1. Human Genome Research The US Human Genome Project (HGP), composed of the DOE and NIH Human Genome Programs, is the national coordinated effort to characterize all human genetic http://www.er.doe.gov/production/ober/hug_top.html

Human Genome Research An Introduction The U.S. Human Genome Project (HGP), composed of the DOE and NIH Human Genome Programs, is the national coordinated effort to characterize all human genetic material by determining the complete sequence of the DNA in the human genome. The HGP's ultimate goal has been to discover all the more than 30,000 human genes and render them accessible for further biological study. To facilitate the future interpretation of human gene function, parallel studies have been carried out on selected model organisms. View timeline and history for background information on the project. The HGP will meet an ambitious schedule to complete the full sequence in 2003, two years ahead of previous projections. Technology available shortly after the start of the HGP in 1990 could have been used to attain HGP objectives, but the cost and time required would have been unacceptable. Because of this, a major emphasis of the project's early years was to optimize existing methods and develop new technologies to increase DNA mapping and sequencing efficiency by 10- to 20-fold. The genome was sequenced with technologies and methods that evolved over the past 10 years. In the course of completing the sequence, an interim "working draft" of the human sequence was produced and published in

2. National Human Genome Research Institute - Home Page The National Human Genome Research Institute led the Human Genome Project for the National Institutes of Health, which culminated in the completion of the full http://www.nhgri.nih.gov/

Genomic Research Intramural Research Research Resources More Genetics FAQ Genetic Disorders Clinical Research More Health Issues More Life in the Lab : A new video for DNA Day open captioned closed captioned New User's Guide to the Human Genome ... Nature Genetics The National Human Genome Research Institute led the Human Genome Project for the National Institutes of Health, which culminated in the completion of the full human genome sequence in April 2003. Now, NHGRI moves forward into the genomic era with research aimed at improving human health and fighting disease. A Vision for the Future of Genomic Research International HapMap Project The ENCODE Project The Ethical, Legal and Social Implications (ELSI) Program ... NHGRI Scientists Return to School for Second National DNA Day April 21, 2004 Scientists Compare Rat Genome With Human, Mouse Press Conference Webcast March 31, 2004 International Sequencing Consortium Launches Online Resource March 24, 2004 DIR Seminar Series June 10, 2004 Dr. Bruce D. Gelb Noonan Syndrome: The Heart and the Blood that Runs Through It Privacy Contact Accessibility Site Index ... Staff Search

3. Human Genome Project Information The main homepage for Human Genome Project information what the project is; its progress, history, and goals; what issues are associated with genome research http://www.ornl.gov/TechResources/Human_Genome/home.html

Human Genome Project Information Genomics:GTL Microbial Genome Program home The Human Genome Program of the U.S. Department of Energy funds this suite of Web sites. Gene Gateway tools for exploring the sequence The Genomics:GTL program is DOE's next step in genomicsbuilding on data and resources from the Human Genome Project, the Microbial Genome Program, and systems biology to accelerate understanding of dynamic living systems for energy and environmental applications. Welcome! Explore this site for information about the U.S. and worldwide Human Genome Project. B egun in 1990, the U.S. Human Genome Project is a 13-year effort coordinated by the Department of Energy and the National Institutes of Health. The project originally was planned to last 15 years, but effective resource and technological advances have accelerated the completion date to 2003. Project goals were to identify all the approximately 30,000 genes in human DNA, determine the sequences of the 3 billion chemical base pairs that make up human DNA

4. DoeGenomes.orggenome Programs Of The US Department Of Energy Site of the US Human Genome Project, GenomicsGTL Program, and Microbial Genome Programall sponsored by the US Department of Energy Genome Programs. http://www.ornl.gov/hgmis/

5. ELSI - Human Genome Project Primarily a collection of links to sites exploring the ELSI. http://www.kumc.edu/gec/prof/geneelsi.html

Ethical, Legal, Social, Implications of Human Genome Project Professional policy papers Ethical, Legal, Public Policy Testing / Insurance / Privacy / Nondiscrimination Health Insurance Portability ... Other Policy papers on specific issues, professional societies American Society of Human Genetics (ASHG) policy papers on Maternal Serum Alpha-Fetoprotein Screening, DNA Analysis, Cystic Fibrosis, Genetics and Adoption, Cystic Fibrosis Carrier Screening. Genetic Testing for Breast and Ovarian Cancer, Testing in Children and Adolescents, Apolipoprotein E Testing for Alzheimer Disease, Disclosure of Familial Genetic Information, Eugenics, and other Genetic Testing Issues American College of Medical Genetics (ACMG) policy papers on Prenatal FISH Studies, Multiple Marker Screening in Women 35 and Older, Fragile X Syndrome Testing, Advanced Paternal Age, Apolipoprotein E Testing for Alzheimer Disease, Testing in Children and Adolescents, Testing for Prader-Willi and Angelman Syndromes, Population Screening for BRCA-1 Mutation in Ashkenazi Jewish Women, Principles of Screening, Carrier Testing for Canavann Disease , Genetic Testing for Cystic Fibrosis, and other testing issues German Society for Human Genetics Statements and Declarations and Position Paper American Society of Gene Therapy policy/ position statements Genetic Disorders and Birth Defects: Compendium of AAP Guidelines for the Primary Care Practitioner , American Academy of Pediatrics, genetic policy statements on Congenital Adrenal Hyperplasia, Evaluation of the Newborn With Developmental Anomalies of the External Genitalia, Folic Acid and Neural Tube Defects, Achondroplasia, Down Syndrome, Fragile X Syndrome, Marfan Syndrome, Neurofibromatosis, Sickle Cell Disease, Turner Syndrome, Williams Syndrome, Maternal Phenylketonuria, Molecular Genetic Testing, Congenital Hypothyroidism, Newborn Screening, Prenatal Genetic Diagnosis

6. The Human Transcript Map A guide to human genes produced by placing cDNA transcripts onto a map of the human genome. The Human Genome Project is expected to produce a sequence of DNA representing the functional blueprint http://www.ncbi.nlm.nih.gov/SCIENCE96

A Gene Map of the Human Genome An update to this work has recently been released. See GeneMap'98 T he Human Genome Project is expected to produce a sequence of DNA representing the functional blueprint and evolutionary history of the human species. However, only about 3% of this sequence is thought to specify the portions of our 50,000 to 100,000 genes that encode proteins. Thus an important part of basic and applied genomics is to identify and localize these genes in a process known as transcript mapping. When genes are expressed, their sequences are first converted into messenger RNA transcripts, which can be isolated in the form of complementary DNAs (cDNAs). Approximately half of all human genes had been sampled as of 15 June, 1996. A small portion of each cDNA sequence is all that is needed to develop unique gene markers, known as sequence tagged sites or STSs, which can be detected in chromosomal DNA by assays based on the polymerase chain reaction (PCR). To construct a transcript map, cDNA sequences from a master catalog of human genes were distributed to mapping laboratories in North America, Europe, and Japan. These cDNAs were converted to STSs and their physical locations on chromosomes determined on one of two radiation hybrid (RH) panels or a yeast artificial chromosome (YAC) library containing human genomic DNA. This mapping data was integrated relative to the human genetic map and then cross-referenced to cytogenetic band maps of the chromosomes. (Further details are available in the accompanying article in the 25 October issue of SCIENCE).

7. BBC News | NEWSNIGHT | Genome Transcript - 12/2/01 Transcript of a discussion with David Baltimore, John Sulston and David Bentley about the project. http://news.bbc.co.uk/1/hi/events/newsnight/1173801.stm

low graphics version feedback help You are in: Events: Newsnight Front Page World ... AudioVideo This transcript has been typed at speed, and therefore may contain mistakes. Newsnight accepts no responsibility for these. However, we will be happy to correct serious errors. Who owns the map of the human body? SUSAN WATTS: Wherever we look, our world has been conquered. We've trodden its contours, mapped its every detail and understand what it holds. Today, a new exploration has begun - the exploration of ourselves. Scientists have had a rough map of our genes since last summer, but only now are they beginning to make sense of this new terrain. It's turning out to be an exhilarating journey. DAVID BALTIMORE: President, California Institute of Technology Shivers ran down my spine because I realised that we were seeing human beings opened to investigation with a depth we'd never seen before. JOHN SULSTON: International Human Genome Project This is an iconic moment when we say we've got to this point - it's only the beginning not the end, in fact it's only halfway through the beginning. WATTS: SULSTON: Without that, not only would we have a privatised genome, but we would not have a genome at all.

8. June 9, 2000, Hour One: Human Genome Project / Genetics Update Where does the push to sequence the human genome stand, and what's the outlook for the near future? And what will knowing the genome be able to tell us? A genetics update on this hour of Science Friday. http://www.sciencefriday.com/pages/2000/Jun/hour1_060900.html

THIS WEEK ON  SCIENCE FRIDAY... Science Friday Archives June Hour One: Human Genome Project / Genetics Update As rumors swirled around the genetics community that the Celera corporation was within days of releasing the full results of their human genome sequencing work, Craig Venter, head of Celera, and Francis Collins, head of the National Institutes of Health genome project, said that their two projects really were not racing to the finish at all. At an NIH conference on genetics and cancer this week, the two scientists said that their roles "complemented" each other. Furthermore, the Celera leader said that all the company's genome data would be made freely available, not sold privately to pharmaceutical and biotech companies. This unusually friendly meeting between the two scientists comes during a busy time for genetics research. Earlier his month, Celera announced that it had sequenced 1/3 of the mouse genome. In March, the company published the data for the gene sequence of the fruit fly, a favorite of biologists. In other news, the actual number of genes in the human genome is in debate. Estimates range from about 30,000 to over 100,000but noone really knows. Dueling papers in the journal Nature Genetics, and a debate at a recent conference at the Cold Spring Harbor Laboratory, have increased the speculation. (There's even a sweepstakes running in which scientists bet on the number of genes that code for proteins, winner take all.)

9. National Human Genome Research Institute - 2004 Release Scientists Compare Rat G of the human genome, said NHGRI Director Francis S. Collins, MD, Ph.D. As we build upon the foundation laid by the Human Genome Project, it s become clear http://www.nhgri.nih.gov/11511308

Rat Genome Press Conference Webcast Current News Releases 2004 Release Scientists Compare Rat Genome Scientists Compare Rat Genome With Human, Mouse Analysis Yields New Insights into Medical Model, Evolutionary Process BETHESDA, Md., Wed., March 31, 2004 - An international research team, supported by the National Institutes of Health (NIH), today announced it has completed a high-quality, draft sequence of the genome of the laboratory rat, and has used that data to explore how the rat's genetic blueprint stacks up against those of mice and humans. In a paper published in the April 1 issue of the journal Nature , the Rat Genome Sequencing Project Consortium describes its efforts to produce and analyze a draft sequence of the Brown Norway strain of the laboratory rat ( Rattus norvegicus ). The project, led by the Human Genome Sequencing Center at Baylor College of Medicine in Houston, was primarily funded by the National Heart, Lung and Blood Institute (NHLBI), $58.5 million, and the National Human Genome Research Institute (NHGRI), $60 million. "This is an investment that is destined to yield major payoffs in the fight against human disease," said NIH Director Elias A. Zerhouni, M.D. "For nearly 200 years, the laboratory rat has played a valuable role in efforts to understand human biology and to develop new and better drugs. Now, armed with this sequencing data, a new generation of researchers will be able to greatly improve the utility of rat models and thereby improve human health."

10. Education And Genetics: Human Genome Project Information A resource for introductory information on the Human Genome Project. http://www.ornl.gov/sci/techresources/Human_Genome/education/education.shtml

Human Genome Project Information Genomics:GTL Microbial Genome Program home ... skip navigation Human Genome Project Education Resources Subject Index Alphabetical Index Send the url of this page to a friend News What's New Genetics Headlines Human Genome News Meetings Calendar ... Media Guide Basic Information FAQs Glossary Acronyms Links ... Publications About the Project What is it? Goals Progress History ... Genetics 101 the New Genetics Home Gene Testing Gene Therapy Pharmacogenomics ... Genetic Counseling Ethical, Legal, Social Issues Home Privacy Legislation Gene Testing Patenting ... Genetics in Courtroom Education Teachers Careers Students Webcasts Audio/Video ... Genética Websites en Español Research Home Sequencing Instrumentation Mapping ... Funding Publications Human Genome News Chromosome Poster Primer Molecular Genetics To Know Ourselves ... List of All Publications Search This Site Contact Us Privacy Statement Site Stats and Credits US Human Genome Project (HGP) Resources for Educators and Students Teachers: Please respond to this short Educator Survey so that we may better serve your needs.

11. CEPE2001 Ethics of information and communication technology as an extension of the human body, as in ionics and in the Human Genome Project. Hosted in Lancaster University, U.K., 14 to 16 December 2001. http://www.lancs.ac.uk/depts/philosophy/conferences/

Computer Ethics: Philosophical Enquiries IT and the Body The cybernetics of men, as you, Socrates often call politics – Plato’s Clitophon Bailrigg Lancaster LA1 4YW (U.K.) Tel: +44 (0) 1524 593321 Fax: +44 (0) 1524 email: cepe@lancaster.ac.uk Now Available! Proceedings of £12 plus postal expenses December 14-16, 2001 Organized by Centre for Study of Technology in Organizations Institute for Environment, Philosophy and Public Policy Now Available! Proceedings of £12 plus postal expenses Authors Guidelines Call for Papers Important dates Paper length and Formatting Requirements Conference Facts Conference Schedule List of accepted papers (Now including abstracts and full papers) Conference Events Registration Conference Fees Registration Form Hotels List Conference Maps Conference venue Campus map Travel information More about Lancaster The Ruskin Library in Lancaster University SPONSORED BY: INSEIT (International Society for Ethics and Information Technology) Ethics and Information Technology Journal Lancaster University Faculty of Social Science National Science Foundation Media Sponsor: Last Update: C onference Co-Chairs Ruth Chadwick Institute for Environment, Philosophy and Public Policy

12. CNN.com - U.S. And Britain To Make Human Genome Project Results Public - March 1 CNN http://www.cnn.com/2000/HEALTH/03/14/human.genome/index.html

health CNN Sites CNN CNNfn CNNSI myCNN AllPolitics Languages myCNN Video Audio Headline News Brief ... Feedback CNN Sites CNN CNN Europe CNNfn CNNSI myCNN CNNfyi AllPolitics Languages Search CNN.com CNNSI.com CNNfn.com The Web HEALTH TOP STORIES New treatments hold out hope for breast cancer patients MORE TOP STORIES Thousands dead in India; quake toll rapidly rising Israelis, Palestinians make final push before Israeli election Davos protesters confront police MORE ... MORE MARKETS 4:30pm ET, 4/16 DJIA NAS SPORTS Jordan says farewell for the third time ... daily almanac MULTIMEDIA: video video archive audio multimedia showcase ... more services E-MAIL: Subscribe to one of our news e-mail lists Enter your address: DISCUSSION: message boards chat feedback CNN WEB SITES: AsiaNow Spanish Portuguese Italian ... Danish FASTER ACCESS: europe japan TIME INC. SITES: Go To ... Time.com People Money Fortune EW CNN NETWORKS: more networks transcripts Turner distribution SITE INFO: help contents search ad info ... jobs WEB SERVICES: U.S. and Britain to make Human Genome Project results public White House announcement expected today March 14, 2000

13. National Human Genome Research Institute Education Kit online education kit, Welcome to the Human Genome Project, Exploring Our Molecular Selves online multimedia educational kit. The http://www.genome.gov/Pages/EducationKit/

Welcome to the Human Genome Project, "Exploring Our Molecular Selves" online multimedia educational kit. The Human Genome Project (HGP) began in 1990 as an effort by researchers from around the world to map and sequence the human genome - the totality of human DNA - as well as the genomes of important experimental organisms, like yeast, the nematode worm, and mouse. In 2000, the collaborators in the HGP announced the completion of a draft revealing 90% of the human sequence and in February 2001, the initial analysis of the human genome sequence was published in the scientific literature. To mark this occasion, the Human Genome Project released a free, multimedia educational kit for high school students and the interested public. A limited number of kits were produced and distributed within the first year of the release in February 2001. In order to continue to provide broad access of these materials, the contents of the education kit were reformatted and are available on this website in two formats; download modules or online viewing. Additionally, the online version contains two segments that are not available for download. The contents of both versions are listed below.

14. National Human Genome Research Institute - Genomic Research Genomic Research began with The Human Genome Project (HGP), the international research effort that determined the DNA sequence of the entire human genome http://www.genome.gov/page.cfm?pageID=10001694

15. UK MRC Human Genome Mapping Resource Centre UK MRC Human Genome Mapping Resource Centre The home page of the UK MRC HGMPRC which exists to provide specialist resources and services for scientists working on the Human Genome Project, http://rdre1.inktomi.com/click?u=http://www.hgmp.mrc.ac.uk/&y=024FDFDD74E50D

16. The Sanger Institute : Human Genome Project Help, Links, Sitemap, Human Genome Project. Human Genome Project at the Sanger Institute. A general overview of the Human Genome Project is available. Percentage. http://www.sanger.ac.uk/HGP/

Sanger Home Acedb YourGenome Ensembl ... HGP Home Chr ? Chr 1 Chr 6 Chr 9 Chr 10 Chr 11 Chr 13 Chr 20 Chr 22 Chr X Annotation Genes Polymorphism RH/EST Maps ... CpG islands Genome browsers Ensembl Chr ? Chr 1 Chr 2 Chr 3 Chr 4 Chr 5 Chr 6 Chr 7 Chr 8 Chr 9 Chr 10 Chr 11 Chr 12 Chr 13 Chr 14 Chr 15 Chr 16 Chr 17 Chr 18 Chr 19 Chr 20 Chr 21 Chr 22 Chr X Chr Y Vega Chr ? VEGA Chr 6 Chr 7 Chr 9 Chr 10 Chr 13 Chr 14 Chr 20 Chr 22 HGP Home Finished Sequence 2003 Publication 2001 Draft 2000 Overview ... Sitemap Human Genome Project Human Genome Project at the Sanger Institute The human genome research programme at The Sanger Institute overview of the human genome project is available. Percentage Draft Finished Total Sequencing status The Sanger Institute is engaged upon collaborative projects to sequence all or part of chromosomes and X Access chromosome sequencing project information, sequence and map data by selecting a chromosome number from the sidebar or click the appropriate chromosome image. You may search individual or combined chromosome project information using our combined search form. We also provide a very fast sequence similarity BLAST search service on a per-chromosome e.g. ( ) or whole genome basis.

17. History Of The Human Genome Project Details about the U.S. Human Genome Project including its goals, history and progress with links to key documents, publications, a timeline, and Project contacts. http://www.ornl.gov/sci/techresources/Human_Genome/project/hgp.shtml

Human Genome Project Information Genomics:GTL Microbial Genome Program home ... skip navigation History of the Human Genome Project Subject Index Alphabetical Index Send the url of this page to a friend News What's New Genetics Headlines Human Genome News Meetings Calendar ... Media Guide Basic Information FAQs Glossary Acronyms Links ... Publications About the Project What is it? Goals Progress History ... Genetics 101 the New Genetics Home Gene Testing Gene Therapy Pharmacogenomics ... Genetic Counseling Ethical, Legal, Social Issues Home Privacy Legislation Gene Testing Patenting ... Genetics in Courtroom Education Teachers Careers Students Webcasts Audio/Video ... Genética Websites en Español Research Home Sequencing Instrumentation Mapping ... Funding Publications Human Genome News Chromosome Poster Primer Molecular Genetics To Know Ourselves ... List of All Publications Search This Site Contact Us Privacy Statement Site Stats and Credits The Human Genome Project (HGP) refers to the international 13-year effort formally begun in October 1990 to discover all the estimated 30,000 to 35,000 human genes and make them accessible for further biological study. Another project goal was to determine the complete sequence of the 3 billion DNA subunits (bases in the human genome). As part of the HGP, parallel studies have been carried out on selected model organisms such as the bacterium

18. NCBI Human Genome Resources facing researchers today is that of piecing together and analyzing the plethora of data currently being generated through the Human Genome Project and scores http://www.ncbi.nlm.nih.gov/genome/guide/

NCBI Home Genomic Biology Homo sapiens Browse Your Genome Click on a chromosome to show Clones Genes Physical Maps Linkage Maps Variation The NCBI Handbook An online guide to the use of NCBI resources. Titles of selected chapters that refer to human genome resources are shown below. The Single Nucleotide Polymorphism Database (dbSNP) of Nucleotide Sequence Variation. by Adrienne Kitts and Stephen Sherry The Gene Expression Omnibus (GEO): A Gene Expression and Hybridization Repository. by Ron Edgar and Alex Lash Online Mendelian Inheritance in Man (OMIM): A Directory of Human Genes and Genetic Disorders. by Donna Maglott, Joanna S. Amberger, and Ada Hamosh The SKY/CGH Database for Spectral Karyotyping and Comparative Genomic Hybridization Data. by Turid Knutsen, Vasuki Gobu, Rodger Knaus, Thomas Ried, and Karl Sirotkin Genome Assembly and Annotation Process. by Paul Kitts The Reference Sequence (RefSeq) Project. by Kim D. Pruitt, Tatiana Tatusova, and James M. Ostell LocusLink: A Directory of Genes. by Donna Maglott Using the Map Viewer to Explore Genomes.

19. Genome Glossary Indexed and crossreferenced collection of genetic's terminology. http://www.ornl.gov/sci/techresources/Human_Genome/glossary/index.shtml

Human Genome Project Information Genomics:GTL Microbial Genome Program home ... skip navigation Genome Glossary Subject Index Alphabetical Index Send the url of this page to a friend News What's New Genetics Headlines Human Genome News Meetings Calendar ... Media Guide Basic Information FAQs Glossary Acronyms Links ... Publications About the Project What is it? Goals Progress History ... Genetics 101 the New Genetics Home Gene Testing Gene Therapy Pharmacogenomics ... Genetic Counseling Ethical, Legal, Social Issues Home Privacy Legislation Gene Testing Patenting ... Genetics in Courtroom Education Teachers Careers Students Webcasts Audio/Video ... Genética Websites en Español Research Home Sequencing Instrumentation Mapping ... Funding Publications Human Genome News Chromosome Poster Primer Molecular Genetics To Know Ourselves ... List of All Publications Search This Site Contact Us Privacy Statement Site Stats and Credits A glossary of genetic terms from the DOE Human Genome Program. Choose terms by using the list of links below Also visit the Human Genome Project Information web : what the project is; its progress, history, and goals; what issues are associated with genome research; frequently asked questions, the science behind the project; and who its sponsors are.

20. DHGP - German Human Genome Project Translate this page German Human Genome Project - Last update May-18-2004 Recommended For Best Viewing 1024 x 768, Internet Explorer 5.0, Netscape 6.1, Opera 7.20. http://www.dhgp.de/

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