101. Human Genome Project History Human Genome Project (HGP) History (a personal account). DOE History of the Human Genome Project. In the process, the internet has played a huge role in the HGP. http://arep.med.harvard.edu/gmc/HGP.html

Human Genome Project (HGP) History (a personal account) The HGP "began" at three meetings in 1984-5: Alta UT, Santa Cruz Ca, and Santa Fe, NM. I was the only person present at all three meetings. Initially stimulated by RNA sequencing by Jack Nichols at Duke, I began dreaming of something like a genome project when Wally Gilbert gave a seminar at Duke in 1976 on a new DNA sequencing method (published in 1977). I got serious about the mammalian genome-scale issues while researching our 1984 "Genomic sequencing" paper. The Alta Summit, December 1984 (Genomics, Oct 1989, by Robert Cook-Deegan) Delehanty J, White RL, Mendelsohn ML. Mutat Res 1986 May;167(3):215-32. Approaches to determining mutation rates in human DNA. DOE launched its "Human Genome Initiative" in 1986. The "OHER Research in Progress: FY 1988" lists three sequencing technology "offsite contractors": Richardson (Harvard), Church (Harvard), and Gesteland/White (U. Utah). The NIH and other agencies became involved soon thereafter. I helped establish three of the first NIH HGP centers in 1990: Stanford, MIT , and CRI (aka Genome Therapeutics Corp.

102. Blazing A Genetic Trail Research on mutant genes and hereditary diseases. Includes family studies, the Human Genome Project, how to conquer hereditary diseases like cystic fibrosis, key to basic genetics and a glossary. http://www.hhmi.org/genetictrail/

The full text and illustrations of the original print version of Blazing a Genetic Trail are available for download as an Adobe Acrobat PDF file (8MB). Download Adobe Acrobat Reader. Updated Spring 2002

103. EMJA: Kirby, The Human Genome Project In The Dock Cracking the Code The Human Genome Project in the Dock. Michael Kirby. From a scientific viewpoint, the Human Genome Project is actually http://www.mja.com.au/public/issues/173_11_041200/kirby/kirby.html

Home Issues Classifieds Contact ... Search Cracking the Code The Human Genome Project in the Dock Michael Kirby From a scientific viewpoint, the Human Genome Project is actually not in the dock, nor even under reasonable suspicion of wrongdoing. Overwhelmingly, it will prove of benefit to humanity. However, from legal, ethical and other societal points of view, there are many problems already being considered by bioethicists, philosophers, religious experts, lawyers and others in dialogue with scientists. MJA Manageable problems More difficult problems The big ones Public debate ... More articles on Genetics I have just returned from meetings of the Ethics Committee of the Human Genome Organisation (HUGO) established by leading genome scientists in 1989 to promote international collaboration in the Human Genome Project (HGP) in London, and of the International Bioethics Committee (IBC) of the United Nations Educational, Scientific and Cultural Organisation (UNESCO) in Quito, Ecuador. At international meetings such as these, in national bodies, in lawmaking institutions and universities, a lot of minds are identifying the chief problems of the HGP. Some of these problems are comparatively straightforward. Others are complex and fundamental. Manageable problems Privacy and confidentiality: Patient confidentiality has long been fundamental to the healthcare professions, having its roots in rules even older than the Hippocratic Oath. However, when a disorder is the result of a genetic characteristic, is the "patient" solely the individual, or does the entire family have rights? Are there circumstances in which family members should be entitled, by law, to override an individual's desire for privacy to obtain information relevant to genetic conditions that may also affect them? Should a patient have a right

104. Gene Therapy Definition, hurdles, ethical issues, and links to more resources on gene therapy provided by the Oak Ridge National Laboratory. http://www.ornl.gov/sci/techresources/Human_Genome/medicine/genetherapy.shtml

Human Genome Project Information Genomics:GTL Microbial Genome Program home ... skip navigation Gene Therapy Subject Index Alphabetical Index Send the url of this page to a friend News What's New Genetics Headlines Human Genome News Meetings Calendar ... Media Guide Basic Information FAQs Glossary Acronyms Links ... Publications About the Project What is it? Goals Progress History ... Genetics 101 the New Genetics Home Gene Testing Gene Therapy Pharmacogenomics ... Genetic Counseling Ethical, Legal, Social Issues Home Privacy Legislation Gene Testing Patenting ... Genetics in Courtroom Education Teachers Careers Students Webcasts Audio/Video ... Genética Websites en Español Research Home Sequencing Instrumentation Mapping ... Funding Publications Human Genome News Chromosome Poster Primer Molecular Genetics To Know Ourselves ... List of All Publications Search This Site Contact Us Privacy Statement Site Stats and Credits Quick Links to this page What is gene therapy?

105. Other Topics: The Human Genome Project - What It Means For You The Human Genome Project What It Means for You James R. Lupski, MD, Ph.D. The Human Genome Project Prospects and implications for clinical medicine. http://thedoctorwillseeyounow.com/articles/other/genome_4/index.shtml

IN THIS ARTICLE Gene mutations Detecting a mutation The mood swings accompanying menopause most likely result from interrupted sleep. more... OTHER TOPICS Sickle cell Breast cancer genetics Enhancement medicine The Human Genome Project: What It Means for You James R. Lupski, M.D., Ph.D. Genetics is becoming a factor in the diagnosis and treatment of all kinds of disorders. While aware of medical genetics' growing importance, many people, both doctors and patients, feel it is difficult to keep pace with this rapidly advancing area. Famed geneticist, Dr. Jim Lupski, outlines the basic terrain of the genome project and introduces some of its issues and vocabulary. The Editors Birth defects are the leading cause of death among infants (0-364 days old). By age 25, eight percent of liveborns will be diagnosed with a disorder that has a major genetic component. The goals of the human genome project are to identify all genes in the human genome, determine their structure and function and determine their involvement in human disease. Let's see if we can walk through some of the basic concepts and terminology.

106. CellNEWS Features fee based documents on the Human Genome Project, ethics debate, molecular biology, and stem cells. Includes photos of cellular structures. http://communities.msn.se/CellNEWS

var nEditorialCatId = 290; Förstasidan Hotmail Shopping Webbgrupper ... Hjälp CellNEWS CellNEWS@groups.msn.com Nytt Gå med CellNEWS Message Board ... Verktyg Welcome to CellNEWS Follow the latest news and participate in discussion about Stem cells and Cloning, the Human Genome Projec t and the Ethics debate that currently takes place. Please enjoy your visit and come back later! Write something here! Post your opinion about the human genome project, bioethics or the threat from bioterror. You can also ask general questions about cell biology! Vote on Cloning! Click Here To Vote! Read the latest on CellNEWS Chinese Researchers Make Cloned hESC’s in Rabbit Eggs UK's First Stem Cell Line Generated CAMR Urges Bush to Expand Access to ESC’s ... How to Make Stem Cells Stay Growing See also some VideoClip from: Clonaid’s cloning claim – CBC 20News Claims Of First Human Clone – Reuters News Video Dr Patrick Dixon, anti-cloning campaigner – BBC MORE: Venter Attempt a Minimalistic Approach of Creating ‘Artificial’ Life Pentagon behind the creation of the ”synthetic” poliovirus Dangerous Virus made from mail-orderkits HERE YOU FIND SELECTED READINGS AND LINKS TO DISCUSSIONS FROM CellNEWS ARCIVE READ THE LATEST HEALTH AND SCIENCE NEWS HERE FROM AP AND REUTERS More NEWS LINK S on STEM CELLS and CLONING Todays Picture 1: Latest Images From Hubble’s New Camera Todays Picture 2: Amorphophallus Titanum A bloom that causes a stink Todays Picture 3: The Cassiopeia A Supernova: Colourful Fireworks Finale éMail to: Last updated: Since 2001-06-28.

107. NOVA Online | Cracking The Code Of Life Heredity From Pythagoras to the Human Genome Project and beyond, find out in this timeline how our understanding of heredity has changed throughout history. http://www.pbs.org/wgbh/nova/genome/

Welcome to the companion Web site to "Cracking the Code of Life," originally broadcast on April 17, 2001. This two-hour special, hosted by ABC "Nightline" correspondent Robert Krulwich, chronicles the race to capture one of the biggest prizes in scientific history: the complete letter-by-letter sequence of genetic information that defines human life the human genome. Here's what you'll find online: Watch the Program Here Beginning April 18, watch the entire two-hour NOVA program "Cracking the Code of Life" online, available in both QuickTime and RealVideo, and closed captioned for deaf and hard-of-hearing viewers. Our Genetic Future (A Survey) Would you want to know if you had a genetic predisposition to a terminal disease, even if that disease was incurable? Should genes be patentable? Who, if anyone, should have access to your genomic information? We'd like to hear your thoughts on these and other questions. Manipulating Genes: How Much is Too Much? Few have given more thought to the moral and ethical implications of molecular medicine than Dr. Philip Kitcher, a philosopher at Columbia University and author of The Lives to Come: The Genetic Revolution and Human Possibilities.

108. The Human Genome Project At UC Santa Cruz The CBSE is one of 19 centers around the world that make up the International Human Genome Mapping Consortium, a crucial component of the Human Genome Project. http://www.cse.ucsc.edu/centers/cbe/Genome/

Center for Biomolecular Science and Engineering (CBSE) director and HHMI investigator David Haussler leads a team of engineers and scientists at UCSC who are assembling and analyzing the human genome . The CBSE is one of 19 centers around the world that make up the International Human Genome Mapping Consortium, a crucial component of the Human Genome Project. The Human Genome Project is an international effort begun in 1990 to determine the sequence of the approximately 3.2 billion subunits that make up our DNA. The human genome is our DNA "blueprint," the chemical code that instructs our cells to produce the proteins that not only give us our physical attributes, but also contribute to many of our less tangible features, such as behavior, learning and predisposition to disease. In the past 10 years, genome centers all over the world generated the raw sequence information by determining the sequence of the DNA subunits (bases) of small fragments of human DNA. Jim Kent , a Reseach Scientist at UCSC and a member of the UCSC human genome team , wrote a program that assembled the sequenced fragments , creating a working draft sequence that spanned all 23 human chromosomes. UCSC was the first site to

109. Human Genome Project Translate this page Human Genome Project. Das Jahrhundertprojekt geht schneller voran als gedacht Das bisher größte Projekt der Biowissenschaften untersucht die Erbanlagen des http://www.lifescience.de/bioschool/sheets/36.html

Human Genome Project Das Jahrhundertprojekt geht schneller voran als gedacht Das bisher größte Projekt der Biowissenschaften untersucht die Erbanlagen des Menschen und verschiedener niedrigerer Organismen. Im ersten Schritt, der Kartierung, ermitteln Forscher die genaue räumliche Lage der schätzungsweise 80.000 menschlichen Gene auf den Chromosomen. Bei der anschließenden Sequenzierung bestimmen sie für jedes Gen die genaue chemische Struktur, die abfolge der Basen in der DNA Warum sind die Daten so begehrt? Die gewonnenen Erkenntnisse gewinnen für die medizinische Diagnostik und bei der Aufklärung von Krankheitsursachen immer größere Bedeutung. Gene für genetisch bedingte Krankheiten des Menschen lassen sich leichter identifizieren als bisher - insgesamt sind es schätzungsweise 4000. Neue Möglichkeiten für Gentherapien und pharmazeutische Wirkstoffen werden entdeckt. Neue Gentests für die Diagnose und Früherkennung von Erbkrankheiten oder Krebs enstehen. Mit dem Humangenomprojekt sind allerdings auch ethische und rechtliche Fragen verbunden: Dürfen aus den Daten exklusive, privatwirtschaftliche Gewinne entstehen?

110. MSN Encarta - Human Genome Project Advertisement. Human Genome Project. The DNA analyzed in the Human Genome Project came from small samples of blood or tissue obtained from many different people. http://encarta.msn.com/encyclopedia_761580681/Human_Genome_Project.html

MSN Home My MSN Hotmail Shopping ... Money Web Search: logoImg('http://sc.msn.com'); Encarta Subscriber Sign In Help Home ... Upgrade to Encarta Premium Search Encarta Tasks Find in this article Print Preview Send us feedback Related Items completion of first stage in 2000 draft findings more... Magazines Search the Encarta Magazine Center for magazine and news articles about this topic Further Reading Editors' Picks Human Genome Project News Search MSNBC for news about Human Genome Project Internet Search Search Encarta about Human Genome Project Search MSN for Web sites about Human Genome Project Also on Encarta Editor's picks: Good books about Iraq Compare top online degrees What's so funny? The history of humor Also on MSN Summer shopping: From grills to home decor D-Day remembered on Discovery Switch to MSN in 3 easy steps Our Partners Capella University: Online degrees LearnitToday: Computer courses CollegeBound Network: ReadySetGo Kaplan Test Prep and Admissions Encyclopedia Article from Encarta Advertisement document.write(''); Human Genome Project Multimedia 2 items Article Outline Introduction The Structure of DNA The Human Genome Mapping and Sequencing ... Project Status I Introduction Print Preview of Section Human Genome Project , international scientific collaboration that seeks to understand the entire genetic blueprint of a human being ( see Genetics ). This genetic information is found in each cell of the body, encoded in the chemical

111. The Human Genome Project - Progress, Problems, And Prospects - Northwestern Univ Explore the implications of the Human Genome Project at an event hosted by Northwestern University on April 14, 2001. http://www.northwestern.edu/science-outreach/genome/

speakers event description what is a genome? genomics resources ... webcast Organized by the Department of Neurobiology and Physiology and University Policy Statements Revised 05/10/2001

112. The Human Genome Project--Human Body/Microscopic World Lesson Plan (grades 9-12) Students learn about the goals of the Human Genome Project as well as its scientific, medical, and ethical implications. http://school.discovery.com/lessonplans/programs/humangenome/

Grades K-5 Grades 6-8 Grades 9-12 Astronomy/Space ... Health History Ancient History U.S. History World History Life Science Animals Ecology Human Body The Microscopic World ... Weather For our newsletter and special teacher promotions. 9-12 > Human Body Grade level: 9-12 Subject: Human Body Duration: Two class periods Objectives Materials Procedures Discussion Questions ... Credit Find a video description and discussion questions. Human Genome Use our free online Teaching Tools to create custom worksheets, puzzles and quizzes on this topic! Students will do the following: Learn about the goals of the Human Genome Project (HGP) Discuss the scientific and ethical implications of the project The class will need the following: Internet access Newspaper and magazine articles and other current resources about the Human Genome Project Poster board Begin the lesson by asking students what they know about genes. Explain to students that genes are made up of double strands of deoxyribonucleic acid, or DNA. The DNA provides the genetic instructions for everything a cell does. In particular, the sequence of the subunits of DNA, called bases, plays a part in determining whether a person will get sick and how well that person will respond to medication. To understand how the body works as well as diseases and treatments, scientists must understand the human genome, or the complete set of genetic instructions. To do so, they are mapping these instructions in the Human Genome Project, or HGP. Share the following information about the HGP with the students

113. Human Genome Project Newsroom Media guide to the Human Genome Project for journalists including HGP history, progress, goals, images, quick facts, and other resources. skip navigation, http://genome.gsc.riken.go.jp/hgmis/resource/media.html

skip navigation Human Genome Project Newsroom Images free, reproducible, high resolution HGP Logos and Overview Images Genetics, Genomics, Proteomics Tools and Technologies Ethical, Legal, and Social Issues ... Medicine Genome Science Primer PDF How is sequencing done? SNPs ... Working Draft Sequence Papers Downloadable PDF Publications Genomics and Its Impact on Medicine and Society: A 2001 Primer Human Genome Project Fact Sheet DNA Sequencing Process Genomes to Life Roadmap (Post-HGP research) Your Genes, Your Choices (ELSI document) Vital Legacy (50 yrs of DOE BER Research) Microbial Genome Program Report Related Topics Genomic Medicine Pharmacogenomics Gene Testing Gene Therapy ... DNA in the Courtroom HGP Background Information History Progress Goals Timeline ... Archives DOE and the HGP Fact Sheet about DOE's involvement in the Human Genome Project DOE investments that contributed to the success of the Human Genome Project Website of the DOE Human Genome Program Post HGP Information Images Genomes to Life What we still don't know Spin-off Research Programs DOE Genomes to Life Program DOE Microbial Genome Project Environmental Genome Project Cancer Genome Anatomy Project ... SNP Consortium Ethical, Legal, and Social Issues Online Publications

114. History Of The Human Genome Project Details about the US Human Genome Project including its goals, history and progress with links to key documents, publications, a timeline, and Project contacts http://genome.gsc.riken.go.jp/hgmis/project/hgp.html

skip navigation History of the Human Genome Project Subject Index Alphabetical Index News What's New Genetics Headlines Human Genome News Meetings Calendar ... Media Guide Basic Information FAQs Glossary Acronyms Links ... Publications About the Project What is it? Goals Progress History ... Genetics 101 the New Genetics Home Gene Testing Gene Therapy Pharmacogenomics ... Genetic Counseling Ethical, Legal, Social Issues Home Privacy Legislation Gene Testing Patenting ... Genetics in Courtroom Education Teachers Careers Students Webcasts Audio/Video ... Genética Websites en Español Research in Progress Home Sequencing Instrumentation Mapping ... Funding Publications Human Genome News Chromosome Poster Primer Molecular Genetics To Know Ourselves ... List of All Publications Search This Site Search Web pages plus publications Contact Us Privacy Statement Site Stats and Credits The Human Genome Project (HGP) refers to the international 13-year effort formally begun in October 1990 to discover all the estimated 30,000-35,000 human genes and make them accessible for further biological study. Another project goal was to determine the complete sequence of the 3 billion DNA subunits (bases in the human genome). As part of the HGP, parallel studies have been carried out on selected model organisms such as the bacterium

115. The San Antonio Genome Center The University of Texas Health Science Center at San Antonio. Human Genome Project. Chromosome 3 Research. DATABASE FOR CHROMOSOME http://apollo.uthscsa.edu/

The University of Texas Health Science Center at San Antonio Human Genome Project Chromosome 3 Research DATABASE FOR CHROMOSOME 3 MARKERS AND CLONES Our public access database offers information (names, genetic positions, primer sequences, sizes, clones, etc.) on STS, EST, Probes, BAC, PAC and Cosmids. Helpful hints for finding clones and sequences. BAC CONTIGS OF CHROMOSOME 3 In collaboration with the Baylor College of Medicine Genome Center, Sue Naylor is constructing BAC contigs of chromosome 3. The draft sequence of chromosome 3 is being compiled from several different sources. CONTIGS FOR DRAFT SEQUENCE All of the data seen on this page is due to the hard work and dedication of past and present members of The Naylor Lab Genome Group: Dawn Garcia, Xin He, Gabe Barrera, Kenny Jastrow, Teresita Martinez, Ana Villasenor, Nicole Buzello, Lisa Trevino, Tammy Morrish, Jason Hawkins and Shanna Moore. We especially thank our informatics expert Ruben Rodriguez for designing and maintaining this web page. Note: There are still frequent updates to the sequence and e-PCR database. For the latest results of each clone, check the ePCR site at

116. Human Genome Project Santa Rosa Press Democrat, CA. Find more news on Human Genome Project. conferences ORDER BY Recently Added Date Descending Date Ascending. Human Genome Project, http://lawgenecentre.org/categories.php?pg=42

117. "The Human Genome Project: A Scientific And Ethical Overview" By Marion L. Carro The Human Genome Project A Scientific and Ethical Overview by Marion L. Carroll, Ph.D., and Jay Ciaffa, Ph.D. http://www.actionbioscience.org/genomic/carroll_ciaffa.html

home search author directory updates signup ... education author bio Marion Carroll, Ph.D., is an Assistant Professor in the Department of Chemistry at Xavier Univ. of Louisiana. ... Jay Ciaffa, Ph.D., is an Associate Professor of Philosophy at Xavier Univ. ... genomics understanding the genome The Human Genome Project: A Scientific and Ethical Overview By Marion L. Carroll and Jay Ciaffa

118. The Human Genome Project Reading the Human Blueprint The Human Genome Project, All human disease is genetic in origin, Nobel laureate Paul Berg of Stanford http://www.hhmi.org/genetictrail/c100.html

Stalking a Lethal Gene In Search of Large Families Reading the Human Blueprint The Human Genome Project Why So Many Errors in Our DNA? How Genetic Disorders Are Inherited How to Conquer a Genetic Disease Of Mice and Men ... HHMI Home Reading the Human Blueprint: The Human Genome Project "All human disease is genetic in origin,'' Nobel laureate Paul Berg of Stanford University told a cancer symposium a few years ago. Berg was exaggerating, but only slightly. It has become increasingly evident that virtually all human afflictions, from cancer to psychiatric disorders and susceptibility to infection, are rooted in our genes. "What we need to do now is find those genes," says James Watson, who shared a Nobel Prize for deciphering the structure of DNA Mapping the human genome actually began in 1911, when the gene responsible for red-green color blindness was assigned to the X chromosome Y chromosome Some other disorders that affect only males were likewise mapped to the X chromosome, but the other 22 pairs of chromosomes remained virtually uncharted until the late 1960s. At that time, biologists fused human and mouse cells to create hybrid cells and found that these uneasy hybrids cast off their human chromosomes until only one or a few of the human chromosomes remained. Any recognizable human proteins found in such cells would therefore have to be produced by genes located on the remaining human chromosomes. Narrowing down the number of chromosomes in this fashion allowed scientists to assign about 100 genes to specific chromosomes.

119. JGI Fugu V3.0 Home With the impending completion of the Human Genome Project the value of the Fugu genome for comparative purposes was noted and in November 2000 the http://genome.jgi-psf.org/fugu/

Search BLAST Browse GO ... Home The Japanese pufferfish Fugu rubripes has the shortest known genome of any vertebrate species. As vertebrates, fish and humans share not only the defining characteristic of a backbone, but also many basic anatomical and physiological similarities. The compact Fugu genome contains the same basic vertebrate blueprint as the human genome in a sequence seven times shorter. This difference is primarily due to the scarcity in Fugu of the large repeat-filled tracts that litter the human genome. The relative compactness of the Fugu genome simplifies the detection and analysis of both gene sequences and gene regulatory elements. "Blue fish," oil painting by Leila Hornick The Fugu Genome Project was initiated in 1989 in Cambridge by Sydney Brenner and his colleagues Greg Elgar, Sam Aparicio, and Byrappa Venkatesh. With the impending completion of the Human Genome Project the value of the Fugu genome for comparative purposes was noted and in November 2000 the International Fugu Genome Consortium was formed, headed by the Joint Genome Institute, IMCB Singapore, and the HGMP Cambridge. During the following year, the

120. Background To The Human Genome Project YourGenome.org, Background to the Human Genome Project. You are here The Human Genome Project is an immense enterprise. The idea of http://www.yourgenome.org/intermediate/hgp/

Background to the Human Genome Project You are here: Home Intermediate The Human Genome Project Homepage ... Timeline Yes No Don't know (27418 votes) The Human Genome Project is an immense enterprise. The idea of sequencing the entire human genome was first proposed by biomedical researchers in the mid-1980s, only a few years after the Sanger method of sequencing DNA had been developed. Two organizations in the United States took up these proposals: the first organization was the Department of Energy, which was interested in finding out more about the damage caused to DNA by radiation. The second was the National Institutes of Health, which receives money from the US government to give to medical research projects. By October 1990, these two organizations had put together a plan to begin sequencing the human genome . Work in the United Kingdom focused initally on mapping the human genome but, in 1992, the Wellcome Trust and the Medical Research Council agreed to fund sequencing on a larger scale. This led to the establishment of the Sanger Centre. last modified : Wed Aug 29 15:15:32 2001 webmaster@yourgenome.org

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