61. Autoimmune Inner Ear Disease (AIED) Both allergy and traditional autoimmune disease such as ankylosing spondylitis, Systemic Lupus Erythematosis (SLE), Sjoegren s syndrome (dry eye syndrome http://www.tchain.com/otoneurology/disorders/autoimmune/aied.html

Autoimmune Inner Ear Disease (AIED) Timothy C. Hain, MD Last edited: 1/2003. Please read our AIED defined How common is it Diagnosis Treatment Education Index Autoimmune inner ear disease or "AIED" consists of a syndrome of progressive hearing loss and/or dizziness which is caused by antibodies or immune cells which are attacking the inner ear. The classic picture is reduction of hearing accompanied by tinnitus (ringing, hissing, roaring) which occurs over a few months. Variants are bilateral attacks of hearing loss and tinnitus which resemble Meniere's disease , and attacks of dizziness accompanied by abnormal blood tests for self-antibodies. About 50% of patients with AIED have balance symptoms. The immune system is complex and there are several ways that it can damage the inner ear. Both allergy and traditional "autoimmune disease" such as Ankylosing spondylitis , Systemic Lupus Erythematosis (SLE), Sjoegren's syndrome (dry eye syndrome), Cogan's disease , ulcerative colitis, Wegener's granulomatosis, rheumatoid arthritis, and scleroderma can cause or be associated with AIED. Another multisystem disease

62. Alan Ebringer: Publications the CYP2D6 gene increase susceptibility to ankylosing spondylitis Human Molecular Genetics 9 15631566 1999 Ebringer A BSE as an autoimmune disease Creutzfeldt http://www.kcl.ac.uk/kis/schools/life_sciences/life_sci/ebringerP.html

Department of Life Sciences Alan Ebringer Publications Selected Publications: 1999 Tiwana H, Wilson C, Alvarez A, Abuknesha R, Bansal S, Ebringer A Cross-reactivity between the rheumatoid arthritis associated motif EQKRAA and structurally related sequences found in Proteus mirabilis Infection and Immunity 1999 Tiwana H, Wilson C, Pirt S J, Cartmell W B, Ebringer A Autoantibodies to brain components and antibodies to Acinetobacter calcoaceticus are present in bovine spongiform encephalopathy (BSE) Infection and Immunity Ebringer A, Pirt J, Wilson C, Thorpe C, Cunningham P, Ettelaie C Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens? Environmental Health Perspectives 1998 Blankenberg-Sprenkels Sabine, Fielder M, Feltkamp TEW, Tiwana H, Wilson C, Ebringer A Antibodies to Klebsiella pneumoniae in Dutch patients with ankylosing spondylitis and acute anterior uveitis and to Proteus mirabilis in rheumatoid arthritis Journal of Rheumatology Further Publications: Ebringer A Molecular mimicry, mad cows and arthritis Science Spectra 19 46-53 2000 Ebringer A, Tiwana H, Wilson C Is rheumatoid arthritis a form of reactive athritis?

63. Alan Ebringer: Research A Antibody responses to gut bacteria in ankylosing spondylitis, rheumatoid arthritis in bovine spongiform encephalopathy (BSE) supports the autoimmune theory. http://www.kcl.ac.uk/kis/schools/life_sciences/life_sci/ebringerR.html

Department of Life Sciences Alan Ebringer Research ANKYLOSING SPONDYLITIS Related References: Ebringer Ebringer and Wilson (1996) The use of a low starch diet in the treatment of patients suffering from ankylosing spondylitis. Clin Rheumatol Vol.15. Suppl.2. Pg:62-66. Tani et al. (1997) Antibodies to Klebsiella, Proteus and HLA-B27 peptides in Japanese patients with ankylosing spondylitis and rheumatoid arthritis. Journal of Rheumatol Vol 24. Pg:109-114. CROHN'S DISEASE Related References: Tiwana et al. (1997) Antibody responses to gut bacteria in AS, RA, Crohn's disease and ulcerative colitis. Rheum Internat Vol.17. Pg:11-16. RHEUMATOID ARTHRITIS Biochemical studies demonstrated that RA patients had antibodies to both EQRRAA/ESRRAL sequences. Further molecular studies identified a second similarity sequence IRRET, present in Proteus urease which showed molecular mimicry with the LRREI sequence found in type XI collagen, a common component of hyaline cartilage. Since erosions of hyaline cartilage are frequently found in RA patients, especially in the small joints of the hands and feet, this could explain the localization of the pathological lesions in this disease to these sites. These results are consistent with the hypothesis that RA is an autoimmune reactive arthritis following infection of the upper urinary tract by Proteus mirabilis microbes.

64. Diffuse Idiopathic Skeletal Hyperostosis choose ankylosing spondylitis as your search term in the Rare Disease Database.) Rheumatoid Arthritis is also suspected of being an autoimmune disease. http://www.bchealthguide.org/kbase/nord/nord826.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord826"; var hwDocTitle="Diffuse Idiopathic Skeletal Hyperostosis"; var hwRank="1"; var hwSectionHWID="nord826"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Diffuse Idiopathic Skeletal Hyperostosis Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Diffuse Idiopathic Skeletal Hyperostosis DISH Spinal Diffuse Idiopathic Skeletal Hyperostosis Spinal DISH Vertebral Ankylosing Hyperostosis Forestier's Disease Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Osteoarthritis Spondylosis Ankylosing Spondylitis Rheumatoid Arthritis General Discussion The conversion of ligamental tissue to bone usually extends along the sides of the vertebrae of the spine. (This may be called flowing calcification.) Also, DISH is associated with inflammation (tendinitis) and calcification of the tendons, especially at the points at which the tendon attaches to the bones. When this happens, the patient is said to have developed bone spurs, especially in the heel and ankles (heel spurs). DISH affects three or more vertebrae that are most often located in the chest or in the spine between the chest and pelvis. It is a disorder of older patients, more often affecting men than women ages 50-60. The disorder is often found in association with diabetes, high blood pressure, heart disease and obesity.

65. Disease Types And Symptoms have ankylosing spondylitis or lupus. Are kids getting lumped into this JRA category as well? Medical editor s note These are both autoimmune diseases, with http://www.healthtalk.com/rheumatoidarthritis/talks/edition14/page02.cfm

Select a Condition Breast Cancer CLL Colon Cancer Crohn's Disease Lymphoma Multiple Myeloma Multiple Sclerosis Psoriasis Rheumatoid Arthritis Other Conditions Disease Types and Symptoms April 5, 2004 Gina: Would you tell us what the different types of juvenile rheumatoid arthritis are and what the symptoms are for each of them? Dr. Lehman: An equally common group is polyarticular (means many joints) JRA, and [this is composed of] children at almost any age up to 16, because if you are over 16, it is not called juvenile [rheumatoid arthritis] anymore. They start off with a large number of joints, five or more, and often they are much thicker at the beginning. [Medical editor's note: That is, the joint tissue, the synovium, is more inflamed (synovitis) and swollen, which can be felt on examination.] They have trouble opening their hands; it frequently involves the small joints of the hands and feet, as well as having troubles with the hips or the knees. They are stiff when they wake up in the morning [and] they often have difficulty walking. [It occurs] often [in] the older children, and you'll notice that not only do they have trouble when they are walking in the morning, but if you take them for a long car ride, they'll have trouble getting out of the car and they'll walk like a little old man, and then in five or 10 minutes, it will get better. These children have much more difficult to treat disease, and often disease that continues on the later life.

66. Department Of Medicine This form can be downloaded at http//www.dermatology.ucsf.edu/autoimmune/ and then Genetic Determinants of ankylosing spondylitis Severity Longitudinal Study http://medicine.ucsf.edu/rheum/research_clinical.html

University of California, San Francisco Department of Medicine School of Medicine Medical Center ... Search UCSF Rheumatology/Arthritis Division ***Note: Clinical research activities of the Rheumatolgy division can also be accessed through the Bio-sketches of the individual faculty M. Kari Connolly, M.D The UCSF Scleroderma Database and Tissue Bank The Scleroderma Lung Study Anti-TGFb in scleroderma patients Immune tolerance therapy in pemphigus patients John Davis, M.D Genetic Determinants of Ankylosing Spondylitis Severity (Longitudinal) Genetic Determinants of Ankylosing Spondylitis Severity (Cross-Sectional) The Use of Topical Tacrolimus in Cutaneous Manifestations of Lupus Effect of Enbrel (Etanercept) on Synovial Histology and MRI in Spondyloarthritis ... The Natural History, Pathogenesis, and Disease Analysis of Systemic Lupus Erythematosus Nancy Lane, MD Patients taking Glucocorticords (e.g. prednisone)

67. UK Wellness: Medical Conditions: Bio-medical: Ankylosing Spondylitis DEFINITION ankylosing spondylitis is an autoimmune disease that causes inflamation of the spine and sacroiliac joints and can cause inflammation of the eyes http://www.ukwellness.com/medical-conditions/biomechanical/ankylosing-spondyliti

Ankylosing Spondylitis Risk Click here for risk definitions Click here to find a qualified fitness trainer Click here to order the Self Help Guide 'Exercise and Back Pain' ... by Dr Allinson SNAPSHOT EXERCISE SUMMARY: Swimming is preferred, as it avoids jarring impact of the spine. Breaststroke is good for spinal extension. Running, tennis, golf, and athletics, but avoid contact sports. Daily stretching. DEFINITION: Ankylosing spondylitis is an autoimmune disease that causes inflamation of the spine and sacroiliac joints and can cause inflammation of the eyes, lungs, and heart valves. It varies from intermittent episodes of back pain that occur throughout life to a severe chronic disease that attacks the spine, peripheral joints and other body organs, resulting in severe joint and back stiffness, loss of motion and deformity as life progresses. A dramatic loss of flexibility in the lumbar spine is an early sign of AS. Although most symptoms begin in the lumbar and sacroiliac areas, they may involve the neck and upper back as well. Arthritis may also occur in the shoulder, hips and feet. As with many of the autoimmune diseases, many body systems can be effected in extreme cases. AT RISK: Ankylosing spondylitis typically starts as an insidious onset of back pain in the late teens or early twenties, and seems to effect men more than women. It is a genetically determined disease, susceptability to which is related to the presence of the HLA-B27 antigen in the patients' cells.

68. Lupus & R.A. mean period of time of 32.5 ± 24.8 months) in healthy subjects and in patients who suffer from autoimmune diseases and from ankylosing spondylitis or reactive http://www.vaccines.net/lupus.htm

Hepatitis B Immunization Linked to Autoimmune Rheumatic Diseases Two abstracts being presented at the 62nd Annual Meeting of the American College of Rheumatology (held November 8-12, 1998, in San Diego, California) link the development of autoimmune rheumatic diseases to immunization with hepatitis B vaccine. A recently published paper from Canada also links the development of rheumatic diseases to immunization with hepatitis B vaccine. In all cases immunization starting after 2 months of life was associated with autoimmunity while immunization starting at birth has not been linked to the development of autoimmunity. The development of rheumatoid arthritis after recombinant hepatitis B vaccination. Pope JE, Stevens A, Howson W, Bell DA Department of Medicine, the University of Western Ontario, London, Canada. J Rheumatol 1998 Sep;25(9):1687-93 OBJECTIVE: Hepatitis B vaccination has been associated with reactive arthritis and rarely rheumatoid arthritis (RA). We defined the clinical, serologic, and immunogenetic background of patients developing RA, soon after recombinant

69. Medical Research / NASC regions on at least two chromosomes implicated in ankylosing spondylitis (AS), stated HLADR gene also affects the predisposition to autoimmune diseases such http://www.spondylitis.org/MedicalResearch/nasc.aspx

Section Home Ankylosing Spondylitis (AS) Psoriatic Arthritis (PsA) Reactive Arthritis/Reiter’s Syndrome (ReA) ... News Central Sun, Jun 6, 2004 Back to Homepage Research Study About the AS Family Genetic Study This is an exciting time in research for ankylosing spondylitis (AS) and related diseases. To keep the momentum going we need the help of people like you to participate in research trials. By volunteering, you are becoming an advocate for continued research into treatment for AS. Visit our AS Family Genetic Study Site to see whether you are eligible to participate in the study. The real excitement is the discovery of regions on at least two chromosomes implicated in ankylosing spondylitis (AS), stated John D. Reveille, MD, the study's Principal Investigator, during the American College of Rheumatology Scientific Meetings in 2002. "We've known for some time that there were between two and nine additional genes involved in the predisposition to AS," Dr. Reveille said. "Without any question, the leader of the pack is HLA-B27. We've just picked up two more in line, but where they stand (as far as importance) is not clear. We believe that HLA-B27 is the biggest factor, these other genes influence the condition, interacting with each other to affect susceptibility.

70. Abbott Laboratories Press Releases (681) ankylosing spondylitis (AS), or arthritis of the spine, is an autoimmune disorder in which a human protein, tumor necrosis factoralpha (TNF-a), appears to http://abbott.com/news/releaseonly.cfm?id=681

71. Arthritis Research & Therapy | Full Text | B Lymphocyte Involvement In Ankylosin B, Fitzgerald O Immunohistologic analysis of peripheral joint disease in ankylosing spondylitis. VH gene segment overrepresented in the autoimmune repertoire http://arthritis-research.com/content/3/3/189

home issues articles reports ... Issue 3 Viewing options Abstract Full text PDF Other links: Cited on BioMed Central E-mail to a friend Download references Post a comment ... ISI Web of Science Search PubMed For Voswinkel J Weisgerber K Pfreundschuh M Gause A Key E-mail Corresponding author Research article B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection Jan Voswinkel Kerstin Weisgerber Michael Pfreundschuh and Angela Gause Arthritis Res The electronic version of this article is the complete one and can be found online at: http://arthritis-research.com/content/3/3/189 Received Revisions requested Revisions received Accepted Published Keywords: ankylosing spondylitis, B lymphocyte immunology, heavy chain genes, immunoglobulins, somatic mutations Outline Abstract Abstract Introduction Materials and methods Results ... References The synovial membrane (SM) of affected joints in ankylosing spondylitis (AS) is infiltrated by germinal center-like aggregates (foci) of lymphocytes similar to rheumatoid arthritis (RA). We characterized the rearranged heavy chain variable segment (VH) genes in the SM for gene usage and the mutational pattern to elucidate the B lymphocyte involvement in AS. Cryosections from an AS-derived SM were stained for B and T lymphocytes. B cells were isolated from different areas of a focus. The rearranged VH genes were amplified by semi-nested polymerase chain reaction (PCR) using oligonucleotides specific for the six different VH families and heavy chain joining segments (JHs). PCR products were cloned and sequenced.

72. PR Newswire - A United Business Media Company The safety and efficacy profile of entanercept in ankylosing spondylitis patients is consistent with other clinical data for related autoimmune conditions and http://www.prnewswire.co.uk/cgi/news/release?id=104263

73. Ann Rheum Dis -- Abstracts: Lakomek Et Al. 50 (11): 776 Download to Citation Manager. Annals of the Rheumatic Diseases, 1991, Vol 50, 776781. PAPERS. ankylosing spondylitis an autoimmune disease? http://ard.bmjjournals.com/cgi/content/abstract/50/11/776

HOME HELP FEEDBACK SUBSCRIPTIONS ... Email this link to a friend eLetters: Submit a response to this article Similar articles found in: Ann Rheum Dis Online PubMed PubMed Citation This Article has been cited by: other online articles Search PubMed for articles by: Lakomek, H. J. Schwochau, M. Alert me when: new articles cite this article Download to Citation Manager Annals of the Rheumatic Diseases, 1991, Vol 50, 776-781 PAPERS Ankylosing spondylitis: an autoimmune disease? HJ Lakomek, M Plomann, C Specker and M Schwochau Department of Medicine, Endocrinology and Rheumatology, Heinrich-Heine- Universitat Dusseldorf, Germany. Identification of several autoantibodies in serum samples from patients with ankylosing spondylitis or suspected ankylosing spondylitis is reported. Five antibodies associated with ankylosing spondylitis were identified by applying cytoimmunofluorescence and immunoblotting techniques to antigen pools from insect tissue. At least one of these antibodies was found in 82% of serum samples from patients with ankylosing spondylitis. A 36 kD drosophila antigen, which showed the most common and most dominant

74. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: Lupus Erythematosus; Dermatomyositis; Juvenile Rheumatoid Arthritis; autoimmune Diseases. Recruiting, Genetics of ankylosing spondylitis Conditions spondylitis http://www.clinicaltrials.gov/ct/gui/action/SearchAction?term=Rheumatoid Arthrit

75. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: Dermatomyositis; Juvenile Rheumatoid Arthritis; autoimmune Diseases. 37. Recruiting, Genetic Determinants of ankylosing spondylitis Severity Condition http://www.clinicaltrials.gov/ct/gui/action/SearchAction?term=Arthritis

76. Medical Encyclopedia interest since they are more common in certain autoimmune diseases. For example, HLAB27 is found in 80-90% of people with ankylosing spondylitis and Reiter´s http://www.medstarhealth.org/body.cfm?id=124&action=display&articlenum=3551

77. University Of Glasgow - Immunology - Max Field Our research involves investigating genetic predispositions to autoimmune disease as demonstrated in ankylosing spondylitis, as well as septic arthritis which http://www.gla.ac.uk/departments/immunology/people/field.htm

NEWS SUBJECTS PEOPLE EDUCATION ... POSITIONS AVAILABLE Max Field, BSc MD FRCP Senior Lecturer in Rheumatology Septic arthritis; Medical education; Genetics of autoimmune disease; Cytokines in synovitis. m.field@clinmed.gla.ac.uk Tel: +44 (0) 141 211 4688 Fax: +44 (0) 141 211 0414 Centre for Rheumatic Diseases, Level 3, QEB, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, MAIN AREA OF RESEARCH Our research involves investigating genetic predispositions to autoimmune disease as demonstrated in ankylosing spondylitis, as well as septic arthritis which may predispose to tissue disorders. BIOGRAPHY Dr Field graduated from University in London in 1977, undertook a clinical career initially in Oxford and subsequently joined the Charing Cross and Westminster University Medical School in London working as a lecturer in the Kennedy Institute of Rheumatology. Dr Field joined the Centre for Rheumatic Diseases in 1991. PROJECTS Septic Arthritis This clinically based project has assessed septic arthritis because this is one of the most rapidly destructive arthritic diseases known to man. We have been investigating mechanisms of this joint destruction and predisposition to infection.

78. Division Of Rheumatology  -  Fellowship Program autoimmune Diseases SLE/lupus, rheumatoid arthritis, scleroderma/systemic sclerosis, ankylosing spondylitis. Basic and Applied Research. http://depts.washington.edu/rheum/research.htm

R e s e a r c h Autoimmune Diseases (SLE/lupus, rheumatoid arthritis, scleroderma/systemic sclerosis, ankylosing spondylitis) Osteoarthritis, Osteoporosis and other Rheumatic Diseases Autoimmune Diseases - SLE/lupus, rheumatoid arthritis, scleroderma/systemic sclerosis, ankylosing spondylitis Basic and Applied Research Keith Elkon studies how dead and dying cells are processed in the body in lupus . In addition, he is investigating how cells grow and cause inflammation in rheumatoid arthritis and scleroderma Chyi-Song Hsieh studies the role of T regulatory cells in controlling autoimmunity. David Martin is investigating the mechanisms whereby nuclear antigens stimulate immune responses to self, such as anti-DNA antibodies in lupus J. Lee Nelson studies how tissue antigens such as HLA influence susceptibility to autoimmune diseases. In addition, she is investigating how transfer of cells between mothers and the fetus influence susceptibility to scleroderma and other diseases.

79. Interleukin 10 Polymorphisms In Ankylosing Spondylitis. promoter region have been implicated in many autoimmune diseases, including susceptibility to and clinical manifestations of ankylosing spondylitis (AS), a http://dreampharm.com/ginger/arthritis-research-abs.117.html

DreamPharm Products: Lutein-20 Milk thistle Saw palmetto Triple B Super Vision ... LaxaColon Genes Immun. 2003 Jan;4(1):74-6. Interleukin 10 polymorphisms in ankylosing spondylitis. Goedecke V, Crane AM, Jaakkola E, Kaluza W, Laiho K, Weeks DE, Wilson J, Kauppi M, Kaarela K, Tuomilehto J, Wordsworth BP, Brown MA. WellcomeTrust Centre for Human Genetics, Roosevelt Drive, Headington, Oxfordm UK. Sudden hair loss and baldness is a problem in many ways. Baldness is indeed becoming an increasing concern in the current aging society. Saw palmetto berry extract is the best known herb for hair loss problems in Western world. However, there are a number of anecdotal herbs that could stop hair loss and start hair growth . For clinically validated prescription medication, check Propecia. DreamPharm Rx stu DreamPharm Rx vwx DreamPharm Rx yza DreamPharm Herbal and Nutritional Supplements Online prescription medications Prescription medications online Constipation and Health ... E-Mail Us

80. Recent Developments In The Treatment Of Arthritis Arthritis has recently been recognized as an autoimmune process and treatment Arthritis 2.4.4 Treatment of Psoriatic Arthritis 2.5 ankylosing spondylitis 2.5.1 http://www.marketresearch.com/map/prod/751071.html

Search for Reports: Recent Developments in the Treatment of Arthritis Published by SMI Publishing, Ltd Jul. 1, 2001 Arthritis is a debilitating disease which largely affects older individuals. There are actually three distinct forms of arthritis: rheumatoid arthritis- a familial, autoimmune disorder; osteoarthritis- a disease which affects the weight-bearing joints; and arthritis related to pathogens which is a temporal disorder which arises as a result of injury or exposure to viruses, bacteria, or parasites. The incidence of arthritis is on the rise due to the aging of the population and also due to an increasing percentage of individuals who are overweight. This marketing report will address the progress in arthritis therapy that has been made in the last two years. Arthritis has recently been recognized as an autoimmune process and treatment for arthritis has changed accordingly. New therapies are in development which will treat the underlying cause of arthritis, rather than the symptoms. This report will address the trends in arthritis research and will prepare the healthcare executive to deal with them. This report will include such features as: background on the epidemiology, etiology, and pathogenesis of all three types of arthritis

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