101. Richard Collyers End To End Page A sponsored cycle ride, by three Norfolk police officers from Lands End to John o'Groats, in June 2000 to raise money for the cystic fibrosis Trust. http://www.collyer.clara.net/

102. Medical References: Cystic Fibrosis cystic fibrosis is an inherited disease that most commonly affects breathing and digestion. There is them. What Is cystic fibrosis? CF http://www.marchofdimes.com/professionals/681_1213.asp

View All Chapters Find Your Local Chapter June 8, 2004 Select one Folic Acid Pregnancy Prenatal Screening Infections/Diseases Loss Concerns Newborn Information Birth Defects Polio Genetics Research Funding Perinatal Statistics Medical References Continuing Education ... Prematurity Quick Reference and Fact Sheets Cystic Fibrosis Cystic fibrosis (CF) is an inherited disease that most commonly affects breathing and digestion. Advances in medical treatment continue to improve the outlook for affected children and adults. However, there is no cure. Most affected individuals survive to about age 30, though some die in childhood and others live to age 40 or beyond. The abnormal gene that causes CF was discovered in 1989. This discovery led to the development of tests that can help determine whether or not couples carry an abnormal gene that can cause CF in their children. Testing usually is offered to couples with a family history of this disease, though now health care providers also are offering this test to couples without a family history of CF who are planning pregnancy or who are already pregnant. Couples will be better able to decide whether they want to have the carrier test if they understand the medical problems that CF can cause and what the tests can and cannot tell them. What Is Cystic Fibrosis?

103. National Human Genome Research Institute - Learning About Cystic Fibrosis Answers to frequently asked questions about cystic fibrosis, published by the National Human Genome Research Institute. Learning About cystic fibrosis. http://www.genome.gov/10001213

Talking Glossary of Genetic Terms Frequently Asked Questions about Genetics Clinical Research Online Health Resources ... Specific Genetic Disorders Learning About Cystic Fibrosis Learning About Cystic Fibrosis What do we know about heredity and cystic fibrosis? Is there a test for the cystic fibrosis gene? NHGRI Clinical Research on Cystic Fibrosis Additional Resources for Cystic Fibrosis Information What do we know about heredity and cystic fibrosis? Cystic fibrosis (CF) is the most common, fatal genetic disease in the United States. About 30,000 people in the United States have the disease. CF causes the body to produce thick, sticky mucus that clogs the lungs, leads to infection, and blocks the pancreas, which stops digestive enzymes from reaching the intestine where they are required in order to digest food. Cystic Fibrosis: A Single Gene Disease Mutations in a single gene - the Cystic Fibrosis Transmembrane Regulator (CFTR) gene - causes CF. The gene was discovered in 1989. Since then, more than 900 mutations of this single gene have been identified. In normal cells, the CFTR protein acts as a channel that allows cells to release chloride and other ions. But in people with CF, this protein is defective and the cells do not release the chloride. The result is an improper salt balance in the cells and thick, sticky mucus. Researchers are focusing on ways to cure CF by correcting the defective gene, or correcting the defective protein.

104. Cystic Fibrosis Foundation ... Adding Tomorrows Every Day Works to assure the development of the means to cure and control cystic fibrosis and to improve the quality of life for those with the disease. Site includes local events, volunteer opportunities, contact information, and links to the national foundation. http://www.cff.org/alabama.htm

About the Cystic Fibrosis Foundation News Publications ... Special Event Prizes Alabama Chapter News and Information Volunteer Leadership Initiative 2003 View this Chapter's News and Information Upcoming Volunteer Opportunities Volunteer With so many events each year, the Alabama Chapter relies heavily on the time and talent of our dedicated volunteers in fund-raising efforts. Th... (more) Calendar Of Events view all past events This chapter has no upcoming events. Sponsors We need your help! The Cystic Fibrosis Foundation is always looking for sponsors! It is through the generosity of our sponsors and volunteers that we are able to wage our battle against cystic fibrosis. For each day we work, and for every dollor we raise, we are adding tomorrows every day for people with cystic fibrosis. Contact Information Alabama Chapter 3918 Montclair Road Suite 201 Mountain Brook, AL 35213 fax: (205) 879-9448 http://www.cff.org/alabama.htm alabama@cff.org

105. Cystic Fibrosis International Medical A-Z Directory Biomedical directory with listings of hospitals, charities, research, and information by topic and location. http://www.cellscience.com/CFmain.html

Cystic Fibrosis rating for web sites is intended to serve only as an indication of the design quality, clarity, presentation and style of the URL, and is in no way intended as a judgement of the quality of services or information provided. To have a site listed is itself an indication that the site is of general interest - (Guide: NR Not rated, strong, good, excellent) Date page was last modified

106. Proteome Systems - Proteomics Technology And Discovery - Home Specializes in the development of new technology for proteomics and its application to discovery programs in the areas of cystic fibrosis, cancer, infectious disease and aging. US and Japanese offices with headquarters in Sydney, Australia. http://www.proteomesystems.com/

Home Contact Us var hcenter=(((window.screen.availWidth-640)/2)-23); var vcenter=(window.screen.availHeight-490)/2; Log On Online Catalogue Search: Advanced Search var baseHREF = "http://www.proteomesystems.com/inc/106/Menu/"; CORPORATE  TECHNOLOGY DISCOVERY DIAGNOSTICS ... INVESTORS Special Feature Proteome Systems and HighQ collaborate to identify and characterise biomarkers for monitoring disease progression and treatment of Huntington’s disease. 19 April 2004 - Proteome Systems and the High Q Foundation today announced an agreement to collaborate on a proteomic program for Huntington’s Disease (HD), comprising biomarker identification and molecular characterization of the Huntingtin protein. Proteome Systems will characterize changes in protein expression and modification that result from malfunction of the Huntingtin protein in order to identify biomarkers of HD. more > Multifunctional electrophoresis systems The IsoelectrIQ ™ and ElectrophoretIQ ™ revolutionise the purification of proteins for proteomics. Each unit is highly integrated, with unique 2-in-1 and 3-in-1 functionality, bringing you an advanced and comprehensive solution for two-dimensional gel electrophoresis... more » Discovery Programs Proteome Systems currently has Discovery projects in the areas of Respiratory disease, Cancer, Infectious disease and Ageing and age-associated disease...

107. Cystic Fibrosis cystic fibrosis. cystic fibrosis (CF) is one of the most common autosomal recessive diseases in the Caucasian population, occurring http://www.phd.msu.edu/DNA/cf_fact.html

B240 Life Science Building, East Lansing, MI 48824-1317, Fax: 517-353-8464 Email: dnadiag@msu.edu TESTS OFFERED TEST INFORMATION FOR: Cystic Fibrosis Hereditary Hemochromatosis Apolipoprotein E Genotyping Fragile X Syndrome Methylenetetrahydrofolate reductase Cystic Fibrosis Cystic fibrosis (CF) is one of the most common autosomal recessive diseases in the Caucasian population, occurring in 1 out of every 2,500 - 3,300 newborns. CF can occur in other ethnic groups, but is most common in Caucasians. CF results from mutations in the CFTR gene, which is important for maintaining chloride balance in the cell. Carrier Risks Vary by Ethnic Group: Ethnic Group Carrier Rate Caucasian (non-Hispanic/non-Ashkenazi Jewish) 1 in 25 Ashkenazi Jewish 1 in 25 Hispanic 1 in 46 African American 1 in 65 Asian 1 in 90 Reasons for CF Testing: Confirmation of diagnosis in affected individuals Carrier identification in persons with a family history Carrier identification in persons currently pregnant or considering pregnancy Screening of sperm and egg donors Abnormal fetal ultrasound (i.e. echogenic bowel)

108. Department Of Paediatrics Cystic Fibrosis cystic fibrosis. Table of Contents. Introduction. cystic fibrosis occurs in about 1 in 2,500 births in Victoria. All patients are seen http://www.med.monash.edu.au/paediatrics/resources/cf.html

Monash M N H S M N H S Home Paediatrics ... Resources DEPARTMENT OF PAEDIATRICS Home About Us Programs Resources ... 5th Year Course Material Cystic Fibrosis Table of Contents Introduction Inpatient Management Children with Possible CF Treatment of Exacerbations of Chest Infection On Discharge Meconium Ileus Equivalent Introduction Cystic fibrosis occurs in about 1 in 2,500 births in Victoria. All patients are seen at the Royal Children's Hospital at the time of diagnosis, which is usually in the first year of life. Some patients living in the south-east of the city or eastern Victoria are cared for jointly by the department of Thoracic Medicine at the RCH and the Department of Paediatric Respiratory Medicine, MMC. The prognosis has improved very considerably over the last 20 years and most patients now reach adulthood. In the ward the resident medical staff will see patients who have acute flare-ups of chest infection and those with severe lung disease. The 50% of patients who have little chest trouble are rarely admitted to the ward, so staff are likely to have a biased view of the condition. The development of a very positive attitude by the parents from the time of diagnosis seems to be very important in the prognosis. The handling of the family at the time of diagnosis is carefully planned. If they are given a gloomy outlook, this can be hard to change.

109. Advances In Cystic Fibrosis Advances in cystic fibrosis. cystic fibrosis is caused by many different mutations of the CF gene; to date, more than 600 unique mutations have been described. http://www.childsdoc.org/fall97/cf/cf.asp

Home Features Index Features Departments Information ... Steven Boas, MD Attending Physician Division of Pulmonary and Critical Care Medicine Medical Director, Pumonary Function Testing/Exercise Laboratory Children's Memorial Hospital Assistant Professor of Pediatrics Northwestern University Medical School Susanna McColley, MD Attending Physician Division of Pulmonary and Critical Care Medicine Children's Memorial Hospital Assistant Professor of Pediatrics Northwestern University Medical School The Cystic Fibrosis Foundation's home page is a great jumping off point for many topics related to CF. For readers interested in more information on the CF's genetic mutations, see the Cystic Fibrosis Mutation Data Base , which is a site belonging to the Department of Genetics, The Hospital for Sick Children in Toronto, Ontario, Canada. Contact us Advances in Cystic Fibrosis STEVEN R. BOAS, MD SUSANNA A. MCCOLLEY, MD THE DISCOVERY OF the gene responsible for cystic fibrosis (CF) in 1989 has led to an explosion of scientific information related to the disease and has transformed our understanding of it. For the first time, investigators are focusing on the development of treatments based on the underlying cellular defect. In this article, we review advances in genetics and molecular biology, as well as in clinical care, during the past decade. We also discuss the significance of the inflammatory response in CF lung disease and new and experimental CF therapies. The molecular basis of CF In 1989, investigators discovered the CF gene using novel approaches. The gene product, called the cystic fibrosis transmembrane conductance regulator (CFTR), is a membrane-based protein with an active transport function. This is consistent with previous findings that the primary defect in CF cells is faulty transport of ions, especially of chloride. Conclusive information regarding the role of CFTR in the basic CF defect came with the demonstration that defective cAMP-dependent chloride conductance in CF cells was restored when CFTR cDNA was transfected and expressed in those cells.

110. The Ortho-McNeil CF Care Website Provides people with cystic fibrosis, family members, and the CF community with quick and easy access to education and information. http://www.cfcare.com

111. Cystic Fibrosis Message Board Topics. cystic fibrosis Message Board. BOARDS; FRIEND WITH cystic fibrosis Alexis 210604 12/22/00 (0) DOES ANYONE HAVE ANY NEW .. http://www.healthboards.com/cystic-fibrosis/

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112. University Of Colorado Health Sciences Center - Duncan Lab Current projects, protocols and facilities combining mass spectrometry, 2D gels and databases, for mapping disease states such as cystic fibrosis, cancer and allergy. Includes terms of use, user login, and meetings in Denver. http://proteomics.uchsc.edu/

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113. New Scientist Curry spice could alleviate cystic fibrosis. 1900 22 April 04. A spice used in curry could help alleviate cystic fibrosis, new research suggests. http://www.newscientist.com/news/news.jsp?id=ns99994912

114. Cyber Campus A computer course aiming to empower and educate people with cystic fibrosis. From the cystic fibrosis Association of Ireland (CFAI). http://www.internet-ireland.ie/horizon/

115. THE MERCK MANUAL, Sec. 19, Ch. 267, Cystic Fibrosis Chapter 267. cystic fibrosis. Topics. General. It encodes a membraneassociated protein called the cystic fibrosis transmembrane regulator (CFTR). http://www.merck.com/mrkshared/mmanual/section19/chapter267/267a.jsp

116. We'll Find A Cure // This Time Around Supports fans with cystic fibrosis. Lyrics, fun, links and campaigns. http://www.fallenstars.com/hmh/

Java Applet list of Hanson fans with cystic fibrosis Please take a moment to let it load. No applet? Click here Best viewed with Microsoft Internet Explorer. To my cousin Rae-Anne, my best friend Felicity and everyone touched by CF, this page is for you. FastCounter by LinkExchange HTP Magazine. House Of Hope Central i'll admit it ... i love hanson.

117. Cysitic Fibrosis - Pulmonology Information on cystic fibrosis. http://www.pulmonologychannel.com/cf/

Home Search SiteMap Ask the Dr. ... Medical Store advertisement CYSTIC FIBROSIS Overview Symptoms Diagnosis Treatment-General ... Additional Info. CONDITIONS Anemia ARDS Asthma Bronchitis ... Solitary Pulmonary Nodule Tuberculosis RESOURCES Anatomy Clinical Trials Links MDLocator ... What Is a Pulmonologist? ABOUT US Healthcommunities.com Pressroom Testimonials Cystic fibrosis (CF) is the most common fatal, inherited disease in the United States (see Statistics ). CF causes the body to produce abnormally thick and sticky mucus in several different parts of the body, most prominently in the lungs and other parts of the respiratory system. It also affects the pancreas, leading to serious digestive problems. CF alters the mucus secretions of the body’s epithelial cells. Epithelial cells make up the outside layer of tissue that lines every open surface of the body, inside and out, including the various tunnels and cavities in the lungs, urinary tract, liver, and reproductive tract. In patients with CF, the mucus that the epithelial cells secrete is much thicker and stickier than normal. It clogs the airways of the lungs, blocking the flow of air and making the tissue vulnerable to continual lung infections. It blocks the flow of pancreatic juices in the pancreas, impeding digestion and the absorption of fats and fat-soluble vitamins, leading to nutrition deficiencies and intestinal complications. CF is a genetic disease resulting from the inheritance of a defective autosomal recessive gene (see Genetics of Cystic Fibrosis ). A recessive gene is one that is expressed only when both copies of the gene are present, so a person with CF must have inherited the gene that causes CF from both parents. A person who has only one copy of the gene is known as a "CF carrier."

118. THE MERCK MANUALSECOND HOME EDITION, Ch. 53, Cystic Fibrosis Section 4. Lung and Airway Disorders. Chapter 53. cystic fibrosis. Topic cystic fibrosis. cystic fibrosis. cystic fibrosis http://www.merck.com/mrkshared/mmanual_home2/sec04/ch053/ch053a.jsp

119. CF Advantage The mutation that causes deadly cystic fibrosis has survived for 52,000 years perhaps because it offers protection against diarrhea. By Josie Clausiusz http://wsrv.clas.virginia.edu/~rjh9u/cysfib.html

Hidden Benefits Josie Clausiusz The mutation that causes deadly cystic fibrosis has survived for 52,000 years - perhaps because it offers protection against diarrhea. When humans left the Near East and invaded Europe around 40,000 years ago, they took with them bone and stone tools for hunting and engraving, early art in the form of beads and pendants, and social skills that were probably superior to those of Europe's resident Neanderthals. It now seems they also took with them a mutant gene: the gene for the deadly disease cystic fibrosis. So robust is this gene that it spread all over Europe; cystic fibrosis is now the most common fatal genetic disorder among Caucasians. How could the disease have been passed from generation to generation for so long, when until the advent of modern medicine it generally killed people before they could have children? Recent experiments on mice offer an answer. They suggest that the 5 percent of all Caucasians who carry just one copy of the cystic fibrosis gene - and thus don't suffer from the disease - are protected against another deadly scourge: diarrhea. The gene for cystic fibrosis was discovered in 1989. It codes for a protein that forms channels in cell membranes, especially the cells lining the intestines and airways. Normally these channels funnel chloride ions out of a cell, thus making its surroundings saltier; that in turn draws water out of the cell by osmosis. In the lungs this fluid washes away bacteria and other unwanted debris. In the intestines it does the same and also brings digestive enzymes into contact with food. In sweat glands chloride channels have an additional function; they recycle salt out of the glands and back into the skin before it can be lost to the outside world.

120. Cystic Fibrosis - Lungs: Pulmonary And Respiratory Health And Medical Informatio cystic fibrosis. cystic fibrosis At A Glance. cystic fibrosis (CF) is one of the most common serious genetic (inherited) diseases. http://www.medicinenet.com/Cystic_Fibrosis/article.htm

document.write(''); MedicineNet Home Lungs Home > Cystic Fibrosis Advanced Search Printer-Friendly Format Add to Favorites Email to a Friend ... Next page Cystic Fibrosis Alternative names for the disease: Cystic fibrosis (CF) Cystic fibrosis of the pancreas Mucoviscidosis Cystic fibrosis transmembrane conductance regulator (CFTR) Respiratory problems: Chronic infections of the lungs Emphysema Progressive respiratory insufficiency Gastrointestinal problems (including pancreas and liver): Pancreatic insufficiency (with no secretion of trypsin and other digestive enzymes into the intestine) Intestinal obstruction at birth (due to this lack of digestive enzymes) Continuing deficiency of pancreatic enzymes Biliary tract obstruction (blockage of the bile system) Constriction of the common bile duct Cirrhosis of the liver (of the type called biliary cirrhosis) Recurrent episodes of pain in the right lower part of the abdomen (mimicking appendicitis) Adenocarcinoma of the ileum, a part of the small intestine (a rare problem) Heart problem: Cor pulmonale (progressive overwork and failure of the right side of the heart from the task of pumping blood through the diseased lungs) Reproductive problem: Infertility of males Laboratory findings: Positive sweat test for CF (due to salty sweat) Lack of trypsin in the stool (and high level of trypsin in blood serum) DNA testing for CF (demonstrates the presence of the common delta-F508 codon deletion or one of the other variant CF mutations)

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