41. On Linking Genotype To Phenotype On Linking genotype to phenotype. Well informed linkages between genotypeand individual phenotypes will require a completely new http://biosystems.ucsf.edu/Observations/geno_to_pheno.html

On Linking Genotype to Phenotype Well informed linkages between genotype and individual phenotypes will require a completely new generation of simulation models that are suitable for rigorous experimentation. Rational development of new therapeutic interventions, including new drugs, requires understanding the functional interactions between subcellular networks, the functional units of cells, organs and systems, and how the emergence of disease alters them. If the required information is somehow encoded in the genome, it is currently invisible. Some of it may be hidden within the protocols used by macromolecules to interact within networks and modules ( Absent the needed information, our current best alternative is to “copy” nature (build models that reflect our current state of knowledge) and compute these interactions (i.e., simulate) to determine the logic of healthy and diseased states. The impressive growth in bioinformatics databases and the relentless growth in computer power have helped open a door to new methods to explore functionality hierarchically from genes to individual patients. In the mean time, the rapid accumulation of biological information and data is overwhelming our ability to understand it.

42. News & Features: Integrating The Genotype And Phenotype In Hominid Paleontology 9 26532657 Integrating the genotype and phenotype in hominid paleontologyLeslea J. Hlusko Abstract Competing interpretations of human origins and http://www.iscid.org/boards/ubb-get_topic-f-1-t-000145.html

my profile register search faq ... General Integrating the genotype and phenotype in hominid paleontology Author Topic: Integrating the genotype and phenotype in hominid paleontology Moderator Administrator Member # 1 posted 10. March 2004 09:21 Integrating the genotype and phenotype in hominid paleontology Leslea J. Hlusko Abstract: Competing interpretations of human origins and evolution have recently proliferated despite the accelerated pace of fossil discovery. These controversies parallel those involving other vertebrate families and result from the difficulty of studying evolution among closely related species. Recent advances in developmental and quantitative genetics show that some conventions routinely used by hominid and other mammalian paleontologists are unwarranted. These same advances provide ways to integrate knowledge of the genotype into the study of the phenotype. The result is an approach that promises to yield a fuller understanding of evolution below the family level. IP: Logged All times are East Coast Printer-friendly view of this topic Hop To: Select a Forum: Category: General The Archive Brainstorms Literature Review Writers Workshop Category: PCID PCID Volume 2.3, Philosophy of Mind Issue

43. From Genotype To Phenotype From genotype to phenotype Linking Bioinformaticsand Medical Informatics Ontologies. http://www.cs.man.ac.uk/~stevensr/g2p/

From Genotype to Phenotype: Linking Bioinformatics and Medical Informatics Ontologies G2P main page G2P participants list G2P Presentations As part of the Manchester Bioinformatics Week there will be a one-day workshop on "From genotype to phenotype: Linking Bioinformatics and Medical Informatics Ontologies". The day-long meeting will be split over Saturday 23rd Sunday 24th March 2002 at the Chancellors Conference Centre at the University of Manchester . The meeting co-charis are Robert Stevens and Alan Rector , of the bioinformatics and Medical Informatics Groups at the Department of Computer Science, University of Manchester. The schedule for this and the other Manchester Bioinformatics Week meetings is available and will be extended closer to the meeting dates. Background The medical informatics community has had an interest and a wealth of experience in developing and using ontologies, that stretches back over many decades. The younger Bioinformatics community has also indicated a growing interest in the subject area. There is both a common interest and a diversity in these fields, that together, we hope can be of mutual interest and benefit to both communities. The linking of genotype and phenotype ontologies offers interesting opportunities for collaboration between Medical Informatics and Bioinformatics. Ontologies should be integral in the storage, management and analysis of data in eScience and eMedicine and it is hoped that this meeting can initiate such collaborations.

44. From Genotype To Phenotype|KLUWER Academic Publishers Books » From genotype to phenotype. From genotype to phenotype. editedby GTN Besley Willink Biochemical Genetics Unit, Royal Manchester http://www.wkap.nl/prod/b/0-7923-8865-8

Title Authors Affiliation ISBN ISSN advanced search search tips Books From Genotype to Phenotype From Genotype to Phenotype edited by G.T.N. Besley Willink Biochemical Genetics Unit, Royal Manchester Children's Hospital, UK G.M. Addison Dept. of Chemical Pathology, Royal Manchester Children's Hospital, UK R. Angus Harkness Institute of Child Health, London, UK R.J. Pollitt Children's Hospital, Sheffield, UK Reprinted from JOURNAL OF INHERITED METABOLIC DISEASE, 17:4 The articles in Issue 4 of JOURNAL OF INHERITED METABOLIC DISEASE , Volume 17 (1994), contain the main lectures presented at the 31st Annual Symposium of the Society for the Study of Inborn Errors of Metabolism (SSIEM), Manchester, UK, 1993, the theme of which was `From Genotype to Phenotype'. Topics discussed include: phenotype expression in homocystinuria, human genome mapping and inherited metabolic disease, genetic imprinting, 21-hydroxylase deficiency, dysmorphic disorders and embryogenesis, signals on proteins, peroxisomal disorders, primary hyperoxaluria type I, metachromatic leukodystrophy, and replacement therapy in Gaucher disease. Participants from many countries provided a state-of-the-art review which will be of interest to clinicians and research workers alike in many different countries.

45. The Predictive Quality Of Genotype And Phenotype Data On Virological Response To The Predictive Quality of genotype and phenotype Data on Virological Response toSalvage Therapy in HIV1 Infected Patients (CNAA2007) Resistance Collaborative http://www.fda.gov/ohrms/dockets/ac/99/slides/3541s1l/

The Predictive Quality of Genotype and Phenotype Data on Virological Response to Salvage Therapy in HIV-1 Infected Patients (CNAA2007)Resistance Collaborative Group Reanalysis Click here to start Table of Contents The Predictive Quality of Genotype and Phenotype Data on Virological Response to Salvage Therapy in HIV-1 Infected Patients (CNAA2007)Resistance Collaborative Group Reanalysis Background Information Methods Baseline Characteristics of Study Population ... Phenotypic Multivariate Analysis:Odds Ratio of Virological FailureClass Phenotypic Sensitivities Author: Jeff Booker, VisCom Inc.

46. 670 - Abstract (11th CROI) 670 Comparison of genotype and phenotype as Predictors of Shortterm Virologic Responseto Didanosine in Nucleoside Analogue-experienced Patients F Clavel* 1 http://www.retroconference.org/2004/cd/Abstract/670.htm

Home Search Abstracts Browse Abstracts Program Committee ... View Session Session 94 Poster Abstracts Resistance Predictors of Virologic Response and Clinical Outcome Tuesday, 1:30 - 3:30 pm Poster Hall Comparison of Genotype and Phenotype as Predictors of Short-term Virologic Response to Didanosine in Nucleoside Analogue-experienced Patients F Clavel* , AG Marcelin , J Pavie , N Schmidely , I Dujardin , G Leleu , V Calvez , and J M Molina Inserm U552, Paris, France; Hosp. Pitié-Salpétrière, Paris, France; Hosp. Saint Louis, Paris, France; and Bristol-Myers Squibb, Rueil, France Background: In patients failing HAART, significant antiviral activity of didanosine (ddI) can be retained in spite of resistance mutations in RT. We have compared the ability of RT genotype and of phenotypic resistance to ddI to predict this activity. Methods: n = 110) or placebo ( n = 58). Plasma HIV RNA change from baseline was evaluated at week 4. RT genotype examined the presence of thymidine analogue mutations (TAM) and of all nucleoside analogue mutations (NAM). Phenotypic resistance to ddI was measured using the Phenoscript assay (Viralliance, Paris) and expressed as a resistance index (RI = fold-change in IC relative to NL4-3). The number of mutations and the RI values were divided into quartiles and their relationship with W4 HIV RNA change was evaluated with the Kruskal-Wallis test. The correlation between genotype and phenotype was analyzed using the Cochran-Mantel Haenszel test.

47. EEB 460 | Genotype And Phenotype Home, genotype and phenotype, s p r i n g 2 0 0 4. Theoretical distributionsof phenotypes in the F 2 generation. The distributions http://web.utk.edu/~pteropus/genotype_and_phenotype.html

Genotype and Phenotype s p r i n g 2 4 Theoretical distributions of phenotypes in the F generation. The distributions were generated using the following assumptions: Heritability = 1.0 A 12-unit difference between the parents is controlled by various numbers of genes with equal phenotypic effects. There is no linkage. Dominance is unidirectional. The graphs demonstrate that as the number of genes which controls a phenotype increases, phenotypic variance becomes less discrete and more continuous. Theoretical distributions of phenotypes in the F generation. The distributions were generated using the following assumptions: The phenotype is controlled by a single gene. There is a 12-unit difference between the parents. The effect of the environment ranges from 0% (heritability = 100%) to 75% (heritability = 25%) The graphs demonstrate that as the environmental influence on a phenotype increases, phenotypic variance becomes less discrete and more continuous.

48. Genotype And Phenotype The summary for this Japanese page contains characters that cannot be correctly displayed in this language/character set. http://www.hannan-u.ac.jp/~tsutsui/ga-intro/sld005.htm

49. Genotype And Phenotype The summary for this Japanese page contains characters that cannot be correctly displayed in this language/character set. http://www.hannan-u.ac.jp/~tsutsui/ga-intro/tsld005.htm

Genotype and Phenotype ‘O‚̽ײÄÞ

50. Genotype And Phenotype First Previous Next Last Index Text. Slide 17 of 25. http://psych.unn.ac.uk/users/nick/BBBpp02/sld017.htm

51. Genotype And Phenotype genotype and phenotype. phenotype observable characteristics that developthrough interactions between the genotype and the environment. http://psych.unn.ac.uk/users/nick/BBBpp02/tsld017.htm

Genotype and Phenotype Genotype: particular alleles that the individual has inherited. Phenotype: observable characteristics that develop through interactions between the genotype and the environment. E.g Siamese cats have dark fur on their tails, paws and ears; this raises the following questions: Is there a gene for colouring the corners of a cat? If such a gene exists, how does it 'know' where the 'corners' are, and how to colour them? Siamese cats have a gene for producing an enzyme responsible for coloration, but is only expressed at certain temperatures. As the extremities are cooler, the gene is expressed and they become dark. For complex human behaviours it is nearly impossible to isolate genetic from environmental variables. Previous slide Next slide Back to first slide View graphic version

52. Cancer Prevention Projects: Glucuronidation In Humans: Genotype And Phenotype (D Glucuronidation in Humans genotype and phenotype (DIGEST). PI JohannaLampe PhD. DIGEST website http//www.fhcrc.org/phs/digest. http://www.fhcrc.org/phs/cprp/projects/digest.html

@import "/wrapper/fhcrc.css"; HOME Science Public Health Sciences Cancer Prevention ... Contact Us Glucuronidation in Humans: Genotype and Phenotype (DIGEST) PI: Johanna Lampe PhD DIGEST website: http://www.fhcrc.org/phs/digest Research has shown that certain fruits and vegetables can increase the activity of a group of enzymes (called glucuronosyltransferases or UGT for short) that help our body get rid of potentially harmful substances, including carcinogens. Genetic differences among individuals can play a role in how effectively these cancer-fighting enzymes work. The DIGEST study will look at how the interplay of genes and diet – in particular, a diet rich in certain fruits and vegetables – may affect the function of the body’s cancer-fighting enzymes. The results of this study, funded by the National Cancer Institute, could be important in making recommendations about diets that prevent cancer. About 300 people, ages 20 to 40, are sought for the first half of this two-part study. They will be asked detailed questions about diet and health. DNA from a sample of blood will be analyzed to determine genetic patterns of enzymes. Activity of these cancer-fighting enzymes will be measured by looking at the rate that the body breaks down aspirin and Tylenol. Of those initially enrolled, 60 will be asked to participate in the second part, two 14-day feeding studies during which the Hutchinson Center will provide all food and beverages. Eligibility will depend on genetic patterns of the enzymes.

53. Blackwell Synergy - Cookie Absent 04156.x. NOD2/CARD15 genotype and phenotype Differences between Ashkenaziand Sephardic Jews with Crohn s Disease. Amir Karban, MD http://www.blackwell-synergy.com/links/doi/10.1111/j.1572-0241.2004.04156.x/enha

 Home An Error Occurred Setting Your User Cookie A cookie is a small amount of information that a web site copies onto your hard drive. Synergy uses cookies to improve performance by remembering that you are logged in when you go from page to page. If the cookie cannot be set correctly, then Synergy cannot determine whether you are logged in and a new session will be created for each page you visit. This slows the system down. Therefore, you must accept the Synergy cookie to use the system. What Gets Stored in a Cookie? Synergy only stores a session ID in the cookie, no other information is captured. In general, only the information that you provide, or the choices you make while visiting a web site, can be stored in a cookie. For example, the site cannot determine your email name unless you choose to type it. Allowing a web site to create a cookie does not give that or any other site access to the rest of your computer, and only the site that created the cookie can read it. Please read our for more information about data collected on this site.

54. Developmental Biology Online: Genotype To Phenotype: Murine Neural Crest Mutatio Printerfriendly version. genotype to phenotype Murine Neural CrestMutations. Spotted mice and growth factors. Two mutations in the http://www.devbio.com/article.php?ch=13&id=133

55. Developmental Biology Online: Genotype To Phenotype: Murine Neural Crest Mutatio Back to devbio.com. genotype to phenotype Murine Neural Crest Mutations.Spotted mice and growth factors. Two mutations in the mouse http://www.devbio.com/printer.php?ch=13&id=133

56. Genotype To Phenotype: Physiological Control Of Trait Size And Scaling In Insect 43, No. 5, pp. 617–634. genotype to phenotype Physiological Control of Trait Sizeand Scaling in Insects. Douglas J. Emlen, a , b and Cerisse E. Allen a , c http://apt.allenpress.com/aptonline/?request=get-abstract&issn=1540-7063&volume=

57. 6 Multiplexor Solution - Genotype And Phenotype 6 Multiplexor Solution genotype and phenotype. Evolved minimal circuit of controlled-controlled-NOT(CCNOT, Toffoli) gates implementing a six way multiplexor. http://www.cs.ucl.ac.uk/staff/W.Langdon/cscs-gp/node19.html

Next: Conclusions or Reasons why Up: Reversible Programs are Normal Previous: Hill climber and Population 6 Multiplexor Solution - Genotype and Phenotype Evolved minimal circuit of controlled-controlled-NOT (CCNOT, Toffoli) gates implementing a six way multiplexor. Two address lines direct one of the four data inputs to the output. Circles with crosses indicate controlled wire. Note there are no additional memory (garbage) lines and only five gates are required. Bill LANGDON 2003-05-26

58. Entrez PubMed Mapping genotype to phenotype for linkage analysis. Saccone NL, DowneyTJ Jr, Meyer DJ, Neuman RJ, Rice JP. Department of Psychiatry http://www.biomedcentral.com/pubmed/10597517

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Genet Epidemiol. 1999;17 Suppl 1:S703-8. Related Articles, Links Mapping genotype to phenotype for linkage analysis. Saccone NL, Downey TJ Jr, Meyer DJ, Neuman RJ, Rice JP. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.

59. Entrez PubMed Error occurred Document internals (TXmlObj) retrieval error 4 http://www.biomedcentral.com/pubmed/15037581

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1149-56. Related Articles, Links Correlations of genotype with phenotype in Indian patients with primary congenital glaucoma. Panicker SG, Mandal AK, Reddy AB, Gothwal VK, Hasnain SE.

60. A3243G - Abstract - Genotype To Phenotype Correlations In Mitochondrial Encephal genotype to phenotype correlations in mitochondrial encephalomyopathiesassociated with the A3243G mutation of mitochondrial DNA. http://www.a3243g.com/abstract_pm_7643139.asp

A G mtDNA Advertisement Above An A to G point mutation at position 3243 on the Mitochondrial DNA causes MELAS and MIDD Home Information Treatments ... Advertisement Below Abstract Publication: J Neurol 1995 May;242(5):304-12 Genotype to phenotype correlations in mitochondrial encephalomyopathies associated with the A3243G mutation of mitochondrial DNA. Mariotti C, Savarese N, Suomalainen A, Rimoldi M, Comi G, Prelle A, Antozzi C, Servidei S, Jarre L, DiDonato S, et al. Istituto Nazionale Neurologico Carlo Besta, Divisione di Biochimica e Genetica, Milan, Italy. Original Abstract Date Page Updated: 14 September 2002 Email this page to a friend. Feedback on this page. We subscribe to the HONcode principles. Verify here Terms Privacy Funding

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 3     41-60 of 88    Back | 1  | 2  | 3  | 4  | 5  | Next 20