61. Huntington's Disease - Preliminary Draft Huntington s disease. Huntington s disease (HD) is a relatively rare genetic disorder that afflicts more than 30,000 people in the US alone (Jerome 33). http://srv2.lycoming.edu/~newman/courses/bio22298/disorderpapers/Huntingtons/pre

Huntington's disease Huntington's disease (HD) is a relatively rare genetic disorder that afflicts more than 30,000 people in the U.S. alone (Jerome 33). Dr. Huntington first described the disease that was eventually named after him in 1872. Although the physical effects of Huntington's are relatively apparent, researchers can only hypothesis as to the exact cause of the lethal disease. Early symptoms of Huntington's usually appear between the ages of thirty-five and fifty-five. The first stages of the disease involve slurred speech and uncontrollable, "jerking" motions. The symptoms gradually worsen, and there is a progressive deterioration of mental functioning. Brain damage occurs and the person becomes incapacitated. Within ten to twenty years of onset (first signs of the disease), the person dies (Bergsma 487). The disease is known to be a result of a dominant lethal allele. In the case of dominant lethal alleles, one wildtype allele is not sufficient enough to support normal development (Klug et.al 87). So even a person who is heterozygous for the trait is afflicted with the disease, because the lethal allele overrides the expression of the wildtype allele. Because it is a dominant allele, all offspring of an affected parent have a fifty-fifty chance of getting the disease. Since penetrance is probably complete, all gene carriers will show Huntington characteristics (Brock et.al 463). Researchers have also determined that Huntington's disease is an autosomal trait (Bennett et.al 2135). An autosomal trait is one that is carried on the autosomal chromosomes instead of the sex chromosomes. Since men and women have the same number of autosomal chromosomes, the disease afflicts both equally.

62. The DRM WebWatcher: Huntington's Disease A Disability Resources Monthly guide to the best online resources about Huntington s disease. http://www.disabilityresources.org/HUNTINGTONS.html

Home Subjects States Librarians ... Contact Us The DRM WebWatcher Huntington's Disease (HD) Updated 10/27/2001 A B C D ... About/Hint/Link An estimated 30,000 Americans have Huntington's disease (HD), a hereditary degenerative brain disorder which usually manifests in midlife. Here are some resources for individuals with HD, families, friends, and researchers. Caring for People with Huntington's Disease Supported by the Department of Neurology at the Kansas University Medical Center and by Huntington's disease support groups, this site includes information about patient abuse, behavioral issues, communication strategies, disability issues, eating and swallowing, genetics, home safety, organizations and support groups, suggestions for safe sleeping arrangements, and more. Facing Huntington's Disease; A Handbook for Families and Friends This excellent British publication provides basic medical and genetic information, guidance for newly diagnosed individuals and for young people at risk, and information about the course of the illness and its impact on everyday life. Hereditary Disease Foundation The foundation is a non-profit, basic science organization dedicated to the cure of genetic disease; its main focus is Huntington's. The web site provides information about testing issues, a reading list, newsletters, and research funding information.

63. Ben Is Coping With Huntington's Disease Ben is Coping with Huntington s disease. By Lynda Appell. Ben is Coping with Huntington s disease. Ben, how HD affects him and how he is dealing with it. http://health.jdwebpages.com/freelance-health-and-fitness-articles/ben-is-coping

Ben is Coping with Huntington's Disease By Lynda Appell Ben is Coping with Huntington's Disease. Ben, how HD affects him and how he is dealing with it. A Dear Male Friend has Huntington's Disease. About the author: Disabled disability activist for over twelve years with local Greater Phila, PA disability organizations. Part 1 Part 2 Part 3 Part 4 ... What's New

64. Lipids In Huntington's Disease Lipids in Huntington s disease. Huntington s disease (HD), though not a neurodevelopmental disorder as such, illustrates the utility http://www.ness-foundation.org.uk/Lipids-in-Huntingtons-disease.html

Home Press Release Foreword by Professor Sir Graham Hills How You Can Help The Ness Foundation ... Dyslexia Huntington's Disease Signs of a Lipid Problem Research Terms Explained Ness Foundation People Contact Details ... Sitemap Search For The Ness Foundation Ness House Dochfour Business Centre Inverness t: 01463 220 407 f: 01463 220 256 e:  info@ness-foundation.org.uk Lipids in Huntington's Disease Huntington's disease (HD), though not a neurodevelopmental disorder as such, illustrates the utility of lipid therapy in the treatment of brain diseases. HD is an inherited disease in which the parts of the brain responsible for movement progressively degenerate. The afflicted person has involuntary movements and progressive cognitive decline, leading to dementia and death over 10 - 20 years. Until recently, there was no treatment available. Using an animal model of the disease, researchers showed that essential fatty acids prevented, or greatly diminished, disturbances in movement. Furthermore, using the niacin patch test, developed at The Ness Foundation, scientists have found evidence of a fatty acid deficit in HD This information has already been applied in human trials of fatty acid studies. In two studies, (

65. The Parkinson's Institute Movement Disorders The onset of Huntington s disease, an inherited, degenerative brain disorder, is usually between 30 and 50, but it has been diagnosed in children as young as http://www.parkinsonsinstitute.org/movement_disorders/huntingtons.html

Treatment Center PD Dystonia ET ... TS The onset of Huntington's Disease, an inherited, degenerative brain disorder, is usually between 30 and 50, but it has been diagnosed in children as young as two and adults as old as 80. Each child of a parent with Huntington's has a 50-50 chance of inheriting the disorder. It is estimated that one in 10,000 people in the United States suffers from Huntington's, exhibiting such symptoms as a loss of physical control (with involuntary body movements) and mental ability (with subsequent impaired reasoning and personality changes). [return to top]

66. Dalhousie Researcher Probes Mysteries Of Huntington's Disease Dalhousie Researcher Probes Mysteries of Huntington s disease. Halifax, Nova Scotia, August 7, 2001 A Dalhousie researcher is trying http://communications.medicine.dal.ca/motm/huntingtons.htm

Dalhousie Researcher Probes Mysteries of Huntington's Disease Halifax, Nova Scotia, August 7, 2001 - A Dalhousie researcher is trying to find out what is happening in the brains of people with Huntington's Disease, and why. Sometimes called the 'mirror' of Parkinson's Disease, a disease that causes rigidity and immobility, Huntington's Disease leads to excessive, uncontrollable flailing and writhing movements. Caused by a mutation in the huntingtin gene, the disease is present at birth but takes four or five decades to manifest. Symptoms, which also include psychiatric disorders and cognitive impairment, get progressively worse over 10 or 15 years, and the victim dies prematurely. There is no cure. What has scientists baffled is that the mutant huntingtin gene and the proteins it produces are found in abundance throughout the body, yet cell destruction occurs only in the caudate/putamen, the area of the brain that controls smooth body movement. "My goal is to pinpoint what is happening in that region of the brain to make the cells misfunction and die," says Dr. Eileen Denovan-Wright, Assistant Professor in the Department of Pharmacology. "If you can understand change at the molecular level, there is a chance you can intervene with a drug to slow or stop the progression of the disease."

67. New Model Of Huntington's Disease New model of Huntington s disease. . . Dyer, RB McMurray, CT Mutant protein in Huntington disease is resistant to proteolysis in affected brain. Nat Genet. http://www.genomenewsnetwork.org/articles/10_01/Huntingtons.shtml

Home About Topics Subscribe New model of Huntington's disease By Edward R. Winstead October 26, 2001 A new study of Huntington's disease finds that the main offender in the brain is a mutant protein, called 'huntingtin,' in its full-length form. This mutant HD protein damages the brain by isolating other molecules that are needed to carry out essential functions in the cell. Normal HD protein is chopped up by enzymes in the brain. Cynthia T. McMurray and Roy B. Dyer, of the Mayo Clinic and Foundation in Rochester, Minnesota, discovered that mutant protein is more resistant to enzymes than is normal HD protein. They also found that mutant protein causes disease by targeting other molecules, including fragments of the normal HD protein. "Our data from multiple human brains confirm that normal HD is indeed targeted by the mutant protein in Huntington disease-affected brain," the researchers write in an advance online publication of Nature Genetics . "The mutation may result in the loss of normal HD function."

68. Gene Expression In Huntington's Disease Gene expression in Huntington s disease. Powerful new tools, however, are now allowing scientists to dissect the progression of Huntington s disease. http://www.genomenewsnetwork.org/articles/05_00/huntingtons.shtml

Home About Topics Subscribe Gene expression in Huntington's disease By Marina Chicurel May 15, 2000 Fig. 1 Scanned image of gene chip from an Affymetrix Mu6500 array set hybridized to complementary RNA probe derived from mouse striatal RNA.* The genes involved in the cascade of brain damage that afflicts patients with Huntington's disease are coming into focus and providing new perspectives on therapy development. Powerful new tools, however, are now allowing scientists to dissect the progression of Huntington's disease. A multi-institutional team led by James Olson, of the Fred Hutchinson Cancer Research Center in Seattle, Washington, monitored the genes of mice carrying a mutated copy of the Huntington's gene, and pinpointed changes that occur just as the first symptoms start to emerge. "The mouse models provide a window into the early stages of the disease," says Ruth Luthi-Carter of the Massachusetts General Hospital in Boston. Fig. 2 N10 in situ hybridization

69. OTdirect Occupational Therapy Revision Notes: Huntington's Disease Occupational Therapy Revision Notes Huntington s disease (HD). Free ad Support the Huntington s disease=. Bobby Approved (v3.2) for accessibility. http://www.otdirect.co.uk/huntingtons.html

Occupational Therapy Revision Notes: Huntington's Disease (HD) Please note: This is a basic revision aid, not a comprehensive and reliable statement of medical fact. These notes should not be used to guide treatment. For reliable information and advice, consult a qualified practitioner. (Last updated: 19 March 2001) Prevalence 1:20000 worldwide, all ethnic groups. Some reports say 1:10000. Age at onset Usually 30-55 years old, but can be earlier or later. Cause Autosomal dominant genetic disorder ( i.e. if one parent has HD, there is a 50% chance of each child developing HD). See our separate guide to genetic conditions for a fuller explanation of genetic transmission. The gene for HD is on chromosome 4 and is involved in producing a protein called Huntingtin, but there is little more useful information on how this leads to damage to the central nervous system. Pathology Caudate nucleus atrophy with generalised cerebral atrophy and atrophy of the corpus striatum. The particular mechanisms are unknown. Presentation and symptoms Progressive dementia with increasingly prominent choreiform movements and likely personality and behavioural changes.

70. Huntington's Disease - Family Medicine Genetics Mount Sinai Hospital, Toronto Huntington s disease. top. Genetics. Huntington s disease involves a genetic defect of the IT15 gene (IT = Interesting Transcript), on chromosome 4p16. http://www.mtsinai.on.ca/FamMedGen/Disorders/huntingtons.htm

Physician Referrals Media MSH Staff Patients ... Auxiliary Quick Links About MSH Contact MSH Events Calendar Fast Facts How to Find MSH MSH in the News Publications Visiting Hours Disorders Genetic Clinics Glossary Links ... Disorders Family Medicine Genetics Program Huntington's Disease Huntington's is a degenerative neurological disorder with age of onset around 40-50 years of age. Patients with the disease have progressive decline in motor control, mood regulation, behavior regulation and cognitive function. It is inherited in an autosomal dominant pattern. The disorder causes abnormalities in two main areas of the brain, the caudate nucleus and the putamen (regions of the striatum), where atrophy and degeneration are usually profound. Death occurs approximately 15-20 years after onset of the illness. Etiology Prevalence Genetics Genetic Counselling ... References Etiology The cause of HD is definitively genetic, the defect having been identified in 1993.

71. HUNTINGTONS-DISEASE HUSBANDS huntingtonsdisease. Broader Terms BRAIN-diseaseS Subject Categories D disease, Symptoms, and Pathological Processes http://www.alzheimers.org/chid/00001388.htm

Search on This Term Main Index TopTerm Index Term Index Prev Term: HUMOR Next Term: HUSBANDS HUNTINGTONS-DISEASE Broader Terms: BRAIN-DISEASES Subject Categories: [D] Disease, Symptoms, and Pathological Processes

72. Neurological Disorders: Huntington's Disease Neurological Disorders Huntington s disease. Support Groups. Australian Huntington s disease Association Inc. Offers support for http://www.puredirectory.com/Health/Conditions-and-Diseases/Neurological-Disorde

Neurological Disorders: Huntington's Disease Home Health Conditions and Diseases Neurological Disorders : Huntington's Disease Support Groups google_ad_client = "pub-3272565765518472";google_alternate_color = "FFFFFF";google_ad_width = 336;google_ad_height = 280;google_ad_format = "336x280_as";google_ad_channel ="7485447737";google_color_border = "FFFFFF";google_color_bg = "FFFFFF";google_color_link = "0000FF";google_color_url = "008000";google_color_text = "000000"; Standard Listings Australian Huntington's Disease Association Inc. Offers support for families living in the Australian states of New South Wales and the Australian Capital Territory. Includes resources and information about NSW. Caring for People with Huntington's Disease Information about caring for people with Huntington's disease, for patients, families and professionals. CureHD Foundation A charity site aiming to spread awareness, information, and news about Huntington's disease. HDSA, Arizona Chapter Contains general information about Huntington's disease and specific information about this chapter's fund raisers and events. Healthubs Links to overviews, clinical trials, case reports, diagnosis, treatment, research programs on Huntington's disease.

73. HUNTINGTON'S DISEASE SOCIETY OF AMERICA Research, assistance, and education. http://www.hdsa.org/

74. Huntington's Disease Information Huntington s disease Information. This alphabetical list provides an easy way to locate specific documents. Bibliographies of Huntington s disease, 19901999. http://www.lib.uchicago.edu/~rd13/hd/

Huntington's Disease Information Announcements Documents Maintained at This Site Links to Outside Resources I am not a health professional or an official representative of any organization - just a librarian with an interest in Huntington's Disease. This is a personal home page, and although it is housed on a computer at The University of Chicago Library, it does not represent the university or the library. Announcements HD Symposium The University of Virginia Center of Excellence for Huntington's Disease will present a symposium, "HD 2003: A Decade of Progress and Promise," on Sat., Oct. 4, 9 a.m. - 5 p.m., in Springfield, Virginia, about 12 miles from Washington, DC. The guest speaker will be Jane Paulsen, PhD, codirector of the Center of Excellence at the University of Iowa and author of "Understanding Behavior in Huntington Disease" and many other publications. She will be giving two talks, one reviewing research advances and the other on understanding behavior in HD. The afternoon will be devoted to breakout sessions on family communication, ADLs, grief and loss, and "the basics." Genetic counselors, students, and other healthcare professionals are welcome to attend. For more information and a registration form, please contact Susan Dietrich at the toll-free HD Program Helpline, 1-866-290-4528.

75. NINDS Huntington's Disease Information Page Huntington s disease information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). More about Huntington s disease, http://www.ninds.nih.gov/health_and_medical/disorders/huntington.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Huntington's Disease Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Huntington's Disease Information Page Reviewed 07-01-2001 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Huntington's Disease? Is there any treatment? What is the prognosis? What research is being done? ... Additional resources from MEDLINEplus What is Huntington's Disease? Is there any treatment? Physicians prescribe a number of medications to help control emotional and movement problems associated with HD. Most drugs used to treat the symptoms of HD have side effects such as fatigue, restlessness, or hyperexcitability. It is extremely important for people with HD to maintain physical fitness as much as possible, as individuals who exercise and keep active tend to do better than those who do not. What is the prognosis?

76. Huntington's Disease - Hope Through Research An information booklet on Huntington s disease compiled by the National Institute of Neurological Disorders and Stroke (NINDS). http://www.ninds.nih.gov/health_and_medical/pubs/huntington_disease-htr.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about a disorder Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health Huntington's Disease — Hope Through Research Get Web page suited for printing Email this to a friend or colleague Request free mailed brochure Table of Contents Introduction What Causes Huntington's Disease? How is HD Inherited? What are the Major Effects of the Disease? ... Information Resources Introduction In 1872, the American physician George Huntington wrote about an illness that he called "an heirloom from generations away back in the dim past." He was not the first to describe the disorder, which has been traced back to the Middle Ages at least. One of its earliest names was chorea which, as in "choreography," is the Greek word for dance. The term chorea describes how people affected with the disorder writhe, twist, and turn in a constant, uncontrollable dance-like motion. Later, other descriptive names evolved. "Hereditary chorea" emphasizes how the disease is passed from parent to child. "Chronic progressive chorea" stresses how symptoms of the disease worsen over time. Today, physicians commonly use the simple term Huntington's disease (HD) to describe this highly complex disorder that causes untold suffering for thousands of families.

77. HDSA What Is Huntington s disease? Huntington’s disease profoundly affects the lives of entire families emotionally, socially and economically. http://www.hdsa.org/about/about.pl?whatishd

78. Redirect http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?143100

79. Huntington's Disease Advocacy Center The Huntington s disease Advocacy Center s purpose is to provide answers to the many tough questions that patients with Huntington s disease and their http://www.hdac.org/

Huntington's Disease Advocacy Center Home Message Board Library F.A.Q. ... Site Map Rooms HDAC Home Page HDAC Message Board Beacon of Hope Kitchen HD Library ... Huntington's Disease Society of America (HDSA) Basement Stuff About Us Site Guide Welcome to HDAC! Getting Started in Self-advocacy Alert!: Genetic Information Nondiscrimination Act of 2003 Sirna Therapeutics Evaluating RNAi to Treat Huntington's Disease ... Farewell to an HD Warrior ... Jerry Lampson, Lighthouse Keeper by Marsha Miller, Ph.D. The Huntington’s Disease community lost one of its greatest warriors with the passing of Gerald (Jerry) Lampson on May 31, 2004, after a short battle with cancer. Jerry was the founder and webmaster for the Huntington’s Disease Lighthouse, one of the earliest and most influential HD websites. Here she comes... Miss America! by Jim Pollard Our former Miss America, Katie Harmon, spoke about quality of life for those sick now, specifically with breast cancer. She made an interesting comment in the interview about how appalled she is at the care for those who are sick now. She expressed concerned about the quality of life for those people right now. Dave of HUNT-DIS posted what was going on with her and about her heartfelt concerns. This resulted in a fascinating post by Jim Pollard. Trudy's Story by Miranda Adkins This story is about the impact that growing up with an HD positive parent had on the author's life, and learning to deal with the inevitable issues.

80. Huntington Society Of Canada The Huntington Society of Canada is a national health charity, consisting of volunteers and professionals united against huntington disease, an inherited http://www.hsc-ca.org/

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