81. Sickle Cell Anemia sickle cell anemia is an inherited chronic anemia in which the red blood cells become sickle or crescentshaped. sickle cell anemia. http://www.mycustompak.com/healthNotes/Concern/Sickle_Cell_Anemia.htm

Sickle Cell Anemia Also indexed as: Crescent Cell Anemia, Sickle Cell Disease Introduction Checklist Symptoms Treatments ... References Anemia is a deficiency of the oxygen-carrying capacity of red blood cells. Sickle cell anemia is an inherited chronic anemia in which the red blood cells become sickle or crescent-shaped. The symptoms of sickle cell anemia are caused by the clogging of small blood vessels by the sickle cells or by poor delivery of oxygen to the tissues due to the anemia itself. A sickle cell crisis is a painful episode that occurs when the body becomes severely deprived of oxygen. The disease and the trait occur in people of African descent, as well as in people from Mediterranean countries, India, and the Middle East, but rarely in people of European descent. Checklist for Sickle Cell Anemia Rating Nutritional Supplements Herbs Fish oil Folic acid (for lowering homocysteine levels) Vitamin B12 (for sickle cell patients with diagnosed B12 deficiencies) Zinc Beta-carotene and other carotenoids Magnesium Vitamin A Vitamin B2 ... Garlic Reliable and relatively consistent scientific data showing a substantial health benefit.

82. Go Ask Alice!: How Common Is Sickle Cell Anemia? General Health. How common is sickle cell anemia? Dear Alice,. What percentage of African Americans in the US are diagnosed with sickle cell anemia? Dear Reader,. http://www.goaskalice.columbia.edu/2061.html

Mac users: please note that our site is optimized for the Safari browser General Health How common is sickle cell anemia? Originally Published: April 23, 2004 Dear Alice, What percentage of African Americans in the U.S. are diagnosed with Sickle Cell Anemia? Dear Reader, Although Sickle Cell Anemia is a relatively rare condition (about one in four thousand Americans have some form of the disease), its significant impact on the African American community and its life-threatening consequences have made it one of the better-known genetic disorders. Approximately 80,000 (or about one in 400) African Americans have some form of Sickle Cell Disease, and another two million (or 1 in 12) African Americans carry the sickle cell trait — a genetic predisposition toward the disease that can be passed down to their children. Even though both sickle cell disease and trait are most common among African Americans, other Americans who trace their ancestry back to the Mediterranean region, South and Central America, Saudi Arabia, and India can also be affected. Sickle cell disease is caused by a defect in the gene that controls the production of hemoglobin. Hemoglobin is the part of red blood cells that is responsible for carrying oxygen in the blood stream throughout the body. Defective hemoglobin produced by the sickle gene become stiff, causing the red blood cells to change from rounded, doughnut-shaped cells that can flow easily through small blood vessels, to pointy sickle-shaped cells. These sickle-shaped cells get stuck in narrow blood vessels and cause traffic jams that interrupt the flow of oxygen to various parts of the body. The body attempts to get rid of these abnormal cells by destroying them, creating sickle cell anemia (anemia is a condition caused by a subnormal level of hemoglobin or red blood cells) that, in turn, can lead to chronic fatigue and decreased resistance to infection.

83. Sickle Cell Anemia(Age 2) Ato-Z Guide sickle cell anemia Age 2 Approved by the ParentCenter Medical Advisory Board. What s below What is sickle cell anemia? http://www.parentcenter.com/refcap/health/ills&inj/atoz/2721.html

Search Home Health A-to-Z Guide A-to-Z Guide Sickle cell anemia Age 2 Approved by the ParentCenter Medical Advisory Board What's below: What is sickle cell anemia? How does a child get sickle cell anemia? Can carriers get the disease? How do doctors diagnose sickle cell anemia? ... How can we cope with this disease? What is sickle cell anemia? Sickle cell anemia is a disease of red blood cells that is passed from parent to child. Normally red blood cells contain a protein called hemoglobin A, which carries oxygen to all the organs in the body. With sickle cell anemia, however, the body makes a different kind of protein, called hemoglobin S. The problem is that when a red blood cell with hemoglobin S releases oxygen, the cell changes from the usual doughnut shape to a sickle or S shape, and becomes stiff rather than soft and flexible like normal red blood cells. This "sickled cell", which resembles a crescent moon, can't continue to glide through the small blood vessels as usual. Instead, it gets stuck in the tiny blood vessels, blocking the flow of blood and causing pain. The spleen, an organ on the left side of the abdomen across from the liver, is responsible for filtering the blood for infections and other abnormalities. Normal red blood cells can change shape and squeeze through this filter, but sickled cells get stuck and cannot recirculate through the body, so that the number of circulating blood cells goes down. Meanwhile, the bone marrow, where red blood cells are made, pitches in by making more cells. It can't keep up with the destruction, though, so the total number of red blood cells drops to a low level and the body becomes anemic. ("Anemic" is the medical word for having a low number of red blood cells.)

84. Sickle Cell Anemia(Ages 3 To 8) Ato-Z Guide sickle cell anemia Ages 3 to 8 Approved by the ParentCenter Medical Advisory Board. What s below What is sickle cell anemia? http://www.parentcenter.com/refcap/health/ills&inj/atoz/2726.html

Search Home Health A-to-Z Guide A-to-Z Guide Sickle cell anemia Ages 3 to 8 Approved by the ParentCenter Medical Advisory Board What's below: What is sickle cell anemia? How does a child get sickle cell anemia? Can carriers get the disease? How do doctors diagnose sickle cell anemia? ... How can we cope with this disease? What is sickle cell anemia? Sickle cell anemia is a disease of red blood cells that is passed from parent to child. Normally red blood cells contain a protein called hemoglobin A, which carries oxygen to all the organs in the body. With sickle cell anemia, however, the body makes a different kind of protein, called hemoglobin S. The problem is that when a red blood cell with hemoglobin S releases oxygen, the cell changes from the usual doughnut shape to a sickle or S shape, and becomes stiff rather than soft and flexible like normal red blood cells. This "sickled cell," which resembles a crescent moon, can't continue to glide through the small blood vessels as usual. Instead, it gets stuck in the tiny blood vessels, blocking the flow of blood and causing pain. The spleen, an organ on the left side of the abdomen across from the liver, is responsible for filtering the blood for infections and other abnormalities. Normal red blood cells can change shape and squeeze through this filter, but sickled cells get stuck and cannot recirculate through the body, so that the number of circulating blood cells goes down. Meanwhile, the bone marrow, where red blood cells are made, pitches in by making more cells. It can't keep up with the destruction, though, so the total number of red blood cells drops to a low level and the body becomes anemic. ("Anemic" is the medical word for having a low number of red blood cells.)

85. Sickle Cell Disease / Family Village The American sickle cell anemia Association 10300 Carnegie Avenue Cleveland Clinic / East Office Building (EEb18) Cleveland, Ohio 44106 Phone 216229-8600 Web http://www.familyvillage.wisc.edu/lib_scd.htm

Sickle Cell Disease Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Sickle Cell" Who to Contact Sickle Cell Disease Association of America 200 Corporate Pointe, Suite 495 Culver City California 90230-8727 (310) 216-6363 Office (310) 215-3722 Fax (800) 421-8453 General Public E-Mail: scdaa@sicklecelldisease.org Website: http://sicklecelldisease.org/ Sickle Cell Disease Association of America, Inc. is helping to promote finding a universal cure for sickle cell disease, and helping to improve the quality of life for individuals and families where sickle cell disease related conditions exist. Sickle Cell Parent and Family Network P.O. Box 19854 Cincinnati, Ohio 45219 513-398-9620 (fax) E-mail: muhjahmarshall@sprintmail.com Web: http://www.cintishares.com/sickle_cell_parent.htm Sickle Cell Parent and Family Network works to find a cure for sickle cell disease and to help families and individuals lead full lives until a cure is found. Our activities center on communication, education, advocacy, support and emergency assistance. The members of the network collaborate with medical, educational, community and religious institutions to meet the many needs of individuals with sickle cell disease and other chronic conditions and disabilities. Through learning programs designed by and for impacted families, our members are empowered to make wise decisions in meeting their life challenges. The American Sickle Cell Anemia Association

86. Texas Department Of Health-Sickle Cell Trait Program. Sickle Cell Disease. sickle cell anemia A Parent s Guide for the School Age Child. Important Facts About sickle cell anemia. http://www.tdh.state.tx.us/newborn/parents.htm

Newborn Screening Case Management Program Sickle Cell Disease Sickle Cell Anemia: A Parent's Guide for the School Age Child Important Facts About Sickle Cell Anemia Understanding the special needs of the child with sickle cell anemia is essential for the child's health and well being. The intent of this guide is to educate parents and others about how to provide the best care to the child with sickle cell anemia. DIAGNOSIS OF A SERIOUS DISEASE IN A HEALTHY CHILD Children with sickle cell anemia are well most of the time, but certain complications can occur which are very serious and sometimes fatal (cause death). It may be hard to believe that a healthy looking child has a life threatening disease, but this is true when a child has sickle cell anemia. At first parents may not want to know what can happen with this disease. They may want to pretend that nothing is wrong until something happens to indicate otherwise. This is a normal reaction to the unpleasant news that a child has a serious disease. Besides feeling sad, parents may feel angry and or guilty. These emotions are very normal and usually temporary. Eventually parents work through their feelings and want to learn everything they can about this disease to provide the best care for their child. ANEMIA Aplastic Crisis Sign and Symptoms Paleness Lethargy "Not feeling good" Headache Fever Low blood count (anemia) Recent upper respiratory infection Passing out (fainting) INFECTION The child with sickle cell anemia will get colds, sore throats, and ear infections just like other children. These minor infections are not serious. The more serious infections that are more likely to occur in the child with sickle cell anemia are septicemia (infection of the blood), meningitis (infection around the brain), pneumonia (infection in the lungs), and osteomyelitis (infection of the bone).

87. Sickle Cell Anemia Association Of Austin The sickle cell anemia Association of Austin is dedicated to providing resources and education to assist in improving the quality of life for clients with http://www.tdh.state.tx.us/newborn/austin_sc.htm

Sickle Cell Association of Austin Marc Thomas Chapter Welcome Highlights Board of Directors What's New Purpose: To promote health awareness, while advocating and providing support and knowledge to all persons affected by sickle cell disease. The Sickle Cell Anemia Association of Austin is dedicated to providing resources and education to assist in improving the quality of life for clients with sickle cell disease. Serving the capital city and surrounding areas - Austin, Bastrop, Cedar Park, Georgetown, Killeen, Pflugerville, Round Rock, and Copperas Cove. WHAT IS THE SICKLE CELL ANEMIA ASSOCIATION OF AUSTIN PHILOSOPHY? The philosophy of the Sickle Cell Anemia Association of Austin is to provide support and assistance to clients with sickle cell disease. Services: Provide education, resources and raise awareness to individuals and groups. Coordinate blood drives and health fairs. Provide support and psychosocial services to clients diagnosed with sickle cell disease. Provide medical, rehabilitative and social service referrals. Assist with medical transportation.

88. BioMed Central | Full Text | Aged Garlic Extract Therapy For Sickle Cell Anemia Aged garlic extract therapy for sickle cell anemia patients Junichiro Takasu 1 , Rolando Uykimpang 1 , Maria Alenor Sunga 1 , Harunobu Amagase 2 and Yutaka http://www.biomedcentral.com/1471-2326/2/3

home journals A-Z journals by subject advanced search ... Volume 2 Viewing options Abstract Full text PDF Pre-publication history Other links: E-mail to a friend Download references Post a comment PubMed record ... Related articles in PubMed Search PubMed For Takasu J Uykimpang R Sunga MA Amagase H ... Niihara Y Key E-mail Corresponding author Research article Aged garlic extract therapy for sickle cell anemia patients Junichiro Takasu Rolando Uykimpang Maria Alenor Sunga Harunobu Amagase and Yutaka Niihara Department of Medicine, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance, CA Wakunaga of America Co., Ltd., Mission Viejo, CA BMC Blood Disorders The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2326/2/3 Received Accepted Published Outline Abstract Abstract Background Methods Results ... Pre-publication history Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). Methods Results Conclusions These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia.

89. Sickle Cell Anemia sickle cell anemia sickle cell anemia is a serious, long term, incurable blood disease which attacks red blood cells. Sickle cell http://www.tele-works.com/htbin/webware/default.asp?HR=13-106&agency=stamford_ci

90. Anemia, Sickle Cell - Medical Dictionary Definitions Of Popular Medical Terms sickle cell anemia affects millions of people throughout the world. In sickle cell anemia, the hemoglobin molecules tend to aggregate after unloading oxygen. http://www.medterms.com/script/main/art.asp?articlekey=9377

91. GENETICS Sickle Cell Case Study sickle cell anemia and Genetics Background Information. Background Those with two mutant S alleles (SS) develop sickle cell anemia. Those http://chroma.gs.washington.edu/outreach/genetics/sickle/sickle-back.html

G E N E T I C S Classroom Activities and Instructional Materials Home Goals Workshops Classroom ... Contact Us Sickle Cell Anemia and Genetics: Background Information Background information to accompany the labs: Allele Frequencies and Sickle Cell Anemia Lab and Sickle Cell Anemia: Diagnosis Using Restriction Analysis of DNA Genetics of Sickle Cell Anemia There are approximately 280 million hemoglobin molecules in each red blood cell (RBC). The protein portion of hemoglobin consists of four globin subunits: two alpha ( a ) and two beta ( b ). These two types of subunits are encoded by the a and b globin genes, respectively. While the binding of oxygen actually occurs at the iron sites, all four globin chains must work together in order for the process to function well. Sickle cell anemia, also known as sickle cell disease, is caused by a point mutation in the b globin gene. As a result of this mutation, valine (a non-polar amino acid) is inserted into the b globin chain instead of glutamic acid (an electrically charged amino acid). The mutation causes the RBCs to become stiff and sometimes sickle-shaped when they release their load of oxygen. The sickle cell mutation produces a "sticky" patch on the surface of the

92. Sickle Cell Disease, Sickle Cell Anemia sleepless parents, Encyclopedia Index S sickle cell disease, sickle cell anemia, Search. sickle cell disease, sickle cell anemia. This is http://www.sleeptight.com/EncyMaster/S/sickle_cell.html

Help for sleepless parents Encyclopedia Index S sickle cell disease, sickle cell anemia Search sickle cell disease, sickle cell anemia This is a condition of the blood cells that affects mainly persons of African or mediterranean descent (Italian, Spanish, etc.). It is caused by an inherited abnormality of the oxygen carrying protein of the blood (hemoglobin). The abnormality is such that the red blood cells behave normally under normal conditions, but certain factors can cause an abnormal clumping together of the hemoglobin. When this happens the red cells assume a characteristic sickle-like shape - hence the name. These abnormal cells clog up the capillaries (smallest blood vessels) and by obstructing blood flow cause oxygen lack in the body tissues. During such an attack of sickling (called a crisis ), the patient experiences excruciating pain in various areas of the body - for example in the bones, or in the abdomen. This pain is related to poor blood flow and oxygen lack in the tissues. The abnormal red cells break down sooner than normal, causing anemia. Sometimes there is a sudden shutdown of production of the red cells - the aplastic crisis - that can cause critical anemia. The abnormal red cells tend to flow sluggishly through the smallest blood vessels (capillaries) and this may lead to

93. Hematopoietic Chimerism After BMT For Sickle Cell Anemia Hematopoietic Chimerism After BMT for sickle cell anemia. Stable Mixed Hematopoietic Chimerism After Bone Marrow Transplantation for sickle cell anemia. http://www.bloodline.net/stories/storyReader$3177

Bloodline Home About Call for Papers Free Membership ... Search Educational Features Image Atlas Case Studies Private Lectures Conference Reviews ... Glossary Resources Conference Calendar Hematology Links Full Text Journals Classifieds Specialties BMT/Stem Cell Cord Blood Thrombosis Hemostasis ... Veterinary News Hematology News BloodLink Newsletter Blood News Update Discussion Today's Discussion Create New Topic List by Topic Members Join Now Login Hematopoietic Chimerism After BMT for Sickle Cell Anemia Stable Mixed Hematopoietic Chimerism After Bone Marrow Transplantation for Sickle Cell Anemia M.C. Walters, M. Patience, W. Leisenring, Z.R. Rogers, V.M. Aquino, G.R. Buchanan, I.A.G. Roberts, A.M. Yeager, L. Hsu, T. Adamkiewicz, J. Kurtzberg, E. Vichinsky, B. Storer, R. Storb, K.M. Sullivan Biology of Blood and Marrow Transplantation 7:665-673 (2001) ABSTRACT: Download a PDF version of the full article Carden Jennings Publishing Co., Ltd. Related Content 1998 European Group for Blood and Marrow Transplantation A "Constant" Problem A Case of Hereditary Elliptocytosis ABMT in Patients with Low-Grade or Mantle Cell Lymphoma ... Minimum TBI in Aplastic Anemia with Unrelated Donor BMT

94. Sickle Cell Anemia sickle cell anemia The child has most or all of the normal hemoglobin (HbA) replaced with the sickle hemoglobin (HbS). This is referred to as HbSS. http://www.chw.org/display/PPF/DocID/1860/router.asp

Anemia Aplastic Anemia Hemolytic Anemia Iron Deficiency Anemia ... Blood Disorders : Sickle Cell Anemia E-mail this page Print this page Sickle Cell Disease What is sickle cell disease? Sickle cell disease is an inherited blood disorder characterized by defective hemoglobin (a protein in red blood cells that carries oxygen to the tissues of the body). Sickle cell disease involves the red blood cells, or hemoglobin and their ability to carry oxygen. Normal hemoglobin cells are smooth, round and flexible, like the letter "O," so they can move through the vessels in our bodies easily. Sickle cell hemoglobin cells are stiff and sticky and form into the shape of a sickle, or the letter "C," when they lose their oxygen. These sickle cells tend to cluster together and cannot easily move through the blood vessels. The cluster causes a blockage and stops the movement of healthy, normal oxygen-carrying blood. This blockage is what causes the painful and damaging complications of sickle cell disease. Sickle cells only live for about 15 days, while normal hemoglobin can live up to 120 days. Also, sickle cells risk being destroyed by the spleen because of their shape and stiffness. The spleen is an organ that helps filter the blood of infections and sickled cells get stuck in this filter and die. Due to the decreased number of hemoglobin cells circulating in the body, a person with sickle cell disease is chronically anemic. The spleen also suffers damage from the sickled cells blocking healthy oxygen carrying cells. Without a normal functioning spleen, these individuals are more at risk for infections. Infants and young children are at risk for life-threatening infections.

95. Human Gene Testing - Summary Article by Drs. Stuart Orkin and Gary Felsenfeld describing how basic research led to genetic testing, including how the discoveries of DNA, restriction enzymes, cloning, PCR (polymerase chain reaction) make tests for diseases like sicklecell anemia and breast cancer possible. http://www.beyonddiscovery.org/content/view.article.asp?a=239

96. Cancer Drug Benefits Sickle Cell Patients CNN http://cnn.com/2003/HEALTH/04/03/sickle.cell.anemia.ap/index.html

97. CNN.com - Health - Devastation Of Sickle Cell Disease Chronicled - February 22, CNN http://cnn.com/2001/HEALTH/conditions/02/22/sickle.cell.anemia/index.html

MAIN PAGE WORLD U.S. WEATHER ... ABOUT US CNN TV what's on show transcripts CNN Headline News CNN International ... askCNN EDITIONS CNN.com Asia CNN.com Europe set your edition Languages Spanish Portuguese German Italian Danish Japanese Korean Arabic Time, Inc. Time.com People Fortune EW Devastation of sickle cell disease chronicled Film documentary scheduled February 28 February 22, 2001 Web posted at: 10:11 a.m. EST (1511 GMT) In this story: Asking questions Treatments studied RELATED STORIES, SITES By Michele Dula Baum CNN.com Health Writer ATLANTA, Georgia (CNN) - Although research continues, sickle cell anemia remains an "orphan disease" attracting little notice despite its harvest of pain and early death. But a new film documentary may help to educate viewers about the disease, which affects about 80,000 people in the United States and millions worldwide. Called "Sickle Cell: The Forgotten Disease," the film will air at 10 p.m. EST on the Discovery Health Channel. It is being co-produced by the Dr. Spock Company. "It's hard to get funding or people interested in trials," said Dr. James Eckman, director of the Georgia Comprehensive Sickle Cell Center at Grady Health System. "But because this is a lifelong, chronic problem, it has a greater impact." CONDITION CLINIC Sickle Cell disease A genetic disorder, sickle cell disease attacks red blood cells, making them rigid and distorting their normally round shape into crescents and points. These misshapen cells can easily clog tiny blood vessels and deprive organs and tissues of vital oxygen, causing intractable pain crises. In addition, children with sickle cell are more prone to stroke, pneumonia, infection and other long-term complications.

98. Sickle-Cell Anemia--Knowledge Is The Best Defense - Jehovah's Witnesses Official An article about sicklecell anemia with an explanation, the symptoms, treatment, prevention and how it is passed on. http://www.watchtower.org/library/g/1996/10/8/anemia_knowledge_defense.htm

Related topics: The Mystery of Ill Health Pestilence Will It Ever End? Knowledge Is the Best Defense BY AWAKE! CORRESPONDENT IN NIGERIA THERE were 32 people in the conference room, mostly women and children. Six-year-old Tope, frail, dressed in pink, sat quietly beside her mother, on a wooden chair. She listened as the nurse spoke to them about what to do when the pain comes. "She is my firstborn," said her mother. "From the beginning she was always sick. I went to many churches, and they prayed over her. But she still got sick. Finally, I took her to the hospital. They tested her blood and found she was a 'sickler.'" What Is It? At the Center for Sickle-Cell Anemia in Benin City, Nigeria, Tope's mother learned that sickle-cell anemia is a disorder of the blood. Contrary to superstitious beliefs, it has nothing to do with witchcraft or spirits of the dead. Children inherit sickle-cell anemia from both parents. It is not contagious. There is no way you can catch the disorder from another person. Either you are born with it or you are not. Tope's mother also learned that while there is no cure, the symptoms can be treated. Sickle-cell anemia occurs mostly in those of African descent. Dr. I. U. Omoike, director of the Center for Sickle-Cell Anemia, told

99. Synthetic Theory Of Evolution: Natural Selection However, these individuals usually die in childhood from sicklecell anemia click this icon to hear the preceding term pronounced and related health problems. http://anthro.palomar.edu/synthetic/synth_7.htm

Natural Selection N atural selection is usually the most important mechanism of evolution. We now know that its effect on individuals depends on their phenotypes which in turn are determined mostly by their genotypes. The environment ultimately selects individuals with the best suited genotypes to survive to adulthood and to reproduce. Those who have more surviving offspring pass on more of their genes to the next generation. F or natural selection to cause evolution, it must select for or against one or more of the genotypes for a trait. In the case of a trait that is determined by a single gene with two alleles, there are five combinations of genotypes that nature can select either homozygote ( AA or aa but not both) both homozygotes ( AA and aa either homozygote and the heterozygote ( AA and Aa or aa and Aa the heterozygote ( Aa all alleles ( AA Aa , and aa Selection Against One Of The Homozygotes F or traits that are controlled by a single gene that has two alleles, selection against one of the homozygotes ( AA or aa ) will result in a progressive decrease in the allele of which that unsuccessful homozygote consists.

100. Anemia, Sickle Cell anemia, sickle cell. other Thalassemia. narrower sickle cell Trait. sickle cell Information Center. anemia, sickle cell;. Management of sickle cell disease. http://omni.ac.uk/browse/mesh/C0002895L0002895.html

low graphics Anemia, Sickle Cell other: Thalassemia narrower: Sickle Cell Trait Sickle Cell Information Center This site aims to provide information to patients and health care professionals on the topic of sickle cell anaemia and also offers a collection of resources on sickle cell for patients, family carers, students and teachers. It is developed and maintained by its advisory board which is made up of the main partner institutions like the Emory University School of Medicine and the Sickle Cell Foundation of Georgia, and states its mission as being to "provide sickle cell patient and professional education, news, research updates and world wide sickle cell resources". It makes available online articles, powerpoint demonstrations, links to books, videos and other useful Web sites. Anemia, Sickle Cell Management of sickle cell disease This is the full-text of a report on the management of sickle cell disease, produced by the National Heart, Lung and Blood Instutute (NHLBI), of the National Institutes of Health (NIH) in the US. It is a clinical guide aimed at health care professionals, and describes the current approach to counseling and also to management of many of the medical complications of sickle cell disease. It is in four sections: Diagnosis and Counseling, Health Maintenance, Treatment of Acute and Chronic Complications, and Special Topics. The document is PDF, which requires the Adobe Acrobat Reader. Updated in May 2002. Sickle Cell Trait Anemia, Sickle Cell

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