21. EMedicine - Aplastic Anemia : Article By Sameer Bakhshi, MD aplastic anemia aplastic anemia is a bone marrow failure syndrome characterizedby peripheral pancytopenia and marrow hypoplasia. aplastic anemia. http://www.emedicine.com/MED/topic162.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Aplastic Anemia Last Updated: December 10, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: progressive hypocythemia, aregeneratory anemia, aleukia hemorrhagica, panmyelophthisis, hypoplastic anemia, toxic paralytic anemia, bone marrow failure syndrome, peripheral pancytopenia AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Sameer Bakhshi, MD , Assistant Professor, Division of Hematology and Oncology, Department of Pediatrics, All India Institute of Medical Sciences Coauthor(s): Roy Baynes, MB, BCh, PhD, FACP , Charles Martin Professor of Cancer Research, Department of Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University; Esteban Abella, MD

22. Hematopathology reduced. This is a case of aplastic anemia. Of sometimes infection. When noknown cause can be found, it is termed idiopathic aplastic anemia. http://medlib.med.utah.edu/WebPath/HEMEHTML/HEME052.html

Hematopoietic elements in this bone marrow biopsy are markedly reduced. This is a case of aplastic anemia. Of course, besides, RBC's the platelets and granulocytes will often be diminished. Sometimes a drug or toxin is the cause and sometimes infection. When no known cause can be found, it is termed idiopathic aplastic anemia.

23. Having Patience When You Are The Patient! A positive survival story. http://www.geocities.com/hotsprings/villa/4803

My name is Shari and I am an Aplastic Anemia Survivor. I am just beginning to build this page, so please be patient! In the mean time, please feel free to e-mail me at MIRACL2100@aol.com Thank you! SOMETHING ABOUT ME!!! I am a 33 year old female in remission with Aplastic Anemia. I was diagnosed in November of 1985. I was treated with over 200 blood transfusions(red cells and platelets), prednisone(steroids), ATG(Anti-Thymocyte Globulin), then, eventually had a splenectomy(removal of the spleen) in September of 1986. I was told I was in remission in the Spring of 1987. I can't ever be told that I'm cured, because, I have never had a bone marrow transplant. A bone marrow transplant is the only known CURE. Unfortunately, a perfect match could not be found for me. When I was diagnosed, my white count didn't exist at all. My hemoglobin was 4.0, and my platelet count was only 500(normal is 150,000-350,000). Therefore, my immune system was "shot". I was open to get all kinds of infections. I was bruised all over, had terrible migraines, and low blood pressure. The doctors even had to stop my menstrual cycle so I wouldn't bleed the little blood that I had left. You may be thinking, well, what's the miracle!! Well, that was all of the negative information. Now, for the positive: I've been in remission for 10 years now; I went on to finish college(I was a junior when I got sick), and, I got married. I didn't know if I'd make it through the Aplastic Anemia, and, not only have I survived the illness, I brought a new life into this world! On March 3, 1995, I delivered a healthy beautiful girl named Alexa. Her middle name is Faythe(for all the faith I had to get through the illness). I had the child that I never thought I could have, due to all of the medications I had taken.

24. Aplastic Anemia: Pathophysiology And Treatment aplastic anemia Pathophysiology and Treatment. aplastic anemia Pathophysiologyand Treatment Author(s) H Schrezenmeier and A Bacigalupo http://www.bloodline.net/stories/storyReader$1702

Bloodline Home About Call for Papers Free Membership ... Search Educational Features Image Atlas Case Studies Private Lectures Conference Reviews ... Glossary Resources Conference Calendar Hematology Links Full Text Journals Classifieds Specialties BMT/Stem Cell Cord Blood Thrombosis Hemostasis ... Veterinary News Hematology News BloodLink Newsletter Blood News Update Discussion Today's Discussion Create New Topic List by Topic Members Join Now Login Aplastic Anemia: Pathophysiology and Treatment Aplastic Anemia: Pathophysiology and Treatment Author(s): H Schrezenmeier and A Bacigalupo Cambridge University Press, n.p., 2000, 391 pages, hardbound. Significant progress has been made in the past several years in understanding the pathophysiology and causes of aplastic anemia. Likewise, the therapy of aplastic anemia has evolved as studies of both bone marrow transplantation and immunosuppressant treatments have been performed and have matured. This book is an effort to provide a concise and up-to-date summary of the currently established body of information on the pathophysiology and treatment of aplastic anemia. The editors indicate that the genesis of the book lay within the aplastic anemia working party of the European Group for Blood and Marrow Transplantation (EBMT). This book is intended for those who desire a deeper understanding of the pathophysiology of aplastic anemia and for those needing practical information on the management of patients with this disorder. A special chapter is devoted to children with acquired aplastic anemia and there is also a chapter on clonal transformation. This section ends with a chapter entitled, "Guidelines for treating aplastic anemia" which is, in fact, a concensus document from a group of international experts. Overall, this section is quite good with a thorough review of bone marrow transplantation and immunosuppressive therapy. The guideline section is practical and well written. Disappointingly, there is little review of an intriguing recent therapy for aplastic anemia using high-dose cyclophosphamide without stem cell infusion. Moreover, although this text is reasonably up-to-date in most sections, some areas are already becoming anachronistic, such as, the advice that allogeneic peripheral blood stem cells are experimental and should not be used.

25. Aplastic Anemia And Traditional Chinese Medicine In China Describes in detail how TCM practitioners in China solve this disorder with traditional Chinese strategies and herbs. http://www.tcmtreatment.com/images/diseases/aplastic-anemia.htm

TCM Hospital: Aplastic Anemia And Traditional Chinese Medicine In China Aplastic anemia is a clinical syndrome caused by a variety of etiological factors (some of them are unknown) which lead to hematopoietic disorder of bone marrow. Clinically, it is characterized by panhematopenia resulting in anemia, hemorrhage and infections. The disease often occurs in young adults. It is more common in males than in female. In TCM, it is categorized as "xu lao" (consumptive disease), "xue zheng" (blood trouble), etc. Main Points of Diagnosis According to the clinical features and pictures of bone marrow, the disease can be divided into two types¡ªacute and chronic. 1. Acute aplastic anemia: The onset is abrupt with rapid progress of the disease. There are marked symptoms of anemia, hemorrhage and infection, particularly symptoms of severe and extensive bleeding. Intracranial hemorrhage is the leading cause of death. 2.Chronic aplastic anemia: The onset of the disease is slow, and the course is persistent. Anemia is the major symptom, while the symptoms of hemorrhage and infection are relatively mild and easy to be controlled.

26. Allogeneic Marrow Grafts For Aplastic Anemia Allogeneic Marrow Grafts for aplastic anemia. Cyclophosphamide andAntithymocyte Globulin to Condition Patients With aplastic anemia http://www.bloodline.net/stories/storyReader$2533

Bloodline Home About Call for Papers Free Membership ... Search Educational Features Image Atlas Case Studies Private Lectures Conference Reviews ... Glossary Resources Conference Calendar Hematology Links Full Text Journals Classifieds Specialties BMT/Stem Cell Cord Blood Thrombosis Hemostasis ... Veterinary News Hematology News BloodLink Newsletter Blood News Update Discussion Today's Discussion Create New Topic List by Topic Members Join Now Login Allogeneic Marrow Grafts for Aplastic Anemia Cyclophosphamide and Antithymocyte Globulin to Condition Patients With Aplastic Anemia for Allogeneic Marrow Transplantations: The Experience in Four Centers Rainer Storb, Karl G.Blume, Margaret R.O'Donnell, Tom Chauncey, Stephen J.Forman, H.Joachim Deeg, Wendy W.Hu, Frederick R.Appelbaum, Kris Doney, Mary E.D.Flowers, Jean Sanders, Wendy Leisenring Biology of Blood and Marrow Transplantation 7:39-44 (2001) Download a PDF version of the full article using the link below: 7.1.Storb.pdf Carden Jennings Publishing Co., Ltd. Related Content A "Constant" Problem A Case of Hereditary Elliptocytosis Anemia Diagnosis, Classification, and Monitoring

27. The Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins aplastic anemia. About this Cancer. aplastic anemia (AA) is the medicalterm for bone marrow failure. The bone marrow, a spongy http://www.hopkinskimmelcancercenter.org/cancertypes/aplastic-anemia.cfm?canceri

28. The Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins The aplastic anemia Controversy. What is the best therapy for the rare but deadlyblood disorder known as aplastic anemia? It depends on whom you ask. http://www.hopkinskimmelcancercenter.org/publications/publication.cfm?DocumentID

29. Ilir's Progress With Aplastic Anemia Includes information about aplastic anemia and Ilir's progress with this disease. http://www.geocities.com/ilir_status/

Ilir Kullolli On this page About Ilir Kullolli Aplastic Anemia Blood elements ... Links On this site Pictures of Ilir Discussion List Recent Pictures. New!!! This page was last updated on: July 5, 2001 Ilir Kullolli is an International Student from Albania. He was attending Cerro Coso Community College in Ridgecrest, California when he was diagnosed with Aplastic Anemia. He was hospitalized on November 17, 1999. After getting better he transferred to Wentworth Institute of Technology in Boston, Massachusetts and graduated with a Bachelor of Science in Computer Engineering in December 2003. Now he's doing very well and he seems to be sick-free. Aplastic Anemia: An injury to the bone marrow; specifically the stem cells. Stem cells make red and white cells and platelets. The injury may be genetic, caused by viruses, drugs or other toxins. One known cause is an antibiotic used in Europe called Chloramphenocol. People who get this have a 1 in 30,000 chance of contracting blood disorders such as Aplastic Anemia. Ilir received this drug three years ago in Albania when he had appendicitis. The doctor is skeptical of this as a cause because of the time between it and the onset of the disease. [back to index] Blood elements Hemoglobin: Carries oxygen from the lungs to the body and Carbon Dioxide back to the lungs.

30. Discovery Health Aplastic Anemia aplastic anemia is a condition in which the bone marrow fails to produceblood cells. search, aplastic anemia. By Thomas Fisher, MD. http://health.discovery.com/diseasesandcond/encyclopedia/533.html

31. Discovery Health :: Aplastic Anemia aplastic anemia is a condition in which the bone marrow fails to produceblood cells. May 22, 2004 EDT. aplastic anemia. By Thomas Fisher, MD. http://health.discovery.com/encyclopedias/533.html

postionList = "compscreen,hedthick,admedia,tower,nuiad"; OAS_RICH("admedia"); June 06, 2004 EDT OAS_RICH("hedthick"); aplastic anemia By Thomas Fisher, MD Aplastic anemia is a condition in which the bone marrow fails to produce blood cells. What is going on in the body? The bone marrow contains special cells known as stem cells. Stem cells are like infant cells. They may develop into red blood cells, white blood cells, and platelets. Red blood cells carry oxygen throughout the body. White blood cells fight infection. Platelets control bleeding by forming blood clots in certain situations. Blood cells have a limited life, so new ones are made constantly. Certain conditions can damage stem cells or change their environment. The stem cells stop making blood cells. The bone marrow fills up with fat, instead of developing blood cells. The low level of red blood cells, white blood cells, and platelets in the body is known as aplastic anemia. What are the signs and symptoms of the condition? A person with aplastic anemia may have the following symptoms: fatigue pale skin rapid heartbeat weakness What are the causes and risks of the condition?

32. MEdIC - Health Explorer - Iron Overload MEdIC aplastic anemia patients who receive repeated blood cell transfussions may develop iron overload. A look at this condition and who needs treatment. http://medic.med.uth.tmc.edu/ptnt/00001041.htm

Iron Overload Aplastic anemia patients who receive repeated blood cell transfussions may develop iron overload. Iron from transfused red cells builds up in the blood and eventually accumulates in the heart, liver, pancreas, and endocrine organs. This excess iron may eventually damage vital organs and cause complications like liver disease, heart disease, and diabetes mellitus. Normal body iron stores are 3-4 grams. Each unit of transfused red cells contains 200-250 mg of iron. Thus, a patient who receives 2 units of blood each month would accumulate approximately 5-6 g of extra iron in one year. Without treatment to remove excess iron, damage to the heart and other organs occurs in patients who have received as few as 100 units of blood, or 20 grams of excess iron. Visible signs of iron overload, such as bronze or slate grey skin pigmentation, don't usually appear until enough iron has accumulated to cause tissue damage. In the United States, the only way to prevent or treat iron overload is with the iron chelating drug deferoxamine (Desferal). Desferal binds excess body iron and promotes its excretion by the kidneys in urine and via the bile in feces. Desferal is administered by subcutaneous or intravenous infusion by a small portable pump about the size of a Walkman. Typically the patient inserts a subcutaneous needle and wears the pump for 9-12 hours each day, usually at night while sleeping. Severely iron overloaded patients may need a continuous infusion through an indwelling central venous catheter. Several studies have demonstrated that regular chelation therapy with Desferal can remove excess body iron, prevent organ damage, and prolong life.

33. InteliHealth: Aplastic Anemia crossreferenced in an AZ format. aplastic anemia. Health A to Z, Reviewedby the Faculty of Harvard Medical School aplastic anemia http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/20861.html

chrome_imgPreload('gifChr_mid_but_home_mo_1','http://img.intelihealth.com/i/C/Chr_mid_but_home-o.gif'); chrome_imgPreload('gifChr_mid_but_comm_mo_2','http://img.intelihealth.com/i/C/Chr_mid_but_comm-o.gif'); chrome_imgPreload('gifChr_mid_but_dental_mo_3','http://img.intelihealth.com/i/C/Chr_mid_but_dental-o.gif'); chrome_imgPreload('gifChr_mid_but_drug_mo_4','http://img.intelihealth.com/i/C/Chr_mid_but_drug-o.gif'); chrome_imgPreload('gifChr_mid_but_askexpert_mo_5','http://img.intelihealth.com/i/C/Chr_mid_but_askexpert-o.gif'); chrome_imgPreload('gifChr_mid_but_medical_mo_6','http://img.intelihealth.com/i/C/Chr_mid_but_medical-o.gif'); chrome_imgPreload('gifChr_mid_but_chats_mo_7','http://img.intelihealth.com/i/C/Chr_mid_but_chats-o.gif'); chrome_imgPreload('gifchr_mid_but_news_mo_8','http://img.intelihealth.com/i/c/chr_mid_but_news-o.gif'); chrome_imgPreload('gifChr_mid_but_privacy_mo_9','http://img.intelihealth.com/i/C/Chr_mid_but_privacy-o.gif'); Advertisement Aplastic Anemia What Is It? Symptoms Diagnosis Expected Duration ... Additional Info What Is It? Aplastic anemia is a rare, potentially fatal disease in which the bone marrow doesn't make enough blood cells. People with aplastic anemia have low levels of all three types of blood cells:

34. Fanconi Anaemia Resource Page A rare disorder found in children that involves the blood and bone marrow. The symptoms include severe aplastic anemia, hypoplasia of the bone marrow, and patchy discoloration of the skin. http://www.cancerindex.org/ccw/fanconi.htm

Home Site Map Cancer Types Treatments ... About Fanconi Anaemia Menu Cancer-Types Fanconi Anaemia What is Fanconi Anaemia ? Fanconi Anaemia is a rare disorder found in children that involves the blood and bone marrow. The symptoms include severe aplastic anemia , hypoplasia of the bone marrow, and patchy discoloration of the skin. This is an autosomal recessive condition, affected children usually develop severe aplastic anemia by age 8 to 9 years. Treatment usually consists of bone marrow transplant. Fanconi Anaemia is not a cancer, though recent research has shown an association between Fanconi Anaemia and leukaemia. There are 8 types of Fanconi Anaemia; known as complementation groups A through to H. Some definitions: Anemia below normal levels of erythrocytes (red blood cells) Aplastic anemia anemia that is resistant to treatment; often accompanied by deficiencies of other blood cells. Hypoplasia incomplete / under development of a part of the body. Pancytopenia deficiency of all types of blood cells. Recessive (genetics) if the required allele (a type of gene) is not present in both members of a pair of chromosomes then that allele is not expressed.

35. InteliHealth: It occurs when the amount of hemoglobin in the blood decreases. aplastic anemia. Anemia,Reviewed by the Faculty of Harvard Medical School aplastic anemia http://www.intelihealth.com/IH/ihtIH/WSIHW000/14294/29412.html

chrome_imgPreload('gifChr_mid_but_home_mo_1','http://img.intelihealth.com/i/C/Chr_mid_but_home-o.gif'); chrome_imgPreload('gifChr_mid_but_comm_mo_2','http://img.intelihealth.com/i/C/Chr_mid_but_comm-o.gif'); chrome_imgPreload('gifChr_mid_but_dental_mo_3','http://img.intelihealth.com/i/C/Chr_mid_but_dental-o.gif'); chrome_imgPreload('gifChr_mid_but_drug_mo_4','http://img.intelihealth.com/i/C/Chr_mid_but_drug-o.gif'); chrome_imgPreload('gifChr_mid_but_askexpert_mo_5','http://img.intelihealth.com/i/C/Chr_mid_but_askexpert-o.gif'); chrome_imgPreload('gifChr_mid_but_medical_mo_6','http://img.intelihealth.com/i/C/Chr_mid_but_medical-o.gif'); chrome_imgPreload('gifChr_mid_but_chats_mo_7','http://img.intelihealth.com/i/C/Chr_mid_but_chats-o.gif'); chrome_imgPreload('gifchr_mid_but_news_mo_8','http://img.intelihealth.com/i/c/chr_mid_but_news-o.gif'); chrome_imgPreload('gifChr_mid_but_privacy_mo_9','http://img.intelihealth.com/i/C/Chr_mid_but_privacy-o.gif'); Advertisement Aplastic Anemia What Is It? Symptoms Diagnosis Expected Duration ... Additional Info What Is It? Aplastic anemia is a rare, potentially fatal disease in which the bone marrow doesn't make enough blood cells. People with aplastic anemia have low levels of all three types of blood cells:

36. MayoClinic.com - Aplastic Anemia aplastic anemia occurs when your bone marrow stops producing new bloodcells. It s aplastic anemia By Mayo Clinic staff Overview http://www.mayoclinic.com/invoke.cfm?id=DS00322

37. Aplastic Anemia - Wikipedia, The Free Encyclopedia aplastic anemia. aplastic anemia is a condition where bone marrow doesnot produce enough, or any, new cells to replenish the blood. http://en.wikipedia.org/wiki/Aplastic_anemia

38. Aplastic Anemia Note All links within content go to MayoClinic.com. Diseases and Conditions.aplastic anemia. From MayoClinic.com Special to CNN.com. Overview. http://www.cnn.com/HEALTH/library/DS/00322.html

International Edition MEMBER SERVICES The Web CNN.com Home Page World U.S. Weather ... Special Reports SERVICES Video E-mail Services CNNtoGO Contact Us SEARCH Web CNN.com In association with: Anemia Anemia Aplastic anemia Iron deficiency anemia Sickle cell anemia ... Vitamin deficiency anemia INFORMATION CENTERS: Pick a category Health Centers Family Health Men's Health Women's Health Children's Health Seniors' Health Working Life Pain Management Condition Centers Immune System Allergy Alzheimer's Arthritis Respiratory System Cancer Endocrine System Digestive System Heart and Blood Infectious Disease Mental Health Note: All links within content go to MayoClinic.com Diseases and Conditions Aplastic anemia From MayoClinic.com Special to CNN.com Overview Anemia occurs when blood is low in red blood cells. Red blood cells carry oxygen from your lungs to all parts of your body. Without enough red blood cells, your body can't get all of the oxygen it needs and you feel fatigued. In aplastic anemia, the bone marrow stops producing enough new blood cells. This means that you have not only a deficit of red blood cells but also a shortage of white blood cells to fight germs and platelets to help blood clot. You're at higher risk of infections and uncontrolled bleeding. A rare and serious condition, aplastic anemia can develop at any age. The cause is a mistaken immune system response that destroys bone marrow. A condition known as secondary aplastic anemia can develop when bone marrow is damaged by cancer, chemotherapy, certain medications, pregnancy or exposure to toxic substances.

39. NORD - National Organization For Rare Disorders, Inc. Disorder Subdivisions General Discussion aplastic anemia is a rare bone marrow disordercharacterized by decreased function of the bone marrow that results in http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Anemia, Aplas

40. Disease Category Listing (282): Aplastic Anemia Clinical Trials aplastic anemia. New York. New York; ColumbiaPresbyterianMedical Center Study of standard chemotherapy and radiotherapy http://www.centerwatch.com/patient/studies/cat282.html

Clinical Trials: Aplastic Anemia New York New York; Columbia-Presbyterian Medical Center Study of standard chemotherapy and radiotherapy before allogeneic stem cell transplantation New York; Columbia-Presbyterian Medical Center Study of transplantation using umbilical cord and placental blood Back to Clinical Trials by Medical Areas Research centers specializing in this illness area Additional resources ... in this illness area This site is run by CenterWatch, a publishing company that focuses on the clinical trials industry. The information provided in this service is designed to help patients find clinical trials that may be of interest to them, and to help patients contact the centers conducting the research. CenterWatch is neither promoting this research nor involved in conducting any of these trials. Trial listing updated: May 4, 2004 at 12:49:04 PM Patient Resources: [ Trial Listing Notification Services Drug Directories About Clinical Research ... Patient Bookstore Professional Resources: [ Research Center Profiles Industry Provider Profiles Industry News Professional Resources ... Professional Bookstore General: [ Search Site Map Your Privacy CW World ... Home This site was developed in association with Illumina Interactive of Boston, MA

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