1. Aplastic Anemia & Myelodysplastic Syndromes International Foundation, Inc. - Ser aplastic anemia MDS (Myelodysplastic Syndromes) International Foundation, Inc. Youare Visitor No aplastic anemia MDS International Foundation, Inc. http://www.aplastic.org/

In The News - Updates on diseases and treatments. Frequently Asked Questions Want to Talk? - Network with other patients and families. Enroll in our Patient Registry to help researchers compile data on these diseases Merchandise Purchases help Fight AA and MDS Collaborative Clinical Trials Study Group You are Visitor No: P.O. Box 613 Annapolis, Maryland 21404-0613 USA Tel: 800.747.2820 Fax 410.867.0240 E-Mail help@aamds.org We subscribe to the HONcode principles of the Health On the Net Foundation This site was selected for inclusion in Current Web Contents , published by ISI (Institute for Scientific Information); and MedlinePlus Health Information , published by NLM (National Library of Medicine). Site designed, marketed and maintained by

2. MEdIC - Aplastic Anemia Answer Book aplastic anemia Answer Book. aplastic anemia The Disease. aplastic anemia is a rare but extremely serious disorder that results from the unexplained failure of the bone marrow to produce blood cells. by providing basic information about aplastic anemia and the various treatment options http://medic.med.uth.tmc.edu/ptnt/00001038.htm

Aplastic Anemia Answer Book Aplastic Anemia - The Disease Aplastic anemia is a rare but extremely serious disorder that results from the unexplained failure of the bone marrow to produce blood cells. In all probability you had never heard of this disease until the time of diagnosis. We hope that this pamphlet helps you deal with your situation by providing basic information about aplastic anemia and the various treatment options. This pamphlet is not intended as a substitute for the advice of a physician. It is important that you ask questions and learn as much as you can about this disease. By contacting the Aplastic Anemia Foundation of America, you can be connected with others in your same situation and receive information free of charge. There are AAFA chapters around the country. You do not need to be alone in dealing with aplastic anemia. Normal Bone Marrow Function The central portion of bones is filled with a spongy red tissue called bone marrow. The bone marrow is essentially a factory producing the cells of the blood: red cells that carry oxygen from the lungs to all areas of the body, white cells that fight infection by attacking and destroying germs, and platelets that control bleeding by forming blood clots in areas of injury. Continuous production of blood cells is necessary all through life because each cell has a finite life span once it leaves the bone marrow and enters the blood: red cells120 days, platelets6 days, and white cellsone day or less!

3. Aplastic Anemia (Severe), Basic This page provides a basic overview of the symptoms, diagnosis, possible treatmentoptions for severe aplastic anemia. aplastic anemia (Severe), basic http://www.marrow.org/MEDICAL/aplastic_anemia_basic.html

Aplastic Anemia (Severe), advanced Home Medical Information Diseases Treatable By Stem Cell Transplantation > Aplastic Anemia (Severe), basic Aplastic Anemia (Severe), basic Many articles on this Web site are written at two levels: The basic version is written at an introductory level and includes explanations of medical terminology. The advanced version contains in-depth information written in the style of a medical journal. Jump to a Section: Symptoms/Diagnosis Treatment Transfusions Drug Therapies ... Blood Stem Cell Transplantation Aplastic anemia is not a single disease, but a group of closely related disorders characterized by the failure of the bone marrow to produce all three types of blood cells: red blood cells, white blood cells and platelets. Aplastic anemia is rare, affecting fewer than 1,000 people each year in the United States. The exact cause of aplastic anemia is unknown, although it has been linked to exposure to chemicals and radiation. It is also believed that some cases of aplastic anemia are inherited and that some cases are due to a viral infection. Symptoms/Diagnosis In aplastic anemia, the quantity of each of the three blood cell types is much lower than normal, which leads to the symptoms that cause a physician to suspect the disease. These symptoms are unexplained infections (due to fewer white blood cells), unexpected bleeding (due to fewer platelets) and fatigue (due to fewer red blood cells).

4. Aplastic Anemia aplastic anemia AA MDS resource center providing useful information to aplastic anemia patients, families, relatives and friends. I was diagnosed with aplastic anemia in January of 2001 and after http://www.aplasticcentral.com/

Aplastic Anemia and Autoimmune Diseases book on sale!! Entire Web Aplastic Central BASICS RESEARCH Talk HOLISTIC ... EHCD DETOX HOLISTIC SPIRIT FIND A DOC COFFEE ENEMA ... Meals Thank you for visiting Aplastic Anemia Central. If this is your first visit, you may want to start by clicking here. I hope you find the information and stories useful in your own personal struggle. You will learn of the successes and failures of many Aplastic Anemia and MDS patients-some using conventional treatment protocols and others using alterative approaches. Judge for yourself what is working and take the time to learn everything you can about yourself, the illnesses and the approaches used to treat them. If you have questions, please visit the forum , an area where patients support patients or feel free to email me directly at bdl@twcny.rr.com

5. Aplastic Anemia & MDS International Foundation, Inc. - Serving Patients With Apl aplastic anemia MDS (Myelodysplastic Syndromes) International Foundation,Inc. It wasn t until 1904 that this disorder was termed aplastic anemia. http://www.aplastic.org/diseases.shtml

The is the only organization in the world maintaining a voluntary Patient Registry to keep track of aplastic anemia, MDS and PNH patients for statistical analysis. Because these are not reportable diseases, statistics are not available to assist research and medical studies. Patients or family members may complete the Patient Registry Questionnaire online or download a print version and postal mail the form to us. Learn more about aplastic anemia, MDS and PNH. Read recent news items. Find out about clinical studies for aplastic anemia, MDS or PNH patients. In the United States, thousands of men, women and children are stricken with these non-contagious bone marrow diseases every year. They occur when the bone marrow stops making enough healthy blood cells. Although all of the causes are still unknown, they have been linked to toxins and viruses that we are in contact with every day. APLASTIC ANEMIA MDS PNH Aplastic anemia can be traced as far back as 1888 when a famous German pathologist, Dr. Paul Ehrlich, studied the case of a pregnant woman who died of bone marrow failure. It wasn't until 1904 that this disorder was termed aplastic anemia. Aplastic anemia occurs when the bone marrow stops making enough blood cells. The bone marrow is almost empty of blood forming cells and is described as

6. Aplastic Anemia-Blood Diseases & Disorders Overview of aplastic anemia aplastic anemia. What is aplastic anemia? aplastic anemia occurs when the bone marrow produces too few of all three What causes aplastic anemia? aplastic anemia has multiple causes http://www.umm.edu/blood/aneaplas.htm

Donations / Banking Blood Diseases Blood Disorders... Anemias ... Site Map Related Resources Within UMM Hematology Pediatric Oncology Blood Diseases Aplastic Anemia What is aplastic anemia? Aplastic anemia occurs when the bone marrow produces too few of all three types of blood cells: red blood cells, white blood cells, and platelets. A reduced number of red blood cells causes hemoglobin to drop. A reduced number of white blood cells makes the patient susceptible to infection. And, a reduced number of platelets causes the blood not to clot as easily. What causes aplastic anemia? Aplastic anemia has multiple causes. Some of these causes are idiopathic, meaning they occur sporadically for no known reason. Other causes are secondary, resulting from a previous illness or disorder. Acquired causes, however, may include the following: history of specific infectious diseases such as infectious hepatitis history of taking certain medications, such as antibiotics and anticonvulsants exposure to certain toxins such as heavy metals exposure to radiation history of an autoimmune disease inherited condition What are the symptoms of aplastic anemia?

7. MEdIC - Aplastic Anemia - Introduction For The General Physician aplastic anemia is a hematologic disorder characterized by a decrease in the cellular elements of the peripheral to bone marrow failure. aplastic anemia develops before age 3040 in http://medic.med.uth.tmc.edu/ptnt/00001040.htm

Aplastic Anemia: Introduction for the General Physician Aplastic anemia is a hematologic disorder characterized by a decrease in the cellular elements of the peripheral blood. This results from underproduction of peripheral blood elements due to bone marrow failure. Aplastic anemia develops before age 30-40 in patients who are predisposed due to a congenital chromosomal abnormality such as Fanconi's anemia or dyskeratosis congenita. Acquired aplastic anemia may be caused by toxic chemicals, radiation, or by idiosyncratic reactions to medications or infections. However, in over 50% of cases there is no identifiable cause and the condition is then referred to as idiopathic aplastic anemia. Making the Diagnosis Patients with aplastic anemia generally present with symptoms of bleeding or bruising due to the thrombocytopenia (low platelets), tiredness or pallor due to the anemia (low hemoglobin), or infection due to the neutropenia (low white blood cell count). A complete blood count and reticulocyte count usually show depression of all blood elements (pancytopenia). The peripheral blood smear shows no abnormal cells. The diagnosis is confirmed by a bone marrow biopsy with an assessment of cellularity. The bone marrow is also evaluated for the degree of maturation of all cell lines. Aplastic anemia is usually categorized as severe if, in addition to a hypocellular bone marrow for age, two of the three following criteria are present: a platelet count of less than 20,000/mm3, a corrected reticulocyte count of less than 1%, and a granulocyte or absolute neutrophil count [ANC = total white count x (segs + bands)] of less than 500/mm3. Patients With pancytopenia, but not severe enough to meet the above criteria, have mild or moderate aplastic anemia. Very severe aplastic anemia exists if the ANC or granulocyte count is less than 200/mm3.

8. Pathology - Table Of Contents An introduction, etiology, incidence, diagnosis and treatment are some of the topics discussed. http://medic.med.uth.tmc.edu/edprog/00000146.htm

Pathology Fall 2002 Table of Contents Announcements Links to Online Lecture Videos Links to Immunopatholgy of Hypersensitivity Diseases Lecture Links to Immunodeficiency Lecture Pulmonary Powerpoint Presentations ... Pathology Image Booklets Block III General Course Policies and Information General Course Information Videotaping Policy UTMS Guidelines of Academic Dishonesty Contact Information and Faculty Participants ... Block 3 Lecture Schedule Laboratory Images Block 3 Lab Images Infectious Disease Lab Infectious Disease Lab Infectious Disease Lab Answers Endocrine Disease Lab Endocrine Disease Lab Endocrine Disease Lab Answers Male Reproductive Disease Male Reproductive Lab Male Reproductive Lab Answers Pediatric Disease Lab Pediatric Pathology Lab, Part 1 Pediatric Pathology Lab, Part 2 Female Reproductive Disease Lab Female Reproductive Lab I Female Reproductive Lab II Gastrointestinal Disease Lab Gastrointestinal Lab I, Part 1

9. Aplastic Anemia / Family Village Library Who to Contact. Where to Go to Chat with Others. Learn More About It. Web Sites. Search Google for "aplastic anemia" Who to Contact. aplastic anemia MDS International Foundation, Inc. P.O. Box 613 . http://www.familyvillage.wisc.edu/lib_apls.htm

Aplastic Anemia Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Aplastic Anemia" Who to Contact P.O. Box 613 Annapolis, Maryland 21404-0613 USA 800-747-2820 (toll-free) 410-867-0242 (phone) 410-867-0240 (fax) E-Mail: help@aamds.org Web: http://www.aplastic.org/ The Aplastic Anemia Foundation of America provides free educational materials and updated medical information, serves as a resource directory for patient assistance and emotional support, and financially support research for Aplastic Anemia and related syndromes. AAFA publishes a quarterly newsletter at no charge. There are also various publications and fact sheets available including, Drug Therapy, and Bone Marrow Transplantation. They have audio tapes and books that are free, and are printed in English, Spanish, French, and Japanese. Where to Go to Chat with Others AA-MDS-TALK A listserve based mailing list in support of Aplastic Anemia (AA) and Myelodysplastic Syndromes (MDS) patients, friends, families, and care providers Learn More About It Aplastic Anemia Aplastic Anemia Answer Book Idiopathic aplastic anemia From the MEDLINEplus Medical Encyclopedia Aplastic Anemia: Pathophysiology and Treatment Web Sites Aplastic Anaemia Trust - United Kingdom Back to [ A - B Family Village Home Library Coffee Shop ... Information Last Updated 11/24/2003 by familyvillage@waisman.wisc.edu

10. Katelyn Rose Hubbell Beats Aplastic Anemia Personal page of this young resident that won her battle against Severe aplastic anemia. http://www.katyhubbell.com/

Click a flag above to translate this page into the language of your choice! To Katelyn Rose Hubbell's Aplastic Anemia Website! Katelyn in May, 2004...looking all grown up! Happy 5th "re-birthday" Katy!!! Taking a cell call from her agent! :o) If you're looking for NEW pictures (added 12/08/03).. CLICK HERE! Katy's Story Katelyn Rose Hubbell turned four years old on June 26th 1997, and had a big party at her home in Fisher, Illinois. She was a happy, healthy little girl, until July 11, 1997 when she was diagnosed with a life threatening bone marrow failure disease called Severe Aplastic Anemia. In case you didn't know, bone marrow is the soft spongy material inside your bones that is home to stem cells. Stem Cells are the little factories that produce the three types of blood cells, that along with a liquid called plasma, makes up your blood. In people with Aplastic Anemia, the workers in the "factory" go on strike. They do not produce enough blood cells to keep the patient alive. There are three main types of blood cells.

11. Catherine's Page Catherine is a currently undergoing a bone marrow transplant. Her page is for those interested in aplastic anemia, myelodysplasia, and bone marrow transplant issues. Includes links to BMT resources. http://www.geocities.com/catmac1991/

12. Aplastic Anemia & Myelodysplastic Syndromes International Foundation, Inc. - Ser AAMDS's mission is to serve as a resource directory for patient assistance and emotional support; provide educational materials and updated medical information; and financially support research to find effective treatments for aplastic anemia and myelodysplastic syndromes. http://www.aamds.org

In The News - Updates on diseases and treatments. Frequently Asked Questions Want to Talk? - Network with other patients and families. Enroll in our Patient Registry to help researchers compile data on these diseases Merchandise Purchases help Fight AA and MDS Collaborative Clinical Trials Study Group You are Visitor No: P.O. Box 613 Annapolis, Maryland 21404-0613 USA Tel: 800.747.2820 Fax 410.867.0240 E-Mail help@aamds.org We subscribe to the HONcode principles of the Health On the Net Foundation This site was selected for inclusion in Current Web Contents , published by ISI (Institute for Scientific Information); and MedlinePlus Health Information , published by NLM (National Library of Medicine). Site designed, marketed and maintained by

13. The National Marrow Donor Program Provides marrow transplants from volunteer unrelated donors to patients with leukemia, aplastic anemia and other potentially lifethreatening blood diseases. http://www.marrow.org/

NEW ON THE SITE: Gift of Life Associate Registry Increases Donor Pool Cord Blood CDs for Medical Professionals NMDP, IBMTR/ABMTR Partner to Expand Transplant Research Download Slides: ... Cord Blood FAQs HOT SPOTS: Update Your Address Join the Registry NMDP Cord Blood Banks Donor Center Map ... Mapping the Maze: A Patient Financial Guide Connecting with Asian and Pacific Islander Medical Students APAMSA Encourages Asian-Americans to Join the NMDP Donor Registry During April, the Asian Pacific American Medical Student Association (APAMSA) is responding to the need for more donors for patients needing a blood stem cell transplant. Continue... NMDP Online Privacy Statement Last Revised 05/20/04

14. NMDP - Treatment Of Acquired Aplastic Anemia, Advanced This page provides a basic overview of the symptoms, diagnosis, possibletreatment options for severe aplastic anemia. NMDP Home, http://www.marrow.org/MEDICAL/aplastic_anemia_advanced.html

Home Medical Information Diseases Treatable By Stem Cell Transplantation Aplastic Anemia (Severe), basic > Aplastic Anemia (Severe), advanced Treatment of Acquired Aplastic Anemia, advanced September, 25, 1998 by Bruce M. Camitta, M.D. Rebecca Jean Slye Professor of Pediatric Hematology-Oncology Midwest Children's Cancer Center, Department of Pediatrics Medical College of Wisconsin and the Children's Hospital of Wisconsin Milwaukee, Wisconsin U.S.A. Many articles on this Web site are written at two levels: The basic version is written at an introductory level and includes explanations of medical terminology. The advanced version contains in-depth information written in the style of a medical journal. Jump to a Section: Abstract Background Definitions: Severity and Response Treatment: Non-Transplant ... References Abstract Return to Top Background Aplastic anemia is a group of acquired and inherited disorders characterized by deficient hematopoietic stem cells, a hypocellular bone marrow, and peripheral blood cytopenias. The incidence of aplastic anemia is approximately 2-3 cases per million population per year in Europe and the United States. For unknown reasons the disease is 2 to 3 times more frequent in many Asian countries. These estimates do not include patients in whom predictable bone marrow suppression develops after exposure to irradiation, chemotherapy or other drugs. Similarly, patients who develop marrow failure as a precursor to acute leukemia or myelodysplastic syndromes are not considered to have aplastic anemia.

15. Earl J. Goldberg Aplastic Anemia Foundation - Home Offers information about the organization, contact details, education and awareness and patient services. http://www.ejgaaf.org/

Upcoming Events Open Board Meeting User ID: Password: While not required, please sign on, in order for us to serve you better! What are Aplastic Anemia and Myelodysplastic Syndromes? Aplastic Anemia and Myelodysplastic Syndromes are diseases that cause bone marrow failure that result in decreased production of red cells, white cells and platelets. Each disease may have multiple causes, either acquired or inherited. Acquired causes include exposure to certain chemicals, drugs, pesticides, excessive radiation or viral infections. Inherited disease is caused by a genetic disorder. Treatments include drug therapies and bone marrow transplantation. These important goals of the EJGAAF are achieved through your support! Take the Challenge! You can make this happen! Our Mission Finding a Cure ... Patient Services EJGAAF is a 501(c)3 non-profit volunteer organization. You are visitor no:

16. EMedicine - Aplastic Anemia : Article By Sameer Bakhshi, MD aplastic anemia aplastic anemia is a bone marrow failure syndrome characterized by peripheral pancytopenia and marrow hypoplasia. Paul Ehrlich, MD, introduced the concept of aplastic anemia in http://www.emedicine.com/med/topic162.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Aplastic Anemia Last Updated: December 10, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: progressive hypocythemia, aregeneratory anemia, aleukia hemorrhagica, panmyelophthisis, hypoplastic anemia, toxic paralytic anemia, bone marrow failure syndrome, peripheral pancytopenia AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Sameer Bakhshi, MD , Assistant Professor, Division of Hematology and Oncology, Department of Pediatrics, All India Institute of Medical Sciences Coauthor(s): Roy Baynes, MB, BCh, PhD, FACP , Charles Martin Professor of Cancer Research, Department of Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University; Esteban Abella, MD

17. Aplastic Anemia And Myelodysplasia Association Of Canada can participate in. Understanding aplastic anemia and Myelodysplasia. Whatare aplastic anemia and Myelodysplasia? aplastic anemia is http://www.aplastic.ualberta.ca/

Aplastic Anemia and Myelodysplasia Association of Canada NEW: View Dr. Well's Presentation on MDS (April 2004) NEW: (updated May 10, 2004) Make a Donation Research you can participate in Understanding Aplastic Anemia and Myelodysplasia Description Causes Treatments How can I help? We also have numerous documents generously supplied by the You can obtain these educational materials and MORE by calling our toll-free line . Also, ask to get on our mailing list. Aquired Aplastic Anemia - Basic Explanations Myelodysplastic Syndromes - Basic Explanations PNH - Basic Explanations Teachers/School Nurses Guide to Bone Marrow Failure Disease The Association Mandate Board of Directors How to Contact Us Other AAMAC Links Alberta Chapter Home Page British Columbia Chapter Home Page Other AA/MDS Associations AA-MDS-TALK Mailing List The Aplastic Anaemia Trust The Myelodysplastic Syndromes Foundation Anemia-Related Links PNH On-Line Support Group Fanconi Canada Anemia Institute for Research and Education Thalassemia Foundation of Canada ... Canadian Celiac Association Blood-Related Links Canadian Blood Services Hema-Quebec Bone Marrow Registry CIMFR - Canadian Inherited Marrow Failure Registry ... Canadian Hemophilia Society What are Aplastic Anemia and Myelodysplasia?

18. Aplastic Anemia And Myelodysplasia Association - Alberta aplastic anemia and Myelodysplasia Association of Canada. AlbertaChapter The members of the Alberta chapter work in their local http://www.aplastic.ualberta.ca/alta.html

Aplastic Anemia and Myelodysplasia Association of Canada Alberta Chapter The members of the Alberta chapter work in their local communities to provide patient support for people with aplastic anemia, myelodysplastic syndromes and PNH, to disseminate information about the disorders, to support the Canadian Blood Services programs directly affecting patients with bone marrow failure diseases, and to raise funds to support research. Our provincial group meets at least once a year. Sometimes it is a formal meeting with a speaker, and at other times we hold patient support group meetings. Each year in the fall we participate in Awareness Week. The idea is to increase the public's awareness of bone marrow failure diseases, and the continual need for blood products and the bone marrow registry. If you would like to do some awareness activities in your region, please contact us at the chapter. We would be happy to help you out! Fundraising is another one of our objectives. Each year we have some fundraisers. This year (2004) we will be participating in the Great Human Race in Edmonton.

19. MedlinePlus Medical Encyclopedia: Idiopathic Aplastic Anemia Idiopathic aplastic anemia. Definition Return to top. Idiopathic aplastic anemiais a failure of the bone marrow to properly form all types of blood cells. http://www.nlm.nih.gov/medlineplus/ency/article/000554.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Idiopathic aplastic anemia Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Bone marrow aspiration Antibodies Alternative names Return to top Anemia - idiopathic aplastic Definition Return to top Idiopathic aplastic anemia is a failure of the bone marrow to properly form all types of blood cells. Causes, incidence, and risk factors Return to top Idiopathic aplastic anemia is a condition that results from injury to the stem cell, a cell that gives rise to other cell types after it divides. Consequently, there is a reduction in all cell types red blood cells, white blood cells and platelets with this type of anemia , which is called pancytopenia. The cause of idiopathic aplastic anemia is unknown, but is thought to be an autoimmune process (the body reacting against its own cells). Causes of other types of aplastic anemia may be chemotherapy radiation therapy toxins , drugs, pregnancy, congenital disorder, or systemic lupus erythematosus Symptoms arise as the consequence of bone marrow failure. Llow red blood cell count (anemia) leads to fatigue and weakness. Low white blood cell count (leukopenia) causes an increased risk of infection. Low platelet count (

20. MedlinePlus Medical Encyclopedia: Secondary Aplastic Anemia Secondary aplastic anemia. Alternative names Return to top. Anemia secondaryaplastic; Acquired aplastic anemia Definition Return to top. http://www.nlm.nih.gov/medlineplus/ency/article/000529.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Secondary aplastic anemia Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Bone marrow aspiration Blood types Alternative names Return to top Anemia - secondary aplastic; Acquired aplastic anemia Definition Return to top Secondary aplastic anemia is a failure of the bone marrow to form enough blood cells. All blood cell types are affected. Causes, incidence, and risk factors Return to top Secondary aplastic anemia results from injury to stem cells. Normal stem cells divide and differentiate into all blood cell types. Thus, when stem cells are injured, there is a reduction in red blood cells, white blood cells, and platelets. This condition can be caused by chemotherapy, drug therapy to suppress the immune system, radiation therapy, toxins such as benzene or arsenic, drugs, pregnancy, and congenital disorders. When the cause is unknown, it is then referred to as idiopathic aplastic anemia The disease may be acute or chronic and is usually gets worse unless the cause is removed.

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