21. DOE Joint Genome Institute Dynamic comparative analysis of the human and mouse genomes. Includes introduction to genomics, historical timeline and poster, operated for the Department of Energy by UC, Berkeley, California. http://www.jgi.doe.gov/

WHO WE ARE Mission Statement Progress Report Organizational Chart ... SEARCH DOE JOINT GENOME INSTITUTE Operated by The University of California for The US Department of Energy MICROBIAL GENOME PROGRAM SEQUENCING TARGETS The DoE Microbial Genome Program is now accepting nominations for Sequencing Targets in support of the Science Missions of the Office of Biological and Environmental Research (BER). Proposals are due July 1, 2004. More information is available here: http://www.ornl.gov/sci/microbialgenomes/ We are no longer accepting proposals for 2004. The next call for CSP proposals will open in six to nine months. Stay tuned to the CSP site for upcoming deadlines. CURRENT JGI SEQUENCING STATISTICS Date Total Q20 Bases Total Runs Pass Rate Read Length 10.365 Million

22. Human Genome Sciences: BLyS human proteins identified through genomics may have medical properties superior toconventional smallmolecule drugs, and may enter clinical trials more quickly http://www.hgsi.com/products/BLyS.html

Giambattista Tiepolo Mercury, Messenger of the Gods B Lymphocyte Stimulator (BLyS) Background In July 1999, Human Genome Sciences (HGS) reported the discovery of a novel human protein called B Lymphocyte Stimulator, or BLyS. (1) BLyS stimulates immune system cells called B cells to mature into plasma B cells, which produce antibodies (see Fig. 1). Plasma B cells and the antibodies they produce constitute a critical part of the body's defense against infections and cancer. Fig. 1: BLyS released from monocytes activates resting B cells, stimulating them to become plasma B cells that secrete antibodies. ( See Detailed Image The discovery of BLyS may lead to therapies for several diseases that involve B cells, including immune deficiencies, autoimmune disease and B cell tumors. Human Genome Sciences' drug development teams are advancing several therapeutic concepts based on the discovery of BLyS: BLyS therapeutic protein, human monoclonal antibodies targeting BLyS, and radiolabeled BLyS. How BLyS Works BLyS is made by immune-cells called monocytes and macrophages. When monocytes and macrophages are activated, BLyS is released and binds to a receptor found only on B cells. B cells arise from stem cells that do not themselves produce antibodies. When BLyS binds to its receptor on B cells, they mature into antibody-secreting plasma B cells. As a result, the number of antibodies in the patient's plasma increases.

23. OSG Global - Executive Placement In Regulatory Affairs, Life Sciences, Bioinform Multinational human Resource Full Service Staffing, Consulting, Professional Executive Search Organization focusing on Biotech, Pharmaceutical, Bioinformatics, Life Sciences, Chemistry, Medical, Clinical Research, Regulatory (FDA), genomics, Information Technology, Accounting and Finance disciplines. http://www.osgglobal.com

OSG Global A Management Recruiters International Network Affiliate MRI is a subsidiary of CDI Corp. Founded 1975 OSG Global an international firm, has been providing Worldwide Search, Recruitment and Human Resource Consulting Services and Solutions since 1975. At OSG-Global you will find highly experienced specialists in Our companies, affiliations and partnerships provide access to the "World's Largest Search Network." 1,100 Offices in 33 Countries "World's Largest Search Organization" 1,100 Offices in 33 Countries - USA - All 50 States and Puerto Rico, Mexico, Canada, Australia, Austria, Belgium, Bulgaria, China, Cyprus, Czech Republic, Finland, France, Germany, Hong Kong, Iceland, Ireland, Japan, Korea, Luxembourg, Malaysia, Malta, Northern Ireland, Netherlands, New Zeland, Norway, Philippines, Portugal, Romania, Russia, South Africa, Scotland, Singapore, Spain, Sweden, Switzerland, Thailand, Turkey, UAE, Ukraine, United Kingdom Google OSG Global Headquartered At: 1400 E. Touhy Ave., Suite 160 Des Plaines, IL 60018

24. The Laboratory Of Professor David E. Housman mouse genetics to develop useful models for understanding the genetic contribution to human disease phenotypes and suggestions regarding this home page to hmangenomics-www@mit.edu http://web.mit.edu/hman-genomics/www

The Laboratory of Professor David E. Housman Center for Cancer Research Massachusetts Institute of Technology 77 Massachusetts Avenue, E17-543 Cambridge, MA 02139 ph: (617) 253-3013 fax: (617) 253-5202 General outline of our research activity: Identification and characterization of mammalian genes involved in diseases and development, Development and implementation of strategies for efficient mapping of mammalian genomes, and Utilization of mouse genetics to develop useful models for understanding the genetic contribution to human disease phenotypes. Genetic Marker Home Page Lab Members Publications Related Links Please send comments and suggestions regarding this home page to: hman-genomics-www@mit.edu Last modified March 2000

25. Cambridge Antibody Technology Company developing human monoclonal antibodies as novel therapeutics. Also applying its technology platform to functional genomics to assist the discovery of new drug targets. http://www.cambridgeantibody.com

26. Www.oscient.com Develops genomicsbased drug discovery technologies which utilize pathogen functional genomics and bioinformatics capabilities to discover and characterize genes of pathogens and human disease genes. (Nasdaq GENE). http://www.genomecorp.com/

27. Nature Genome Gateway - Human Genome - Overview - Press Releases Comprehensive information on the first draft of the human genome from Nature. http://www.nature.com/genomics/human/overview/press-releases.html

genome gateway human genome press releases press releases The mapping, sequence and analysis of the human genome are a fundamental advance in self-knowledge and will strike a chord with many people. Application of this knowledge will, in time, materially benefit almost everyone in the world. As such the publication of the human genome is likely to attract a large amount of news coverage in both specialist scientific, and general media alike. Part of Nature 's role as a scientific journal is to act as a conduit for the transfer of information from scientists to the 1600 science journalists and writers who receive our press releases. This press release material, written by Nature 's science writing team acts as a concise and accessible 'walk-through' of the content of Nature 's human genome special issue. A web cast of the joint Celera and International Human Genome Sequencing Consortium press conference is available on the NIH's web site the genome article Initial sequencing and analysis of the human genome THE GENOME INTERNATIONAL SEQUENCING CONSORTIUM Nature 860-921 (15 February 2001) Summary Full Text PDF the comparison The authors compare the vital statistics for the publicly funded Human Genome Project and the private Celera effort in terms of amount of sequence, gaps, number of unique sequences and continuity of sequence. They find that the two sequences are essentially comparable.

28. Science -- Table Of Contents {16 February 2001; 291 (5507)} in Science A Tale of Two Sequences * The Data Horizon * Insights from Genomic Data* The Sequence of the human Genome * Medicine and genomics * Metaphors and http://www.sciencemag.org/content/vol291/issue5507/

Table of Contents 16 February 2001 Volume 291 Number 5507 The Human Genome Previous Issue Next Human Genome Special Issue: Free Access to All Users Editorial Overview The Human Genome Sequence The Story Behind the Genome (with Timeline How to Access the Data SPECIAL ISSUE Editorial The Human Genome Barbara R. Jasny and Donald Kennedy Science Feb 16 2001: 1153. [Summary] Review The Sequence of the Human Genome Science Feb 16 2001: 1304-1351. [Abstract] [Full Text] [Supplemental Data] [Web Fig. 1] ... [Japanese Language PDF] RESEARCH This Week in Science A Tale of Two Sequences * The Data Horizon * Insights from Genomic Data * The Sequence of the Human Genome * Medicine and Genomics * Metaphors and Meanings Science Feb 16 2001: 1155 [Full Text] Editors' Choice: Highlights of the recent literature GEOCHEMISTRY: Silicon's Travels * APPLIED PHYSICS: Twisting an Arm Gently * MOLECULAR BIOLOGY: The Tail End of mRNA Decay * ECOLOGY/EVOLUTION: Evolution of Testis Size * PSYCHOLOGY: The Fleeting Nature of Fame * CLIMATOLOGY: The Rainy Season * CHEMISTRY: Tying Up Triplexes * MICROBIOLOGY: Not So Silent Passenger * STKE: Taking up Residence Science Feb 16 2001: 1159 [Full Text] Reports Analysis of Genetic Information Apoptotic Molecular Machinery: Vastly Increased Complexity in Vertebrates Revealed by Genome Comparisons L. Aravind, Vishva M. Dixit, and Eugene V. Koonin

29. WTCHG Multidisciplinary research teams in human genetics, functional genomics, bioinformatics, statistical genetics and structural biology. Research areas, divisions, people, seminars, software and data resources, external links. http://www.well.ox.ac.uk/

About the Centre Research Areas Divisions People ... Internal use only The Wellcome Trust Centre for Human Genetics (WTCHG) was established in 1994 to undertake research into the genetic basis of common diseases. Since June 2000 the Centre has been located in the Henry Wellcome Building of Genomic Medicine, University of Oxford. The scientific objective of the Centre is to explore all aspects of the genetic susceptibility of disease including the localisation of genes involved in common diseases, characterisation of the variants responsible for susceptibility, the understanding of how these DNA variants may contribute to risk of disease in the population and finally, how such genetic factors contribute biologically to a disease process. The Centre houses multi-disciplinary research teams in human genetics, functional genomics, bioinformatics, statistical genetics and structural biology.

30. CombiMatrix Corporation - Nanotechnology, DNA Microarrays, SiRNA Solutions CombiMatrix develops life science research products based on proprietary technologies in the areas of genomics and proteomics. CombiMatrix' products are designed to aid in the discovery and development of new drugs and diagnostics for human healthcare. The flexible and customizable technology is also suitable for animal and plant research, as well as industrial and biothreat applications. http://www.combimatrix.com

of CombiMatrix on CNBC's click here to watch video Latest News CombiMatrix Names Michael Tognotti Director of Sales - May 18, 2004 CombiMatrix Group to Receive $13.6 Million From Acacia Research Registered Direct Offering - April 14, 2004 CombiMatrix Names RNAi Pioneer Dr. Mark A. Kay of Stanford University to its Scientific Advisory Board - April 12, 2004 here to learn more about our DNA CustomArrays. here CombiMatrix has received funding from the US Government to develop highly sensitive, flexible, and cost-effective systems for the detection of biological warfare agents. Click here to learn more about our Biological and Chemical Warfare Detection Technology. Utilizing a recently discovered molecular biology phenomenon, CombiMatrix is attempting to discover new drugs for common and deadly viral diseases such as AIDS, Influenza, SARS, Hepatitis, and others. CombiMatrix is leveraging its chip technology to synthesize nucleic acid compounds in a high throughput manner to target these viruses. Click here to learn more about our RNAi drug discovery program.

31. Znomics, Inc. Functional genomics drug discovery company working on the zebrafish as a system to identify genes underlying human disease. http://www.znomics.com

Developing medicines through functional genomics Znomics is a functional genomics company located in Portland, Oregon OR. Using zebrafish, retroviral mutagenesis techniques and other capabilities, the company will improve and speed development of medicines for human health. biotechnology, functional genomics, zebrafish, disease models, drug discovery

32. LLNL Human Genome Center the Center, namely a highresolution, sequence-ready map of human chromosome 19 Programwhich integrates our resources and strengths in genomics with programs http://www-bio.llnl.gov/bbrp/genome/genome.html

LLNL Human Genome Center General description of the Human Genome Center Maps of Human Chromosome 19 Genomic sequencing Informatics ... LLNL Human Genome Center Personnel < with contact information Jobs listing Link to the DOE Joint Genome Institute Homepage In the past two years, the goals of the Human Genome Center have undergone a dramatic evolution. This change is the result of several factors both intrinsic and extrinsic to the Human Genome Initiative. They include: 1) the successful completion of the first phase goal of the Center, namely a high-resolution, sequence-ready map of human chromosome 19; 2) advances in DNA sequencing that allowed us to accelerate scaling this operation; 3) the development of a strategic plan for the Biology and Biotechnology Research Program which integrates our resources and strengths in genomics with programs in DNA repair, individual susceptibility, structural biology, and microbial biotechnology; and 4) the formation of a Joint Genome Institute for the Department of Energy with its three Genome Centers at Livermore, Berkeley, and Los Alamos as anchors. In addition to genomic sequence, over 50 complementary DNA clones (cDNAs) from genes on human chromosome 19 were fully sequenced and submitted to public sequence databases. We have expanded the basis of the LLNL-based I.M.A.G.E. Consortium, an effort to characterize the transcribed human genome, through interactions with numerous collaborators (in particular, Washington University - Merck) such that the clone collection is now the largest public collection of sequenced cDNA clones, with over 500,000 arrayed clones, over 500,000 sequences in public databases, and over 15,000 mapped cDNAs.

33. CuraGen Corporation Simplifying in order to accelerate genomics based product discovery and development. Has created technologies to better understand the role of genes in improving human health, animal health and agricultural vitality. http://www.curagen.com/

June 3, 2004 CuraGen and TopoTarget Announce License and Collaboration Agreement for Development and Commercialization of Novel Phase I HDAC Inhibitor for Oncology Click here for June 4, 2004 Webcast Click here to View Presentation April 21, 2004 CuraGen Initiates Study of CG53135 in Bone Marrow Transplant Patients Mar 30, 2004 CuraGen Presents Advances in Therapeutic Pipeline at AACR Annual Meeting Corporate Profile (PD F) 2003 Annual Report and 10K Read CuraGen's Wall Street Transcript interview from June 2003 (PDF)

34. LLNL Human Genome Center LLNL human Genome Center. genomics is a multidisciplinary approach tocharacterize the genetic material of the human and other species. http://www-bio.llnl.gov/genome/html/genomics.overview.html

LLNL Human Genome Center Click on individual images within picture to see image legends. Click on this image for information about Magellan. Genomics is a multidisciplinary approach to characterize the genetic material of the human and other species. This work is carried out within the Human Genom e Center, whose primary goal is to characterize the mammalian genome at optimal resolution and to provide the information and material resources to other projec ts in house or with collaborators that allow us to exploit the biology of the ge nome in a synergistic manner. We are currently working within the DOE Joint Geno me Institute with emphasis on high-throughput DNA sequencing, sequencing technol ogy development, and functional genomics. With DNA sequence information now prov iding the biological driver for functionalizing the genome, our priorities are to: generate highly accurate sequence for all of chromosome 19; generate highly accurate sequence for genomic regions of high biological int erest to the DOE/OHER mission, e.g. genes involved in DNA repair, replication, recombination, xenobiotic metabolism, cell cycle control, etc.; sequence, in parallel with human, selected corresponding regions of the mouse genome;

35. SpringerLink - Publication Focuses on the experimental, theoretical, and technical aspects of genomics and genetics in mouse, human, and other species, particularly those aspects bearing on studies of gene function. http://link.springer.de/link/service/journals/00335/index.htm

Articles Publications Publishers Home Publication Mammalian Genome Publisher: Springer-Verlag New York, LLC ISSN: 0938-8990 (Paper) 1432-1777 (Online) Subject: Life Sciences Issues in bold contain article full text that you are entitled to view. Volume 15 Number 5 Number 4 Number 3 Number 2 ... Request a sample Volume 14 Number 12 Number 11 Number 10 Number 9 ... Number 1 Volume 13 Number 12 Number 11 Number 10 Number 9 ... Number 1 Volume 12 Number 12 Number 11 Number 10 Number 9 ... Number 1 Volume 11 Number 12 Number 11 Number 10 Number 9 ... Number 1 Volume 10 Number 12 Number 11 Number 10 Number 9 ... Number 1 Volume 9 Number 12 Number 11 Number 10 Number 9 ... Number 1 Volume 8 Special Issue Number 12 Number 11 Number 10 ... Number 1 Volume 7 Number 12 Number 11 Number 10 Number 9 ... Supplement / 1997 Publication 1 of 1 Previous Publication Next Publication Linking Options About This Journal Editorial Board Manuscript Submission Quick Search Search within this publication... For: Table Of Contents Alerting Click the button below to enable Table Of Contents Alerting for this publication.

36. The Human Genome The Wellcome Trust. The human Genome. Music A new opera withn a genomics theme.human senses Chimps shed light on evolution of sight, smell and speech. http://www.wellcome.ac.uk/en/genome/

document.writeln(''); The Human Genome Explore the human genome, and the impact of human genes on health, disease and society. FROM THE NEWS ROOM Diabetes: AKT2 mutation and insulin resistance Genome: Human chromosomes 9 and 10 completed. 27/5/04 ... Genes and alcoholism: Finding the genes that drive us to drink. Robert Waterston: Key figure in nematode worm genome sequencing. 'Gene X for disease Y': Why genetic association studies should be viewed with caution. Rosalind Franklin: Biography of the 'dark lady of DNA'. Angiozyme: Inhibiting the growth of new blood vessels around tumours. Stephen Jay Gould: Evolutionist and prolific writer, who died in May 2002. Antenatal counselling: Non-directiveness is not always easy. VIEW ARTICLES News Features Background GLOSSARY PAGE ... RSS NEWSFEED

37. The Wellcome Trust Sanger Institute SRS, human BLAST, C.elegans BLAST Genome Sequencing Annotation Vega, human, Mouse,Zebrafish, X.tropicalis, Worm, Pathogens, S.pombe genomics Genetics http://www.sanger.ac.uk/

Information Teams Faculty People ... Advertised Jobs 3rd Jun 2004 More Ensembl version 22 released We are pleased to announce the release of Ensembl v22. This release contains the first release of MultiContigView, a new ... 3rd Jun 2004 More DECIPHER Database Released The DECIPHER database of submicroscopic chromosomal imbalance collects clinical information about ... 28th May 2004 More Richard Durbin, Elected to the Royal Society Dr Richard Durbin, Deputy Director of The Sanger Institute, is elected Fellow of the UK's most prestigious scientific organization, the Royal Society. ... 28th May 2004 More Following the Diabetes Pathways Today in Science Inês Barroso from the Sanger Institute and colleagues describe a "Critical Protein in the Response to Insulin". ... Finished Sequence: 2,260,242,135 bases (06-Jun-2004, 03:56 PM) Detailed Statistics www www.sanger.ac.uk Contact us Sitemap

38. Celera Discovery System Login 296, p. 1661 (2002)) on the comparison of whole genome shotgunderived human andthe human genome illustrates the power of comparative genomics based on large http://publication.celera.com/humanpub/index.jsp

39. BBC NEWS | In Depth | Human Genome You are in In Depth human genome. News Front Page, World, UK, England, Internetlinks. human Genome Project. Celera genomics. DNA from the beginning. Sanger Centre. http://news.bbc.co.uk/hi/english/in_depth/sci_tech/2000/human_genome/default.stm

CATEGORIES TV RADIO COMMUNICATE ... INDEX SEARCH You are in: In Depth: Human genome News Front Page World ... Programmes SERVICES Daily E-mail News Ticker Mobile/PDAs Text Only ... Help EDITIONS Change to World Monday, 6 January, 2003, 11:30 GMT Complete genome map 'in 2003' The sequencing of the human genome will be finished by next year, a leading scientist says at a conference in China. Row over 'Book of Life' Genome 'treasure trove' The essence of maleness Nature or nurture? ... 'The end of the beginning' JUNE 2000 ANNOUNCEMENT Scientists crack human code Researchers produce a rough draft of the three billion letters of genetic code that describe human life. Gene row is over What they said: Genome in quotes G-Day for biology GENOME ISSUES What the genome can do for you All the rows and all the money spent in pursuing the human code for life will be well worth it if it fulfils even some of its medical promise. Morality and a code of conduct Employment and insurance How the code was cracked Nature versus nurture ... The history of genetics ARCHIVE: GENOME MILESTONES Scientists detail rice code Researchers read the genetic code of rice - a major achievement that will have a huge impact on world food production.

40. BBC NEWS | Science/Nature | Human Genome Data To Be Released human genome data to be released. The human genetic database compiled bythe private company Celera genomics is to be released to the public. http://news.bbc.co.uk/2/hi/science/nature/3499877.stm

News Sport Weather World Service ... Programmes Last Updated: Wednesday, 18 February, 2004, 13:37 GMT E-mail this to a friend Printable version Human genome data to be released By Dr David Whitehouse BBC News Online science editor Soon to be available to anyone The human genetic database compiled by the private company Celera Genomics is to be released to the public. Celera completed a draft of the human genome three years ago at the same time that a rival, publicly funded, group of scientists finished its own draft. Both groups announced the scientific milestone together at the White House. Experts say the two versions of the human genetic code complement each other, and form the basis for finding the genetic causes of disease. 'Order and orientation' At the time of the 2001 announcement, heralded as a major achievement in science, the Celera genome sequence was only available to paying subscribers of its database. The rival sequence, obtained by the Human Genome Project (HGP) was publically available. Now the Celera sequence is to join it. It will soon be deposited into GenBank, an online DNA database.

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