81. ANTIBIOTICS TO TREAT RHEUMATOID ARTHRITIS, SCLERODERMA, LUPUS, JUVENILE RHEUMATO Antibiotic treatment for rheumatoid arthritis, scleroderma, lupus, juvenile rheumatoid arthritis, polymyositis, dermatomyositis, Reiter s Syndrome, psoriatic http://rheumatic.org/

Home Scientific Publications Frequently Asked Questions Information for you and your doctor ... Useful Links A LEGACY OF HEALTH The life and work of Thomas McPherson Brown M.D TREATMENT OF INFLAMMATORY RHEUMATIC DISEASE WITH LOW DOSE ANTIBIOTIC THERAPY: RHEUMATOID ARTHRITIS, SCLERODERMA, LUPUS, POLYMYOSITIS, DERMATOMYOSITIS, PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS, REITER'S SYNDROME AND JUVENILE RHEUMATOID ARTHRITIS The information on this site is provided by physicians experienced in the treatment of inflammatory rheumatic diseases with low dose antibiotics according to the protocol developed by the late Dr. Thomas McPherson Brown, M.D. and by many of the multiple thousands of patients who have benefited from this treatment. The website includes all the information necessary to administer this therapy. Physicians should not attempt antibiotic therapy until they have read the protocol completely as this therapy is unlike any other they may be currently using. There are many components to these diseases and their treatment and antibiotic therapy must be tailored to the individual. Treatment periods are usually long and medication and dosage adjustments may be required. Nearly two million doctors and rheumatic patients visited this site last year The authors of this web page do not engage in the practice of medicine; we are not a medical authority, nor do we claim to have medical knowledge. In all cases we recommend that you consult your own physician regarding any course of treatment or medicine.

82. Julie's Linear Scleroderma Page Read about a daughter's struggle with linear scleroderma and find out some of what this family has learned over the years about this illness and its possible treatments. http://www.geocities.com:80/Heartland/Park/8412/linearscleroderma.htm

I'm sorry but I've taken Julie's story down out of respect for her desire for privacy. I'll leave this page up because the links may be of use to someone. Here are some useful links: Antibiotic therapy I Have Scleroderma Scleroderma Resources Health Link USA ... JSD resources This "Hope Ring" site is owned by Jodi Want to join the The Hope Ring Previous 5 Sites Previous Next ... List Sites This Special Angels Ring site is owned by Jodi Want to join the Special Angels Ring Skip Prev Prev Next ... Julie's Linear Scleroderma Page

83. What Is Scleroderma? What is scleroderma, an autoimmune disease that acts as a connective tissue disorder causing a thickening or hardening of the body tissues. http://ohoh.essortment.com/whatisslcerode_rqlw.htm

What is scleroderma? What is scleroderma, an autoimmune disease that acts as a connective tissue disorder causing a thickening or hardening of the body tissues. Scleroderma is a rare autoimmune disease that acts as a connective tissue disorder. However, unlike other connective tissue disorders, there is a thickening and hardening of the skin. This thickening can take place in various parts of the body, including internal organs. Scleroderma seems to appear most frequently in women ages 30-60. There are many aspects and symptoms associated with this disease which can make it difficult to treat, and doctors are still unsure what causes scleroderma. Some of the signs of this disease include: bodyOffer(18128) - hands, toes, and other parts of the body turning blue or red when cold - pulmonary hypertension - gastrointestinal problems - problems swallowing food - diarrhea and abdominal cramps - pain and burning in body tissues - inflammation of the lungs - change in skin color - digital ulcers and sores - difficulty maintaining body hear Controlling scleroderma is difficult and mostly involves various drug therapies. To help with the problem maintain body heat, a patient may be prescribed Altace, Trental, or Procardia XL. Procardia XL can also be prescribed for pulmonary problems, and in worse cases, oxygen. For gastrointestinal problems, simple things can help such as Tums and Maalox along with diet modification. However, prescriptions may be given for more severe symptoms.

84. Tamlynn's Story A mom shares her story about her daughter's battle with juvenile scleroderma. http://www.expage.com/TammlynnsStory

85. Dana's Story A story written by a mom regarding her 18 year old daughter's diffuse scleroderma. http://expage.com/DanasStory

Dana's Story The Wind Beneath My Wings "Go With All Your Heart" Dana was diagnosed with Systemic Scleroderma in September of 1993 when she was ten years old. She also has Raynaud's disease and living in New York City, she struggles with the cold. She has been able to obtain a disability-parking pass from the state and her college. Dana has had bouts with Alopecia Areata, and looses patches of scalp hair, eyelashes, and eyebrows from time to time. As her mother, I find this very hard to handle but she just combs her hair in another direction and goes on. The prognosis for this disease is very troubling but as we have learned, each person has a different set of symptoms. Dana has the support of a fine doctor, Dr. Thomas J.A. Lehman, at the Hospital for Special Surgery in New York City. She continues to take a scary combination of medicine. Dana is fine young woman now and we cannot predict what the future holds for her, or for any of us for that matter, but we know that she lives her life with all her heart. She is my hero, the wind beneath my wings. She makes her father and I proud as well as hopeful that soon we can find a way to stop this awful disease. Until then she knows the world what it means to "go with all your heart". For More Information on Juvenile Scleroderma: Juvenile Scleroderma Network, Inc

86. Scleroderma scleroderma. scleroderma is Greek term meaning “hard skin,” but it is not just a skin disease. scleroderma can be diagnosed through the following tests http://www.hmc.psu.edu/rheumatology/aservices/scleroderma.htm

87. Uhrad.com - Musculoskeletal Imaging Teaching Files uhrad.com Musculoskeletal Imaging Teaching Files. Case Forty Eight - Systemic Sclerosis (scleroderma). Diagnosis Systemic sclerosis (scleroderma). http://www.uhrad.com/msiarc/msi048.htm

uhrad.com - Musculoskeletal Imaging Teaching Files Case Forty Eight - Systemic Sclerosis (Scleroderma) (Image #1 and Image #2) (Image #3 and Image #4) Click On Images for Enlarged View Clinical History: Not given. Findings: Image #1 is a plain film of the hand demonstrating acroosteolysis of the distal tufts of the bilateral fourth and fifth distal phalanges. Image #2 is a plain film of the hands in a second patient with the same diagnosis demonstrating acroosteolysis as well as flexion contractures. Image #3 is a PA chest x-ray demonstrating mild basilar interstitial prominence as well as calcifications projecting over the left shoulder soft tissues. Image #4 is a plain film of the pelvis demonstrating extensive soft tissue calcifications. Diagnosis: Systemic sclerosis (scleroderma). Discussion: Progressive systemic sclerosis (scleroderma) is a disorder of connective tissue dysfunction which affects whole organ systems including skin, lungs, GI, heart, kidneys and musculoskeletal. The characteristic radiographic presentation is generally defined as soft tissue atrophy, calcifications, and distal phalangeal resorption in the hand. In addition, recently described findings include erosion involving the distal interphalangeal disease (DIP) and less commonly proximal interphalangeal (PIP) joints. Although there has been no definite pathogenesis identified, it is felt that progressive systemic sclerosis secondary to a structural defect in the microvasculature. This is supported by the fact that there are often vascular changes identified in multiple tissues.

88. Esophagus: Scleroderma esophagus scleroderma. females (80%), 3555 y/o. decreased LES pressure, decreased peristalsis; smooth muscle atrophy +/- loose fibrosis; http://chorus.rad.mcw.edu/doc/00152.html

CHORUS Collaborative Hypertext of Radiology Esophagus Feedback Search esophagus: scleroderma females (80%), 35-55 y/o decreased LES pressure, decreased peristalsis smooth muscle atrophy +/- loose fibrosis dermatomyositis may include involvement of upper 1/3 (striated) dysphagia to solids > liquids ("steakhouse syndrome") wide-open LES or HH +/- basilar pulmonary fibrosis other GI sites a/w CREST syndrome Charles E. Kahn, Jr., MD - 2 February 1995 Last updated 26 May 2004 Medical College of Wisconsin

89. Scleroderma scleroderma. progressive systemic sclerosis (PSS) hypertrophy then atrophy of collagen fibers; 46th decade, MF = 13. bones punctate http://chorus.rad.mcw.edu/doc/00831.html

CHORUS Collaborative Hypertext of Radiology Multisystem entities Feedback Search scleroderma progressive systemic sclerosis (PSS) hypertrophy then atrophy of collagen fibers 4-6th decade, M:F = 1:3 bones punctate soft tissue ca++ (finger tips, shoulder, hips) acro-osteolysis intercarpal joint space narrowing (late) chest evident in 10-25% pulmonary fibrosis with diffuse reticulate infiltrate predominantly in lower lungs GI esophageal dilation and aperistalsis hiatus hernia + GE reflux + esophagitis + distal esophageal stricture gastroparesis dilation and dysmotility of small bowel pseudosacculation and dysmotility of colon see: CREST syndrome Yong H. Hahn, MD - 2 February 1995 Last updated 26 May 2004 Medical College of Wisconsin

90. Localized Scleroderma Morphea scleroderma means hard skin and is pronounced sklero-derma. scleroderma is a disease that causes fibrosis (hardening) of the skin http://www.skinsite.com/info_scleroderma_localized.htm

Localized Scleroderma I. Definition: Scleroderma means "hard skin" and is pronounced skler-o-derma. Scleroderma is a disease that causes fibrosis (hardening) of the skin and sometimes the internal organs. Scleroderma can range from a form localized to the skin to a severe disease the effects the internal organs known as systemic scleroderma. Localized scleroderma can range from just a few spots on the skin to covering almost the entire skin surface. The skin lesions of localized scleroderma feel firm and hard. The color is ivory to yellowish in color. The skin lesions of localized scleroderma are usually seen on the trunk but can also occur on the face, arms, and legs. Localized scleroderma may last for a few months to many years. The condition is four times more common in women and usually starts between the ages of twenty and fifty. II. Cause: The cause of scleroderma is unknown. III. Treatment: There is not a known medication that will stop or reverse the process of scleroderma. Milder forms of scleroderma may be helped by topical cortisone medications or cortisone injections.

91. The Scientist :: Scleroderma Exposed scleroderma exposed. Systematic analysis provides means for early detection of systemic scleroderma By Cathy Holding. Comparison http://www.biomedcentral.com/news/20030930/02

Previous Next Scleroderma exposed By Cathy Holding Comparison of gene expression profiles using microarray analysis of tissues from patients suffering from systemic scleroderma and of those from unaffected individuals is reported in the September 29, 2003 PNAS by Michael Whitfield and colleagues at University of California at San Francisco . Results provide the possibility of a means of identifying affected individuals before symptoms appear and of early treatment to prevent the disease becoming sufficiently advanced to threaten the life of the patient ( PNAS , DOI:/10.1073/pnas.1635114100, September 29, 2003). Gene expression profiles in cell lines derived from tissues constituting normal skin provided explanation for the observed expression profiles. Fibroblast cell lines outgrown from the biopsies failed to give differential gene expression profiles, precluding their use for diagnostic purposes. An expression profile similar to B lymphocytes suggested the involvement of this inflammatory cell type where previously only T cells were thought to be present, providing a new direction for research into the disease. In addition, several potential diagnostic disease markers were identified. "This approach has the advantage of identifying multiple genes representing multiple different cell types in a complex disease whose underlying pathogenesis is still unknown. From a research perspective, it may give rise to new hypotheses about pathogenesis that can be tested," the authors conclude.

92. "Paul Klee And Scleroderma " By E. Carwile LeRoy, M.D. And Richard M. Silver, M. Paul Klee and scleroderma by E. Carwile LeRoy, MD and Richard M. Silver, MD. The diagnosis of scleroderma in 1936 coincided with a severe case of measles. http://www.musc.edu/rheumatology/klee.html

Paul Klee and Scleroderma by E. Carwile LeRoy, M.D. and Richard M. Silver, M.D. Division of Rheumatology and Immunology Department of Medicine Paul Klee was perhaps the most famous person to develop scleroderma (systemic sclerosis) and die from it. Born in a suburb of Bern, Switzerland, he trained in art in Munich and became a principal in the "Blue Rider" school which included Kandinsky, whose painting gave the movement its name. The members of this school contributed integrally to the development of art as we know it today. Their ability to convey a mood with abstract figures remains impressive. Klee's position as a pioneer in modern art has increased steadily in the decades since his death in 1940, four years after the diagnosis of scleroderma was made at age 56. Klee studied, taught and practiced etching from 1898-1914, when on a trip to Tunisia with August Macke and Louis Moilliet he embraced color and temporarily became occupied with cubism. Recognition of his works increased steadily from 1908 to the present. His work was exhibited in New York in 1924, in London in 1934, and, in 1931, 252 works were exhibited at the Kunstverein in Dusseldorf in 1931; in addition, there were numerous exhibitions in Munich. Having previously interacted with Kandinsky, Macke, Marc, Kubin (the Blue Rider artists), he met Delauney, Le Fauconnier, Kahnweiler and Uhde in Paris in 1912, where he saw the work of Picasso, Braque, Matisse and Rousseau. Klee was a revered teacher and kept extensive and methodical notes on his paintings, placing importance on his titles for interpretation by his audience.

93. Virtual Hospital: The International Thoracic Teaching Resource: Diseases Of Alte Etiology. scleroderma. Jeffrey Etiology/Pathophysiology The pathogenesis of scleroderma lung disease is poorly understood. Pathology On http://www.vh.org/adult/provider/radiology/ITTR/Scleroderma/Scleroderma.html

For Providers The International Thoracic Teaching Resource: Diseases of Altered Immunity and Diseases of Uncertain Etiology Scleroderma Jeffrey R. Galvin, M.D.; Michael P. D'Alessandro, M.D.; Yasayuki Kurihara, M.D. Peer Review Status: Internally Peer Reviewed Clinical Sx: Pulmonary symptoms are similar to those seen inpatients with IPF and other patients with fibrosing alveolitis. They include dyspnea (60%), nonproductive cough, wheezing (19%), pleuritic chest pain (16%), and hemoptysis. Cardiac decompensation may develop as a result of cor pulmonale, sclerosis of the cardiac muscle, or a combination of the two. Pulmonary function test shows a restrictive defect with a decreased vital capacity and residual volume. Esophageal involvement results in dilatation and disturbed motility causing difficulty in swallowing. Etiology/Pathophysiology: The pathogenesis of scleroderma lung disease is poorly understood. Pathology: On postmortem pathologic examination, about;70% of patients with scleroderma have interstitial lung disease. The histopathologic features are similar to those observed in patients with usual interstitial pneumonia (UIP) and rheumatoid arthritis. Pulmonary vascular lesions are common and include capillary obliteration, medial thickening, and intimal proliferation. Imaging: Chest radiographic abnormalities often are subtle in the patients with scleroderma. Diffuse interstitial lung disease, lung base dominant reticulonodular opacities or honeycombing, (Arrows)are detectable only in the more severe forms of the disease. Cardiomegaly (primarily due to right heart enlargement) and pulmonary artery enlargement caused by pulmonary artery hypertension are detectable on chest radiograph. The chest radiograph may also show bone resorption (rib notching), esophageal dilatation, and soft tissue calcification (arrowhead).

94. Virtual Hospital : Health Topics A-Z : Scleroderma scleroderma. The International Thoracic Teaching Resource scleroderma University of Iowa Family Practice Handbook Systemic Sclerosis And scleroderma http://www.vh.org/navigation/vh/topics/adult_provider_scleroderma.html

Health Topics A-Z Scleroderma All Topics Adult Patient Topics Adult Provider Topics Pediatric Patient Topics ... Pediatric Provider Topics For Adult Providers The International Thoracic Teaching Resource: Scleroderma University of Iowa Family Practice Handbook: Systemic Sclerosis And Scleroderma All Topics Adult Patient Topics ... UI Health Care Home http://www.vh.org/navigation/vh/topics/adult_provider_scleroderma.html

95. Clinical Trial: Psychological Treatments For Scleroderma Psychological Treatments for scleroderma. This study is currently recruiting patients. Sponsored by. Official Title Psychosocial Interventions for scleroderma. http://www.clinicaltrials.gov/ct/show/NCT00007267?order=6

96. Clinical Trial: Oral Type I Collagen For Relieving Scleroderma Oral Type I Collagen for Relieving scleroderma. This Phase. scleroderma Connective Tissue Diseases, Drug Bovine type I collagen, Phase II. http://www.clinicaltrials.gov/ct/gui/show/NCT00005675?order=1&JServSessionIdzone

97. Scleroderma Note All links within content go to MayoClinic.com. Diseases and Conditions. scleroderma. From MayoClinic.com Special to CNN.com. Overview. http://www.cnn.com/HEALTH/library/DS/00362.html

International Edition MEMBER SERVICES The Web CNN.com Home Page World U.S. Weather ... Special Reports SERVICES Video E-mail Services CNNtoGO Contact Us SEARCH Web CNN.com In association with: WOMEN'S HEALTH Hair/Nails/Skin Corns and calluses Nail fungal infection Ingrown toenails Moles ... Folliculitis INFORMATION CENTERS: Pick a category Health Centers Family Health Men's Health Women's Health Children's Health Seniors' Health Working Life Pain Management Condition Centers Immune System Allergy Alzheimer's Arthritis Respiratory System Cancer Endocrine System Digestive System Heart and Blood Infectious Disease Mental Health Note: All links within content go to MayoClinic.com Diseases and Conditions Scleroderma From MayoClinic.com Special to CNN.com Overview At first, you thought it was just dry skin. But the patches started getting thicker and harder. Then you noticed them developing on your hands, arms, face, neck and feet. What you may have is scleroderma (sklere-o-DER-muh), a progressive disease that leads to hardening and scarring of the skin and connective tissues. Scleroderma literally means "hard skin." Also known as systemic sclerosis, scleroderma is one of a group of arthritic conditions called connective tissue diseases. Researchers haven't established a definitive cause for scleroderma. About 150,000 Americans have the disease. It's more common in women than in men and more common in adults than in children. Scleroderma can run in families, but in most cases it occurs without any known family tendency for the disease. It's not considered contagious or cancerous.

98. Scleroderma / Systemic Sclerosis By Drdoc On-line scleroderma / Systemic sclerosis, by drdoc online. abnormal nailfold capillaries. The clinical features Of scleroderma. The main clinical http://www.arthritis.co.za/scleroderma.htm

Scleroderma / Systemic sclerosis by drdoc on-line Table of contents Definition and Epidemiology Musculoskeletal involvement in Scleroderma Classification Renal disease in Scleroderma ... Go to Arthritis index page Systemic sclerosis is a generalized disorder of connective tissue, leading to progressive tissue fibrosis. The condition characterized by fibrosis of the skin, but with involvement also of joints, tendons, muscles, and internal organs The condition was first described by Curzio in the 1753. Initially it was seen as a condition affecting the Skin but in 1945, Goetz proposed a description of progressive systemic sclerosis. He described visceral lesions in autopsy cases, whilst studying Medicine and forensic pathology at the University of Cape Town, South Africa. In addition, a limited Scleroderma was described in 1964 by Winterbauer. He referred to a syndrome with calcinosis raynauds phenomenon esophageal dysmotility sclerodactyly , and Telangiectasia . This subsequently became known as the C R E S T syndrome.

99. Morphoea (localised Scleroderma, Morphea). DermNet NZ It is also known as localised scleroderma. It may affect adults or children. Linear scleroderma. This is most often found on the limb of a child. http://www.dermnetnz.org/dna.morphoea/morphoea.html

@import url("/common/screen.css"); DermNet NZ Ad Authoritative facts about the skin from the New Zealand Dermatological Society Home For patients For doctors ... Site map Search: Home Immune Morphoea Morphoea (morphea) is an uncommon persistent condition in which there are areas of thickened skin. It is also known as localised scleroderma . It may affect adults or children. In nearly all cases the cause of morphoea is unknown. It can however sometimes follow: Localised injury Tick bites - it has been associated with Lyme disease (not known in New Zealand) Pregnancy Measles and other viral infections Autoimmune diseases including lichen sclerosus and lichen planus Clinical features Plaques. This is the most common pattern of morphoea. There are thickened scar-like oval patches of skin from 1- 20 cm or more in diameter. They start off mauve in colour, then over several months they usually become ivory white in the middle with a lilac edge. Old lesions may be brown. The surface is smooth, shiny and hairless. The patches do not sweat. Several plaques may be present, on both sides of the trunk and limbs distributed asymmetrically. Linear scleroderma.

100. Sclero The scleroderma Center at Boston University School of Medicine and Boston Medical Center is a multidisciplinary effort encompassing basic and clinical research http://medicine.bu.edu/sc/sclero.htm

Joseph H. Korn, MD, Director Robert Simms, MD, Associate Director, Clinical Programs Peter Merkel MD, Clinical Trials Kate Schrade, Admin. Asst. Clinical Programs Tina Elias-Todd, MD Fellow Harrison Farber MD, Pulmonary Eugene Kissin, MD, Fellow Dennis Liu, MD Fellow Arthur Theodore MD, Pulmonary Basic Research Programs Allesandra Farina, MD Robert Lafyatis, MD Raphael Lemaire, Ph.D. Lauren Kim, MD Fellow Tako Ogawa, MD David Strehlow, PhD Russell Widom, PhD The Scleroderma Center at Boston University School of Medicine and Boston Medical Center is a multidisciplinary effort encompassing basic and clinical research, clinical trials and patient care. The Scleroderma Center is part of the Boston University Arthritis Center, which has an extensive research program in immunology, molecular and cell biology, biochemistry and epidemiology. Clinical care is provided at the Boston Medical Center, including clinical trials at the NIH-funded Clinical Research Center of Boston University Medical Center. Research is supported by grants from the NIH, Arthritis Foundation, Scleroderma Research Fund, and kind gifts from patients and corporate donors. The support we receive allows us to provide a broad range of clinical and advisory services to patients with scleroderma and other autoimmune diseases. Clinical Programs Over the last 9 years, approximately 800 patients with scleroderma have been evaluated, including patients from Southeast Asia, South America, the Middle East and various parts of the U.S. Special programs for the evaluation of lung disease and pulmonary hypertension are in place. Our program is part of the international Scleroderma Clinical Trials Consortium, a group that conducts multicenter trials of therapies in scleroderma. We currently have two studies for skin disease in early scleroderma, anti-body to TGFß and interferon ß-1.

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