1. Huntingtons Disease huntingtons disease Menu. This is a webforum to discuss and comment on huntingtons disease. Click here to Enter a new Neurology WebForum article Click Here to Read our Forum Disclaimer and Statement of Purpose http://neuro-www.mgh.harvard.edu/forum/HuntingtonsDiseaseMenu.html

Huntingtons Disease Menu This is a webforum to discuss and comment on Huntingtons Disease. Click here to Enter a new Neurology WebForum article... This Web Forum is not moderated in any sense. Anyone on the Internet can post articles or reply to previously posted articles, and they may do so anonymously. Therefore, the opinions and statements made in all articles and replies do not represent the official opinions of MGH and MGH Neurology. Neither is MGH or MGH Neurology responsible for the content of any articles or replies. No messages are screened for content. - Very Important Message! - Please Click Here to Read Current Posts: Oct 10, 1997 to Present Useful Websites can be found and posted here! Hurt by insensitvity (1/14/00) 3:54 AM Exam Project!!! (1/11/00) 5:59 PM Chorea (1/8/00) 7:41 AM ... Good to be back (10/14/97) 9:59 PM IMPORTANT: If this page seems to be missing recently added documents, click the "Reload Page" button on your Web Browser to update the menu. Return to the main Neurology WebForum Page. These forums are maintained by the Department of Neurology at Massachusetts General Hospital John Lester - Webspinner

2. Huntingtons Disease Association Online HDA Online provides news of fund raising events, health care information and details of research into curing huntingtons disease. http://www.hda.org.uk/

Click on the topics listed above to find your way around the site Calls for bids to support the Euro HD Network HDA Family Conference/AGM - Come to the event of the year! Drugs on the Shelf May Treat HD! Bile acid inhibits cell death in Huntington's disease ... r Updated document.write(document.lastModified);

3. Huntingtons Disease Menu huntingtons disease 3/18/95 to 1/27/97. huntingtons disease Menu - 1/27/97 to present. These are articles related to huntingtons disease issues. Please feel free to browse http://neuro-www.mgh.harvard.edu/neurowebforum/HuntingtonsDiseaseMenu.html

Archives Huntingtons Disease - 3/18/95 to 1/27/97 Huntingtons Disease Menu - 1/27/97 to present These are articles related to Huntingtons Disease issues. Please feel free to browse... ATTENTION: The Neurology Webforums have changed software...you cannot reply to any of these posts! Please go immediately to the Main Neurology WebForum page for more information! Friends (2/24/97) 1:12 PM Need HD neurologist in San Diego (2/18/97) 4:10 PM Help Me!!! Info. (2/14/97) 11:50 PM Help me!!! Info. (2/14/97) 11:44 PM ... Australian's at risk (1/28/97) 3:44 AM IMPORTANT: If this page seems to be missing recently added documents, click the "Reload Page" button on your Web Browser to update the menu. Return To the main Neurology Web-Forum Page.

4. HDA NORTH WEST LANCASHIRE BRANCH Lists general information, branch meetings, local and national contacts, young carers, photographs and diary dates. http://members.aol.com/hdanwlancs/index.html

HUNTINGTON'S DISEASE ASSOCIATION North West Lancashire Branch Dedicated to the Care and Support of Huntington's Families General Information Branch Meetings Local and National Contacts Young Carers ... The whole world owes a debt of gratitude to this community without which the Human Genome Project would not be where it is today! Fact Sheets from the Huntington's Disease Association Fact Sheet 1 All about the Huntington's Disease Association Fact Sheet 2 General Information about Huntington's Disease ... EMail Webmaster - John Griffiths s="na";c="na";j="na";f=""+escape(document.referrer) View My Guestbook Sign My Guestbook [Previous] [Join] ... [Skip Next] This webring is hosted by: HACKERSONS E-Mail: Ringmaster

5. Electronic Resources On Huntington's Disease, 1990-1999 Electronic Resources on Huntington s Disease, 19901999. Compiled by Renette Davis. Wilson, Wanda. My huntingtons disease Family (Peters). http://www.lib.uchicago.edu/~rd13/hd/electron.html

Electronic Resources on Huntington's Disease, 1990-1999 Compiled by Renette Davis This document is no longer being maintained in terms of adding new resources. However, information on existing resources will be maintained if possible. If you discover a link on this page which doesn't work, please notify Renette Davis at rd13@midway.uchicago.edu , giving the new address if you know it. "2nd Annual Jay Peddy Memorial Raffle." http://www.lib.uchicago.edu/~rd13/hd/2nd.html "10 Easy Ways to Help an HD Family." http://www.lib.uchicago.edu/~rd13/hd/10easy.html "10 Facts About Family Caregivers." Available on the Internet at: http://www.lib.uchicago.edu/~rd13/hd/facts.html 17th International Meeting of the World Federation of Neurology Research Group on Huntington's Disease. Mode of access: Internet and World Wide Web. Address: http://prospero.fmc.flinders.edu.au/hd_conference.html "20 Steps to Help Caregivers." Mode of access: Internet and World Wide Web. Address: http://www.lib.uchicago.edu/~rd13/hd/steps.html Adams, Sue. The Life and Times of a Person With Huntington's Disease.

6. HDSA For HD Rehab for Lowell. huntingtons disease Society of America untingtonsDisease? huntingtons disease (HD) is an patients with huntingtons disease and to their families http://fisher.mgh.harvard.edu/alzheimers/patient_resources/huntingtons_disease_u

THE NEW ENGLAND HDSA CENTER OF EXCELLENCE FOR HUNTINGTON’S DISEASE Massachusetts General Hospital Tewksbury Hospital Boston University Medical Center Huntington’s Disease Society of America What is Huntington’s Disease? The Genetics of Huntington’s Disease The New England HDSA Center of Excellence Clinical Evaluations ... The HDSA W hat i s H untington’s Disease? Huntington’s disease (HD) is an inherited neurologic disorder that causes involuntary movements, emotional symptoms, and loss of cognitive abilities. The involuntary movements may first appear as restlessness, and later include random movements of the limbs and face. In addition, many patients also develop stiffness, difficulty with walking, reduced control of fine movements, and problems with speech and swallowing. Emotional symptoms may include depression, reduced control over feelings and impulses, or irritability. Cognitive symptoms may include problems with memory, concentration, motivation, and planning. Weight loss is an important complication. Return to top The Genetics of Huntington’s Disease.

7. Huntington's Disease - Treatment - Neurologychannel There is no cure for huntingtons disease. Treatment focuses Treatment There is no cure for Huntington s disease. Treatment focuses http://www.neurologychannel.com/huntingtons/treatment.shtml

Home Search SiteMap Ask the Dr. ... Medical Store advertisement HUNTINGTON'S DISEASE Overview Symptoms Diagnosis Treatment ... Find a Neurologist CONDITIONS ADHD ALS Alzheimer's Disease Autism ... Carpal Tunnel Syndrome Cephalic Disorders Cerebral Palsy Charcot-Marie-Tooth Disease Chronic Pain Dementia Encephalitis Epilepsy ... Guillain-Barre Syndrome Headache Huntington's Disease Hydrocephalus Lou Gehrig's Disease ... Traumatic Brain Injury Vertigo TREATMENT OPTIONS Botulinum Toxin Therapy Epidural Injection Trigger Point Injection Vagus Nerve Stimulation RESOURCES neurologychannelMD Clinical Trials Links MDLocator ... What Is a Neurologist? Videos ABOUT US Healthcommunities.com Pressroom Testimonials print this ... email this Treatment There is no cure for Huntington's disease. Treatment focuses on reducing symptoms, preventing complications, and providing support and assistance to the patient and those close to him or her. Medication Physicians often prescribe various medications to help control emotional and movement problems. Antipsychotics (hallucinations, delusions, violent outbursts): haloperidol, chlorpromazine, olanzapine (contraindicated if patient has dystonia) Antidepressants (depression, obsessive-compulsive behavior): fluoxetine, sertraline hydrochloride, nortriptyline

8. Huntington's Disease Hub huntingtons disease Menu webforum to discuss and comment on Huntington s Disease by the Department of Neurology at Massachusetts General Hospital. http://www.healthubs.com/huntingtons/

Huntington's disease hub Huntington's disease results from genetically programmed degeneration of nerve cells, called neurons, in certain areas of the brain. Huntington's disease is a familial disease, passed from parent to child through a mutation in the normal gene. Acne Allergy Antibiotics Antioxidants ... Wedding Overviews - Clinical trials - Case reports - Diagnosis - Treatment - Research programs Huntington's Disease — Hope Through Research - an information booklet on Huntington's disease compiled by the National Institute of Neurological Disorders and Stroke (NINDS). Huntington's disease - from Macalester College. Baltimore Huntington's Disease Center - research center at the Johns Hopkins University School of Medicine. Huntington's Disease - an overview by Christy Taylor. Huntington's disease by NCBI The Huntington's Disease Program of the University of Connecticut Health Center Huntington's Disease Programs and Services - by University of Virginia Health System. Parkinsons Chorea and Huntington's Disease Clinical features of Huntington's Disease - by Rush Neuroscience Institute. Huntington's Disease Center at Columbia University Fact Sheet: Huntington's Disease - by Family Caregiver Alliance.

9. Australian Huntingtons Disease Association Australian, Huntingtons, Disease, Association, Australian huntingtons disease Association, Australia, huntingtons disease, Resources, Support, Huntingtons http://www.ahda.asn.au/

About Us What is HD? Community Support Education ... Contact Us This page was sponsored by Bovis Lend Lease Website Design by Spin Technologies

10. Huntingtons Disease Scotland ASK Service. ASK Service If you are a family member or professional with a question about Huntington s disease try our on line advice service. http://www.hdscotland.org/

Home Whats On Branches Advisory Services ... Or support us by visiting our shop This site was last updated on 24 May 2004 Registered Office: Thistle House, 61 Main Road, Elderslie, PA5 9BA, Scotland - T: +44 01505 322245 - e: sha-admin@hdscotland.org "The Scottish Huntington's Association" is a Charity No 121496

11. HD Information Page Moved previously available at this site has been replaced by the new pages published by the Western Pennsylvania Chapter of the huntingtons disease Society of America http://ww3.telerama.com/~mccarren/

Pages moved The information page previously available at this site has been replaced by the new pages published by the Western Pennsylvania Chapter of the Huntingtons Disease Society of America . Please update you bookmark files to refer to the new locations. I am still involved with these organizations, so feel free to email me with any questions. mike

12. Hardin MD : Huntingtons Disease From the University of Iowa, the *best* lists of Internet sources in huntingtons disease Huntington s Chorea. huntingtons disease. http://www.lib.uiowa.edu/hardin/md/huntingtons.html

Huntingtons Disease "We list the best sites that list the sites" Site Map Diseases Home Free Articles in PubMed Search Hardin MD See also: Home Neurology All links on this page hand-checked Popular Women's Health Dermatology Nursing Pharm Infect Disease Alzheimers Disease +Pictures Brain Pictures Genetic Disorders Medical Pictures Nervous System +Pictures Parkinsons Disease +Pictures Pictures of Huntingtons Disease NOAH: Huntington's disease Rita Neri, NY Online Access to Health Links to organizations Personal sites Huntington's disease advocacy center Information links Huntington's Disease Society of America LookSmart : Huntington's disease or Huntington's chorea Open Directory Project : Health : ... : Neurological disorders : Huntington's disease (Other versions: Google AOL MEDLINE plus Huntington's disease National Library of Medicine ClinicalTrials.gov : Huntington disease National Library of Medicine, National Institutes of Health Yahoo : Huntington's disease OMNI : Huntington disease Univ Nottingham, United Kingdom

13. Huntington's Scene In  New Zealand Website Huntingtons Disease New Zealand The Huntington s Disease Scene In. New Zealand. Site Maintained by Graham Taylor Graham Taylor. This site last updated. 04/04/04. http://homepages.ihug.co.nz/~ghtaylor/

The Huntington's Disease Scene In New Zealand Site Maintained by Graham Taylor Graham Taylor This site last updated About the Associations Auck BOP Wgtn ... Contacts in New Zealand (Updated Behavorial Problems Living with HD (NZ) Brain Donor Protocol Young Peoples Pages ... A Family Perspective (New) Contributions Wanted Canadian Resources Introduction to HD Publications Research Education ... International HDA Addresses Member Countries Articles sent by The International Huntingtons Assocation (New updated 02-04 Huntingtons Disease New Zealand Key NZ Site Resources National Annual Camp forYoung People from HD Families Newsletter Diet Book ... Naturapathic Medicines and Therapies 21-22 September Annual Camp For Young People 14-26 years old 12-17 April 2004 Judy Lyon's Conference talk " Keeping Myself Well Using Naturopathic Medicines" NZ Research Neurological Foundation Brain Bank By Alison Gray. By Alison Gray Studies by Richard Faull and his team at Auckland University International Research News Being such small community groups we operate within small budgets and limited resources. We acknowledge the generosity of the

14. CMGS-Huntingtons Disease/14.12.99 MRCPath Self Help 1999 Meeting4 / Session2 Genevieve Creed. huntingtons disease (HD). Clinical HD. HD is a progressive fatal neurodegenerative disease. http://www.ich.ucl.ac.uk/cmgs/hd99.htm

MRCPath Self Help 1999 Genevieve Creed Huntingtons Disease (HD) Clinical HD Incidence HD HD gene spans ~185 kb of genomic DNA contains 67 exons. (CAG repeat in exon 1) 2 major mRNA transcripts (13.5 and 10.5 kb) encodes ~350 kDa "huntingtin" protein. CAG repeat size ranges Majority (95%) of adult onset cases = 40-55 repeats. Genotype / Phenotype correlations : repeat length / age of onset For low repeat numbers ( and older ages at onset) the correlation is weaker. This implies that CAG repeat length is the major determinant of age of onset in juvenile HD. But in HD which only develops at an elderly age other factors are involved in determining the age of onset. Intergenerational Instability of the CAG repeat Instability occurs during gametogenesis, showing a greater instability in male transmissions. This could be influenced by the continual mitotic divisions during spermatogenesis. For example,a sperm gaining an extra 20 CAG repeats could be due to: one mutation event at one cell division multiple smaller expansions at several different divisions (a cumulative effect) a history of several expansions and contractions shows mutation spectra of sperm samples from donors with different somatic CAG repeat lengths (Ref 1). The larger the somatic allele, the greater the average allele length of the mutant sperm.

15. CMGS-HUNTINGTON’S DISEASE/17.12.98 huntingtons disease (HD) is an autosomal dominant untreatable neurodegenerative disorder associated with expansions of the CAG repeat found in the Huntingtin http://www.ich.ucl.ac.uk/cmgs/hunt98.htm

HUNTINGTON'S DISEASE Huntingtons Disease (HD) is an autosomal dominant untreatable neurodegenerative disorder associated with expansions of the CAG repeat found in the Huntingtin gene. HD occurs equally in both sexes and is found in all races but most frequently in West Europeans where it affects 1 in 10,000 individuals. Clinical Symptoms Huntington's Disease is characterised by : Progressive chorea Psychiactric changes Intellectual decline 'Chorea' refers to the characteristic peculiar movement disorder which begins subtly and progresses to exaggerated dance like motions that involves the entire body. The clinical progression of HD is paralleled by neuronal degeneration in the brain: The hallmark in HD is loss of the medium spiny neurons of the striatum which begins in the caudate nucleus and spreads to the putamen and deep layers of the cerebral cortex (Fig.1). Recurved dendritic endings and changes in spine density, shape and size are associated with loss of function and ultimately neuronal cell death. The extensive neuronal loss may reduce the overall brain weight by 25% or more.

16. Huntington's Disease To find help or more information about huntingtons disease, there is a nonprofit national voluntary heath organization dedicated to the disorder http://ms.essortment.com/huntingtondisea_rkhm.htm

Huntington's disease Symptoms,diagnostic tests, treatment and resourses for Huntington's Disease. In 1872 an American doctor, George Huntington, wrote about his observations concerning a strange, hereditary illness that made its victims squirm, twist and writhe uncontrollably. Although he was not the first to describe this nervous disorder, he is the one whose name was attached. Before Dr. Huntington the disease was known as Chorea. As stated, Huntington's Disease (HD) is a hereditary problem that seems to run in successive generations of a family. It destroys the ability to feel, think or move. It wasnt until 1993, when the gene (located on chromosome 4) that causes Huntington's Disease was found in a laboratory headed by molecular geneticist James Gusella at Massachusetts General Hospital, that researchers began to have a better understanding of the disorder. Because of this discovery a test has now been developed to allow family members of patients with Huntington's Disease to find out if they too carry the disease. Knowing the results either way can cause severe emotional stress and testing is only done after the person has undergone psychological counseling. Regardless of the results, it is recommended these people come in for follow-up counseling as well. bodyOffer(31560) There is an estimated one person in every ten thousand that has Huntington's Disease. At that ratio there are approximately thirty thousand with the disease in the United States alone. Each child of a Huntington's Disease patient has a fifty percent chance of inheriting the disease, which means approximately 150,000 people are said to be at risk.

17. WebRing: Hub About this Ring. This Webring is for all people who are connected in some way with huntingtons disease. For carers and caregivers http://r.webring.com/hub?ring=huntingtons

18. Research Projects - Huntington's Disease - Genetic Testing More Facts About Finding the HD Gene, DNA Banking and Genetic Testing for huntingtons disease WHAT DOES THIS MEAN FOR ME? In the http://www.iupui.edu/~medgen/research/hd/genetic_testing/facts_about _testing2.h

More Facts About Finding the HD Gene, DNA Banking and Genetic Testing for Huntingtons Disease WHAT DOES THIS MEAN FOR ME? In the immediate future, there will be no changes. The methods for diagnosing and treating HD will remain the same. However, with continued investigation, many new possibilities will arise. Finding the gene is expected to simplify the testing process. Until now, many blood specimens from specific family members were necessary in order for an at-risk person to undergo presymptomatic testing. Now that the gene has been located, a two step testing process has been proposed. First, an affected family member's sample will be tested for the presence of the HD gene. Second, if, in fact, the gene is present (meaning HD was the correct family diagnosis), then the at-risk person who desires to know whether or not he too has inherited the gene, could be tested for its presence. Thus, it is our recommendation that families continue to store DNA on persons who are presumed to have HD. Of course, genetic testing for Huntingtons Disease remains a personal decision which should be considered very carefully. Although the test may be technically less complex, the personal implications remain the same and are substantial. Our recommendation is that anyone seeking genetic testing do so only through programs in which protocols for testing have been submitted to the Huntingtons Disease Society of America and which are known to have reputable pre-test and post-test counseling programs.

19. UK Psychiatrists Huntington's Disease Group huntingtons disease the UK Psychiatrists huntingtons disease Group - with links, information and contacts. UK Psychiatrists Huntington s Disease Group. http://www.huntingtons.org.uk/

UK Psychiatrists Huntington's Disease Group UK Psychiatrists Huntington's Disease Group

20. Bbc.co.uk - Health - Illnesses And Conditions Huntington's Disease Trust 51 Lisburn Road Belfast BT9 7AB Tel 028 9026 3555 Provides support and advice to those affected by huntingtons disease, living in Northern Ireland. http://www.bbc.co.uk/health/conditions/huntingtons.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index WEDNESDAY 9th June 2004 Text only BBC Homepage Health Home Lifestyle Home ... Conditions QUICK GUIDE A-Z Children's Ailments IN-DEPTH Addictions Allergies Arthritis Asthma ... Help Like this page? Send it to a friend! A-Z Illnesses and Conditions Huntington's Disease by Dr Trisha Macnair and Dr Rob Hicks A significant step forward in science A progressive brain disease Genetic testing brings problems ... Related links Nearly 150 years ago American family doctor George Huntington went out riding, joining his father (also a doctor) on his rounds. They came across 'two women, mother and daughter, both tall, thin, almost cadaverous, both bowing, twisting, grimacing...'. Huntington was amazed and almost fearful, and the encounter triggered his lifelong interest in the disease now named after him. First called Huntington's chorea (a term which describes strange dancing movements) it's now known as Huntington's disease. A significant step forward in science How Huntington's Disease progresses Early symptoms include mood swings, depression, irritability, memory problems, difficulty learning new things or making decisions

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