61. About Prostate Cancer And Genetics Prostate cancer and genetics Noone knows what causes prostate cancer,but some conditions may make you more likely to develop the disease. http://hcp.prostateline.com/article/500255.aspx

Skip to content Home News Prostate cancer ... Patient counselling Genetics Prostate Cancer and Genetics No-one knows what causes prostate cancer, but some conditions may make you more likely to develop the disease. Hereditary factors can contribute to the development of prostate cancer. However, the great majority of prostate cancer is not associated with genes that confer a high level of risk. If your father or brother has developed the disease at a young age, particularly under 50, or you have two close relatives including a father or brother, you may have an increased risk of developing prostate cancer yourself. In addition, if other family members have developed certain types of cancer including breast or ovarian cancer, then your risks of developing prostate cancer may also be greater than would otherwise be the case. A number of genes which predispose to some extent to prostate cancer have now been identified (including the so-called breast cancer genes BRCA1 and BRCA2) and there is also now evidence of the existence of at least two prostate cancer specific genes. If you are concerned about hereditary risk of cancer, your GP may refer you to a Consultant Urologist, who might wish to co-operate with a Clinical Geneticist to determine your risk of developing prostate cancer.

62. CMGS-Cancer Molecular Genetics/Part 2 Study Day 19.02.01 MRCPath Part 2 study day 2001. Recent developments / Future provision of cancermolecular genetics. Methods for cancer genetics and Prognosis Prediction. http://www.ich.ucl.ac.uk/cmgs/part2/cancerde.htm

MRCPath Part 2 study day 2001 Recent developments / Future provision of cancer molecular genetics Imprinting and Cancer Tumour-suppressor genes are accepted to be commonly inactivated by mutations, however, for some TS genes an epigenetic pathway may be more common. In a cancer cell there is a clear distortion in expression profiles, much of which can be explained by a dramatic change in methylation patterns. Dysregulation of methylating enzymes, global methylation (possibly causing global genomic fragility) and, local and discrete hypermethylation are all seen. Hypermethylation of TS genes is associated with loss of expression, absence of a coding mutation, and restoration of transcription by demethylating agents. It has been recorded for many tumour types: MSI is a feature of (familial) HNPCC due to MMR gene mutations. However, MMR mutations are found in only 10%of MSI positive (MSI+) sporadic cases. The MLH1 promoter is hypermethylated in the remaining 90% MSI+ tumours. Of MSI- tumours, 95% exhibit a normal pattern of methylation of MLH1. Hypermethylaion of MLH1 has been shown to be an early event in tumourigenesis. E-cadherin Promoter hypermethylaion demonstrated in sporadic gastric, breast, prostate and colorectal cancers.

63. Division Of Genetics, URMC Featured is information on laboratory testing, genetic susceptibility to cancer, cystic fibrosis, and sickle cell, thalassemia and other hemoglobinopathies. In addition there are links to counseling services, the graduate program, the Sickle Cell Clinic, newsletters, and list of staff. http://www.urmc.rochester.edu/Genetics/

Home Services Counseling Services Sickle Cell Clinic Newsletters OncoGene News Sickle Selections Staff Department of Medicine The Division of Genetics offers information on: Genetic Susceptibility to Cancer Sickle Cell, Thalassemia and other Hemoglobinopathies Breast Cancer Recommendations Brochure* A Patient's Perspective Colon Cancer Brochure* Recommendations Brochures/Fact Sheets Our Role in Newborn Screening* ... Brochure* *These files are available as Adobe Acrobat Reader 3.0 files - online versions that look just like the originals. The Adobe Acrobat Reader software is freely available for you to download and use from Adobe's software site. Comments/Suggestions to: Mary_True@urmc.rochester.edu . For questions or suggestions concerning the content of these pages, contact the URMC Webmaster

64. Prostate Cancer And Genetics Prostate cancer and genetics. Advice for patients on prostate cancer and geneticsis contained in the leaflet listed below. PIL Prostate cancer and genetics. http://www.cancerlineuk.net/prostate-cancer/patient-support/prostate-cancer.asp

CONTACT US SEARCH LEGAL INFORMATION PRIVACY STATEMENT ... SITE MAP Prostate Cancer - Patient support Prostate Cancer and Genetics Advice for patients on prostate cancer and genetics is contained in the leaflet listed below. PIL: Prostate Cancer and Genetics Updated March 2002 to top Prostate Cancer Incidence Symptoms / History Investigations Differential diagnosis ... CANCER LINKS

65. Johns Hopkins Hospital Specializing in an array of comprehensive services such as AIDS, asthma, allergies, cancer, children's health, genetics, heart disease, infectious diseases, neurosurgery, ophthalmology, orthopaedics, organ transplantation, women's health. (Baltimore, Maryland) http://www.hopkinsmedicine.org/hopkinshospital/

Print This Page No Menu Image/Title Selected The Johns Hopkins Hospital Patient Information Rated best hospital in the nation year after year for excellence in every specialty, this flagship of Hopkins Medicine includes such renowned centers as the Brady Urological Institute, the Wilmer Eye Institute, the Sidney Kimmel Comprehensive Cancer Center and the Johns Hopkins Children's Center. A treatment magnet for patients from around the world, The Johns Hopkins Hospital also provides more charity care than any other hospital in Baltimore. The Mission of The Johns Hopkins Hospital is: To be the world's preeminent health care institution To provide the highest quality care and service for all people in the prevention, diagnosis and treatment of human illness To operate cooperatively and interdependently with the faculty of The Johns Hopkins University to support education in the health professions and research and development into causes and treatment of human illness To be the leading health care institution in the application of discovery To attract and support physicians and other health care professionals of the highest character and greatest skill To provide facilities and amenities which promote the highest quality care, afford solace and enhance the surrounding community.

66. Colorectal Cancer And Genetics Colorectal cancer Patient support. Colorectal cancer and genetics.If a close member of your family (mother, father, brother or http://www.cancerlineuk.net/colorectal-cancer/patient-support/psl/colorectal-can

CONTACT US SEARCH LEGAL INFORMATION PRIVACY STATEMENT ... SITE MAP Colorectal Cancer - Patient support Colorectal Cancer and Genetics If a close member of your family (mother, father, brother or sister) has developed bowel cancer before the age of 45 years, or if several members of your family have suffered from bowel cancer, then it is likely that your GP will refer you to a Clinical Geneticist. This is because you are more likely to develop bowel cancer yourself if you have a positive family history of the disease. Some forms of hereditary bowel cancer are linked to other cancers, such as cancer of the breast, bladder, kidneys, stomach or uterus. The Clinical Geneticist will be able to advise you on which tests and procedures may be necessary to keep an eye on your condition, so that any necessary action can be taken as soon as possible. As yet there is no national screening programme for colorectal cancer. Probably the most widely used screening method is the testing of samples of faeces (stools) for the presence of blood. Another method which has been considered is the passage of a flexible sigmoidoscope (an illuminated, flexible telescope) through the back passage and into the rectum and lower colon to inspect the bowel lining. Updated March 2002 to top Colorectal Cancer Incidence Symptoms / History Investigations Differential diagnosis ... CANCER LINKS

67. Cancer Molecular Genetics cancer Molecular genetics Program. Molecular analysis of human tumorshas led to the identification of a number of genes that are http://www-uccrc.uchicago.edu/molgene.html

68. San Antonio Cancer Institute University affiliate and associate of the cancer Therapy and Research Center in Texas. Includes genetics, drug development, prevention and control. http://www.ccc.saci.org/

Search A National Cancer Institute-designated Cancer Center SACI 2004 Research Symposium UPCOMING EVENT November 11, 2004 Keynote speaker will be Douglas L. Weed, MD, MPH, PhD Director, Cancer Prevention Fellowship Program, National Cancer Institute will speak on The Future of Cancer Prevention 27th Annual San Antonio Breast Cancer Symposium Announcement! December 8-11, 2004 Scheduled for December 8 - 11, 2004 at the Henry B. Gonzalez Convention Center, San Antonio, TX. Home About SACI Research Programs Clinical Trials ... Site Map Designed by nuMEDIA Group Inc.

69. Doi:10.1226/0896038688 Prostate Cancer: Biology, Genetics, And The New Therapeut Prostate cancer Biology, genetics, and the New Therapeutics Author(s) Chung,Leland WK, Isaacs, William B., and Simons, Jonathan W. Format Hardcover DOI http://dx.doi.org/10.1226/0896038688

Please click on the choices below to learn more about this item: Prostate Cancer: Biology, Genetics, and the New Therapeutics Author(s): Chung, Leland W. K., Isaacs, William B., and Simons, Jonathan W. Format: Hardcover DOI: 10.1226/0896038688 Publisher's Catalog Page View Table of Contents Other Formats eBook Related Titles Genetics Adenovirus Methods and Protocols Animal Cell Electroporation and Electrofusion Protocols Animal Models in Psychiatry, I ... Email Humana Press Powered by Content Directions, Inc. (CDI) and the Digital Object Identifier (DOI) View additional CDI examples Want to Add This Link to Your Site?

70. Institut Curie, L'union D'un Hôpital Et D'un Centre De Recherche Contre Le Canc The main research activities ranging from the physical chemistry of organized molecular complexes to basic biological research and cancer genetics - are conducted in the Research Division of the Curie Institute. This basic research is targeted to the development new diagnostic methods and cancer treatments. http://www.curie.fr

Rechercher SmartForm('mot','#A5CCE9'); Revocation brevet Myriad Contacts Plan du site intranet Hôpital ... intranet Recherche

71. Genetics In Aging The future of colorectal cancer and genetics Further Genes involved in colorectalcancer. The future of colorectal cancer and genetics. This http://www.agingresearch.org/geneticsinaging/coc_1_5.html

The future of colorectal cancer and genetics Further discoveries about colorectal cancer genes will allow doctors to develop personalized prevention, diagnosis, treatment, and prognosis based upon the strengths and weaknesses found in a person's genes. Treatment - better use of existing treatments Genes and gene alterations in a malignant colorectal tumor often determine how the tumor responds to treatment. Learning about these treatment-response genes, will allow oncologists to pick the best treatment to use in each individual person. Treatment — discovery of new treatments Whenever science discovers a gene that is involved in colorectal cancer, it's a doorway to designing new treatments. Trials of gene therapy in colorectal cancer are already underway. Researchers are putting genes into tumors that will make them more sensitive to existing medications. They are also inserting genes designed to stop or slow down the growth of the tumor. These trials are in the early stages. However, scientists are not yet able to "fix" an altered gene in a person. Prevention, Diagnosis, Prognosis

72. Division Of Cancer Epidemiology And Genetics (DCEG): Branches: Clinical Genetics ntegrates clinical observations into an interdisciplinary approach involving clinical, genetic, epidemiologic, statistical and laboratory methods to define the role of susceptibility genes in cancer etiology. http://www-dceg.ims.nci.nih.gov/clinical.html

Home Organization Research Publications Search: Overview Branches Clinical Genetics Branch "Saving lives by conquering cancer through research in clinical cancer genetics." About the Branch Overview Staff Directory Staff Biographies Branch Fellowships Prospective fellows should see DCEG-wide Fellowship information Recent Branch Publications Rosenberg PS, Greene MH, Alter BP Cancer Incidence in persons with Fanconi Anemia. Blood 2003; 101:822-826 Giusti RM et al: A two-fold increase in BRCA mutation-related prostate cancer among Ashkenazi Israelis is not associated with distinctive histopathology . J Med Genet 2003; 40:787-792 Rutter JL et al: Mutational analysis of the BRCA1-interacting genes ZBRK1 and BRIP1 among BRCA1/2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals. Human Mutation 2003; 22:121-128 Modugno F et al Ovarian cancer and high-risk women: Implications of screening, prevention and early detection.

73. Genetics In Aging The future of prostate cancer and genetics The future of prostate cancer and genetics.This module made possible by an educational grant from, Visit DNA Sciences. http://www.agingresearch.org/geneticsinaging/pro_1_5.html

The future of prostate cancer and genetics Further discoveries about prostate cancer genes will allow doctors to develop personalized prevention, diagnosis, treatment, and prognosis based upon information found in a person's genes. Treatment — better use of existing treatments Specific genes may influence the responses to different treatments. Better genetic information could explain why some drugs work better in some people than others. This will make choosing treatments less hit-and-miss than in the past. Treatment — discovery of new treatments Whenever scientists discover a gene involved in prostate cancer, it's a doorway to designing new treatments. Prevention, Diagnosis, Prognosis Prevention, diagnosis, and prognosis all improve when our ability to calculate risk improves. Scientists believe genes will tell us a lot about the risk of developing prostate cancer and the progression of prostate cancer. Discoveries about the underlying genetic contribution to prostate cancer can have an enormous impact. Knowing which genes are involved allows doctors to screen individuals and identify those more likely to develop prostate cancer. If prostate disease is detected early, it is much easier to cure. Discovering the genes provides insights into how the disease begins and how to cure it. Scientists also can begin to discover drugs that reverse the effects of those genes. The areas below provide more information on the exciting and promising research in this cutting edge area of science as well as links to more information.

74. The University Of Chicago Cancer Research Center Comprehensive academic cancer institution specializes in molecular biology, genetics, immunology, clinical trials and diagnostics. http://www-uccrc.uchicago.edu/

Home About Us For Researchers For Patients ... How You Can Help The University of Chicago Cancer Research Center is a collaborative effort of more than 150 researchers and physicians engaged in discovering new insights into cancer’s causes, qualities and cures. The Center’s six dynamic programs focus on Cell Signaling and Gene Regulation, Cancer Molecular Genetics and Hematopoiesis, Immunology and Cancer, Clinical and Experimental Therapeutics, Advanced Imaging, and Clinical Cancer Genetics and Prevention. IN THE NEWS Dr Michelle Lebeau named Cancer Center Director © 2004 The University of Chicago Cancer Research Center (updated 05/29/2004 22:30)

75. Cancer Center If you cannot find the information in which you are interested, please visit theCancer genetics Online Resources page in this Web site for an Internet/World http://www.rush.edu/rumc/page-P07206.html

Bone Marrow Transplant Gynecologic Oncology Myeloid Disease Cancer Center The Genetics of Colorectal Cancer Approximately 25 percent of individuals with colorectal cancer have at least one relative with colorectal cancer, while 75 percent of cases are persons without a family history of the disease. Approximately 5 percent to 6 percent of colorectal cancers are due to known predisposing genetic factors. This means that the majority of colorectal cancers are, in fact, not inherited. Specifically, 3 percent to 5 percent of all cases of colorectal cancer are due to hereditary nonpolyposis colon cancer (HPNCC), while approximately 1 percent is due to familial adenomatous polyposis (FAP). The following sections will provide an overview to the genetics of colorectal cancer, as well as examples of genetic syndromes associated with an increased risk for colorectal cancer. If you cannot find the information in which you are interested, please visit the Cancer Genetics Online Resources page in this Web site for an Internet/World Wide Web address that may contain additional information on that topic. Cancer Center - Home page Cancer Types Cancer Center - Online Resources Familial Adenomatous Polyposis (FAP) ... Site Map

76. Community And Family Health Administrations Works to assure that Core Public Health Functions and Essential Public Health Services are provided to every person, in every community, everywhere in Maryland. Oversite of many offices on topics including fitness, genetics, cancer, maternal and child health, chronic disease prevention, injury and disability prevention, and epidemiology and disease control. http://mdpublichealth.org

WELCOME! Community and Family Health Administrations now have their own sites. Please click the links below to visit either site. Thank you. Family Health Administration Genetics and Children with Special Health Care Needs Women, Infants, and Children Program Center for Maternal and Child Health ... Local Health Departments Match ALL words Match ANY word View this page in German Spanish French Italian Portuguese Family Health Administration Community Health Administration Local Health Departments Site Use Policies To address technical problems or make suggestions regarding this site send email to: webmaster@dhmh.state.md.us Last Modified 03/08/2004 09:56:13 AM

77. Cancer Center genetics cancer The genetics of Prostate cancer. The geneticsof Prostate cancer. The genetics of prostate cancer As many as http://www.rush.edu/rumc/page-P07214.html

Bone Marrow Transplant Gynecologic Oncology Myeloid Disease Cancer Center Cancer Programs The Genetics of Prostate Cancer The genetics of prostate cancer: As many as 9 percent of Caucasian males and 10 percent of African-American males in the US will develop prostate cancer in their lifetime. The majority of cases of prostate cancer are sporadic, which means that one person in the family developed prostate cancer by chance at a typical age of onset. In these cases, other male relatives have little to no increased risk of developing prostate cancer. About 15 percent of prostate cancers are familial, which means there is a father or brother also affected, at typical ages of onset. Familial cancers may be due to a combination of genes and shared lifestyle factors or environmental exposures (multifactorial inheritance). On the other hand, some of these histories can represent a chance occurrence of sporadic cancers. A familial history may also arise due to a single gene mutation (hereditary cancer) that has reduced penetrance (a mutation associated with lower cancer risks and later onset of cancer). In general, with familial cancer, close relatives have a modestly increased risk of developing the cancer in question. The chance that genetic testing will be beneficial in further assessing cancer risks is usually small. Studies have found a trend of an increased chance to develop prostate cancer, with an increasing number of family members. In other words, the more relatives you have with prostate cancer, the higher the risk:

78. Molecular Oncology Unit Home Page Dedicated to researching the causes of and treatments for cancer. Includes description of the molecular genetics of pancreatic cancer, and related research into screening, diagnosis, treatment, and genetic vaccination. http://www.lif.icnet.uk/axp/mphh/

Head: Professor Nick Lemoine We are a Clinical Unit of Cancer Research UK based at The Hammersmith Hospital with strong links to Imperial College of Science, Technology and Medicine 7th/8th Floor, Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W12 0HS Tel: +44 (0) 20 8383 3257 Fax: +44 (0) 20 8383 3258 How to get here Current job vacancies This page was last modified on Top MOU Home

79. Genetics And Cancer : Human Genetics : Genetics cancer breast family disease cancer cigarette body skin form result division leukemiahuman chemical sperm liver person development genetic. genetics and cancer. http://www.bioproject.info/GENERAL_BIOLOGY/Genetics/Human_genetics/Genetics_and_

WASP Website navigation : home GENERAL BIOLOGY Genetics Human genetics ... Human genetics Genetics and cancer Cancer is a common name for many diseases that affect different body tissues, including the skin and the liver. All cancers involve alterations in genes that control cell division. These alterations cause cells to replicate abnormally and form tumors. Cancers generally arise from mutations that occur directly in the somatic cells, any cells of the body with the exception of the gametes (sperm and egg cells). Since the genetic mutations have not occurred in gametes, the mutations are not inherited by the next generation. While cancer is not a traditional inherited genetic disorder, scientists have determined that a genetic component plays a strong role in the development of the disease. Geneticists have identified many different genes with certain alleles that appear to increase an individual’s susceptibility to cancer. A notable example involves two genes linked to breast cancer. Researchers estimate that more than half of the women with a family history of breast cancer who inherit mutated alleles of these two genes, known as BRCA1 and BRCA2, will develop breast cancer by the age of 70. In contrast, women who lack either of the mutated alleles have only a 13 percent chance of developing the disease. For many cancers, researchers believe that mutations in several different genes must accumulate before cancer develops. As a person ages, errors in DNA replication may occur during cell division, or cells may be damaged by exposure to certain environmental factors, including cigarette smoke, radiation, and chemical pollutants. As a result, an accumulation of mutations may develop in two types of genes: tumor suppressor genes and oncogenes. Tumor suppressor genes normally function to halt cell division, while oncogenes function to activate cell division. A mutation in either type of gene can stimulate nonstop cell division. These types of defects have been linked to some cases of leukemia as well as to cancers of the ovaries, lungs, colon, and other organs.

80. Cruk.leeds.ac.uk Areas include clinical trials, psychosocial oncology, biological and immunotherapy work, genetics and screening. http://cruk.leeds.ac.uk

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