101. AAAAI - Member Center: Hot Topic: FDA Approves Omalizumab (Xolair), A Recombinan June 2003 article on the drug's US approval. Includes information about results of clinical trials. http://www.aaaai.org/members/hottopic/omalizumab/professional.stm

FDA Approves Omalizumab (Xolair), a Recombinant Anti-IgE Antibody, to Treat Moderate to Severe Allergic Asthma For Professionals Hot Topics articles are provided by AAAAI as a service to its members for educational and informational purposes only. They are provided solely on an "as is" basis and any use or reliance on the information contained in such articles is solely at the user's risk. Hot Topics articles are not intended to serve as the primary basis for making medical decisions. These articles are prepared and reviewed by AAAAI members and reflect the opinions of the author(s) and do no necessarily represent the opinions or positions of AAAAI. As with all such resources, these articles reflect medical science at the time they are written; AAAAI assumes no responsibility to update these articles or to remove them from its web site as future developments occur. Date June 23, 2003 Background Omalizumab (Xolair) is a recombinant humanized monoclonal anti-IgE antibody that binds to IgE on the same Fc site as Fc R1. Omalizumab causes a reduction in total serum IgE in atopic patients, which attenuates the amount of antigen-specific IgE that can bind to and sensitize tissue mast cells and basophils. This, in turn, leads to a decrease in symptoms of allergic diseases. The monoclonal antibody contains 5% murine sequences (needed for the IgE binding portion) and 95% human residues from a human IgG 1 kappa framework. Omalizumab reduces the amount of free IgE (the unbound form present in the circulation) available to bind to Fc R1 receptors and results in a reduction in the expression of high affinity IgE receptors. Omalizumab does not bind to IgE already bound to effector cells.

102. Occupational Asthma - Current Perspectives Occupational asthma Current perspectives. Contents employs one). Clickhere to go back to Top of page asthma Links. Pages relevant http://www.agius.com/hew/resource/ocasthma.htm

Occupational Asthma: Current perspectives Contents: A basis for primary prevention Health surveillance and secondary prevention Case management and tertiary prevention Case Studies Research on occupational asthma hazards: Predictive programme Asthma links Definition, and Frequency "Occupational asthma is a disease characterised by variable air flow limitation and/or airway hyper-responsiveness due to causes and conditions attributable to a particular occupational environment and not to stimuli encountered outside the workplace" (Bernstein et al 1993). Within this definition two types of occupational asthma can be distinguished: In the first instance, there is agreement, that the syndrome of chest tightness, wheezing, shortness of breath, dry cough etc, which appears after a latent period of occupational exposure constitutes occupational asthma. The second category of occupational asthma is that developing without a period of latency and often associated with exposure to high concentrations of irritants. Its symptoms may be somewhat different from that of asthma that follows a latent period. This is often referred to as Reactive Airways Dysfunction Syndrome ( RADS It should be borne in mind that the airways that are afflicted by asthma are a continuation of the airways starting in the nose. It is therefore not surprising that many asthma cases also have rhinitis, (often preceding the asthma). Rhinitis literally means inflammation of the nose. Its symptoms are commonly those which the lay person associates with "hay fever" - an itchy, blocked or runny nose, often red and accompanied by sneezes. There may also be eye symptoms (itchy, glazed or runny). Thus

103. CNN.com - Health - Racial Gap Widening In U.S. For Childhood Asthma - October 13 CNN http://www.cnn.com/2000/HEALTH/children/10/13/asthma.race.reut/index.html

children Editions myCNN Video ... Feedback CNN Sites CNN CNN Europe CNNfn CNNSI myCNN CNNfyi AllPolitics Languages Search CNN.com CNNSI.com CNNfn.com The Web HEALTH TOP STORIES New treatments hold out hope for breast cancer patients MORE TOP STORIES Thousands dead in India; quake toll rapidly rising Israelis, Palestinians make final push before Israeli election Davos protesters confront police MORE ... MORE MARKETS 4:30pm ET, 4/16 DJIA NAS SPORTS Jordan says farewell for the third time ... LOCAL EDITIONS: CNN.com Europe change default edition MULTIMEDIA: video video archive audio multimedia showcase ... more services E-MAIL: Subscribe to one of our news e-mail lists Enter your address: DISCUSSION: chat feedback CNN WEB SITES: CNNfyi.com CNN.com Europe AsiaNow Spanish ... Korean Headlines TIME INC. SITES: Go To ... Time.com People Money Fortune EW CNN NETWORKS: CNN anchors transcripts Turner distribution SITE INFO: help contents search ad info ... jobs WEB SERVICES: Racial gap widening in U.S. for childhood asthma ATLANTA, Georgia (Reuters) African-Americans were significantly more likely than whites to experience childhood asthma, according to U.S. health statistics that showed on Thursday a widening racial gap among the young for the chronic lung disease. The Centers for Disease Control and Prevention (CDC) said a 1998 survey found that black children were 31 percent more likely than white children to have had an episode of asthma or an asthma attack during the previous year.

104. ScienceDirect - Asthma Magazine - List Of Issues Chronic Respiratory Diseases their efforts to reduce the toll of morbidity, disability and premature mortalityrelated to Chronic Respiratory Diseases, and specifically, asthma and chronic http://www.sciencedirect.com/science/journal/10880712

This Feature requires JavaScript Register or Login: Password: Athens Login Asthma Magazine Bookmark this page as: http://www.sciencedirect.com/science/journal/10880712 Volume 9 Volume 9, Issue 3 , Pages 3-35 (May - June 2004) Volume 9, Issue 2 , Pages 3-35 (March - April 2004) Volume 9, Issue 1 , Pages 3-32 (January - February 2004) Volume 8 Volume 7 Volume 6 Alert me when new Journal Issues are available Add this journal to My Favorite Journals Sample Issue Online More Publication Info Information for Authors Feedback ... Elsevier B.V.

105. Asthma News In The UK And Ireland Information about this condition from a UK perspective. Includes news articles, statistics and complementary therapies. http://www.asthma-uk.co.uk/

Asthma and Allergy news, Books and Videos, Complementary Therapies, Statistics, Research, Asthma A to Z, and Links Welcome to "Asthma News in the UK and Ireland". If you are viewing this text, your browser lacks the ability to read frames. Don't worry, you can still enjoy the site. All the pages can be viewed from the contents page, and by using your browser's back button. Please come inside! Contents var site="s13asthma"

106. NW Asthma About NAAC Click here for more information about Northwest asthma and Allergy Clinic,including profiles of our physicians, employment opportunities, and a http://www.nwasthma.com/

107. Johns Hopkins Division Of Allergy & Asthma JOHNS HOPKINS MEDICINE. ABOUT JOHNS HOPKINS MEDICINE. HEALTH INFORMATION. PATIENTCARE. RESEARCH. EDUCATION. THE DIVISION OF ALLERGY CLINICAL IMMUNOLOGY. WHAT SNEW. http://www.hopkinsmedicine.org/allergy/

Support Our Mission Job Postings Allergy Grand Rounds JHM Appointments Support Our Mission Job Postings Allergy Grand Rounds JHM Appointments ... The Web Center

108. Urticaria General information on urticaria, what can trigger it, types and identification, and treatment from the American College of Allergy, asthma, and Immunology. http://allergy.mcg.edu/advice/urtic.html

ACAAI Homepage About ACAAI Bulletins Information for: Patients Physicians Employers News Media Urticaria Urticaria, commonly known as hives, usually strikes suddenly. First the skin itches, then it erupts into red welts. The itching may be severe, keeping people from working or sleeping. It's a distressing disorder which affects an estimated 20 percent of the population at one time or another in their lives. What is urticaria? Most cases of urticaria are acute, lasting from a few hours to less than six weeks. Some cases are chronic, lasting more than six weeks. The welts may appear in one place, disappear after a short time, then erupt at another spot, then another. They are made worse by scratching. Each individual hive lasts no more than 24 hours. What kinds of things can trigger attacks of urticaria? Bouts of urticaria have been traced to such triggers as infections, drugs (including aspirin), certain foods and additives, cold, sun exposure, insect stings, alcohol, exercise, endocrine disorders and emotional stress. In some people, pressure caused by belts and constricting clothing causes eruption. Urticaria may be a response to infection including the common cold, strep throat and infectious mononucleosis. In the urticaria-prone person, these triggers cause the body to release chemical mediators, including histamine, from cells. Histamine (which causes itchy, runny noses and watery eyes in hay fever sufferers) dilates the walls of blood vessels, allowing fluids to leak out into the surrounding tissues. Swelling and itching are the result.

109. Annals Of Allergy, Asthma, & Immunology Official publication of the American College of Allergy, asthma, ImmunologyCan you identify this? Please register here for access to the issues. http://www.annallergy.org/

Can you identify this? Please register here for access to the issues. AllergyWatch A Synopsis of Allergy and Asthma Literature, Resulting from an Unbiased, Comprehensive Review of Nineteen Major Medical Journals. Contact the help desk or call 877-215-7935 x142 for registration assistance.

110. CNN.com - UK, Saudi Study Shows Junk Food-child Asthma Link - August 22, 2000 CNN http://www.cnn.com/2000/HEALTH/diet.fitness/08/22/asthma.junkfood.reut/index.htm

Editions myCNN Video Audio ... Feedback CNN Sites CNN CNN Europe CNNfn CNNSI myCNN CNNfyi AllPolitics Languages Search CNN.com CNNSI.com CNNfn.com The Web HEALTH TOP STORIES New treatments hold out hope for breast cancer patients MORE TOP STORIES Thousands dead in India; quake toll rapidly rising Israelis, Palestinians make final push before Israeli election Davos protesters confront police MORE ... MORE MARKETS 4:30pm ET, 4/16 DJIA NAS SPORTS Jordan says farewell for the third time ... LOCAL EDITIONS: CNN.com Europe change default edition MULTIMEDIA: video video archive audio multimedia showcase ... more services E-MAIL: Subscribe to one of our news e-mail lists Enter your address: DISCUSSION: chat feedback CNN WEB SITES: CNNfyi.com CNN.com Europe AsiaNow Spanish ... Korean Headlines TIME INC. SITES: Go To ... Time.com People Money Fortune EW CNN NETWORKS: CNN anchors transcripts Turner distribution SITE INFO: help contents search ad info ... jobs WEB SERVICES: UK, Saudi study shows junk food-child asthma link LONDON (Reuters) Diets rich in junk food could be the culprits behind the rapid rise of asthma and allergies in children, scientists in Scotland and Saudi Arabia said in research published on Tuesday. "This study suggests that dietary factors during childhood are an important influence in determining the expression of wheezy illness," the researchers said in the latest edition of the medical journal Thorax.

111. Asthma Familydoctor.org About AAFP, familydoctor.org Home Conditions A to Z asthma. Insomniasufferers, grab a pen! Keeping track asthma. asthma A chronic disorder http://familydoctor.org/x2445.xml

Advanced Search familydoctor.org Home Conditions A to Z Want to breathe easier? Tune in to your local weather report. It will alert you to any unhealthy air pollution levels in your area. More info... Dictionary Find a Doctor BMI Calculator ... Web Site Reviews Asthma Asthma: A chronic disorder characterized by shortness of breath, wheezing, coughing and tightness of the chest. Search for more medical terms. The Basics What Is Asthma? Asthma Flare-ups When It Doesn't Get Better Asthma Action Plan ... Occupational Respiratory Disease

112. The Asthma Wizard Teaches Kids All About Asthma! The asthma Wizard teaches kids all about asthma! Children learn what asthmais, symptoms, medicines, attacks and more. The asthma Wizard. Hello kids! http://asthma.nationaljewish.org/about/kids/wizard.php

About Asthma What Is Asthma? What Are Asthma Symptoms? What Causes Asthma? ... Asthma Info for Kids Wizard Home Page Living With Asthma for Kids Printer friendly version Sitemap About Asthma Treatments and ... Programs The Asthma Wizard Hello kids! Meet The Asthma Wizard! He is an expert about asthma, and he's here to teach kids like you everything he knows, so let's get started. How many kids have asthma? Asthma is one of the most common chronic illnesses affecting children in this country. As many as 5% of children less than 15 years old, or almost 5 million children, have asthma. Asthma is the most common pediatric chronic lung disorder. What can I learn from The Asthma Wizard? The Asthma Wizard will guide you through each chapter to help you learn all about asthma and how it affects kids. The Asthma Wizard speaks English and Spanish, so you can select your language below to get started and go to the list of chapters. Each chapter has an introduction, learning objectives, background information, developmental issues and lots of fun activities for kids. What activities will I get to do with The Asthma Wizard?

113. PULMICORT TURBUHALER - Home Features information about how to use the drug, full prescribing information for US residents, and a glossary as well as asthma information and resources. http://www.twistclickinhale.com/

Welcome to the PULMICORT TURBUHALER Web Site, your on-line source for asthma information and treatment with PULMICORT TURBUHALER. Bookmark this page as we will continually provide updates to help you better manage your asthma. PULMICORT TURBUHALER is used to treat asthma in adults and children 6 years of age and older. PULMICORT TURBUHALER is not a bronchodilator and should not be used to treat acute, or sudden, asthma attacks. Common side effects with PULMICORT TURBUHALER include respiratory infection, headache, oral candidiasis (thrush in the mouth), pharyngitis (sore throat), voice alteration (hoarseness), and sinusitis. IMPORTANT: If you are switching to PULMICORT TURBUHALER from an oral corticosteroid, follow your doctor's/health care provider's instructions to avoid health risks associated with stopping the use of oral corticosteroids. Please see full Prescribing Information Home Prescribing Information Search ... Legal Information This product information is intended for US consumers only. PULMICORT TURBUHALER is a registered trademark and Core of Confidence and the budesonide logo are trademarks of the AstraZeneca group of companies.

114. Asthma Information Information on symptoms and triggers. http://www.mamashealth.com/asthma.asp

Mamashealth.com Home Allergy Pages Allergies Allergy Relief Asthma Control Asthma ... My Asthma Links Email Mama What is asthma? Asthma is a disease that affects the lungs and the airways that deliver air to the lungs. It causes periodic attacks of wheezing and difficult breathing. Periodic attacks are caused by an oversensitivity of the lungs and airways, which overreact to certain "triggers" and become inflamed and clogged. Asthma is Greek for "panting". Asthmatics pant during an asthma attack because their air passages, which start in the throat and end in the lungs, become narrowed and sometimes almost completely obstructed. Asthma can develop at any age. An asthma attack occurs when the airways become inflamed in response to a trigger, such as dust, mold, pets, exercise, or cold weather. However, some attacks start for no apparent reason. Triggers may inflame the airways to the lungs , allowing disease-fighting cells to accumulate and causing swelling in the lungs. In addition, the airways may become blocked or obstructed when the muscles surrounding the lungs tighten or go into spasm. Spasms keeps air from circulating freely in the lungs. Mucus may also cause an asthma attack. Mucus may clog and narrow the airways in the lungs, making breathing even more difficult. Read a personal story about asthma Symptoms?

115. ASTHMA Information: All About Asthma Symptoms, Treatment, Medications And Manage Information about asthma for children and adults, including asthma symptoms,triggers, treatment, medications and how to manage asthma. http://asthma.nationaljewish.org/

Asthma Information: Learn all about asthma symptoms, asthma medications, asthma management and asthma treatment programs at National Jewish. About Asthma Treatments and Medications Living With Asthma Our Asthma ... Information for Healthcare Professionals To find specific asthma information, select a category and then click GO. Sitemap Children Adults Pregnancy Healthcare Professionals Advanced Search National Jewish Home About Us Diseases We Treat ... Contact Us #1 Respiratory Hospital in the U.S. , Six consecutive years

116. Asthma, Allergy, And Pulmonary Associates Philadelphia, Pennsylvania subspecialty medical practice. Includes patient information, about the staff, the Research Center and directions including hours of operation. http://asthmallergy.com/

A sthm A llergy.com 1015 Chestnut Street, Suite 1300, Philadelphia, PA 19107 Tel: 215-923-7685 Click our link to see our new page with Flu Advice or go to www.CDC.gov for more information. Attention Allergy Shot Patients In order to adequately meet the needs of patients who have appointments and patients coming for immunotherapy, we have made changes in our scheduling. Dr. Cohn has added Monday morning hours for patient visits. However, we have had to eliminate Monday allergen immunotherapy hours, so we will have adequate support staff. If you know a great nurse who would like to join our wonderful staff, please have him or her call! Effective April 1, 2004, allergen immunotherapy will not be given on Mondays. If this represents a significant problem for you, please speak with our nurse manager, Pat Padams. Due to holidays, meetings and other obligations, modified allergy shot hours will be as follows. We thank you for your cooperation and apologize for any inconvenience: March 22, 2004 11:00AM to 2:30PM March 23, 2004 10:00AM to 3:00PM

117. Allergy Asthma Technology: Asthma & Allergy Products And Information Welcome to Allergy asthma Technology. Allergy asthma TechnologyLtd. 8224 Lehigh Avenue, Morton Grove, IL 60053 1800-621-5545. http://www.allergyasthmatech.com/

Checkout View Cart item(s) total: $0.00 Go Search Bedding Protectors Dust Mite Control Bedding Products ... Automotive Products Welcome to Allergy Asthma Technology. Here you will find valuable information on allergy, asthma and environmental control along with a wide range of products that will enhance your quality of life. Allergy Asthma Technology is the most respected company of its kind and has been helping allergic and asthmatic individuals for over thirty years. Recommended by thousands of physicians throughout the world, our company is noted as an information resource and provider of quality products. We guarantee that any information sent to our site is encrypted, protected and non-disclosed. 8224 Lehigh Avenue, Morton Grove, IL 60053

118. Project A: Knock The Breath Out Of Asthma Designed to increase teens' awareness of asthma and help sufferers take control of their disease. Requires Flash plugin. http://www.project-a.ca/

The website you are about to enter uses flash menus and may take some time to load. Please be patient, it is worth the wait. Click to Proceed

119. Asthmalearninglab.com welcome to asthmalearninglab.com, Get Free Car Quotes Here Make this your StartPage. • asthma • asthma treatment • asthma relief • Bronchial asthma http://www.asthmalearninglab.com/

welcome to asthmalearninglab.com Get Free Car Quotes Here Make this your Start Page Asthma ... Contact Us

120. Allergy, Asthma & Immunology Glosssary Words frequently encountered in literature on allergy and asthma. http://allergy.mcg.edu/glossary/index.html

ACAAI Homepage About ACAAI Bulletins Information for: Patients Physicians Employers News Media Allergy-Immunology Glossary Here are definitions of some of the words frequently encountered in literature on allergy and asthma. Please notify us if there are other words you would like added to the list. Allergy Allergies are inappropriate or exaggerated reactions of the immune system to substances that, in the majority of people, cause no symptoms. Symptoms of the allergic diseases may be caused by exposure of the skin to a chemical, of the respiratory system to particles of dust or pollen (or other substances), or of the stomach and intestines to a particular food. Anaphylaxis Anaphylaxis, or anaphylactic shock, is a severe, frightening and life-threatening allergic reaction. The reaction, although rare, can occur after an insect sting or as a reaction to an injected drug - for example, penicillin or antitetanus (horse) serum. Less commonly, the reaction occurs after a particular food or drug has been taken by mouth. Antibody An antibody is a protein (also called an immunoglobulin) that is manufactured by lymphocytes (a type of white blood cell) to neutralize an antigen or foreign protein. Bacteria, viruses and other microorganisms commonly contain many antigens, as do pollens, dust mites, molds, foods, and other substances. Although many types of antibodies are protective, inappropriate or excessive formation of antibodies may lead to illness. When the body forms a type of antibody called IgE (immunoglobulin E), allergic rhinitis, asthma or eczema may result when the patient is again exposed to the substance which caused IgE antibody formation (allergen).

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