61. THE OVERHOLT-BLUE CROSS EMPHYSEMA SURGERY TRIAL (0BEST) A multicenter randomized clinical trial on lung volume reduction surgery. http://www.ctsnet.org/doc/2375

THE OVERHOLT-BLUE CROSS EMPHYSEMA SURGERY TRIAL (0BEST); A MULTICENTER RANDOMIZED CLINICAL TRIAL ON LUNG VOLUME REDUCTION SURGERY A. SPONSOR Blue Cross Blue Shield of Massachusetts (Tel. No. 1 800 214 0019) B. PARTICIPATING HEALTH PLAN Blue Cross Blue Shield of Massachusetts Harvard Pilgrim Health Plan Others: being negotiated C. SUPPORTERS U.S. Surgical Corp., BioVascular Co. GlaxoWellcome and The Thoracic Foundation granted the funds for the research component of OBEST. D. PARTICIPATING CLINICAL SITES Medical-Surgical Centers. Medical-Surgical Centers are designated to perform all screening and diagnostic procedures, pulmonary rehabilitation, LVRS, and follow-up studies. Medical-Surgical Center Telephone Number Beth Israel-Deaconess Medical Center, Boston Brigham and Women's Hospital, Boston 1 888 BWH LUNG Lahey-Hitchcock Clinic, Burlington Massachusetts General Hospital, Boston U. Mass-Memorial Hospitals, Worcester Satellite Consortium Centers. The Satellite Consortium Centers are designated to provide all screening and diagnostic procedures, pulmonary rehabilitation and follow-up studies but will not perform LVRS. It is anticipated that by participating in the activities of OBEST, the Consortium Center staff will gain sufficient expertise to perform LVRS independently and set up second generation OBEST Medical Surgical Centers, if and when the demand for LVRS increases. The following hospitals were selected as Satellite Consortium Centers: Satellite Consortium Center Telephone Number Bay State Medical Center, Springfield

62. Specimen 156.9 Lung Emphysema From a library of medical images, a lung with emphysema ( smoker's lung ). http://www.med.unsw.edu.au/pathology/Pathmus/F0839044.htm

Specimen 156.9 Lung : Emphysema ("Smoker's Lung") History of Illness Description of Specimen This specimen shows a smoker's lung with cystic spaces (emphysema) due to destruction of airsac walls. Use the left mouse button to click on areas of interest. Click on a "hotspot", and a brief description will appear in a frame to right of screen. Return to index of images Return to Museum of Human Disease Page

63. Emphysema - American Lung Association Site emphysema. October 2003. emphysema and chronic bronchitis together comprisechronic obstructive pulmonary disease (COPD). HOW SERIOUS IS emphysema? http://www.lungusa.org/site/pp.asp?c=dvLUK9O0E&b=35043

64. Breathing Problems? Then Get In Control! Use The Buteyko Breathing Method And Se The training video teaches a healthy, drugfree way to manage asthma symptoms, bronchitis, emphysema and other breathing problems. http://www.buteykovideo.com/home.htm

ASTHMA, BRONCHITIS, EMPHYSEMA AND ALLERGY SUFFERERS... This is the first highly acclaimed, professionally produced video to teach you the Buteyko Method based on clear facts and simple, easy to learn steps. Do these symptoms sound familiar? constant tightness or wheezing, especially after exercise coughing, sneezing. poor concentration, lethargy (no energy). allergic reactions. excessive production of mucus in your nose and chest. broken sleep and tiredness. tension, head aches, feeling panic or somtimes out of control. Frequent visits to your Doctor or Health Centre. Incorrect breathing can cause these and other problems! So use this breathing method as a major tool to regulate your breathing, reclaim control and begin to restore yourself to good health. THE BUTEYKO BREATHING METHOD Is the most effective, natural, self help method for the relief of breathing problems.

65. Alpha-1 Related Emphysema - American Lung Association Site Alpha1 Related emphysema. March 2003. WHAT IS ALPHA-1 RELATED emphysema?Alpha-1 related emphysema or Alpha-1 deficiency, is caused http://www.lungusa.org/site/lookup.asp?c=dvLUK9O0E&b=35014

66. What Is Emphysema? What is emphysema? What is Asthma? What s Asthma? Some good places to go for moreinformation on chronic bronchitis and emphysema include the following http://www.smokinglungs.com/whatemph.htm

What is emphysema? What is Asthma? This document was last revised on August 13, 2002 by F.W. Grannis Jr. MD. Emphysema is physical destruction of lung tissue that results in obstruction to air flow and development of enlarged air sacs. Emphysema is a smoking related disease that causes progressive obstruction of the airways and destruction of lung tissue. Because the airway is obstructed, more energy is required to ventilate the lungs. The patient will experience shortness of breath, and as the disease progresses, will become progressively limited in the ability to exercise. Chronic Bronchitis is a chronic disease of the airways that results in production of excess secretions and chronic infection. Both chronic bronchitis and emphysema reduce the ability of the patient to safely recover from surgical or radiation therapy. Patients with severe COPD are unable to cough effectively and clear secretions. The result can be steadily worsening difficulty in breathing during the post-operative period, culminating in respiratory failure and sometimes death. Damage to the lungs begins early on in smokers. Forced Expiratory Volume in one second (FEV1) is a commonly used measure of lung function. In adolescent smokers FEV1 is reduced by an average of 390 ml in boys and 360 ml in girls (i.e. approximately 10-15% reduction). Reduction in FEV1 occurs normally with aging, but is faster in smokers by 15ml./year. By middle age 18% of male smokers have FEV1 reduced more than 2 standard deviations. The deficits are larger if there are other causes of obstruction such as asthma "the horse racing effect". Kerstjens et. al.. Decline in FEV1 by age and smoking status: facts figures and fallacies. Thorax 1997;52:820-7.

67. University Of Iowa Family Practice Handbook A detailed description of emphysema and chronic bronchitis. http://indy.radiology.uiowa.edu/Providers/ClinRef/FPHandbook/Chapter03/04-3.html

68. What Is Chronic Obstructive Pulmonary Disease COPD emphysema is what occurs as more and more of the walls between air sacs get destroyed. Often,people with COPD have both chronic bronchitis and emphysema. http://quitsmoking.about.com/cs/nicotinepatch/a/COPD.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') About Smoking Cessation Respiratory Disease Home ... Photo Gallery zau(256,152,145,'gob','http://z.about.com/5/ad/go.htm?gs='+gs,''); Why Quit Smoking Prepare to Quit Quit Smoking Aids After You Quit ... Help zau(256,138,125,'el','http://z.about.com/0/ip/417/0.htm','');w(xb+xb); Stay Current Subscribe to the About Smoking Cessation newsletter. zau(256,152,100,'hs','http://z.about.com/5/ad/hs.htm?zIhsid=00',''); Search Smoking Cessation Email to a friend Print this page Stay Current Subscribe to the About Smoking Cessation newsletter. Suggested Reading Why You Don't Want Emphysema Christine's Quit Smoking Story Detecting COPD Most Popular 4 Steps to Understanding and Defeating the Urge to Smoke How Your Body Heals After Quitting Smoking Tobacco Withdrawal Symptoms and How To Cope After The Last Cigarette The First 2 Days ... The List of Additives in Cigarettes What's Hot Lung Cancer Causes, Symptoms, Diagnosis and Staging Cheryl is Diagnosed with Small Cell Lung Cancer Secondhand Smoke Poll Questions should smoking be banned Secondhand Smoke Facts Information Statistics ... Small Cell and Non-Small Cell Lung Cancer What is COPD? From Terry Martin Your Guide to Smoking Cessation Sign up for my Newsletter Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease (COPD) is a disease in which the airways and air sacs inside the lungs are partially obstructed or destroyed. The result is that it gets hard to breathe. There are varying degrees of this illness, and different names for them, but it all comes back to damaged airways and air sacs. This disease occurs when a person breathes in lung irritants of some kind: smoke, chemicals, pollution, dust. It makes sense then, that the most common cause of COPD is smoking.

69. Alpha1-Antitrypsin Deficiency Of Inherited Emphysema-Medfacts-National Jewish Me Alpha1Antitrypsin Deficiency of Inherited emphysema and Management MedFact fromNational Jewish Medical and Research Center 1 Respiratory Hospital in America. http://www.nationaljewish.org/medfacts/alpha1.html

Alpha1-Antitrypsin Deficiency of Inherited Emphysema Chronic obstructive pulmonary disease or COPD for short, is a lung disease that affects millions of people each year. COPD is a general term used to describe diseases such as emphysema and chronic bronchitis. In emphysema there is damage to the walls of the air sacs (alveoli) in the lungs. What is Inherited Emphysema? Most cases of emphysema are caused by smoking or other environmental factors. However, in a small number of cases of emphysema, there is a hereditary basis for the disease. The earliest symptom of emphysema is shortness of breath during activity. Later the shortness of breath occurs with rest also. The inherited form of emphysema is called alpha1 antitrypsin deficiency or "alpha - one" for short. People with this disease don't have enough of a major protein in the blood. This protein is alpha1 antitrypsin. Although there are many different genetic variations of this protein, only some will cause lung disease. It is more often seen in people of northern European descent, especially Scandinavians. What Does the Alpha1 Protein do in the Body?

70. Emphysema emphysema. emphysema Wheelchairs EZ Chair a wheelchair for emphysema patients AbnormalLung Anatomy emphysema What Happens With emphysema. http://www.ability.org.uk/Emphysema.html

Our Aims Services Stats ... Z Emphysema Emphysema Wheelchairs: EZ Chair a wheelchair for Emphysema patients Emphysema / Bronchitis Medical Information - A professionally moderated, consumer focused free virtual medical clinic offering detailed medical and drug information and support groups on Emphesyma, Bronchitis and other long term medical conditions. National Emphysema Foundation - An organization dedicated to improving the quality of life for people with emphysema, asthma and related diseases. Abnormal Lung Anatomy: Emphysema - What Happens With Emphysema Emphysema treatment, prevention, and much more. BP-Chronic Bronchitis and Emphysema Emphysema - Johns Hopkins University: Interactive Respiratory Physiology Efforts - A non-profit organization formed, funded and operated by patients with the disease, working to promote research for emphysema and COPD. Bronchitis, Emphysema Health Information Abnormal Lung Anatomy: Emphysema - When you have emphysema, some of the air sacs deep in your lungs have been damaged. Mediconsult.com : Bronchitis, Emphysema Health Information

71. Pulmonary Services to address medical and emotional needs caused by emphysema, asthma, chronic bronchitis and other lung diseases. http://www.stmh.org/patient_services/pulmonary.html

Pulmonary Rehabilitation For further information, call us at 203/709-6246.

72. BBC NEWS | Health | Medical Notes | Emphysema emphysema is a progressive lung condition which leaves sufferers struggling forbreath. In heriditary emphysema, the missing protein is given as a therapy. http://news.bbc.co.uk/1/hi/health/medical_notes/456591.stm

CATEGORIES TV RADIO COMMUNICATE ... INDEX SEARCH You are in: Health: Medical notes News Front Page World ... Programmes SERVICES Daily E-mail News Ticker Mobile/PDAs Text Only ... Help EDITIONS Change to World Friday, 24 September, 1999, 14:27 GMT 15:27 UK Emphysema Cigarette smoking causes 80% of emphysema Emphysema is a progressive lung condition which leaves sufferers struggling for breath. Miners who say their job left them with irreversible emphysema have been at court fighting for compensation from their former employers. Emphysema is caused by gradual damage to the structure of the lungs, which makes it harder to exhale. The tiny air sacs in the lungs called alveoli, through which oxygen is absorbed into the bloodstream, lose their natural elasticity, meaning spent air is pushed back out into the lungs. This leaves the lungs feeling continually over full, and it is a struggle for sufferers to force air in and out. This eventually means that the body is not getting enough oxygen, leading to fatigue and weight loss. Although it can start simply as mild breathlessness during exercise and a persistent cough, it can leave sufferers housebound and reliant on oxygen supplies, and eventually contribute to death.

73. Emphysema - Wikipedia, The Free Encyclopedia emphysema. From Wikipedia, the free encyclopedia. emphysema is achronic lung disease. It is often caused by exposure to toxic http://en.wikipedia.org/wiki/Emphysema

Emphysema From Wikipedia, the free encyclopedia. Emphysema is a chronic lung disease. It is often caused by exposure to toxic chemicals or long-term exposure to tobacco smoke Table of contents 1 Signs and symptoms 2 Diagnosis 3 Pathophysiology 4 Pathogenesis ... edit Signs and symptoms Emphysema is characterised by loss of elasticity of the lung tissue. The result is that the small airways collapse early during exspiration, leading to an obstructive form of lung disease. Features are: shortness of breath on exertion (and later in rest), cyanosis and an expanded chest. Often clubbing of the fingers is observed, a feature of longstanding hypoxia Emphysema patients are occasionally referred to as "blue bloaters", a slightly derogatory term that combines their cyanosis with another feature, namely the tensing of the upper airways to create a positive end-expiratory pressure (PEEP) and keep the small airways open. edit Diagnosis Diagnosis is by spirometry lung function testing ), including diffusion testing . Other investigations might include X-rays bronchoscopy (when other lung disease is suspected, including

74. InteliHealth: Emphysema listed and crossreferenced in an AZ format. emphysema. Health A toZ, Reviewed by the Faculty of Harvard Medical School emphysema http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/9885.html

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75. This Week's Program Statistics don't tell the whole story of tobacco disease and death. That's why PBS is running a program on Pam Laffin, a woman who tells her own story of emphysema caused by tobacco products. The story of how she got started smoking, how she discovered she had the disease, and how she lives her live now with one lung, is more compelling sometimes than any amount of statistics. http://www.pbs.org/healthweek/featurep3a_320.htm

Resources: American Cancer Society Web site If you want to contact Pam you can do so at Pamlaf fin@aol.com Massachusetts Dept. of Public Health Smoking's Deadly Effects Books are a good way to learn. But they often fall short when it comes to teaching children the dangers of smoking. And that's why a 29-year-old woman named Pam Laffin is heading out to Massachusetts schools and appearing in TV ads, to share her moving story of smoking's deadly effects. PAM LAFFIN: "I've lost so many things to this disease. I can't play with my kids. I can't go bike riding. I can't enjoy a walk on the beach. I thought I was the only person in the world that was young with emphysema, and when I found out that that wasn't the case, I thought maybe I should warn people." "I started smoking when I was ten. Did you ever see the movie Grease? I made my mother take me to get a perm to I could have curly hair like Sandy. It seemed like to me that most of the people in her new school didn't accept her, and she started smoking, and then she was friends with everybody. So I thought maybe if I smoked I could be like her." "I ran track, I was active and healthy. I figured that nothing bad was going to happen to me. When I was 21, I started getting bronchitis a lot. Over the next couple of years, my breathing got worse and worse. Until I couldn't like walk across the street to get the bus, if I walked up the stairs to get into my apartment, it took me 20 minutes to catch my breath."

76. Chronic Bronchitis And Emphysema - Symptoms And Treatment The common symptoms, causes and complications of chronic bronchitis and emphysemalung conditions BUPA health information factsheet. emphysema. http://hcd2.bupa.co.uk/fact_sheets/html/Chronic_bronchitis.html

search home services health information ... BUPA Products and services Health insurance Financial protection Hospitals Care homes ... International cover Visitor interest areas Individuals Business Intermediaries Health professionals ... BUPA members Facilities finder Find local health and fitness facilities World of BUPA BUPA services around the world at bupa.com health information ABC of health Chronic bronchitis and emphysema Published by BUPA's Health Information Team December, 2002 Download this factsheet Chronic bronchitis and emphysema stop the lungs from working properly, typically causing breathlessness and wheezing. The two conditions lead to similar symptoms and are often referred to as "chronic obstructive pulmonary disease", or COPD for short. What causes COPD? The biggest single cause of COPD is smoking, and the risk increases with the number of cigarettes smoked. Due to industrial smoke and pollutants, it is also more common in people living in cities than in the country, and in people who work in dusty environments. Generally, it is more likely to affect older people and the vast majority of sufferers are aged 70 to 85. Each year, around 28,000 people die from COPD.

77. CNN.com - Health: Condition Clinic CNN http://www.cnn.com/HEALTH/condition.clinic/emphysema.html

MAIN PAGE WORLD U.S. WEATHER ... ABOUT US/HELP CNN TV what's on show transcripts CNN Headline News CNN International ... askCNN EDITIONS CNN.com Asia CNN.com Europe CNNenEspanol.com CNNArabic.com ... set your edition Languages Spanish Portuguese German Italian Korean Arabic Japanese Time, Inc. Time.com People Fortune EW InStyle Business 2.0 Emphysema Choose Another ADHD Alzheimer's Angina Anxiety Disorders Arthritis Asthma Back Pain Br. Cancer Bronchitis Chronic Fatigue Colon Cancer Cold Depression Diabetes Emphysema Flu Hay Fever Heart Disease Hodgkin's Disease Hypertension Impotence Irritable Bowel Kid. Cancer Leukemia Liver Cancer Lung Cancer Lupus Lymphoma Measles Melanoma Menopause Multiple Sclerosis Osteoporosis Ovarian Cancer PMS Pregnancy Prostate Cancer Rect. Cancer SAD Schizophren STDs Sickle Cell Sinusitis Stroke Stress TMJ Toxic Shock Testicular Cancer Ulcers Uter. Cancer WEB LINKS: Visit other Web sites related to emphysema. Select another topic: Choose One ADHD AIDS Alzheimers Angina Asthma Back Pain Breast Cancer Bronchitis CFS Colon Cancer Common Cold Depression Diabetes Digestion Emphysema Flu Hay Fever Heart Disease Hodgkins Hypertension IBS Kidney Cancer Leukemia Liver Cancer Lung Cancer Lupus Lymphoma Measles Melanoma Menopause MS Osteoporosis Ovar. Cancer

78. Emphysemastudy.org emphysemastudy.org, Home. Tue, 25 May 2004 GMT. Top Searches. • Travel• Health • Cars • Mortgage • Computers • Gifts • Flowers http://www.emphysemastudy.org/

79. Emphysema emphysema. Bullous emphysema. emphysema is an enlargement of air spaces caused bydestruction of alveolar walls. Centriacinar emphysema/distal acinar emphysema. http://pathhsw5m54.ucsf.edu/overview/emphysema.html

Emphysema Bullous emphysema Emphysema is an enlargement of air spaces caused by destruction of alveolar walls. Air spaces greater than one cm are bullae. This photo shows apical bullous disease with relatively little involvement of the rest of the lung. Centriacinar emphysema/distal acinar emphysema This lung shows centriacinar emphysema with holes located around the terminal bronchioles and preservation of more distal air spaces. The parenchyma along the major fissure shows some distal acinar emphysema. Panacinar emphysema involves the entire acinus. Centriacinar emphysema This section of centriacinar emphysema shows the enlarged air spaces around a small airway. Respiratory epithelium remains at the arrow. The more peripheral alveoli are normal. Pathogenesis of emphysemaproposed This photo is taken from a patient with alpha-1-antitrypsin deficiency-related emphysema. It shows an increased number of PMNs in capillaries (arrows and many more) and some alveolar and interstitial blood. These PMNs, if activated, can potentially digest the collagen and elastin of the alveolar wall. Note the megakaryocyte in a capillary (arrowhead at top). Its function is not known, but any contribution of platelets would help to preserve the integrity of the capillary bed. Contents

80. PersonalMD.com - Your Lifeline Online Over 700 health topics for COPD and emphysema patients. http://www.personalmd.com/pulmonarycenter.shtml

Home Noticias de Salud Family Centers Health Centers ... My Health Manager Search PersonalMD Services Family Health Women's Health Children's Health ... Health Encyclopedia Pulmonary Center In the Spotlight Health Topics for you Over 700+ Topics Asthma COPD Emphysema Lung Cancer Pneumonia Quit Smoking Tuberculosis Is Your School Asthma-Friendly? Asthma Statistics Smog-Related Health Problems The term smog is generally used to mean chemical air pollution. The word is a combination of the words "smoke" and "fog." Smog primarily comes from the combustion of fossil fuels. A common example is car exhaust, which comes from the combustion of gasoline More Features So, What's Sarcoidosis? Sarcoidosis is a multi-organ system disease with no known cause. It commonly affects the lungs, skin, eye and lymph nodes where the abnormal tissue development is seen in multiple areas... More Patches, Pills And Gum: The Uphill Battle Against Cigarette Smoking (Part 2)

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