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         Albinism Genetics:     more detail
  1. Albinism: An entry from Thomson Gale's <i>Gale Encyclopedia of Genetic Disorders, 2nd ed.</i> by Melissa Knopper, 2005
  2. Griscelli syndrome: An entry from Thomson Gale's <i>Gale Encyclopedia of Genetic Disorders, 2nd ed.</i> by Sonya Kunkle, 2005
  3. Hermansky-Pudlak syndrome: An entry from Thomson Gale's <i>Gale Encyclopedia of Genetic Disorders, 2nd ed.</i> by Suzanne, MS, CGC Carter, 2005

81. Rick Guidotti - About POSITIVE EXPOSURE
community worldwide. albinism is a genetic condition that reduces oreliminates pigmentation in the skin, hair and eyes. Insults, fear
http://www.rickguidotti.com/about.htm

About

What is POSITIVE EXPOSURE? What does POSITIVE EXPOSURE do? Why is POSITIVE EXPOSURE needed? What has POSITIVE EXPOSURE accomplished so far? POSITIVE EXPOSURE has a unique focus on albinism. Why albinism? Is POSITIVE EXPOSURE working with other genetic onditions? What are the next steps? How can I find out more? What is POSITIVE EXPOSURE? POSITIVE EXPOSURE is a not-for-profit, 501(c)(3) organization whose innovative programs challenge the stigma associated with difference and celebrates the richness of genetic variation with positive images and powerful life stories. The program is a unique partnership between visual arts, genetics, mental health and human rights driven by former fashion photographer Rick Guidotti and Diane McLean, MD, PhD, MPH. BACK TO TOP OF PAGE
What does POSITIVE EXPOSURE do? Utilizing photography and video interviews, POSITIVE EXPOSURE investigates the social and psychological experiences of people living with genetic, physical and mental health conditions of all ages and ethnocultural heritages. POSITIVE EXPOSURE attacks public fears about difference with positive images and powerful life stories. POSITIVE EXPOSURE constructs a mirror that simultaneously reflects society's injustices and potentials, developing practical methods that demonstrate how personal transformation and social transformation are inextricably intertwined.

82. CRL-Rodent Genetics And Genetic Quality Control For Inbred And F1 Hybrid Strains
Mendelian Inheritance Mouse Coat Color genetics. In mice, the mutant allele foralbinism is a recessive gene designated c. The dominant wild type allele for
http://www.criver.com/techdocs/rodent1.html
FALL 1991 Rodent Genetics and Genetic Quality Control
for Inbred and F Hybrid Strains,
Part I The best animals for research are those free of adventitious infections shown to cause disease or alter research findings. For certain types of research, animals with stable, identifiable, genetically determined characteristics are also essential. This document reviews the development of such animals by selection and inbreeding, defines basic genetic terms and concepts, and describes how breeders prevent and detect genetic contamination. It ends with an introduction to genetic quality control, including a brief discussion of colony management. Genetic monitoring, the main component of quality control, is detailed in the 1992 document, Part II of this series. The subject of transgenics is covered in other issues.
Selection
Identifiable changes from the norm arise spontaneously. Visible changes (e.g., allopecia, a change in coat color, or obesity) may or may not be associated with invisible changes. For example, two years after Flanagan discovered the nude mouse in 1966 ( Genet. Res.

83. CRL-Rodent Genetics And Genetic Quality Control For Inbred And F1 Hybrid Strains
albino D/d=nondilute/dilute Identifying biochemical markers to develop allelic profiles.The principal procedure used at Charles River is biochemical genetic
http://www.criver.com/techdocs/rodent2.html
WINTER 1992 Rodent Genetics and Genetic Quality Control
for Inbred and F Hybrid Strains,
Part II Genetically defined rodent strains with stable, identifiable phenotypes have played a central role in the advances made in biomedical research. Such strains have been developed by selection and inbreeding, as was discussed in the fall 1991 document (Part I of this two-part series). That Bulletin also defined basic genetic terms, introduced the concept of genetic quality control, and reviewed the role of colony management in detection and prevention of subline divergence. This document addresses the important role of genetic monitoring, especially the monitoring of qualitative biochemical and immunological markers. Routine genetic monitoring is necessary to detect genetic contamination, the most important cause of subline divergence. Ideal markers for monitoring display simple Mendelian inheritance. They have a phenotype that is not altered by environmental factors but corresponds to the genotype. Markers should be monitored on chromosomes or linkage groups found throughout the genome. Alleles should be codominant so homozygotes and heterozygotes can be distinguished.
Skin Grafting
Skin grafting is a classical and still essential technique for characterizing inbred strains. It was developed in the 1950s by Billingham and others to detect histocompatibility differences. As histocompatibility (H) is determined by several hundred H genes found on virtually every chromosome, skin grafting reveals subline divergence due to mutation as well as to genetic contamination. Acceptance of reciprocal skin grafts, or isohistogenicity, indicates that animals are isogeneic. Isohistogenicity can therefore be used to define a strain as inbred. Various type of grafts can be performed:

84. Geckogenetics
Tremper Albino Leopard Gecko genetics Pictures of Tremper Albinos.Bell Albino Leopard Gecko genetics; Rainwater/Vegas Albino Leopard
http://www.compusmart.ab.ca/kbush/geckogenetics.htm
T h e G e c k o G e n e t i c s P a g e s D E F I N I T I O N I N F O R M A T I O N B E G I N N E R S S T A R T H E R E A U T O S O M A L R E C E S S I V E M U T A T I O N S

85. AngelfishBR
One of these was based on albino genetics and the various color forms thatmight be obtained. See my other page on Albino Angels of Many Colors.
http://home.fuse.net/fishfarmer/angelfishBR.html
Angelfish Breeding Report
I have been breeding angelfish since the late 1980's for sale to local pet shops. Along with this I have conducted various genetic experiments in order to produce new color varieties. One of these was based on albino genetics and the various color forms that might be obtained. See my other page on Albino Angels of Many Colors Along the way, I have learned many things about breeding angelfish that I will include in this report. Small angels typically for sale in pet stores are probably from 6 weeks to 3 months old. While this may seem like a wide range, it results from the variety of conditions that they may have come from. If baby angelfish are raised under ideal conditions they can reach saleable size (dime to nickel sized body) in 6 weeks. Under less ideal conditions they can take 12-16 weeks to reach the same size. Ideal conditions are at least 3 or more feedings per day of a variety of foods, daily water changes and a stocking density of 1-2 fish per gallon. Good foods for newly swimming fry up thru 3 weeks old, include microworms and baby brine shrimp. By a week old, addition of powdered flake foods is a good idea and by 3-4 weeks of age frozen brine shrimp is another food to add to their diet. Angelfish (Pterophyllum Scalare or Leopoldi-ongoing debate but probably a mixture, another more difficult species is the Altum) originated from South America living in soft acid water conditions. Spawnings of these wild fish required duplicating these conditions in the aquarium. The fry from the aquarium breedings were easier to breed and thru the generations they have become much more tolerant of various water conditions. I have bred them in water as hard as 400ppm hardness with pH's ranging upwards of 7.8. They do best with temperatures between 78-82F. One of the watch outs is that continuously breeding related angelfish can lead to weakening of the strain. Watchouts, include smaller egss/fry, loss or mishapenment of the two "feeler" fins and other defects in body shape.

86. Brief Coat Color Genetics
References and/or other genetics sites Mildred Adams. Recessive mutations found inthe chinchilla Violet (vi) Sapphire (s) Albino (a) Stone White (sw) Wellman
http://www.blueflagfarms.com/genetics.htm
Some aspects of coat color genetics in the chinchilla.
References and/or other genetics sites:
Mildred Adams

Dominant genes (simple Mendelian) express themselves over another gene in both the homozygous and heterozygous states. Recessive genes (simple Mendelian) are only expressed when in the homozygous state. Dominant mutations found in the chincihilla:
Beige (Be) - aka: Tower Beige
Wilson White (W)
Mosaic and Silver: crossover mutation of white may yield mosaic or silver coloration
TOV (Bl) - aka: Black Velvet, Gunning Black ; TOV = Touch of Velvet Accumulative
Ebony Recessive mutations found in the chinchilla:
Violet (vi)
Sapphire (s)
Albino (a) Stone White (sw) Wellman Beige (g) Phenotype Genotype Standard Gray bebe blbl ww SS AA ViVi Heterozygous Beige - eye typically is deep red/brown. Be be blbl ww SS AA ViVi Homozygous Beige - lighter than the hetero beige (more of a cream), eye is typically red with an opalescent ring surrounding pupil. BeBe blbl ww SS AA ViVi White - lethal factor so is never seen in the homozygous state (WW), cross-over and linkage explains the appearance of mosaics and silvers (also Ww).

87. Genetics And Inheritance
Albino individuals must be extremely careful about skin cancer and sunburn becauseof Most people have very limited knowledge of genetics in general, and do
http://www.dartmouth.edu/~cbbc/courses/bio4/bio4-1997/01-Genetics.html
Genetics and Inheritance
Edited notes by Jill Hunter (1996) and Rita Mitchell (1997)
Other topics in this lecture: Linkage Pedigree Analysis Autosomal Dominant Inheritance Genetic Counseling
Gregor Mendel
Gregor Mendel's research with genes and the way they work was the main starting point towards future research in the field of genetics. Mendel first entered a monastery in order to "free [himself] from the bitter struggle for existence." The Abbot of this monastery had an interest in plant breeding- particularly pea plants - and organized a course in crossbreeding during Mendel's first year at the monastery. Mendel was intrigued by the results of crossbreeding. After his participation in the Abbot's course, he left the monastery to study math and physics at the University of Vienna. Two years later he returned to the monastery, where he began his own experiments with pea plants. In 1865, Mendel published the paper " Experiments in Plant Hybridization ", which appeared in the journal of a local natural history society. This paper showed that each organism has physical traits that correspond to invisible elements within the cell . These invisible elements, which we now call genes

88. Albino Bluebirds
When I taught med school genetics, I had some slides showing albinoHopi native Americans, AfricanAmericans, and circus performers.
http://www.bestofbbml.audubon-omaha.org/albino.htm
Welcome to The Bluebird Box since 1995
Best of Bluebird Mailing Lists Classified
Albino Bluebirds
Date: Wed, 10 May 2000 12:44:34 EDT
From: KCBSP"at"aol.com
To: BLUEBIRD-L"at"cornell.edu
Subject: White Bluebirds have vanished Kathy Clark
New Cumberland, PA Hello! I thought I'd give the fella a call about the white birds. They were around last winter, but it seems nobody has seen them for a few months now. I just thought I'd let the list know. I was hoping they were still around. Nobody really knows what became of them. If they are seen again or there are anymore birds seen they promised to call. ... Date: Wed, 10 May 2000 13:06:17 -0400 (EDT)
From: Barry Whitney barryw"at"therock.mcg.edu
To: KCBSP"at"aol.com
Cc: Bluebird-L"at"cornell.edu
Subject: Re: White Bluebirds have vanished On Wed, 10 May 2000 KCBSP"at"aol.com wrote:

89. ThirdAge - Adam - Albinism
decreased visual acuity; functional blindness. Signs and tests The most accurateway to determine albinism and the specific type is genetic testing.
http://www.thirdage.com/health/adam/ency/article/001479.htm
Activities Games Health Horoscopes ... Prevention
Albinism
Definition: Albinism refers to a group of related conditions. These conditions are the result of altered genes that cause a defect of melanin production. This defect results in the partial or full absence of pigment from the skin, hair, and eyes.
Alternative Names: Hypopigmentation; Oculocutaneous albinism; Ocular albinism
Causes, incidence, and risk factors: An amino acid called tyrosine is normally converted by the body to the pigment melanin . Albinism results when the body is unable to produce or distribute melanin because of one of several possible defects. In particular, defects in the metabolism of tyrosine leading to failure to convert it into melanin, can cause albinism.
Albinism appears in different forms and may be inherited by one of several modes: autosomal recessive, autosomal dominant, or X-linked. Complete albinism involves a total absence of pigment from the hair, eyes, and skin (this is also called tyrosinase-negative oculocutaneous albinism). It is the most severe form of the condition. Affected people may appear to have hair, skin, and iris color that are white as well as vision defects. They also have photophobia (sunlight is painful to their eyes), they

90. Vision Of Children - Childhood Blindness And Vision Impairment: Research Updates
Summary of Nature genetics Paper Identification of the Gene for Ocular AlbinismType 1 (1995). UPDATE FROM TELETHON INSTITUTE OF genetics AND MEDICINE (2000).
http://www.visionofchildren.org/research.html
UPDATE FROM TELETHON INSTITUTE OF GENETICS AND MEDICINE (2000) Andrea Ballabio M.D.,
Director, Telethon Institute of Genetics and Medicine (TIGEM),
Naples, Italy
Back to top SUMMARY OF NATURE GENETICS PAPER (1999): Recent Results On The Causes of Ocular Albinism Type 1 Open New Perspectives In Biology And Medicine.
The results of this study have been published in the September 1999 issue of Nature Genetics (Schiaffino, M.V., D'Addio, M., Alloni, A., Baschirotto, C., Valetti, C., Cortese, K., Puri, C., Bassi, M. T., Colla, C., De Luca, M., Tacchetti, C. and Ballabio, A.: Ocular Albinism: evidence for a defect in an intracellular signal transduction system Nature Genetics, 1999; vol. 23

91. Vision Of Children - Second Annual World Symposium On Ocular Albinism
established by Sam and Vivian Hardage of Rancho Santa Fe lead to the discovery ofthe gene which causes the disease Ocular albinism and a genetic test for the
http://www.visionofchildren.org/news/031902.html

Back to News Main Page
Foundation sponsors research to cure childhood blindness and vision disorders. Twenty-one scientists attended the symposium representing such institutions as University of California at San Diego, UCLA, UCSB, USC, University of Pennsylvania, Baylor College of Medicine in Houston, NYU School of Medicine and two institutions in Italy, the Telethon Institute of Genetics and Medicine in Naples and the Scientific Institute San Raffaele in Milan. In addition, Peter A. Dudley, Ph.D., the Director of the Retinal Diseases Program at the National Eye Institute attended. The symposium allowed researchers to share and discuss progress they have made in better understanding the causes of childhood hereditary blindness and vision disorders since the first symposium held in April of 2000. In addition, new attendees were able to present research relating to vision disorders, increasing the number of scientific presenters to two times that of the first symposium. "We were thrilled to have so many scientists involved in cutting edge vision research come together to present and discuss their scientific discoveries. Each discovery brings us closer to finding a cure for childhood vision disorders and blindness," said Vivian Hardage of Rancho Santa Fe, a founder of the Vision of Children Foundation. Research supported by The Vision of Children Foundation established by Sam and Vivian Hardage of Rancho Santa Fe lead to the discovery of the gene which causes the disease Ocular Albinism and a genetic test for the disease. The foundation continues to support ongoing vision research and promotes interaction of the scientific community by hosting the World Symposium on Ocular Albinism.

92. Health Encyclopedia
Decreased visual acuity; Functional blindness. Signs and Tests. The most accurateway to determine albinism and the specific type is genetic testing.
http://healthcontent.baptistregional.com/adamcontent/ency/article/001479.asp
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Disease
Injury ... Test
Albinism
Nevus, halo

Overview
Symptoms Treatment ... Prevention
Alternate Names
Hypopigmentation; Oculocutaneous albinism; Ocular albinism
Definition
Albinism refers to a group of related conditions. These conditions are the result of altered genes that cause a defect of melanin production. This defect results in the partial or full absence of pigment from the skin, hair, and eyes.
Causes and Risk
An amino acid called tyrosine is normally converted by the body to the pigment melanin. Albinism results when the body is unable to produce or distribute melanin because of one of several possible defects. In particular, defects in the metabolism of tyrosine leading to failure to convert it into melanin, can cause albinism.
Albinism appears in different forms and may be inherited by one of several modes: autosomal recessive, autosomal dominant, or X-linked inheritance. Complete albinism involves a total absence of pigment from the hair, eyes, and skin (this is also called tyrosinase-negative oculocutaneous albinism). It is the most severe form of the condition. Affected people may appear to have hair, skin, and iris color that are white as well as vision defects. They also have photophobia (sunlight is painful to their eyes), they sunburn easily, and do not tan.

93. GEMdatabase - Browse Titles
Oculocutaneous albinism Type 1 This review focuses on the diagnosis, management,and genetic counseling of patients and families with oculocutaneous albinism.
http://www.gemdatabase.org/GEMDatabase/BrowseTitles.asp?curpage=29

94. Search Health Information
Decreased visual acuity; Functional blindness. Signs And Tests. The most accurateway to determine albinism and the specific type is genetic testing.
http://www.ihsdesmoines.org/body.cfm?id=692&action=detail&AEProductID=AdamEncy&A

95. Rep
by Nerd were bred together by Ralph Davis in 2001 and a clutch of four produced allLavender Albino babies proving this mutation to be genetic For Pictures
http://www.reptimania.co.uk/albinoball.htm
Home GENETICS Genetics Articles Reptile Morphs Morph Forum Mutation Survey Morphamania Species Information Genetics Encyclopedia Vivarium DIY Classified Forum Suggested Reading ... Your Account
l Paradox Albino
Photo Ralph Davis
Albino Caramel
Photo NERD Lavender Albino
Photo NERD White Smoke Albino
Photo NERD Caramel Glow Albino
Photo NERD eft Reptile Morphs Albino Ball Python
Updated 30.11.03
Albino Morphs Albino Morphs Albino Lavender Albino Caramel White Smoke Faded Albino Hi Contrast Albino Caramel Glow Paradox Albino Ball Python Morphs
Click Thumbnail Samples for Photo of that Morph Albino Ball Pythons are what has made this species so popular, Amelanistic T- (tyrosinase negative) were the first to emerge in the hobby some 12 years ago, since then several other lines have been produced. One of the most recent and surely the most spectacular looking is the oddity labeled the Paradox Albino. Not all of these morphs have been proven to be genetic a

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