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         Creutzfeldt-jacob Disease:     more detail
  1. Chronic neurological diseases: Subacute Sclerosing Panencephalitis, progressive multifocal Leukoencephalopathy, Kuru, Creutzfeldt-Jakob Disease by Jacob A Brody, 1976

41. Health Information
Back to Search. creutzfeldtjacob disease (Disease). creutzfeldt-jacob diseaseis a disorder involving rapid decrease of mental function and movement.
http://www.allenhospital.org/body.cfm?id=57&action=detail&AEProductID=AdamEncy&A

42. Bioweb Biolex - Ord Der Starter Med Cr..
Eng. Creatine. CreutzfeldtJacob-Disease creutzfeldt-jacob disease (CJD) er en hjernesygdomder rammer mennesker. Eng. Creutzfeldt-Jacob-Disease. Foreslå et ord.
http://www.bioweb.dk/biolex.php?viewCat=126

43. Disease - Creutzfeldt-Jacob Disease - Detroit, Michigan
Disease creutzfeldt-jacob disease. Definition creutzfeldt-jacob diseaseis a disorder involving rapid decrease of mental function and movement.
http://www.henryfordhealth.org/15382.cfm
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Disease - Creutzfeldt-Jacob disease
Creuztfeldt-Jakob disease
Central nervous system
Definition: Creutzfeldt-Jacob disease is a disorder involving rapid decrease of mental function and movement. These are abnormalities believed to be caused by damage done to the brain by a protein called a prion. This protein folds abnormally, and seems to encourage other proteins to become similarly misshapen, affecting their ability to function. Alternative Names: Transmissible Spongiform Encephalopathy; New variant CJD - "the human form of mad cow disease" Causes And Risk: Creutzfeldt-Jakob disease can occur sporadically (for no known reason), as a result of exposure to contaminated products. Rarely, it can be genetically inherited. The disorder itself is rare, occurring in about 1 out of 1 million people. It usually first appears in midlife, beginning between ages 20 and 70, with average age at onset of symptoms in the late 50s. However, some cases have occurred in adolescents who have received

44. Creutzfeldt-Jacob Disease
creutzfeldtjacob disease. Definition creutzfeldt-jacob disease is adisorder involving rapid decrease of mental function and movement.
http://www.shands.org/health/information/article/000788.htm
Disease Injury Nutrition Poison ... Central nervous system
Creutzfeldt-Jacob disease
Definition: Creutzfeldt-Jacob disease is a disorder involving rapid decrease of mental function and movement. These are abnormalities believed to be caused by damage done to the brain by a protein called a prion. This protein folds abnormally, and seems to encourage other proteins to become similarly misshapen, affecting their ability to function.
Alternative Names: Transmissible Spongiform Encephalopathy; New variant CJD - "the human form of mad cow disease"
Causes, incidence, and risk factors: Creutzfeldt-Jakob disease is a disease which can occur sporadically (for no known reason), as a result of exposure to contaminated products. Rarely, it can be genetically inherited. The disorder itself is rare, occurring in about 1 out of 1,000,000 people. It usually first appears in midlife, beginning between ages 20 and 70, with average age at onset of symptoms being in the late 50's. However, some cases have occurred in adolescents who have received growth hormone derived from the pituitary glands of cadavers. Prions cannot be destroyed by ordinary disinfection techniques used to prevent transmission of viruses and bacteria. As a result, the hormone remains contaminated, and this exposure is believed to be responsible for the early onset of the disease in these people.

45. Millipore - Applications Bibliography - Investigation Of Variant Creutzfeldt-Jac
Title Investigation of variant creutzfeldtjacob disease and other humanprion diseases with tonsil biopsy samples. Author AF Hill et al.
http://www.millipore.com/bibliography.nsf/docs/Imm137
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Millipore Applications Bibliography
Title: Investigation of variant Creutzfeldt-Jacob disease and other human prion diseases with tonsil biopsy samples Author:
A.F. Hill et al. Citation: Lancet, 353, 9148, 183(1), Jan. 16, 1999 Additional
Information: Immobilon P

Application: Immunoassay
Please note: This information is provided to you for technical reference. A reprint of the document cited is available from the publisher or from your local library and is not available from Millipore. For further assistance, please contact Technical Service.
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46. Mad Cow Disease Article At Pet By Pet
about 100 cases of feline spongiform encephalopathy in Great Britain) and alsointo humans, where the disease is called variant creutzfeldtjacob disease.
http://www.petbypet.com/information central_mad cow disease.htm
Information Central Mad Cow Disease Mad Cow Disease BSE, which stands for bovine spongiform encephalopathy and has been nicknamed "mad cow disease," has made a lot of headlines since its recent discovery in North America. While the disease is fatal in cattle and there are forms of spongiform encephalopathies in other species, including humans, cats, and deer, BSE poses an extremely low health risk in the United States because of the way it is transmitted.
"This disease was first described in England in 1986. The epidemic peaked in 1993 with 1,000 new cases every week, but is currently expected to be eradicated from Great Britain within 5 years. Most European countries as well as Japan, Israel, and Oman have diagnosed positive cases," explains Dr. Peter Constable, a large animal veterinarian at the University of Illinois Veterinary Teaching Hospital in Urbana.
The current theory is that BSE is caused by a modified infectious protein, called a "prion." BSE prions are found mainly in the brain, spinal cord, and ileum (a segment of the intestines). It is thought that the BSE outbreak in England occurred because brains from infected cows were fed to uninfected cattle as a source of protein.
"Since BSE affects the brain, many of the clinical signs in cattle are neurological. Infected cows have trouble standing and walking. They tend to lose weight, exhibit alterations in their behavior, and may appear frenzied in the late stages of the disease, leading to the nickname 'mad cow disease,' "says Dr. Constable.

47. ECR 2000 - Presentation 11-023
11023. Z. Ursprung 1 , G. Nagy 1 , F. Garzuly 2 , K. Majtényi 3 ; 1 Zalaegerszeg/HU,2 Szombathely/HU, 3 Budapest/HU. creutzfeldt-jacob disease.
http://www.ecr.org/T/ECR00/sciprg/abs/p110023.htm
Z. Ursprung , G. Nagy , F. Garzuly Zalaegerszeg/HU, Szombathely/HU, Budapest/HU Creutzfeldt-Jacob disease
Purpose:
Creutzfeldt-Jacob diesase (CJD) is a rare dementing illness, characterized by a rapidly progressive dementia, ataxia and myoclonus. The diagnosis is often suspected on the basis of EEG and clinical findings. MR examinations can be helpful with hyperintens signal abnormalities in the basal ganglia being found on T2-WI images of patients with Creutzfeldt-Jakob diease.
Materials and methods: We retrospectiwely reviewed the MR imaging findings of three patients (59-69) who had pathologically proved Creutzfeldt-Jacob disease and whose MR examination showed hyperintense signal in the basal ganglia on T2 weighted images. All imaging protocols included axial proton density and T2 weighted spin-echo (SE) sequences with a slice thickness of 6 mm.
Results: The three patiens had MR examinations 6 month and 1 year after the onset of symptoms. In all three cases the hyperintense signal abnormalities in the basal ganglia on T2 weighted images were diffuse and bilaterally symmetric. The T1-weighted images were normal.
Conclusion: Creutzfeldt-Jakob disease is uniformly fatal, with a mean suvival time of 6 months to 1 year after diagnosis. The characteristic neuropathologic feature of CJD is spongiform encephalopathy, prominent depletion of neurons and astrocytes and marked gliosis are often seen. Bilateral hyperintense abnormalities on T2-weighted images of the basal ganglia can be seen in several disorders. We believe that bilaterally symmetric, diffuse hyperintens abnormalities in the basal ganglia on T2-weighted images of adults with a rapidly progressive dementia may be a specific sign of Creutzfeldt-Jacob disease.

48. Disease - Creutzfeldt-Jacob Disease, North Carolina
Disease creutzfeldt-jacob disease. Definition creutzfeldt-jacob diseaseis a disorder involving rapid decrease of mental function and movement.
http://www.uhseast.com/17761.cfm

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Disease - Creutzfeldt-Jacob disease
Creuztfeldt-Jakob disease
Central nervous system
Definition: Creutzfeldt-Jacob disease is a disorder involving rapid decrease of mental function and movement. These are abnormalities believed to be caused by damage done to the brain by a protein called a prion. This protein folds abnormally, and seems to encourage other proteins to become similarly misshapen, affecting their ability to function. Alternative Names: Transmissible Spongiform Encephalopathy; New variant CJD - "the human form of mad cow disease" Causes And Risk: Creutzfeldt-Jakob disease can occur sporadically (for no known reason), as a result of exposure to contaminated products. Rarely, it can be genetically inherited. The disorder itself is rare, occurring in about 1 out of 1 million people. It usually first appears in midlife, beginning between ages 20 and 70, with average age at onset of symptoms in the late 50s. However, some cases have occurred in adolescents who have received

49. Study Of Growth Hormone Treatment And Creutzfeldt-Jacob Disease Underscores Need
April 7, 2004 Study of Growth Hormone Treatment and CreutzfeldtJacobDisease Underscores Need for Prevention of Adrenal Crises.
http://www.nichd.nih.gov/new/releases/growth_hormone.cfm
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National Institute of Child Health and Human Development
April 7, 2004
Study of Growth Hormone Treatment and Creutzfeldt-Jacob Disease Underscores Need for Prevention of Adrenal Crises The largest study of its kind, designed to track the development of Creutzfeldt-Jakob disease in people who received human growth hormone from cadavers, has found that the vast majority of those who received the hormone did not contract the fatal condition. However, some recipients (26 out of approximately 7,700) did develop the disease. A larger number (59) died from adrenal crisis, a sometimes-fatal complication that can be prevented if it is recognized and treated promptly. Adrenal crisis does not affect all patients who require growth hormone, but may occur in a subgroup of patients whose pituitary gland fails to make not only growth hormone but also the hormone needed to regulate the adrenal glands. Human growth hormone is now manufactured synthetically, and the synthetic form does not transmit Creutzfeldt-Jakob Disease (CJD). The study tracks individuals who received cadaver-derived human growth hormone, to determine their risk of developing CJD and to observe their health status. The federal study's findings appear in the April Journal of Pediatrics. It was conducted by scientists at several agencies in the U.S. Department of Health and Human Services (HHS). At the National Institutes of Health, researchers from the National Institute of Child Health and Human Development, the National Institute of Neurological Disorders and Stroke, and the National Institute of Diabetes and Digestive and Kidney Diseases, took part in the study. Researchers from two other HHS agencies, the U.S. Food and Drug Administration and the Centers for Disease Control and Prevention, also participated, as did the research corporation Westat.

50. Biblio.com - Creutzfeldt-Jacob Disease. From Sheep To Cow To Man The Link 327p B
Narang, H creutzfeldtjacob disease. From Sheep to Cow to Man the Link 327p. CREUTZFELDT-JACOBDISEASE. FROM SHEEP TO COW MAN THE LINK 327P ALLMED2.
http://illiad.biblio.com/books/9511870.html
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Narang, H: Creutzfeldt-Jacob Disease. From Sheep to Cow to Man the Link 327p
H. H. Publisher, (£23.95), 1997. 0953076407. CREUTZFELDT-JACOB DISEASE. FROM SHEEP TO COW MAN THE LINK 327P ALLMED2. Catalogs: AllMED2. (Inventory #263-M)
  • Publisher : H. H. Publisher, (£23.95), 1997
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  • 51. Resource Library Find Information On Creutzfeldt-Jacob Disease At
    creutzfeldtjacob disease. Definition creutzfeldt-jacob disease is adisorder involving rapid decrease of mental function and movement.
    http://www.mercksource.com/pp/us/cns/cns_hc_women_content_adam.jspzQzpgzEzzSzppd

    52. Healthinmind/Menthal Health Disorders/Dementias/Creutzfeld-Jacob
    creutzfeldtjacob disease. This type of dementia, like Alzheimer sor Huntington s, is caused by organic changes in the brain, but
    http://healthinmind.com/english/creutz-ja.htm

    Healthinmind
    Mental Health Disorders Cognitive Disorders Dementias Creutzfeldt-Jacob Disease
    The Creutzfeldt-Jacob Foundation web site contains much additional information. Last updated

    53. Search The Library
    creutzfeldtjacob disease (Disease). Definition. creutzfeldt-jacob diseaseis a disorder involving rapid decrease of mental function and movement.
    http://www.deaconess.com/body.cfm?id=245&action=detail&AEProductID=AdamEncy&AEAr

    54. The Truth Regarding Mad Cow Disease Symptoms With Cats And Humans
    Cow Disease Symptoms (feline spongiform encephalopathy) in Great Britain) and alsointo humans, where the disease is called variant creutzfeldtjacob disease.
    http://www.kitten-cat-magazine.com/mad-cow-disease-symptoms.html
    What Cat Owners, And Other People, Should Know
    About Mad Cow Disease Symptoms
    There are extremely low risks, for cats and humans,
    of showing any Mad Cow Disease Symptoms
    The Mad Cow Disease is also referred as "BSE", which stands for bovine spongiform encephalopathy. While the disease is fatal in cattle and there are forms of spongiform encephalopathies in other species, including humans, cats, and deer, BSE poses an extremely low health risk in North America because of the way it is transmitted. "This disease was first described in England in 1986. The epidemic peaked in 1993 with 1,000 new cases every week, but is currently expected to be eradicated from Great Britain within 5 years. Most European countries as well as Japan, Israel, and Oman have diagnosed positive cases," explains Dr. Peter Constable, a large animal veterinarian at the University of Illinois Veterinary Teaching Hospital in Urbana. The current theory is that Mad Cow Disease Symptoms are caused by a modified infectious protein, called a "prion." BSE prions are found mainly in the brain, spinal cord, and ileum (a segment of the intestines). It is thought that the BSE outbreak in England occurred because brains from infected cows were fed to uninfected cattle as a source of protein. "Since BSE affects the brain, many of the clinical signs in cattle are neurological. Infected cows have trouble standing and walking. They tend to lose weight, exhibit alterations in their behavior, and may appear frenzied in the late stages of the disease, leading to the nickname 'mad cow disease,' "says Dr. Constable.

    55. What's At Stake: Protect Americans Against Mad Cow Disease
    possibility that American consumers are at risk of suffering its human counterpart—thedevastating and invariably fatal variant creutzfeldtjacob disease.
    http://actionnetwork.org/campaign/madcow/explanation
    What's At Stake!
    Protect Americans Against Mad Cow Disease After years of trepidation the unwanted happened: U.S. last December. Holstein cow immediately caused cattle prices to plunge, Japan and other countries to refuse U.S. To its credit, the USDA has said that it will require the industry to track animals. It will also bar from the food supply injured or sick animals, as well as the brains and spinal cords of older cattle. (Those are the tissues that would most likely contain the misfolded proteins called prions that cause mad cow disease and variant Creutzfeldt-Jacob disease.) But the USDA needs to do more. For further details, please visit http://www.cspinet.org/madcow Go Back Tell-A-Friend Jump to: Main Nutrition Action About CSPI Alcohol Policy Antibiotic Resistance Biotechnology Canada Donate to CSPI! Food Safety Nutrition and Health Integrity in Science International Newsroom Take Action!

    56. WDFW -- Chronic Wasting Disease
    known to science include scrapie in domestic sheep, bovine spongiform encephalopathy(BSE) in cattle, kuru in humans, and creutzfeldtjacob disease in humans.
    http://wdfw.wa.gov/wlm/cwd/gametrails.htm
    Chronic Wasting Disease Introduction WDFW Fact Sheet on CWD 2002 WDFW GameTrails: CWD Information Related Links Chronic Wasting Disease Alliance World Health Organization USGS National Wildlife Health Center USDA ... Southeastern Cooperative Wildlife Disease Study Briefs (PDF 79KB) Colorado Wisconsin
    Dowload the FREE Adobe
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    and print PDF documents. 2002 WDFW Game Trails: Chronic Wasting Disease Information
    Jerry Nelson, Deer and Elk Section Manager If you’ve read an outdoor magazine recently or watched the news on TV, you’ve probably been inundated with sensationalized reports of diseases in both domestic livestock and wild animals. One of the maladies that may have been discussed is a disease of the central nervous system found in deer and elk called chronic wasting disease. Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE). Other TSE’s currently known to science include scrapie in domestic sheep, bovine spongiform encephalopathy (BSE) in cattle, kuru in humans, and Creutzfeldt-Jacob disease in humans.

    57. Editor
    Iatrogenic creutzfeldtjacob disease From Surgical Instruments. NorthAmerica has been spared the ominous threat of future, widespread
    http://www.animalvoice.com/ortho.htm

    Editor: Charles Sorbie, MB, C
    H B, FRCS(E), FRCS(C)
    Seeking a Loose Body—of a Prosthesis
    Radiography is not a reliable method for determining whether a femoral prosthesis is loose. The reported accuracy rate can be as low as 50%. A.P. Georgiou and J.L. Cunningham ( Clin Biochem. 2001; 16:315-323) have used a vibrator to detect loosening of components. Engineers have long used vibration techniques to determine the integrity of laminated structures, eg, boat hulls. Excitation of a secure bone implant produces an output characteristic of a single unit having one resonant frequency and no harmonics, ie, the output wave is pure. After loosening or “delaminaton” of an implanted component, the separated elements respond to excitation differently. Appropriate instruments can demonstrate the differences. The authors used the diagnostic vibration technique on 23 patients admitted for revision total hip arthroplasty surgery and on 10 patients with recent and presumably secure implants. The technique was 100% accurate in its findings of hip implant loosening.
    Light at the End of the Tunnel
    Intensive “keyboarding” by computer users is a controversial cause of carpal tunnel syndrome. Much work time is lost from symptoms that are labeled carpal tunnel syndrome. There is a considerable cost for confirmatory nerve conduction studies, keyboard ergonomics are expensively applied, and the carpal ligament may be unnecessarily incised.

    58. Oak Ridger - Health
    this disease to cattle. The human form of this condition is called variant creutzfeldtjacob disease. . Mad cow disease and variant
    http://oakridger.com/stories/012804/hea_20040128040.shtml
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    Story last updated at 12:26 p.m. on January 28, 2004
    Mad cow disease: Researchers work to find treatments
    By:
    The first case of mad cow disease in the United States was reported in December 2003. Agencies of the federal government and the scientific community are putting a great effort into identifying what needs to be done for the safety of the meat supply and prevention of this disease. Although no treatment to cure or control this devastating illness exists at present, researchers continue work to identify medicines that will provide consistent benefits for people affected by the human form of mad cow disease. Anti-malarial agents such as chloroquine and quinacrine, as well as anti-psychotics drugs such as chlorpromazine (Thorazine), are some promising candidates for treatment. Jose Valedon, M.D., is a board-certified neurologist on the staff of Methodist Medical Center of Oak Ridge. A graduate of the Ponce School of Medicine in Ponce, Puerto Rico, he completed an internal medicine internship at Maryland General Hospital. At Vanderbilt University Medical Center, Valedon completed a residency in adult neurology and a fellowship in epilepsy and clinical neurophysiology. He also served as a clinical instructor in neurology. He is a member of the American Epilepsy Society, American Society of Clinical Neurophysiology, American Academy of Neurology, American Society or Neuroimaging, and National Stroke Association.

    59. European Report : HEALTH: IMAGING TECHNIQUES TO DETECT NEW VARIANT CREUTZFELDT-J
    Read European Report HEALTH IMAGING TECHNIQUES TO DETECT NEW VARIANTcreutzfeldtjacob disease with your FREE TRIAL @ HighBeam Research.
    http://static.highbeam.com/e/europeanreport/april262000/healthimagingtechniquest
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    • Current Article: HEALTH: IMAGING TECHNIQUES TO DETECT NEW VARIANT CREUTZFELDT-JACOB DISEASE
    Start E European Report April 26, 2000 ... HEALTH: IMAGING TECHNIQUES TO DETECT NEW VARIANT CREUTZFELDT-JACOB DISEASE
    HEALTH: IMAGING TECHNIQUES TO DETECT NEW VARIANT CREUTZFELDT-JACOB DISEASE
    European Report; April 26, 2000;
    European Report
    April 26, 2000
    new variant, creutzfeldt-jacob disease, european report, nvcjd, imaging techniques, disease, variant creutzfeldt-jacob, detect new, mri, pre, brain, anomaly, central region, rear part, detect
    Magnetic resonance imaging (MRI) was used to detect an anomaly, a "
    signal", in a central region of the brain, close to the rear part
    of the thalamus, according to scientists James Ironside, Martin Zeidler
    and Robert Will of the national monitoring unit for human Creutzfeldt-
    Jacob Disease, based in Edinburgh, Scotland. The comparative study

    60. Issues And Legislation
    These include BSE ( mad cow disease ) in cattle, chronic wasting diseasein deer and elk and creutzfeldtjacob disease in humans.
    http://www.senate.gov/~durbin/sitepages/Issues/consumer-madcow.htm
    Tuesday, 08-Jun-04 04:42:01 EDT Home Consumer Safety Mad Cow MAD COW DISEASE Prion diseases are brain wasting diseases of humans and animals. These include BSE ("mad cow disease") in cattle, chronic wasting disease in deer and elk and Creutzfeldt-Jacob Disease in humans. Senator Durbin has introduced this public health, animal health, and food safety bill to strengthen our response to BSE and improve surveillance and research for prion disease in other animals and in humans. Although just one cow within the U.S. has tested positive for mad cow disease, the meat and meat by-products from that animal potentially contaminated 2.8 million pounds of meat, animal feed, cosmetics and other products by the time the recall order was issued. The BSE and Other Prion Disease Prevention and Public Health Protection Act (S. 2007) makes a number of improvements to the current system: Better Testing The Durbin bill modifies USDA procedures to require all cattle over the age of 30 months to be tested for BSE. Currently, USDA tests only animals that are "downers" or showing symptoms of neurological disease – just 40,000 out of the 35 million cattle to be slaughtered in 2004. While animals over 30 months of age constitute less than 10% of total cattle slaughtered annually, animals at this age are the most likely to harbor detectible BSE. Targeting Risk Materials The Durbin bill updates and expands the definition of "Specified Risk Materials (SRM)" – those parts of an animal that can harbor the infective agent of prion diseases. The legislation defines SRMs to include the small intestinal tract, brain, skull, eyes, tonsils, spinal cord, spinal column and other central nervous system tissue.

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