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41. Autoimmune Disorders
ankylosing spondylitis. Immunesystem induced degeneration of the joints and soft tissue of the spine. Vasculitis. A group of autoimmune disorders in which the
http://www.arthritis-symptom.com/a-c/autoimmune-disorders.htm
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Autoimmune disorders
Definition of Autoimmune disorders
The word "auto" is the Greek word for self. The immune system is a complicated network of cells and cell components (called molecules ) that normally work to defend the body and eliminate infections caused by bacteria, viruses, and other invading microbes. If a person has an autoimmune disease, the immune system mistakenly attacks self, targeting the cells, tissues, and organs of a person's own body. A collection of immune system cells and molecules at a target site is broadly referred to as inflammation. There are many different autoimmune diseases, and they can each affect the body in different ways. For example, the autoimmune reaction is directed against the brain in multiple sclerosis and the gut in Crohn's disease. In other autoimmune diseases such as systemic lupus erythematosus (lupus), affected tissues and organs may vary among individuals with the same disease. One person with lupus may have affected skin and joints whereas another may have affected skin, kidney, and lungs. Ultimately, damage to certain tissues by the immune system may be permanent, as with destruction of insulin-producing cells of the pancreas in Type 1 diabetes mellitus.

42. Ankylosing Spondylitis - Healing With Herbs, Vitamins And Minerals.
Previous urinary or lung infections often affect ankylosing spondylitis. Vitamin E has also proven beneficial in this autoimmunerelated disease.
http://www.herbs2000.com/disorders/ankylosing.htm
Welcome to herbs 2000.com - Number one source of nutritional and traditional health care. herbs2000.com
Amino acids

Aromatherapy

Bach flower remedies
... Z Let herbs be your medicine and medicine be your herbs !
Ankylosing spondylitis
Ankylosing spondylitis is a type of arthritis that principally affects the spine. It typically strikes men between the ages of twenty and forty, developing over years with periods of progression and remission typical for many rheumatic illnesses. The first sign is often intense lower- back pain in the early morning in bed, with noticeable stiffness upon rising. During the day, the problem becomes hardly apparent. These attacks need not be severe in every case, and their length and number vary according to the individual. Early on, heel pain or an eye infection accompanies the back pain. Over time, Minerals deposit in the previously inflamed tissue around the spine, and the vertebrae fuse together to eventually cause what looks like a "bamboo spine," if its progression is not halted. Although it is not life-threatening, severe cases of ankylosing spondylitis cause a complete stiffening of the spine, preventing twisting of the body or neck, or bending of any kind. The body's own immune system attacks the soft tissue and the joints in the body. A strong genetic influence is linked to this illness, but, as in other types of arthritis, diet plays a role, and

43. Autoimmune Disorders
ankylosing spondylitis. Immune system induced degeneration of the joints and soft tissue of the spine. Vasculitis. A group of autoimmune disorders in which the
http://www.ehendrick.org/healthy/000172.htm
MAIN SEARCH INDEX
Autoimmune disorders
Definition
Autoimmune disorders are conditions in which a person's immune system attacks the body's own cells, causing tissue destruction.
Description
Autoimmunity is accepted as the cause of a wide range of disorders, and it is suspected to be responsible for many more. Autoimmune diseases are classified as either general, in which the autoimmune reaction takes place simultaneously in a number of tissues, or organ specific, in which the autoimmune reaction targets a single organ. Autoimmune disorders include the following:
  • Systemic lupus erythematosus . A general autoimmune disease in which antibodies attack a number of different tissues. The disease recurs periodically and is seen mainly in young and middle-aged women.
  • Rheumatoid arthritis . Occurs when the immune system attacks and destroys the tissues that line bone joints and cartilage. The disease occurs throughout the body, although some joints may be more affected than others. Goodpasture's syndrome. Occurs when antibodies are deposited in the membranes of both the lung and kidneys, causing both inflammation of kidney glomerulus (

44. Ankylosing Spondylitis Directory
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45. Juvenile Ankylosing Spondylitis
Some of these disorders, such as JAS, are autoimmune related and inherited in a multifactorial manner. Who is affected by juvenile ankylosing spondylitis?
http://www.chw.org/display/PPF/DocID/1651/router.asp
Juvenile Rheumatoid Arthritis Juvenile Ankylosing Spondylitis Psoriatic Arthritis Systemic Lupus Erythematosus (SLE, or Lupus) ... Common Types of Juvenile Arthritis and Other Rheumatic Diseases : Juvenile Ankylosing Spondylitis E-mail this page Print this page
Juvenile Ankylosing Spondylitis
What is juvenile ankylosing spondylitis? Juvenile ankylosing spondylitis (JAS) is a type of arthritis that affects the spine and the sites where the muscles, tendons, and ligaments are attached to bone. "Ankylosing" means stiff or rigid, "spondyl" means spine, and "itis" refers to inflammation. The disease causes inflammation of the spine and large joints, resulting in stiffness and pain. The disease may result in erosion at the joint between the spine and the hip bone (the sacroiliac joint), and the formation of bony bridges between vertebrae in the spine, fusing those bones. In addition, bones in the chest may fuse.
JAS is considered to be a multifactorial condition. Multifactorial inheritance means that "many factors" are involved in causing a health problem. The factors are usually both genetic and environmental, where a combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition. Often one gender (either males or females) is affected more frequently than the other in multifactorial traits. Multifactorial traits do recur in families because they are partly caused by genes. A group of genes on chromosome 6 code for HLA antigens play a major role in susceptibility and resistance to disease. Specific HLA antigens influence the development of many common disorders. Some of these disorders, such as JAS, are autoimmune related and inherited in a multifactorial manner. When a child has a specific HLA antigen type associated with the disease, he/she is thought to have an increased chance to develop the disorder. The HLA antigen associated with JAS is called B27. Children with the B27 HLA antigen are thought to have an increased chance (or "genetic susceptibility") to develop JAS; however, it is important to understand that a child without this antigen may also develop JAS. Individuals may have antigen and no disease. This means HLA antigen testing is not diagnostic or accurate for prediction of the condition. Males are affected with JAS three times more often than females.

46. Ankylosing Spondylitis And The Spondyloarthropathies By Drdoc On-line
The continued exposure of the antigen from such an organism, results in a autoimmune problem by molecular mimicry, rather than direct ankylosing spondylitis, 90
http://www.arthritis.co.za/ankspond.html
Spondyloarthropathy by drdoc on-line Index:
General :The Spondyloarthropathies

Ankylosing Spondylitis

Reactive arthritis

Reiter Syndrome
...
Enteropathic Arthropathy

Ankylosing Spondylitis
Reactive arthritis
Reiter Syndrome
Enteropathic Arthritis
Psoriatic spondyloarthropathy The Spondyloarthropathies are a group of disorders that share certain characteristics : 1. Arthritis - including peripheral arthritis and spinal involvement, usually involving also the sacroiliac joints. 2. They are Seronegative for Rheumatoid factor. 3. They may be involved with other medical problems - including... Psoriasis. Inflammatory bowel disease- ulcerative colitis or crohns disease. Post infective or reactive -to urogenital or gastrointestinal infections. Overlaps of these disorders may be seen. A strong genetic association with Class 1 HLA B27 gene (on chromosome 6) is described. Clinically they present with swelling of joints or an enthesopathy - inflammation of tendon insertions into bone. There is pain swelling and joint stiffness. The joint distribution depends on the subtype of the disease. Spinal involvement is characterised by sacroiliitis and inflammatory back pain. The latter consists of pain stiffness and progressive spinal restriction.

47. EMedicine - Ankylosing Spondylitis And Undifferentiated Spondyloarthropathy : Ar
A variant, ankylosing tarsitis, is described in children active disease, sacroiliitis and spondylitis are either are the only known autoimmune diseases linked
http://www.emedicine.com/med/topic2700.htm
(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Rheumatology
Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy
Last Updated: February 24, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: Marie-Strümpell disease, von Bechterew disease, von Bechterew's disease, spondyloarthropathies, SpAs, AS, rheumatoid spondylitis, UspA, peripheral enthesitis, sacroiliitis, Schober test, cauda equina syndrome, dactylitis, European Spondyloarthropathy Study Group criteria, Amor criteria, New York criteria, Rome criteria, Romanus lesion, bamboo spine, fused spine AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography
Author: Lawrence H Brent, MD , Chair, Program Director, Associate Professor, Department of Medicine, Division of Rheumatology, Albert Einstein Medical Center, Thomas Jefferson University Lawrence H Brent, MD, is a member of the following medical societies:

48. Ankylosing Spondylitis A View On Its Cause And Treatment
common. ankylosing spondylitis is not an autoimmune disease of the sort in which there are antibodies to our own tissues. It seems
http://www.ucl.ac.uk/~regfjxe/ANK.htm
Back to homepage
Ankylosing Spondylitis: A view on its cause and treatment
Professor Jonathan Edwards
First posted July 2001
under construction
Ankylosing spondylitis is a condition which can lead to pain and stiffening in the spine and also to inflammation in joints in the arms and legs. Recognising ankylosing spondylitis often takes time because it may be disregarded either by the person affected or their doctor as simple backache. However, with a detailed story of the person's symptoms and an x-ray of the sacroiliac joints a rheumatologist should be able to make a clear diagnosis. Blood tests are not very useful. The information given below is intended chiefly for people who have been told they have ankylosing spndylitis by their doctor and may want to know more about its cause and treatment.
What sort of a condition is ankylosing spondylitis?
Although ankylosing spondylitis was at one time thought to be a variant of rheumatoid arthritis it is now clear that the two conditions have little or nothing in common. Ankylosing spondylitis is not an autoimmune disease of the sort in which there are antibodies to our own tissues. It seems more likely that a "volume control" on the way certain cells of the immune system generate inflammation is set too high. It could be seen as due to an overenthusiastic security system within the body. This may have advantages. It may provide better than average protection against "burglars", which for the body means infections. However, it also means that alarms go off in the middle of the night for no good reason. The exact mechanism is not clear, but probably will be by 2004.

49. B Cells And T Cells In Autoimmunity
may well be important in ankylosing spondylitis (see ankylosing spondylitis webpage) but led in recent time to the suggestion that some autoimmune diseases are
http://www.ucl.ac.uk/~regfjxe/BandT.htm
B cells and T cells in autoimmunity: 2002
Immunologists are currently in the middle of a debate about which cells are responsible for autoimmunity, and, in particular the relative importance of B cells and T cells. This page explains how our research group at UCL looks at it in 2002. It is chiefly intended for those with some scientific knowledge but is written as simply as possible.
The general view of a normal immune response is that it initially involves T cells recognising a molecule as foreign. These T cells are divided into cytotoxic (TC) and helper (TH).
TC cells kill infected cells directly. There is not much evidence that anti-self TC cells ever cause problems, although anti-graft TC cells take part when a transplanted organ is rejected. TC cells may well be important in ankylosing spondylitis (see ankylosing spondylitis webpage) but there is no clear evidence that they are anti-self.
TH cells can both set up a defensive reaction directly and encourage B cells to make antibody to a foreign molecule. These two activities are often dubbed TH1 and TH2. Immune responses to microbes may show predominance of TH1 or TH2 features. This has led in recent time to the suggestion that some autoimmune diseases are "TH1 diseases" and some are "TH2 diseases". As will be discussed later this seems to be an entirely unhelpful approach. Looking at the evidence from autoimmune disease it becomes clear that something quite unlike a normal immune response is going on.
Some of the key differences between normal and autoimmune responses are as follows:

50. Ankylosing Spondylitis
ankylosing spondylitis. An autoimmune disease known to be associated with tissue type HLA B27, affecting facet joints between vertebrae; joints become inflamed
http://www.drlockie.com/disease/ankyl.htm
Ankylosing spondylitis An Autoimmune disease known to be associated with tissue type HLA B27, affecting facet joints between vertebrae; joints become inflamed, then stiff, effectively fusing vertebrae together, causing spine to become increasingly rigid. Condition usually starts in sacroiliac joint (joint between sacrum and ilium of pelvis) with low backache and morning stiffness; if stiffness progresses up spine, joints between ribs and spine may be affected, causing chest pain or breathing difficulties; if upper spine is affected, jaw and movement and even eyes may be affected. Orthodox treatment is physiotherapy, steroids or other anti-inflammatory drugs, and in severe cases surgery. Homeopathy offers constitutional treatment and, in the early stages, the remedy below. Specific remedy to be taken 3 times daily for up to 5 days
  • Pain around sacroiliac joint, aggravated by walking and stooping Aesculus 30c
Self-help Take Calcium Fluor . 3 times daily, and do some form of daily exercise - swimming is especially good. Deep breathing for several minutes each day will help to keep the joints between your spine and ribs mobile. Use a hard mattress, and sleep on your front without a pillow, rather than on your back or side; that way your spine can relax into its natural curve. Avoid prolonged sitting, especially driving; if you have a sedentary job, get up and walk about every 30 minutes or so. You should also do as little bending and lifting as possible. If you smoke, try to stop. Try the arthritis diet.

51. AllRefer Health - Uveitis (Anterior Uveitis, Chorioretinitis, Chroiditis, Iritis
The inflammation may be associated with autoimmune diseases such as rheumatoid arthritis or ankylosing spondylitis, but most cases occur in healthy people and
http://health.allrefer.com/health/uveitis-info.html
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Alternate Names : Anterior Uveitis, Chorioretinitis, Chroiditis, Iritis, Pars Planitis, Posterior Uveitis Definition Uveitis is an inflammation of the the uvea , the layer between the sclera and the retina , which includes the iris ciliary body , and the choroid
Eye
Visual Field Test Uveitis is an inflammation inside the eye, affecting the uvea. The uvea provides most of the blood supply to the retina. Causes of uveitis can include autoimmune disorders, infection, or exposure to toxins. However in many cases, the cause remains unknown. The most common form of uveitis is anterior uveitis, which involves inflammation in the front part of the eye, which is usually isolated to the iris. This condition is often called iritis. The inflammation may be associated with

52. AllRefer Health - HLA-B27 Antigen (Human Leukocyte Antigen B27) - Test/Medical E
interest since they are more common in certain autoimmune diseases. For example, HLAB27 is found in 80-90% of people with ankylosing spondylitis and Reiter s
http://health.allrefer.com/health/hla-b27-antigen-info.html
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You are here : AllRefer.com Health HLA-B27 Antigen
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Definition Why is the Test Performed? How is the Test Performed? How to Prepare for the Test? How will the Test Feel?
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Alternate Names : Human Leukocyte Antigen B27 Definition This is a blood test to detect the presence of HLA-B27 on lymphocytes (white blood cells). See also Histocompatibility antigens test. In the past, this test was performed using serum that specifically reacts with HLA-B27 on the cells (known as serologic tissue typing). Newer methods are now available that use genetic testing to identify the type of HLA-B27 in a particular individual. The HLA-B27 gene is designated as HLA-B*2701, HLA-B*2702, etc.
Blood Test Why is the Test Performed?

53. Hep C And Autoimmune Diseases
Subject Hep C and autoimmune Diseases Topic Area Hepatitis C Forum The Because I have juvenile rheumatoid arthritis and ankylosing spondylitis my doctor
http://www.medhelp.org/forums/hepatitis/messages/30222a.html
Questions in The Hepatitis Forum have been answered by
doctors from Henry Ford Health System. Subject: Hep C and Autoimmune Diseases
Topic Area: Hepatitis C
Forum: The Hepatitis Forum
Question Posted By: Nancy on Saturday, April 15, 2000
I was diagnosed with Hep C about 2 years ago, and genotyped 1b. Because I have juvenile rheumatoid arthritis and ankylosing spondylitis my doctor recommended I do not have Interferon treatment. Are there any other options at this point or do I just wait until another treatment becomes available? Are there any other drugs in clinical studies at this time? My ALT and AST's are in the 70's. Answer Posted By: HFHSM.D.-D.M. on Sunday, April 16, 2000
Dear Nancy:
I appreciate your question and I also imagine you are a little frustrated. I understand that you have hepatitis C and you are not an ideal candidate for interferon based therapies because of your juvenile rheumatoid arthritis and ankylosing spondylitis.
The first question, I have for you is: do you know what your liver biopsy shows. If you have a benign liver biopsy with little scarring or fibrosis, you might not want to do anything right now. Hepatitis C typically causes liver disease over decades and doesn’t even cause cirrhosis in half of infected individuals. Typically women who do not drink alcohol are likely to have relatively slow progressing disease.
One drug that is being used in clinical trials is a drug called interleukin-10 (IL-10). This is a drug that does not get rid of the virus but has anti-inflammatory activity that some liver specialist feel can slow the level of fibrosis in individuals with hepatitis C. Because it is anti-inflammatory or even immune-suppressing it might be safe in individuals with juvenile rheumatoid arthritis and ankylosing spondylitis. However, I think most of the studies looking at IL-10 in hepatitis C require a liver biopsy.

54. MedPix™ Radiology Teaching Files, Cases, And Medical Image Database - Cat_brows
Infection, Generalized expand Infection, NOS expand Infection, parasite expand Infection, viral collapse Inflammatory, autoimmune, image, ankylosing spondylitis.
http://rad.usuhs.mil/medpix/medpix.html?mode=cat_browse&table=card&expand=14

55. Gale Encyclopedia Of Alternative Medicine:
ankylosing spondylitis. Some naturopathic healers link the cause of AS to its autoimmune origins in food allergies and abnormal bowel function, sometimes
http://www.findarticles.com/cf_dls/g2603/0001/2603000161/p2/article.jhtml?term=

56. LookSmart - Article Search For " Ankylosing Spondylitis"
Herself.(why women may suffer from more autoimmune diseases) 5 pages approval of Enbrel for the treatment of ankylosing spondylitis - etanercept - Pipeline
http://www.findarticles.com/cf_dls/PI/search.jhtml?isp=FA&cat=ref&cat=health&key

57. Conditions And Diseases - Ankylosing Spondylitis Top Links
Notebook ankylosing spondylitis - Extensive information on the causes, pathology, clinical features, investigations and treatment of this common autoimmune
http://www.disease-resources.com/Top_Health_Conditions_and_Diseases_Musculoskele
Sub Categories
Related Healthcare Subjects Disabilities Environmental Health Fitness Health Insurance ... Men's Health
Ankylosing Spondylitis Web Site Links Spondylitis Association of America Provides free access to peer-networking via bulletin boards, chat, "ask the experts", support groups and educational materials. Membership available.
National Ankylosing Spondylitis Society - UK
Information and support online along with addresses for other societies worldwide.
AS Support Group
For people who suffer with ankylosing spondyitis and all the other ailments that come with it. Offers communication, medical and support centers.
Washington University
Description of ankylosing spondylitis, and ideas for reducing symptoms.
Enable Center
Support and information for Ankylosing Spondylitis and other musculoskeletal conditions.
An AS Story
The personal experiences of living with Ankylosing Spondylitis, what it is and the reality of living with it.
Ankylosing Spondylitis Scientific Research
Cross between nutrient and disease associations, scientific research information. Includes nutrient and lifestyle options and medical options and precautions.
Ankylosing Spondylitis International Federation
World-wide roof organization, lists addresses and additional data of self-help societies of patients suffering from AS or related diseases in 30 countries.

58. Genetic Test For Ankylosing Spondylitis - Isis Innovation Licensing Opportunity
of Musculoskeletal Sciences have identified a number of genetic variations associated with the autoimmune disease ankylosing spondylitis which constitute an
http://www.isis-innovation.com/licensing/1326.html

Introduction
New Technologies Agricultural Chemistry (Industrial) ... Technology Search
Project Number Genetic Test For Ankylosing Spondylitis
Researchers at Oxford University's Institue of Musculoskeletal Sciences have identified a number of genetic variations associated with the autoimmune disease Ankylosing Spondylitis which constitute an accurate diagnostic for the disease.
Background
Ankylosing spondylitis (AS) is the prototype for a variety of diseases known collectively as the seronegative spondyloarthropathies. Other diseases in this group include Reiter's syndrome (RS), reactive arthritis, and other inflammatory diseases such as psoriatic arthritis, arthritis associated with inflammatory bowel disease, and acute anterior uveitis (AAU). Currently there is no single diagnostic test for AS and diagnosis is frequently delayed for several years after presentation of symptoms. HLA-B27 is a major histocompatibility complex (MHC) antigen strongly associated with spondyarthropathy. 96% of patients with AS are HLA B27-positive; the incidence is slightly lower in other spondyloarthropathies. However, conventional HLA B27 testing is not a useful screening or diagnostic test, because the antigen is present in 6-9% of the UK Caucasian population.
Oxford Invention
Oxford researchers have identified polymorphisms within particular genes in the interleukin-1 gene region of chromosome 2 associated with AS. The discovery is based upon 227 sibling-pair families and 317 parent case trios, all Caucasian. These genes can be used for detecting whether a subject has or is genetically predisposed to a seronegative spondyloarthropathy. Such a test would also assist in diagnosis of a patient showing seronegative spondyloarthropathy symptoms.

59. Autoimmune Diseases / Family Village
Diseases This group is for people with autoimmune diseases like nodosa,progressive systemic sclerosis, Alopecia Areata,ankylosing spondylitis,Behcet s Disease
http://www.familyvillage.wisc.edu/lib_auto.htm
Autoimmune Diseases
Who to Contact
Where to Go to Chat with Others

Learn More About It

Web Sites
...
Search AltaVista for "Autoimmune"
Who to Contact
American Autoimmune Related Diseases Association, Inc. (AARDA)
22100 Gratiot Ave.
Eastpointe
E. Detroit, MI 48021
800-598-4668 (Literature Requests)
Website: http://www.aarda.org/
Dedicated to the eradication of autoimmune diseases and the alleviation of suffering and the socioeconomic impact of autoimmunity through fostering and facilitating collaboration in the areas of education, research, and patient services in an effective, ethical and efficient manner.
Where to Go to Chat with Others
  • Autoimmunity
    The Autoimmune Conditions Group Most of these conditions are fairly rare. Seeking help and support is NOT easy, but it is available.
  • Living with Autoimmune Diseases This group is for people with autoimmune diseases like Lupus, Fibromyalgia, Arthritis, MS, Raynaud's Phenomenon, Narcotizing Vasulitis, Celiac Diseas(SPRUE)Peroarteritis nodosa,progressive systemic sclerosis, Alopecia Areata,Ankylosing Spondylitis,Behcet's Disease, Chronic Fatigue Syndrome, Crohn's Disease, Myasthenia Gravis, Psoriasis, Scleroderma, Juvinile Dermatomyosistis, Granulomatous Angiitis of the Central Nervous System(GACNS), Hashimoto's Disease, etc.
  • Teens Autoimmune This is a group for teens suffering from different autoimmune disorders/disease. Please feel free to join. It is open to anyone from ages 10-25.

60. Ankylosing Spondylitis : Information For Health Professionals And Interested Lay
ankylosing spondylitis, Patent List (when available) for ankylosing spondylitis 6,417,219 Hetero and preventing body weight wasting in autoimmune disease by
http://www.health.xq23.com/arthritis/Ankylosing_spondylitis.html
Ankylosing spondylitis : Information for health professionals and interested laypersons on Arthritis, Osteoarthritis, and Rheumatoid Artheritis.
Recommended References and Products. [see index for total category]
Books:

Ankylosing Spondylitis: The Facts (The Facts Series)
by Muhammad Asim Khan
The Spondylarthritides
by Andrei Calin
HLA-B27 in the development of spondyloarthropathies
by R.G. Landes
Molecular Pathogenic Mechanisms of Spondyloarthropathies (Medical Intelligence Unit)
by Luis R. Espinoza
Farlige menn i hvitt? : [En pasients opptegnelser]
by Thorstein Jakobsen
Spondyloarthropathies, Involvement of the Gut: Proceedings (International Congress Series, No 720)
by H. Mielants
Ankylosing spondylitis
by Churchill Livingstone
Ankylosing Spondylitis (New Clinical Applications Rheumatology)
by John J. Calabro Ankylosing spondylitis : discussions in patient management by Andrei Calin PUBMED Citations: Software: Innovations and emerging technologies in Ankylosing spondylitis, Patent List (when available) for Ankylosing spondylitis: 6,417,219: Hetero-substituted cyclic amine metalloprotease inhibitors

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