry series Series edited by David W. Robertson , clinical http://www.harcourt-international.com/catalogue/title.cfm?ISBN=0120405326

97. MEDICINAL CHEMISTRY MEDCH 435 Diagnostic medicinal chemistry (3) S. Nelson Examination of clinicaldiagnostic tests with regard to the chemical or biochemical rationale of the http://www.washington.edu/students/crscat/medchem.html

Search Directories Reference Tools UW Home ... Student Guide Course Catalog Glossary Search Course Catalog UW Bothell Course Catalog UW Tacoma Course Catalog SCHOOL OF PHARMACY MEDICINAL CHEMISTRY Detailed course offerings (Time Schedule) are available for Spring Quarter 2004 Summer Quarter 2004 Autumn Quarter 2004 To see the detailed Instructor Class Description, click on the underlined instructor name following the course description. MEDCH 400 Fundamental Concepts in Medicinal Chemistry (3) W. Nelson Principles of physical organic chemistry; chemical bonding, stereochemistry, acids/bases, and reaction mechanisms relevant to processes such as drug distribution, specificity, and metabolism. Prerequisite: either CHEM 239 or CHEM 337. Offered: A. MEDCH 401 Immunizing and Antimicrobial Agents (4) Daggett, Elmer Chemical and biologic properties of agents used to prevent or treat infectious diseases, including diagnostic, prophylactic, and therapeutic uses of immunizing biologicals and spectrum, action mechanisms, resistance patterns, toxicity, and therapeutic applications of antibiotics, antifungals, and antivirals. Prerequisite: MICROM 301, MICROM 302, MEDCH 450, or equivalent, PharmD major, or permission of instructor. Offered: Sp. MEDCH 402 Medicinal Chemistry (3) S. Nelson

98. Chemistry: Admissions: Undergraduate Degrees Both programmes provide a good introduction for those interested in careers in clinicaland medicinal chemistry or the pharmaceutical industry, while ensuring http://www2.warwick.ac.uk/fac/sci/chemistry/admissions/ug/degrees/medchem/

Skip to main content navigation Notify Stats ... Sign in [m] Home About News Prospective Students ... Directory [n] Local Navigation Undergraduate Degrees Medical Chemistry Visiting us Entry requirements EU students Non-EU students ... Postgraduate Powered by Sitebuilder Medical Chemistry [c] UCAS Code: F121 BSc/ChMC, F125 MChem/ChMC The MChem and BSc degree programmes are identical during Years One and Two. All students will initially be registered for the MChem degree with the real decision as to whether to continue to a BSc or MChem being made at the end of the second year, with candidates needing to obtain at least a lower second class pass (2:2) in their Second Year to be allowed to proceed to MChem. The BSc degree is especially suitable for those with ability in Chemistry and a wish to enhance their understanding of the subject but who see their careers as science-related (teaching, sales, management, etc.) rather than fully committed to chemical research. The MChem degree is more suitable for those whose interests develop towards a research career: the MChem programme aims to develop the knowledge and skills required by those who have postgraduate study and employment in Chemistry as their career goals. The achievement of a high degree of proficiency in transferable skills is an essential feature of both degrees. European placements are available as options to both BSc and MChem students: BSc students may take a one term placement with one of our partner universities in the summer of their final year, and MChem students have the additional option of extending this placement over the summer or taking a 6 month Australian placement or even taking the whole of their 3rd year abroad.

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